muscimol has been researched along with Nerve Pain in 16 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study investigated the involvement of mediodorsal thalamic (MD) GABA-A receptors in cetirizine/morphine-induced anti-allodynia using a rat model of neuropathic pain." | 4.31 | Pharmacological activation of mediodorsal thalamic GABA-A receptors modulates morphine/cetirizine-induced changes in the prefrontal cortical GFAP expression in a rat model of neuropathic pain. ( Alijanpour, S; Asgharpour-Masouleh, N; Delphi, L; Rezayof, A, 2023) |
| "Mechanical and cold allodynia, thermal and mechanical hyperalgesia were evaluated before injection and 15 and 60 min after injection." | 1.56 | Simultaneous intrathecal injection of muscimol and endomorphin-1 alleviates neuropathic pain in rat model of spinal cord injury. ( Hosseini, M; Janzadeh, A; Karami, Z; Nasirinezhad, F; Yousefifard, M; Zamani, E, 2020) |
| "Thus, mechanical hyperalgesia and allodynia, and the pattern of c-Fos staining in the amygdala subnuclei were evaluated in rats with chronic constriction of the sciatic nerve, as well as sham-operated and naïve rats." | 1.48 | The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy. ( Antunes, GF; Assis, DV; Gouveia, F; Kuroki, M; Martinez, RCR; Oliveira, CC; Pagano, RL; Santos, LCT; Seno, MDJ, 2018) |
| "These phases of neuropathic pain involve changes in the GABAergic control of descending pathways that travel through the dorsolateral funiculus (DLF)." | 1.43 | The lesion of dorsolateral funiculus changes the antiallodynic effect of the intrathecal muscimol and baclofen in distinct phases of neuropathic pain induced by spinal nerve ligation in rats. ( Dias, QM; Prado, WA, 2016) |
| "The muscimol treated, hemisection-SCI rats also exhibited increased hindpaw withdrawal thresholds and latencies." | 1.43 | Suppressed GABAergic signaling in the zona incerta causes neuropathic pain in a thoracic hemisection spinal cord injury rat model. ( Cho, CB; Lee, YJ; Moon, HC; Park, YS, 2016) |
| "After establishment of neuropathic pain model with the lumbar 5 spinal nerve ligation (L5 SNL), the GABA-evoked currents were recorded in the acutely dissociated L4 DRG neurons using whole-cell patch clamp." | 1.40 | The role of the GABA-A receptor of the adjacent intact dorsal root ganglion neurons in rats with neuropathic pain. ( Fu, J; Gu, J; Gu, Y; Li, G; Ran, R; Wang, L; Wang, Q; Zhang, A; Zhao, Y; Zhong, H, 2014) |
| "0 microg) were administered to obtain the dose-response curve and the 50% effective dose (ED(50))." | 1.31 | The interaction between intrathecal neostigmine and GABA receptor agonists in rats with nerve ligation Injury. ( Choi, IC; Han, SM; Hwang, JH; Hwang, KS; Kim, JU; Park, PH, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 9 (56.25) | 24.3611 |
| 2020's | 5 (31.25) | 2.80 |
| Authors | Studies |
|---|---|
| Nagasaka, K | 1 |
| Takashima, I | 1 |
| Matsuda, K | 1 |
| Higo, N | 1 |
| Wei, H | 1 |
| Chen, Z | 1 |
| Lei, J | 1 |
| You, HJ | 1 |
| Pertovaara, A | 1 |
| Asgharpour-Masouleh, N | 1 |
| Rezayof, A | 1 |
| Alijanpour, S | 1 |
| Delphi, L | 1 |
| Maegawa, H | 1 |
| Usami, N | 1 |
| Kudo, C | 1 |
| Hanamoto, H | 1 |
| Niwa, H | 1 |
| Hosseini, M | 1 |
| Karami, Z | 1 |
| Yousefifard, M | 1 |
| Janzadeh, A | 1 |
| Zamani, E | 1 |
| Nasirinezhad, F | 1 |
| Seno, MDJ | 1 |
| Assis, DV | 1 |
| Gouveia, F | 1 |
| Antunes, GF | 1 |
| Kuroki, M | 1 |
| Oliveira, CC | 1 |
| Santos, LCT | 1 |
| Pagano, RL | 1 |
| Martinez, RCR | 1 |
| Jiang, H | 1 |
| Fang, D | 1 |
| Kong, LY | 1 |
| Jin, ZR | 1 |
| Cai, J | 1 |
| Kang, XJ | 1 |
| Wan, Y | 1 |
| Xing, GG | 1 |
| Ran, R | 1 |
| Gu, J | 1 |
| Fu, J | 1 |
| Zhong, H | 1 |
| Zhao, Y | 1 |
| Gu, Y | 1 |
| Zhang, A | 1 |
| Li, G | 1 |
| Wang, L | 1 |
| Wang, Q | 1 |
| Dias, QM | 1 |
| Prado, WA | 1 |
| Chiou, CS | 1 |
| Chen, CC | 1 |
| Tsai, TC | 1 |
| Huang, CC | 1 |
| Chou, D | 1 |
| Hsu, KS | 1 |
| Moon, HC | 1 |
| Lee, YJ | 1 |
| Cho, CB | 1 |
| Park, YS | 1 |
| Hama, A | 1 |
| Sagen, J | 1 |
| Asiedu, MN | 1 |
| Mejia, G | 1 |
| Ossipov, MK | 1 |
| Malan, TP | 1 |
| Kaila, K | 1 |
| Price, TJ | 1 |
| Liu, HY | 1 |
| Li, YX | 1 |
| Hao, YJ | 1 |
| Wang, HY | 1 |
| Dai, XY | 1 |
| Sun, T | 1 |
| Yu, JQ | 1 |
| Rode, F | 1 |
| Jensen, DG | 1 |
| Blackburn-Munro, G | 1 |
| Bjerrum, OJ | 1 |
| Hwang, JH | 1 |
| Hwang, KS | 1 |
| Kim, JU | 1 |
| Choi, IC | 1 |
| Park, PH | 1 |
| Han, SM | 1 |
16 other studies available for muscimol and Nerve Pain
| Article | Year |
|---|---|
Pharmacological inactivation of the primate posterior insular/secondary somatosensory cortices attenuates thermal hyperalgesia.
Topics: Animals; Hyperalgesia; Muscimol; Neuralgia; Primates; Somatosensory Cortex | 2022 |
Reduced mechanical hypersensitivity by inhibition of the amygdala in experimental neuropathy: Sexually dimorphic contribution of spinal neurotransmitter receptors.
Topics: Amygdala; Animals; Female; GABA-A Receptor Antagonists; Male; Muscimol; Neuralgia; Rats; Receptors, | 2022 |
Pharmacological activation of mediodorsal thalamic GABA-A receptors modulates morphine/cetirizine-induced changes in the prefrontal cortical GFAP expression in a rat model of neuropathic pain.
Topics: Animals; Cetirizine; Chronic Pain; Disease Models, Animal; GABA-A Receptor Agonists; Glial Fibrillar | 2023 |
Dopaminergic Modulation of Orofacial Mechanical Hypersensitivity Induced by Infraorbital Nerve Injury.
Topics: Animals; Cranial Nerves; Dopamine; Extracellular Signal-Regulated MAP Kinases; Facial Nerve Injuries | 2020 |
Simultaneous intrathecal injection of muscimol and endomorphin-1 alleviates neuropathic pain in rat model of spinal cord injury.
Topics: Animals; Hyperalgesia; Injections, Spinal; Muscimol; Neuralgia; Oligopeptides; Rats; Spinal Cord; Sp | 2020 |
The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Basolateral Nuclear Complex; Central Amygdaloid Nucle | 2018 |
Sensitization of neurons in the central nucleus of the amygdala via the decreased GABAergic inhibition contributes to the development of neuropathic pain-related anxiety-like behaviors in rats.
Topics: Action Potentials; Animals; Anxiety; Apoptosis; Behavior, Animal; Bicuculline; Blotting, Western; Ca | 2014 |
The role of the GABA-A receptor of the adjacent intact dorsal root ganglion neurons in rats with neuropathic pain.
Topics: Animals; Biophysics; Cell Size; Cells, Cultured; Disease Models, Animal; Electric Stimulation; GABA- | 2014 |
The lesion of dorsolateral funiculus changes the antiallodynic effect of the intrathecal muscimol and baclofen in distinct phases of neuropathic pain induced by spinal nerve ligation in rats.
Topics: Animals; Baclofen; Bicuculline; Functional Laterality; GABA Agents; Hyperalgesia; Injections, Spinal | 2016 |
Alleviating Bone Cancer-induced Mechanical Hypersensitivity by Inhibiting Neuronal Activity in the Anterior Cingulate Cortex.
Topics: Animals; Bone Neoplasms; Disease Models, Animal; Gyrus Cinguli; Hyperalgesia; Male; Mice; Mice, Inbr | 2016 |
Suppressed GABAergic signaling in the zona incerta causes neuropathic pain in a thoracic hemisection spinal cord injury rat model.
Topics: Action Potentials; Animals; Bicuculline; GABA Agonists; GABA-A Receptor Antagonists; gamma-Aminobuty | 2016 |
Combinations of intrathecal gamma-amino-butyrate receptor agonists and N-methyl-d-aspartate receptor antagonists in rats with neuropathic spinal cord injury pain.
Topics: Analgesia, Epidural; Animals; Baclofen; Dose-Response Relationship, Drug; Drug Synergism; Drug Thera | 2012 |
Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
Topics: Analgesia; Analgesics; Animals; Benzodiazepines; Chlorides; GABA-A Receptor Agonists; Isoxazoles; K | 2012 |
Effects of oxymatrine on the neuropathic pain induced by chronic constriction injury in mice.
Topics: Alkaloids; Animals; Chronic Disease; Constriction; Disease Models, Animal; Dose-Response Relationshi | 2012 |
Centrally-mediated antinociceptive actions of GABA(A) receptor agonists in the rat spared nerve injury model of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Agonists; GABA-A | 2005 |
The interaction between intrathecal neostigmine and GABA receptor agonists in rats with nerve ligation Injury.
Topics: Animals; Baclofen; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; G | 2001 |