muscimol has been researched along with Spinal Cord Injuries in 17 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mechanical and cold allodynia, thermal and mechanical hyperalgesia were evaluated before injection and 15 and 60 min after injection." | 1.56 | Simultaneous intrathecal injection of muscimol and endomorphin-1 alleviates neuropathic pain in rat model of spinal cord injury. ( Hosseini, M; Janzadeh, A; Karami, Z; Nasirinezhad, F; Yousefifard, M; Zamani, E, 2020) |
| "The muscimol treated, hemisection-SCI rats also exhibited increased hindpaw withdrawal thresholds and latencies." | 1.43 | Suppressed GABAergic signaling in the zona incerta causes neuropathic pain in a thoracic hemisection spinal cord injury rat model. ( Cho, CB; Lee, YJ; Moon, HC; Park, YS, 2016) |
| "At 4 weeks after Th9-10 spinal cord transection awake cystometry and recordings of external urethral sphincter electromyogram were performed to examine the effect of intrathecal application of the gamma-aminobutyric acid A and B agonists muscimol and baclofen or the gamma-aminobutyric acid A and B antagonists bicuculline and saclofen (Tocris Cookson, Ellisville, Missouri), respectively, at the level of the L6-S1 spinal cord." | 1.35 | GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats. ( Chancellor, MB; de Groat, WC; Hiragata, S; Miyazato, M; Sasatomi, K; Sugaya, K; Yoshimura, N, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Suzuki, M | 1 |
| Onoe, K | 1 |
| Sawada, M | 2 |
| Takahashi, N | 1 |
| Higo, N | 1 |
| Murata, Y | 1 |
| Tsukada, H | 2 |
| Isa, T | 3 |
| Onoe, H | 3 |
| Nishimura, Y | 3 |
| Hosseini, M | 1 |
| Karami, Z | 1 |
| Yousefifard, M | 1 |
| Janzadeh, A | 1 |
| Zamani, E | 1 |
| Nasirinezhad, F | 1 |
| Brown, AR | 1 |
| Martinez, M | 1 |
| Whitt, JL | 1 |
| Masri, R | 2 |
| Pulimood, NS | 1 |
| Keller, A | 1 |
| Kato, K | 1 |
| Kunieda, T | 1 |
| Mikuni, N | 1 |
| Miyamoto, S | 1 |
| Sindhurakar, A | 1 |
| Butensky, SD | 1 |
| Meyers, E | 1 |
| Santos, J | 1 |
| Bethea, T | 1 |
| Khalili, A | 1 |
| Sloan, AP | 1 |
| Rennaker, RL | 1 |
| Carmel, JB | 1 |
| Moon, HC | 1 |
| Lee, YJ | 1 |
| Cho, CB | 1 |
| Park, YS | 1 |
| Huang, YJ | 2 |
| Lee, KH | 2 |
| Murphy, L | 1 |
| Garraway, SM | 1 |
| Grau, JW | 2 |
| Krajacic, A | 1 |
| Weishaupt, N | 1 |
| Girgis, J | 1 |
| Tetzlaff, W | 1 |
| Fouad, K | 1 |
| Hama, A | 1 |
| Sagen, J | 1 |
| Cha, M | 1 |
| Ji, Y | 1 |
| Sokal, DM | 1 |
| Chapman, V | 1 |
| Morichika, Y | 1 |
| Perfiliev, S | 1 |
| Miyazato, M | 2 |
| Sasatomi, K | 2 |
| Hiragata, S | 2 |
| Sugaya, K | 2 |
| Chancellor, MB | 2 |
| de Groat, WC | 2 |
| Yoshimura, N | 2 |
| Eidelberg, E | 1 |
| Nguyen, LH | 1 |
| Polich, R | 1 |
| Walden, JG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sensory-Motor Rehabilitation Post Stroke[NCT02369770] | 140 participants (Anticipated) | Interventional | 2019-04-26 | Recruiting | |||
| Effect of Wrist Flexors Inhibition in Comparison to Wrist Extensors Facilitation Through Kinesiotaping Technique in Chronic Hemiplegic Stroke Patients With Limited Wrist Extension[NCT05526859] | 24 participants (Anticipated) | Interventional | 2022-08-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 other studies available for muscimol and Spinal Cord Injuries
| Article | Year |
|---|---|
The Ventral Striatum is a Key Node for Functional Recovery of Finger Dexterity After Spinal Cord Injury in Monkeys.
Topics: Animals; Fingers; Functional Neuroimaging; GABA-A Receptor Agonists; Macaca; Motor Skills; Muscimol; | 2020 |
Simultaneous intrathecal injection of muscimol and endomorphin-1 alleviates neuropathic pain in rat model of spinal cord injury.
Topics: Animals; Hyperalgesia; Injections, Spinal; Muscimol; Neuralgia; Oligopeptides; Rats; Spinal Cord; Sp | 2020 |
Chronic inactivation of the contralesional hindlimb motor cortex after thoracic spinal cord hemisection impedes locomotor recovery in the rat.
Topics: Animals; Female; GABA-A Receptor Agonists; Hindlimb; Locomotion; Motor Cortex; Muscimol; Rats; Rats, | 2021 |
Pathological activity in mediodorsal thalamus of rats with spinal cord injury pain.
Topics: Action Potentials; Afferent Pathways; Animals; Disease Models, Animal; Functional Laterality; GABA-A | 2013 |
Function of the nucleus accumbens in motor control during recovery after spinal cord injury.
Topics: Animals; Fingers; Functional Laterality; GABA-A Receptor Agonists; Macaca; Motivation; Motor Skills; | 2015 |
An Automated Test of Rat Forelimb Supination Quantifies Motor Function Loss and Recovery After Corticospinal Injury.
Topics: Animals; Automation, Laboratory; Disease Models, Animal; Equipment Design; Female; Food; Forelimb; M | 2017 |
Suppressed GABAergic signaling in the zona incerta causes neuropathic pain in a thoracic hemisection spinal cord injury rat model.
Topics: Action Potentials; Animals; Bicuculline; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobuty | 2016 |
Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization.
Topics: Acetates; Analysis of Variance; Animals; Bicuculline; Bumetanide; Capsaicin; Disease Models, Animal; | 2016 |
Complete spinal cord injury (SCI) transforms how brain derived neurotrophic factor (BDNF) affects nociceptive sensitization.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cadherins; Capsaicin; Disease Models, Animal; Electrosho | 2017 |
Training-induced plasticity in rats with cervical spinal cord injury: effects and side effects.
Topics: Animals; Cervical Vertebrae; Evoked Potentials, Motor; Female; Motor Skills; Muscimol; Neural Pathwa | 2010 |
Combinations of intrathecal gamma-amino-butyrate receptor agonists and N-methyl-d-aspartate receptor antagonists in rats with neuropathic spinal cord injury pain.
Topics: Analgesia, Epidural; Animals; Baclofen; Dose-Response Relationship, Drug; Drug Synergism; Drug Thera | 2012 |
Motor cortex stimulation activates the incertothalamic pathway in an animal model of spinal cord injury.
Topics: Action Potentials; Analysis of Variance; Animals; Brain Mapping; Disease Models, Animal; GABA-A Rece | 2013 |
Effects of spinal administration of muscimol on C- and A-fibre evoked neuronal responses of spinal dorsal horn neurones in control and nerve injured rats.
Topics: Animals; Bicuculline; Evoked Potentials; GABA Agonists; GABA Antagonists; Injections, Spinal; Male; | 2003 |
Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury.
Topics: Adaptation, Physiological; Animals; Brain Mapping; Female; Fingers; GABA Agonists; Learning; Macaca; | 2007 |
GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
Topics: Animals; Baclofen; Bicuculline; Disease Models, Animal; Female; GABA Agonists; GABA Antagonists; Glu | 2008 |
Suppression of detrusor-sphincter dysynergia by GABA-receptor activation in the lumbosacral spinal cord in spinal cord-injured rats.
Topics: Animals; Baclofen; GABA Agonists; GABA Antagonists; Lumbosacral Region; Muscimol; Muscle Contraction | 2008 |
Transsynaptic degeneration of motoneurones caudal to spinal cord lesions.
Topics: Animals; Colchicine; Male; Motor Neurons; Muscimol; Nerve Degeneration; Nomifensine; Rats; Rats, Inb | 1989 |