muscimol has been researched along with Substance Withdrawal Syndrome in 43 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intraperitoneal injection of ethanol (1-2 g/kg) and chlordiazepoxide (2-16 mg/kg) suppressed susceptibility to audiogenically induced, clonic-tonic seizures and antagonized forelimb tremor in rats undergoing ethanol withdrawal, 30 min after treatment." | 7.66 | Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. ( Breese, GR; Frye, GD; McCown, TJ, 1983) |
| "Intraperitoneal injection of ethanol (1-2 g/kg) and chlordiazepoxide (2-16 mg/kg) suppressed susceptibility to audiogenically induced, clonic-tonic seizures and antagonized forelimb tremor in rats undergoing ethanol withdrawal, 30 min after treatment." | 3.66 | Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. ( Breese, GR; Frye, GD; McCown, TJ, 1983) |
| " It is suggested that this lack of effect was possibly due to the desensitization of the GABAA receptors, as well as by the decrease on the responsiveness of the functions of μ opioid receptors, resulting from chronic administration of ethyl alcohol." | 1.40 | Impaired fear inhibitory properties of GABAA and μ opioid receptors of the dorsal periaqueductal grey in alcohol-withdrawn rats. ( Nobre, MJ; Silva, LBC, 2014) |
| "Long-term, periodic, transmeningeal muscimol delivery with the SPD is essentially a safe procedure." | 1.38 | Long-term behavioral, electrophysiological, and neurochemical monitoring of the safety of an experimental antiepileptic implant, the muscimol-delivering Subdural Pharmacotherapy Device in monkeys. ( Baptiste, SL; Carlson, C; Devinsky, O; French, JA; Kuzniecky, RI; Ludvig, N; Medveczky, G; Stefanov, DG; Tang, HM; Vaynberg, JK; Vazquez-DeRose, J, 2012) |
| "Sleep-wake states were studied following withdrawal in 36 adult male wistar alcohol-dependent rats, after chronic administration of ethanol (10 g/kg/24 h) for 13 days." | 1.30 | Effects of muscimol or homotaurine on sleep-wake states in alcohol-dependent rats during withdrawal. ( Bajenaru, O; Dall'Ava-Santucci, J; Dinh-Xuan, AT; Emmanouilidis, E; Manicom, R; Poenaru, S; Rouhani, S; Tran, G, 1998) |
| "Laudanosine was almost ineffective at [3H]muscimol binding to high-affinity GABA receptors (IC50 = 100 microM)." | 1.29 | Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity. ( Fonia, O; Gavish, M; Katz, Y; Liu, L; Pasternak, GW; Pick, CG; Weizman, A, 1994) |
| "Audiogenic seizures were suppressed for at least 3 hr after muscimol (30 ng)." | 1.27 | Characterization of susceptibility to audiogenic seizures in ethanol-dependent rats after microinjection of gamma-aminobutyric acid (GABA) agonists into the inferior colliculus, substantia nigra or medial septum. ( Breese, GR; Frye, GD; McCown, TJ, 1983) |
| " Picrotoxin, and agent which blocks the chloride ionophore of GABA-receptor complex, exhibited a parallel dose-response curve with respect to muscimol." | 1.26 | Acute and chronic effects of pentobarbital in relation to postsynaptic GABA receptors: a study with muscimol. ( Ho, IK; Nabeshima, T; Sivam, SP, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (34.88) | 18.7374 |
| 1990's | 11 (25.58) | 18.2507 |
| 2000's | 11 (25.58) | 29.6817 |
| 2010's | 6 (13.95) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, R | 1 |
| Zhang, B | 1 |
| Chen, T | 1 |
| Zhang, S | 1 |
| Chen, L | 1 |
| Topkara, B | 1 |
| Yananli, HR | 1 |
| Sakallı, E | 1 |
| Demirkapu, MJ | 1 |
| Glover, EJ | 1 |
| Starr, EM | 1 |
| Chao, Y | 1 |
| Jhou, TC | 1 |
| Chandler, LJ | 1 |
| Silva, LBC | 1 |
| Nobre, MJ | 2 |
| Li, X | 1 |
| Zeric, T | 1 |
| Kambhampati, S | 1 |
| Bossert, JM | 1 |
| Shaham, Y | 1 |
| Cabral, A | 1 |
| Ruggiero, RN | 1 |
| Brandão, ML | 1 |
| Castilho, VM | 1 |
| Vargas-Perez, H | 1 |
| Ting-A Kee, R | 1 |
| Walton, CH | 1 |
| Hansen, DM | 1 |
| Razavi, R | 1 |
| Clarke, L | 1 |
| Bufalino, MR | 1 |
| Allison, DW | 1 |
| Steffensen, SC | 1 |
| van der Kooy, D | 3 |
| Seo, YJ | 1 |
| Kwon, MS | 1 |
| Choi, SM | 1 |
| Lee, JK | 1 |
| Park, SH | 1 |
| Jung, JS | 1 |
| Sim, YB | 1 |
| Suh, HW | 1 |
| Ludvig, N | 1 |
| Tang, HM | 1 |
| Baptiste, SL | 1 |
| Medveczky, G | 1 |
| Vaynberg, JK | 1 |
| Vazquez-DeRose, J | 1 |
| Stefanov, DG | 1 |
| Devinsky, O | 1 |
| French, JA | 1 |
| Carlson, C | 1 |
| Kuzniecky, RI | 1 |
| Jang, SY | 1 |
| Kim, Y | 1 |
| Oh, S | 2 |
| Laviolette, SR | 2 |
| Gallegos, RA | 1 |
| Henriksen, SJ | 1 |
| Goussakov, I | 1 |
| Chartoff, EH | 1 |
| Tsvetkov, E | 1 |
| Gerety, LP | 1 |
| Meloni, EG | 1 |
| Carlezon, WA | 1 |
| Bolshakov, VY | 1 |
| Mirzaii-Dizgah, I | 1 |
| Karimian, SM | 1 |
| Hajimashhadi, Z | 1 |
| Riahi, E | 1 |
| Ghasemi, T | 1 |
| DeFeudis, FV | 1 |
| Sivam, SP | 1 |
| Nabeshima, T | 1 |
| Ho, IK | 2 |
| Linnoila, M | 1 |
| Stowell, L | 1 |
| Marangos, PJ | 1 |
| Thurman, RG | 1 |
| Frye, GD | 3 |
| McCown, TJ | 3 |
| Breese, GR | 3 |
| Gonzalez, LP | 2 |
| Hettinger, MK | 1 |
| Kuruvilla, A | 1 |
| Fung, YK | 1 |
| Uretsky, NJ | 1 |
| Katz, Y | 1 |
| Weizman, A | 1 |
| Pick, CG | 1 |
| Pasternak, GW | 1 |
| Liu, L | 1 |
| Fonia, O | 1 |
| Gavish, M | 1 |
| El-Kadi, AO | 1 |
| Sharif, SI | 1 |
| Kang, M | 1 |
| Spigelman, I | 1 |
| Sapp, DW | 1 |
| Olsen, RW | 1 |
| Rouhani, S | 1 |
| Dall'Ava-Santucci, J | 1 |
| Bajenaru, O | 1 |
| Emmanouilidis, E | 1 |
| Tran, G | 1 |
| Manicom, R | 1 |
| Dinh-Xuan, AT | 1 |
| Poenaru, S | 1 |
| Zarrindast, MR | 1 |
| Mousa-Ahmadi, E | 1 |
| Calixto, E | 2 |
| López-Colomé, AM | 1 |
| Casasola, C | 2 |
| Montiel, T | 2 |
| Bargas, J | 2 |
| Brailowsky, S | 2 |
| Kong, JQ | 1 |
| Meng, J | 1 |
| Biser, PS | 1 |
| Fleming, WW | 1 |
| Taylor, DA | 1 |
| Arias-Montaño, JA | 1 |
| Galarraga, E | 1 |
| Rägo, L | 1 |
| Saano, V | 1 |
| Auvinen, T | 1 |
| Adojaan, A | 1 |
| Holma, R | 1 |
| Airaksinen, MM | 1 |
| Galpern, WR | 1 |
| Lumpkin, M | 1 |
| Greenblatt, DJ | 2 |
| Shader, RI | 2 |
| Miller, LG | 2 |
| Buck, KJ | 1 |
| McQuilkin, SJ | 1 |
| Harris, RA | 1 |
| Tanaka, S | 1 |
| Aoki, K | 1 |
| Satoh, T | 1 |
| Yoshida, T | 1 |
| Kuroiwa, Y | 1 |
| Lopez, F | 1 |
| Chesley, S | 1 |
| Schatzki, A | 1 |
| Ulrichsen, J | 1 |
| Clemmesen, L | 1 |
| Barry, D | 1 |
| Hemmingsen, R | 1 |
| Czachura, JF | 1 |
| Gray, PL | 1 |
| Taberner, PV | 1 |
| Nordberg, A | 2 |
| Wahlström, G | 2 |
| Eriksson, B | 2 |
| Peterson, SL | 1 |
| Bagetta, G | 1 |
| Sakurada, S | 1 |
| Corasaniti, MT | 1 |
| Froio, F | 1 |
| Nisticò, G | 1 |
| Kaneto, H | 1 |
| Kaneda, H | 1 |
| Kawatani, S | 1 |
43 other studies available for muscimol and Substance Withdrawal Syndrome
| Article | Year |
|---|---|
Postpartum estrogen withdrawal impairs GABAergic inhibition and LTD induction in basolateral amygdala complex via down-regulation of GPR30.
Topics: Animals; Basolateral Nuclear Complex; Contraceptive Agents; Down-Regulation; Estradiol; Estrogens; E | 2017 |
Effects of Injection of Gamma-Aminobutyric Acid Agonists into the Nucleus Accumbens on Naloxone-Induced Morphine Withdrawal.
Topics: Animals; Baclofen; GABA Agonists; Injections; Locomotion; Male; Morphine Dependence; Muscimol; Nalox | 2017 |
Inhibition of the rostromedial tegmental nucleus reverses alcohol withdrawal-induced anxiety-like behavior.
Topics: Action Potentials; Animals; Anxiety; Behavior, Animal; Ethanol; GABA-A Receptor Agonists; Male; Musc | 2019 |
Impaired fear inhibitory properties of GABAA and μ opioid receptors of the dorsal periaqueductal grey in alcohol-withdrawn rats.
Topics: Alcohols; Analgesics, Opioid; Animals; Conditioning, Classical; Disease Models, Animal; Dose-Respons | 2014 |
The central amygdala nucleus is critical for incubation of methamphetamine craving.
Topics: Amphetamine-Related Disorders; Animals; Baclofen; Basolateral Nuclear Complex; Central Amygdaloid Nu | 2015 |
GABA and opioid mechanisms of the central amygdala underlie the withdrawal-potentiated startle from acute morphine.
Topics: Amygdala; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GABA Agonists; GABA-A Re | 2009 |
Ventral tegmental area BDNF induces an opiate-dependent-like reward state in naive rats.
Topics: Animals; Bicuculline; Brain-Derived Neurotrophic Factor; Conditioning, Psychological; Dopamine; Dopa | 2009 |
Possible involvement of the hypothalamic pro-opiomelanocortin gene and beta-endorphin expression on acute morphine withdrawal development.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Baclofen; beta-Endorphin; Dose-Response Relationship, Drug | 2009 |
Long-term behavioral, electrophysiological, and neurochemical monitoring of the safety of an experimental antiepileptic implant, the muscimol-delivering Subdural Pharmacotherapy Device in monkeys.
Topics: Animals; Anticonvulsants; Behavior, Animal; Body Weight; Cerebrospinal Fluid Proteins; Chromatograph | 2012 |
The bindings of [3H]muscimol and [3H]flunitrazapam are elevated in discrete brain regions of butorphanol-withdrawal rats.
Topics: Animals; Autoradiography; Brain; Butorphanol; Flunitrazepam; Immunohistochemistry; Male; Muscimol; R | 2002 |
Opiate state controls bi-directional reward signaling via GABAA receptors in the ventral tegmental area.
Topics: Animals; Bicuculline; Carbonic Anhydrases; Conditioning, Classical; Cyclic AMP Response Element-Bind | 2004 |
GABAA receptors signal bidirectional reward transmission from the ventral tegmental area to the tegmental pedunculopontine nucleus as a function of opiate state.
Topics: Animals; Bicuculline; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Muscimol; Opioid- | 2004 |
LTP in the lateral amygdala during cocaine withdrawal.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Behavior, Animal; Cocaine; Dopamine Uptake | 2006 |
Attenuation of morphine withdrawal signs by muscimol in the locus coeruleus of rats.
Topics: Animals; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; GABA Agonists; GABA Antago | 2008 |
gamma-Aminobutyric acid-ergic analgesia: implications for gamma-aminobutyric acid-ergic therapy for drug addictions.
Topics: Animals; Baclofen; Brain; Drug Tolerance; Endorphins; GABA Antagonists; gamma-Aminobutyric Acid; Hum | 1984 |
Acute and chronic effects of pentobarbital in relation to postsynaptic GABA receptors: a study with muscimol.
Topics: Animals; Brain; Drug Tolerance; gamma-Aminobutyric Acid; Humans; Male; Mice; Mice, Inbred ICR; Musci | 1982 |
Effect of ethanol and ethanol withdrawal on 3H-muscimol binding and behaviour in the rat: a pilot study.
Topics: Animals; Behavior, Animal; Brain; Ethanol; Humans; Male; Muscimol; Oxazoles; Pilot Projects; Rats; R | 1981 |
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aminobutyrates; Animals; Chlordiazepoxide; Disea | 1983 |
Characterization of susceptibility to audiogenic seizures in ethanol-dependent rats after microinjection of gamma-aminobutyric acid (GABA) agonists into the inferior colliculus, substantia nigra or medial septum.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Ethanol; GABA Antagonists; Humans; Infe | 1983 |
Intranigral muscimol suppresses ethanol withdrawal seizures.
Topics: Acoustic Stimulation; Alcoholism; Animals; gamma-Aminobutyric Acid; Humans; Male; Muscimol; Oxazoles | 1984 |
BehavioraL and biochemical changes caused by muscimol in mice withdrawN from haloperidol administration.
Topics: Animals; Behavior, Animal; Corpus Striatum; Dopamine; Haloperidol; Homovanillic Acid; Humans; Male; | 1982 |
Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity.
Topics: Animals; Bicuculline; Binding, Competitive; Brain; Cell Membrane; Cerebral Ventricles; GABA Antagoni | 1994 |
Modification by muscimol of naloxone-precipitated withdrawal symptoms in morphine-dependent mice.
Topics: Animals; GABA Agonists; Male; Mice; Morphine Dependence; Muscimol; Naloxone; Narcotic Antagonists; S | 1995 |
Persistent reduction of GABA(A) receptor-mediated inhibition in rat hippocampus after chronic intermittent ethanol treatment.
Topics: Animals; Brain; Chlorides; Drug Administration Schedule; Electric Stimulation; Electrophysiology; Et | 1996 |
Effects of muscimol or homotaurine on sleep-wake states in alcohol-dependent rats during withdrawal.
Topics: Alcoholic Intoxication; Alcoholism; Animals; Behavior, Animal; Body Weight; Central Nervous System D | 1998 |
Effects of GABAergic system on naloxone-induced jumping in morphine-dependent mice.
Topics: Animals; Baclofen; Behavior, Animal; Bicuculline; GABA Agonists; GABA Antagonists; GABA-A Receptor A | 1999 |
Changes of [3H]muscimol binding and GABA(A) receptor beta2-subunit mRNA level by tolerance to and withdrawal from pentobarbital in rats.
Topics: Animals; Autoradiography; Brain; Cerebellum; Drug Tolerance; Frontal Lobe; Gene Expression Regulatio | 1999 |
Neocortical hyperexcitability after GABA withdrawal in vitro.
Topics: Animals; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Muscimol; Neocortex | 2000 |
Cellular depolarization of neurons in the locus ceruleus region of the guinea pig associated with the development of tolerance to opioids.
Topics: Animals; Drug Implants; Drug Tolerance; GABA Agonists; Guinea Pigs; Immunohistochemistry; In Vitro T | 2001 |
Hippocampal hyperexcitability induced by GABA withdrawal is due to down-regulation of GABA(A) receptors.
Topics: Animals; Bicuculline; Down-Regulation; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Ki | 2001 |
The effect of chronic treatment with peripheral benzodiazepine receptor ligands on behavior and GABAA/benzodiazepine receptors in rat.
Topics: Animals; Behavior, Animal; Benzodiazepinones; Brain; Convulsants; Injections, Intraperitoneal; Isoqu | 1992 |
Chronic benzodiazepine administration. VII. Behavioral tolerance and withdrawal and receptor alterations associated with clonazepam administration.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cereb | 1991 |
Modulation of gamma-aminobutyric acidA receptor-operated chloride channels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity.
Topics: Animals; Benzodiazepines; Carbolines; Chloride Channels; Chlorides; Convulsants; Ethanol; Flunitraze | 1991 |
Characteristic changes of the GABAA receptor in the brain of phenobarbital-dependent and withdrawn rats.
Topics: Animals; Brain; Male; Membranes; Muscimol; Phenobarbital; Rats; Receptors, GABA-A; Substance Withdra | 1991 |
Chronic administration of benzodiazepines--V. Rapid onset of behavioral and neurochemical alterations after discontinuation of alprazolam.
Topics: Alprazolam; Animals; Behavior, Animal; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo C | 1990 |
The GABA/benzodiazepine receptor chloride channel complex during repeated episodes of physical ethanol dependence in the rat.
Topics: Alcoholism; Animals; Chlorides; Diazepam; Ion Channels; Male; Muscimol; Radioligand Assay; Rats; Rat | 1988 |
Reduced behavioral responses to intranigral muscimol following chronic ethanol.
Topics: Animals; Ethanol; Male; Motor Activity; Muscimol; Rats; Rats, Inbred Strains; Stereotyped Behavior; | 1989 |
Evidence for GABA tolerance in barbiturate-dependent and withdrawn mice.
Topics: Animals; Barbital; Barbiturates; Drug Tolerance; Female; gamma-Aminobutyric Acid; Humans; Imidazoles | 1985 |
[3H]muscimol and [3H]quinuclidinyl benzilate binding in rat cortex in the abstinence after long-term barbital treatment.
Topics: Animals; Barbital; Barbiturates; Cerebral Cortex; Male; Muscimol; Rats; Rats, Inbred Strains; Recept | 1986 |
GABAergic modulation of inferior colliculus excitability: role in the ethanol withdrawal audiogenic seizures.
Topics: Acoustic Stimulation; Animals; Baclofen; Benzodiazepinones; Bicuculline; Ethanol; Geniculate Bodies; | 1986 |
Behavioural and electrocortical changes induced by muscimol in rats withdrawn from chronic treatment with diazepam.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Diazepam; Electroencephalography; Muscimol; Rats; Rats, | 1987 |
Pharmacological characterization of alcohol and barbital physical dependence in mice.
Topics: Animals; Atropine; Barbital; Barbiturates; Clonidine; Ethanol; Male; Mice; Muscimol; Propranolol; Su | 1987 |
Relations between muscimol, quinuclidinyl benzilate and nicotine binding sites in brain after very long treatment with ethanol in rats.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Ethanol; Kinetics; Male; Muscimol; Quinuclidines; Quinucl | 1985 |