mycolactone-b and Mycobacterium-Infections

mycolactone-b has been researched along with Mycobacterium-Infections* in 1 studies

Other Studies

1 other study(ies) available for mycolactone-b and Mycobacterium-Infections

Article	Year
A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins. Chemistry (Weinheim an der Bergstrasse, Germany), 2011, Dec-16, Volume: 17, Issue:51 Mycolactones are complex macrolides responsible for a severe necrotizing skin disease called Buruli ulcer. Deciphering their functional interactions is of fundamental importance for the understanding, and ultimately, the control of this devastating mycobacterial infection. We report herein a diverted total synthesis approach of mycolactones analogues and provide the first insights into their structure-activity relationship based on cytopathic assays on L929 fibroblasts. The lowest concentration inducing a cytopathic effect was determined for selected analogues, allowing a clear picture to emerge by comparison with the natural toxins. Topics: Animals; Bacterial Toxins; Buruli Ulcer; Fibroblasts; Macrolides; Mice; Molecular Structure; Mycobacterium Infections; Mycobacterium ulcerans; Structure-Activity Relationship	2011

Article

Year

A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins.

Chemistry (Weinheim an der Bergstrasse, Germany), 2011, Dec-16, Volume: 17, Issue:51

Mycolactones are complex macrolides responsible for a severe necrotizing skin disease called Buruli ulcer. Deciphering their functional interactions is of fundamental importance for the understanding, and ultimately, the control of this devastating mycobacterial infection. We report herein a diverted total synthesis approach of mycolactones analogues and provide the first insights into their structure-activity relationship based on cytopathic assays on L929 fibroblasts. The lowest concentration inducing a cytopathic effect was determined for selected analogues, allowing a clear picture to emerge by comparison with the natural toxins.

Topics: Animals; Bacterial Toxins; Buruli Ulcer; Fibroblasts; Macrolides; Mice; Molecular Structure; Mycobacterium Infections; Mycobacterium ulcerans; Structure-Activity Relationship

2011