musk and Myasthenia-Gravis

Topics: Fatty Acids, Monounsaturated; Humans; Myasthenia Gravis; Receptor Protein-Tyrosine Kinases; Receptors, Cholinergic

Topics: Fatty Acids, Monounsaturated; Humans; Immunoglobulin G; Immunoglobulin G4-Related Disease; Myasthenia Gravis; Receptor Protein-Tyrosine Kinases; Receptors, Cholinergic

Topics: Fatty Acids, Monounsaturated; Humans; Myasthenia Gravis; Prospective Studies; Rare Diseases; Rituximab

The diagnostic sensitivity of repetitive nerve stimulation (RNS) in patients with myasthenia gravis (MG) varies as a function of the number of muscles or the choice of muscles studied.. By exploring 12 muscles bilaterally, we evaluated the global sensitivity of RNS at rest, the sensitivity in different clinical forms, and the sensitivity of different combinations of muscles studied.. The global sensitivity of RNS was 82%, and specificity was 100%. The sensitivity in the MG subgroups was as follows: ocular (O) = 67%; oculobulbar (OB) = 86%; and generalized (G) = 89%. The most sensitive muscles were the anconeus in group O, orbicularis oculi (OO) or nasalis in group OB, and the trapezius in group G. Maximum sensitivity was obtained by exploring OO, trapezius, and anconeus bilaterally.. We recommend bilateral exploration of at least 3 muscles, a facial muscle, trapezius, and anconeus. Muscle Nerve 55: 532-538, 2017.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Electric Stimulation; Electromyography; Fatty Acids, Monounsaturated; Female; Humans; Male; Middle Aged; Muscle, Skeletal; Myasthenia Gravis; Neurologic Examination; Receptors, Cholinergic; Retrospective Studies; Sensitivity and Specificity; Severity of Illness Index; Young Adult

Susceptibility to myasthenia gravis (MG) has been demonstrated with several HLA in different disease subgroups. HLA-DR14, -DR16 and -DQ5 were reported as predisposing factors in muscle-specific kinase antibody positive MG (MuSK-MG). These markers were evaluated in MG subgroups from Turkey. Among 164 generalized MG patients, 116 had antibodies against anti-acetylcholine receptor (AChR-MG) and 48 had MuSK-MG. Only HLA-DRB1 and DQB1 allele groups reported to be associated with MuSK-MG were compared with 250 healthy controls (HC). Highly significant associations of both DRB1(∗)16 and DRB1(∗)14 were found with MuSK-MG compared to HC (p = 1.9 × 10(-5), OR: 4.95 and p = 0.0028, OR: 3.1). On the contrary, HLA-DRB1(∗)03 was less frequent in MuSK-MG (p = 0.006, OR: 0.09). DQB1(∗)05 was also associated with MuSK-MG (p = 2.5 × 10(-6) OR: 4.8). This study provides a replication of the highly significant associations of both HLA-DRB1(∗)16,-DRB1(∗)14 and -DQB1(∗)05 with MuSK-MG. Moreover, HLA-DRB1(∗)03 appears to have a distinguishing role for this disease subgroup compared to early-onset and AChR-MG.

Topics: Adolescent; Adult; Aged; Alleles; Fatty Acids, Monounsaturated; Female; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; HLA-DQ beta-Chains; HLA-DRB1 Chains; Humans; Male; Middle Aged; Myasthenia Gravis; Receptor Protein-Tyrosine Kinases; Receptors, Cholinergic; Turkey; Young Adult

Topics: Antibodies, Monoclonal, Murine-Derived; Antigens, CD19; B-Lymphocytes; Cell Count; Fatty Acids, Monounsaturated; Female; Humans; Immunologic Deficiency Syndromes; Immunologic Factors; Middle Aged; Myasthenia Gravis; Rituximab

Topics: Autoantibodies; Fatty Acids, Monounsaturated; Female; Humans; Middle Aged; Myasthenia Gravis; Ocular Motility Disorders

Topics: Adult; Antibodies; Atrophy; Fatty Acids, Monounsaturated; Humans; Male; Myasthenia Gravis; Tongue