mycophenolic-acid and Dilatation--Pathologic

Cardiovascular involvement occurring in 20-30% patients is the second most common cause of mortality in patients with relapsing polychondritis. Aortic insufficiency occurs as a result of aortic root dilatation rather than primary valvular involvement. We are reporting a patient of relapsing polychondritis with aortic root dilatation, in whom institution of early and aggressive therapy successfully prevented the progression of aortic insufficiency.

Topics: Aorta; Aortic Diseases; Aortic Valve Insufficiency; Azathioprine; Cyclophosphamide; Dilatation, Pathologic; Drug Substitution; Drug Therapy, Combination; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Methylprednisolone; Middle Aged; Mycophenolic Acid; Polychondritis, Relapsing; Prednisolone