muscimol has been researched along with Reperfusion Injury in 7 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 7.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 3.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "Ischemia or reperfusion injury after orthotopic liver transplantation (OLT) or shear stress after split OLT (SOLT) with a small-for-size graft causes OS-induced graft damage." | 1.39 | Liver graft pretreated in vivo or ex vivo by γ-aminobutyric acid receptor regulation. ( Baine, AM; Chen, F; Gardner, LB; Hata, T; Hori, T; Nguyen, JH; Uemoto, S, 2013) |
| "In baclofen/muscimol treated eyes the ERG b-wave went from 426+/-101 microV to 148+/-118 microV (n=6)." | 1.35 | GABA agonists fail to protect the retina from ischemia-reperfusion injury. ( Agnarsson, BA; Eysteinsson, T; Stefánsson, E; Traustason, S, 2009) |
| "In global cerebral ischemia, focal cerebral ischemia and oxygen-glucose deprivation, application of muscimol and baclofen, agonists of GABA(A) receptor and GABA(B) receptor, exerted neuroprotection." | 1.35 | Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion. ( Han, D; Li, C; Wang, W; Yan, JZ; Yu, CZ; Zhang, GY; Zhang, QG; Zong, YY, 2008) |
| "Rats treated with muscimol or MK-801 exhibited significantly better visual-spatial learning compared with saline-treated subjects (p less than 0." | 1.28 | Protective effect of synaptic inhibition during cerebral ischemia in rats and rabbits. ( Hedges, B; Lyden, PD, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hori, T | 2 |
| Gardner, LB | 2 |
| Hata, T | 2 |
| Chen, F | 2 |
| Baine, AM | 2 |
| Uemoto, S | 2 |
| Nguyen, JH | 2 |
| Traustason, S | 1 |
| Eysteinsson, T | 1 |
| Agnarsson, BA | 1 |
| Stefánsson, E | 1 |
| Qi, SH | 1 |
| Liu, Y | 1 |
| Wang, WW | 1 |
| Wang, M | 1 |
| Zhang, GY | 2 |
| Han, D | 1 |
| Zhang, QG | 1 |
| Li, C | 1 |
| Zong, YY | 1 |
| Yu, CZ | 1 |
| Wang, W | 1 |
| Yan, JZ | 1 |
| Ito, H | 1 |
| Watanabe, Y | 1 |
| Isshiki, A | 1 |
| Uchino, H | 1 |
| Lyden, PD | 1 |
| Hedges, B | 1 |
7 other studies available for muscimol and Reperfusion Injury
| Article | Year |
|---|---|
Pretreatment of liver grafts in vivo by γ-aminobutyric acid receptor regulation reduces cold ischemia/warm reperfusion injury in rat.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Bicuculline; Cold Ischemia; DNA Repair; GABA Agonis | 2013 |
GABA agonists fail to protect the retina from ischemia-reperfusion injury.
Topics: Animals; Baclofen; Drug Combinations; Drug Evaluation, Preclinical; Electroretinography; Female; GAB | 2009 |
Neuroprotection of ethanol against cerebral ischemia/reperfusion induced brain injury through GABA receptor activation.
Topics: Animals; Benzamides; Bicuculline; Brain; Brain Injuries; Brain Ischemia; Cell Death; Ethanol; GABA A | 2009 |
Liver graft pretreated in vivo or ex vivo by γ-aminobutyric acid receptor regulation.
Topics: Animals; Apoptosis; GABA Agonists; Graft Survival; Lipid Peroxidation; Liver; Liver Transplantation; | 2013 |
Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion.
Topics: Animals; Apoptosis; Baclofen; Brain Ischemia; Disks Large Homolog 4 Protein; GABA Agonists; GluK2 Ka | 2008 |
Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Baclofen; Brain Ischemia; Dose-Response Relationship, Drug; GABA | 1999 |
Protective effect of synaptic inhibition during cerebral ischemia in rats and rabbits.
Topics: Animals; Brain Ischemia; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Aci | 1992 |