Page last updated: 2024-10-31

muscimol and Rett Syndrome

muscimol has been researched along with Rett Syndrome in 1 studies

Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.

Rett Syndrome: An inherited neurological developmental disorder that is associated with X-LINKED INHERITANCE and may be lethal in utero to hemizygous males. The affected female is normal until the age of 6-25 months when progressive loss of voluntary control of hand movements and communication skills; ATAXIA; SEIZURES; autistic behavior; intermittent HYPERVENTILATION; and HYPERAMMONEMIA appear. (From Menkes, Textbook of Child Neurology, 5th ed, p199)

Research Excerpts

ExcerptRelevanceReference
"Rett syndrome is an autism spectrum disorder resulting from defects in the gene encoding the methyl-CpG-binding protein 2 (MeCP2)."1.39GABAergic synaptic inputs of locus coeruleus neurons in wild-type and Mecp2-null mice. ( Cui, N; Jiang, C; Jin, X; Jin, XT; Zhong, W, 2013)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jin, X1
Cui, N1
Zhong, W1
Jin, XT1
Jiang, C1

Other Studies

1 other study available for muscimol and Rett Syndrome

ArticleYear
GABAergic synaptic inputs of locus coeruleus neurons in wild-type and Mecp2-null mice.
    American journal of physiology. Cell physiology, 2013, May-01, Volume: 304, Issue:9

    Topics: Animals; Baclofen; Female; GABA Antagonists; GABA-A Receptor Agonists; GABA-B Receptor Agonists; GAB

2013