mycophenolic-acid and Esophagitis

Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antineoplastic Agents; Cathartics; Colchicine; Contraceptives, Oral; Diuretics; Ergotamine; Esophagitis; Humans; Imidazoles; Intestinal Diseases; Ion Exchange Resins; Iron; Laxatives; Mycophenolic Acid; Olmesartan Medoxomil; Stomach Diseases; Tetrazoles

Topics: Amyloid Neuropathies, Familial; Esophageal Stenosis; Esophagitis; Female; Heart Transplantation; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Liver Transplantation; Middle Aged; Mycophenolic Acid; Prednisone; Tacrolimus

Topics: Aged; Esophagitis; Esophagoscopy; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Mycophenolic Acid; Transplant Recipients

Topics: Adult; Esophagitis; Esophagoscopy; Female; Humans; Hydrocortisone; Mycophenolic Acid; Pemphigus; Ranitidine

Topics: Biopsy, Needle; Drug Therapy, Combination; Endoscopy, Digestive System; Esophagitis; Female; Fluorescent Antibody Technique, Direct; Follow-Up Studies; Humans; Immunohistochemistry; Middle Aged; Mouth Mucosa; Mycophenolic Acid; Pemphigus; Prednisolone; Risk Assessment; Treatment Outcome

To describe a case in which a patient developed Candida esophagitis (CE) after treatment of atopic dermatitis (AD) with mycophenolate mofetil (MMF) for 22 months.. A 59-year-old Caucasian female with long-standing history of AD successfully treated with MMF presented to the dermatology clinic for follow-up appointment with 3 months' history of projectile vomiting, choking, and trouble swallowing. Patient underwent esophagogastroduodenoscopy (EGD) that demonstrated whitish plaques in esophagus consistent with CE, which was confirmed by biopsy and cytology.. MMF is a lymphocyte selective immunosuppressive agent that has demonstrated very good therapeutic effects against cutaneous inflammatory skin disease and proved to have good efficacy and bioavailability. Generally, MMF is a safe medication with relatively low side effects. There are no case reports to date that describe CE in patients treated with MMF. Clinicians should be aware of this rare complication to enable timely intervention and treatment.

J Drugs Dermatol. 2016;15(10):1267-1269.

Topics: Candida; Candidiasis; Dermatitis, Atopic; Enzyme Inhibitors; Esophagitis; Female; Humans; Middle Aged; Mycophenolic Acid

We report a case of herpes esophagitis in a 35-year-old man with pemphigus vulgaris (PV) who was undergoing treatment with corticosteroids and mycophenolate mofetil (MMF). Pemphigus vulgaris is an autoimmune intraepithelial bullous disease resulting from pathogenic IgG antibodies toward desmoglein antigens that often requires long-term immunosuppressive therapy for control of disease symptoms. Herpes esophagitis is an ulcerative eruption caused by viral reactivation in the setting of immunosuppression. Acute odynophagia in patients undergoing systemic treatment of active PV has a broad differential and warrants prompt endoscopic evaluation.

Topics: Acyclovir; Adrenal Cortex Hormones; Adult; Antiviral Agents; Esophagitis; Esophagoscopy; Herpes Simplex; Humans; Immunosuppressive Agents; Male; Mycophenolic Acid; Pemphigus