muscimol has been researched along with Status Epilepticus in 8 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigate whether microinjections of GABAergic agonists into the AN were protective against pilocarpine-induced generalized seizures and status epilepticus (SE)." | 7.76 | Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus. ( Andrade, D; Bittencourt, S; Covolan, L; Dubiela, FP; Hamani, C; Lozano, A; Mello, LE; Queiroz, C, 2010) |
| "Functional modulation of gamma-aminobutyric acid(A) (GABA(A)) receptors by Zn(2+), pentobarbital, neuroactive steroid alphaxalone, and flunitrazepam was studied in the cerebral cortex and cerebellum of rats undergoing status epilepticus induced by pilocarpine." | 7.70 | Zinc inhibition of gamma-aminobutyric acid(A) receptor function is decreased in the cerebral cortex during pilocarpine-induced status epilepticus. ( Banerjee, PK; Olsen, RW; Snead, OC, 1999) |
| " We investigate whether microinjections of GABAergic agonists into the AN were protective against pilocarpine-induced generalized seizures and status epilepticus (SE)." | 3.76 | Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus. ( Andrade, D; Bittencourt, S; Covolan, L; Dubiela, FP; Hamani, C; Lozano, A; Mello, LE; Queiroz, C, 2010) |
| " Two animal models of TLE--amygdala kindling and pilocarpine-induced status epilepticus (Pilo-SE)--were tested." | 3.75 | Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. ( Leung, LS; Long, JJ; Luo, T; McMurran, TJ; Shen, B; Stewart, L, 2009) |
| "Functional modulation of gamma-aminobutyric acid(A) (GABA(A)) receptors by Zn(2+), pentobarbital, neuroactive steroid alphaxalone, and flunitrazepam was studied in the cerebral cortex and cerebellum of rats undergoing status epilepticus induced by pilocarpine." | 3.70 | Zinc inhibition of gamma-aminobutyric acid(A) receptor function is decreased in the cerebral cortex during pilocarpine-induced status epilepticus. ( Banerjee, PK; Olsen, RW; Snead, OC, 1999) |
| "Limbic status epilepticus was induced in awake, unrestrained rats by electrically stimulating the anterior piriform cortex or the basal amygdaloid nucleus for about 40 min." | 1.29 | The functional anatomy of limbic status epilepticus in the rat. II. The effects of focal deactivation. ( Price, JL; White, LE, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Long, JJ | 1 |
| Shen, B | 1 |
| Luo, T | 1 |
| Stewart, L | 1 |
| McMurran, TJ | 1 |
| Leung, LS | 1 |
| Bittencourt, S | 1 |
| Dubiela, FP | 1 |
| Queiroz, C | 1 |
| Covolan, L | 1 |
| Andrade, D | 1 |
| Lozano, A | 1 |
| Mello, LE | 1 |
| Hamani, C | 1 |
| López-Meraz, ML | 1 |
| Rocha, LL | 1 |
| Miquel, M | 1 |
| Ortega, JC | 1 |
| Perez-Estudillo, CA | 1 |
| García, LI | 1 |
| Hernandez, ME | 1 |
| Manzo, J | 1 |
| White, LE | 1 |
| Price, JL | 1 |
| Banerjee, PK | 1 |
| Olsen, RW | 1 |
| Snead, OC | 1 |
| Molnár, P | 1 |
| Nadler, JV | 1 |
| Moshé, SL | 1 |
| Sperber, EF | 1 |
| Brown, LL | 1 |
| Tempel, A | 1 |
| Lothman, EW | 1 |
| Bertram, EH | 1 |
| Kapur, J | 1 |
| Stringer, JL | 1 |
8 other studies available for muscimol and Status Epilepticus
| Article | Year |
|---|---|
Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics.
Topics: Anesthetics, General; Animals; Brain; Consciousness Disorders; Convulsants; Disease Models, Animal; | 2009 |
Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus.
Topics: Animals; Anterior Thalamic Nuclei; Bicuculline; Convulsants; Electroencephalography; GABA Agents; Hu | 2010 |
Amino acid tissue levels and GABAA receptor binding in the developing rat cerebellum following status epilepticus.
Topics: Alanine; Amino Acids; Animals; Cerebellum; Female; Glutamine; Male; Muscimol; Rats; Rats, Wistar; Re | 2012 |
The functional anatomy of limbic status epilepticus in the rat. II. The effects of focal deactivation.
Topics: Amygdala; Animals; Autoradiography; Brain; Carbon Radioisotopes; Deoxyglucose; Hippocampus; Lidocain | 1993 |
Zinc inhibition of gamma-aminobutyric acid(A) receptor function is decreased in the cerebral cortex during pilocarpine-induced status epilepticus.
Topics: Animals; Biological Transport; Cerebellum; Cerebral Cortex; Chlorides; GABA Agonists; GABA-A Recepto | 1999 |
Lack of effect of mossy fiber-released zinc on granule cell GABA(A) receptors in the pilocarpine model of epilepsy.
Topics: Action Potentials; Animals; Dendrites; Excitatory Postsynaptic Potentials; GABA Agonists; gamma-Amin | 2001 |
Age-dependent changes in substantia nigra GABA-mediated seizure suppression.
Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; Dominance, Cerebral; Energy Metabolism; Flu | 1992 |
Recurrent spontaneous hippocampal seizures in the rat as a chronic sequela to limbic status epilepticus.
Topics: Action Potentials; Animals; Chronic Disease; Disease Models, Animal; Electric Stimulation; Electroen | 1990 |