mycalamide-b has been researched along with Cell-Transformation--Neoplastic* in 1 studies
1 other study(ies) available for mycalamide-b and Cell-Transformation--Neoplastic
Article | Year |
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Change of ras-transformed NRK-cells back to normal morphology by mycalamides A and B, antitumor agents from a marine sponge.
Mycalamide A and mycalamide B, isolated as antiviral and antitumor agents from a New Zealand sponge of the genus Mycale, converted the morphology of ras-transformed NRK-cells to normal morphology at 10 and 1 ng/ml, respectively. The effect on protein synthesis suggests that these agents converted the morphology by preferentially inhibiting the biosynthesis of p21 protein. Topics: Animals; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; Genes, ras; Porifera; Protein Synthesis Inhibitors; Pyrans; Tumor Cells, Cultured | 1991 |