mycophenolic-acid has been researched along with Intestinal-Obstruction* in 2 studies
2 other study(ies) available for mycophenolic-acid and Intestinal-Obstruction
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IgG4-related sclerosing disease of the small bowel presenting as necrotizing mesenteric arteritis and a solitary jejunal ulcer.
Since first described in the mid 1990s, there has been burgeoning literature on IgG4-related sclerosing disease. The number of sites that may be involved is ever increasing, with the pancreas, salivary glands, and lymph nodes being the most commonly affected organs. There are no well-documented cases arising in the gastrointestinal tract. In this report, we present the first case to our knowledge of IgG4-related sclerosing disease involving the small bowel with a distinctly unusual clinicopathologic presentation. A previously well 46-year-old woman presented with a 2-year history of intermittent abdominal pain with recent worsening due to small bowel obstruction. Following imaging, which showed jejunitis with surrounding mesenteric inflammatory changes, she proceeded to a segmental small bowel resection. The resected jejunum revealed an isolated, stenosing chronic ulcer associated with a necrotizing mesenteric arteritis. A transmural inflammatory infiltrate rich in IgG4 plasma cells was seen in the wall of the bowel and mesenteric artery. Abundant IgG4 interfollicular plasma cells were also identified in a mesenteric lymph node. The serum IgG4 level was elevated at >800 mg/dL (reference range 8 to 140 mg/dL). Although phlebitis is an almost constant feature of this disease, arteritis is not described other than in the lung and aorta. In this report, we also discuss the diagnostic pitfalls and the differential diagnoses that should be considered when this condition arises in the gastrointestinal tract. Topics: Anti-Inflammatory Agents, Non-Steroidal; Autoimmune Diseases; Biomarkers; Chronic Disease; Diagnosis, Differential; Female; Humans; Immunoglobulin G; Intestinal Obstruction; Jejunal Diseases; Jejunum; Mesenteric Arteries; Middle Aged; Mycophenolic Acid; Plasma Cells; Polyarteritis Nodosa; Prednisolone; Sclerosis; Treatment Outcome; Ulcer | 2012 |
Successful treatment of encapsulating peritoneal sclerosis with immunosuppressive therapy.
Encapsulating peritoneal sclerosis is a rare, but potentially lethal, complication of peritoneal dialysis. Treatment of patients with encapsulating peritoneal sclerosis is controversial. Conservative treatment carries a poor outcome, and immunosuppressive drugs are now used frequently. Most commonly, these immunosuppressive regimens include steroids with or without azathioprine or cyclosporine. Mycophenolate mofetil is a reversible DNA synthesis inhibitor that frequently replaces azathioprine in renal transplantation because of its improved immunosuppressive potency and better side-effect profile. We report 3 cases of encapsulating peritoneal sclerosis in continuous ambulatory peritoneal dialysis patients for which an association of prednisone and mycophenolate mofetil significantly modified the evolution of the disease. All 3 patients showed significant improvement within a month and are still alive more than 2 years after the diagnosis of encapsulating peritoneal sclerosis. None experienced a relapse or abdominal symptoms, and body weights are stable. This is the first report of 3 cases of successful treatment of patients with encapsulating peritoneal sclerosis with prednisone and mycophenolate mofetil. Topics: Adult; Anti-Inflammatory Agents; Ascites; Ascitic Fluid; Candida glabrata; Candidiasis; Female; Fibrosis; Humans; Immunosuppressive Agents; Intestinal Obstruction; Intestine, Small; Middle Aged; Mycophenolic Acid; Peritoneal Dialysis, Continuous Ambulatory; Peritoneal Diseases; Peritoneum; Peritonitis; Prednisone; Sclerosis; Staphylococcus epidermidis | 2008 |