muscimol has been researched along with Nerve Degeneration in 15 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Two animal models of TLE--amygdala kindling and pilocarpine-induced status epilepticus (Pilo-SE)--were tested." | 3.75 | Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. ( Leung, LS; Long, JJ; Luo, T; McMurran, TJ; Shen, B; Stewart, L, 2009) |
| "Hypertension is a major risk factor for cerebrovascular diseases, leading to vascular dementia and neurodegeneration." | 1.40 | Antihypertensive and neuroprotective effects of catestatin in spontaneously hypertensive rats: interaction with GABAergic transmission in amygdala and brainstem. ( Alò, R; Avolio, E; Canonaco, M; Facciolo, RM; Mahata, SK; Mantuano, E; Mele, M; Talani, G, 2014) |
| " A better understanding of the mechanism underlying these adverse effects should allow for the safer use of these agents and might clarify mechanisms underlying certain clinical disorders." | 1.32 | Muscimol prevents NMDA antagonist neurotoxicity by activating GABAA receptors in several brain regions. ( Dikranian, K; Farber, NB; Jiang, X; Nemmers, B, 2003) |
| "These results suggest that cases of Alzheimer's disease express heterogeneities in neocortical pathology which are reflected in the laminar patterns of binding to postsynaptic receptors." | 1.28 | Laminar alterations in gamma-aminobutyric acidA, muscarinic, and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease. ( Crino, PB; Vogt, BA; Volicer, L, 1991) |
| "Muscimol is a direct-acting GABA agonist that presumably substituted for the absent GABA at the interface between the degenerating striatonigral GABAergic terminals and the GABAergic receptors located on SNr neurons." | 1.28 | Rescuing neurons from trans-synaptic degeneration after brain damage: helpful, harmful, or neutral in recovery of function? ( Lindner, MD; Schallert, T, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Avolio, E | 1 |
| Mahata, SK | 1 |
| Mantuano, E | 1 |
| Mele, M | 1 |
| Alò, R | 1 |
| Facciolo, RM | 2 |
| Talani, G | 1 |
| Canonaco, M | 2 |
| Long, JJ | 1 |
| Shen, B | 1 |
| Luo, T | 1 |
| Stewart, L | 1 |
| McMurran, TJ | 1 |
| Leung, LS | 1 |
| Zizza, M | 1 |
| Giusi, G | 1 |
| Crudo, M | 1 |
| Farber, NB | 1 |
| Jiang, X | 1 |
| Dikranian, K | 1 |
| Nemmers, B | 1 |
| Deng, C | 1 |
| Huang, XF | 1 |
| Goto, S | 1 |
| Yamada, K | 1 |
| Yoshikawa, M | 1 |
| Okamura, A | 1 |
| Ushio, Y | 1 |
| Rambold, H | 1 |
| Helmchen, C | 1 |
| Büttner, U | 1 |
| Tomitaka, S | 1 |
| Tomitaka, M | 1 |
| Tolliver, BK | 1 |
| Sharp, FR | 1 |
| Li, CS | 1 |
| Andersen, RA | 1 |
| Vogt, BA | 1 |
| Crino, PB | 1 |
| Volicer, L | 1 |
| Schallert, T | 1 |
| Lindner, MD | 1 |
| Eidelberg, E | 1 |
| Nguyen, LH | 1 |
| Polich, R | 1 |
| Walden, JG | 1 |
| Nishino, N | 1 |
| Fujiwara, H | 1 |
| Noguchi-Kuno, SA | 1 |
| Tanaka, C | 1 |
| Wässle, H | 1 |
| Chun, MH | 1 |
| Müller, F | 1 |
| Saji, M | 1 |
| Reis, DJ | 1 |
15 other studies available for muscimol and Nerve Degeneration
| Article | Year |
|---|---|
Antihypertensive and neuroprotective effects of catestatin in spontaneously hypertensive rats: interaction with GABAergic transmission in amygdala and brainstem.
Topics: Age Factors; Amygdala; Animals; Antihypertensive Agents; Blood Pressure; Brain Stem; Chromogranin A; | 2014 |
Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics.
Topics: Anesthetics, General; Animals; Brain; Consciousness Disorders; Convulsants; Disease Models, Animal; | 2009 |
Lead-induced neurodegenerative events and abnormal behaviors occur via ORXRergic/GABA(A)Rergic mechanisms in a marine teleost.
Topics: Animals; Behavior, Animal; Bicuculline; Brain; Feeding Behavior; GABA-A Receptor Antagonists; Gene E | 2013 |
Muscimol prevents NMDA antagonist neurotoxicity by activating GABAA receptors in several brain regions.
Topics: Animals; Cell Count; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Excitator | 2003 |
Increased density of GABAA receptors in the superior temporal gyrus in schizophrenia.
Topics: Adaptation, Physiological; Adult; Binding, Competitive; GABA Agonists; gamma-Aminobutyric Acid; Hall | 2006 |
GABA receptor agonist promotes reformation of the striatonigral pathway by transplant derived from fetal striatal primordia in the lesioned striatum.
Topics: Animals; Apomorphine; Brain Damage, Chronic; Brain Ischemia; Brain Tissue Transplantation; Cell Coun | 1997 |
Vestibular influence on the binocular control of vertical-torsional nystagmus after lesions in the interstitial nucleus of Cajal.
Topics: Animals; Eye Movements; Functional Laterality; Macaca mulatta; Muscimol; Nerve Degeneration; Nystagm | 2000 |
Bilateral blockade of NMDA receptors in anterior thalamus by dizocilpine (MK-801) injures pyramidal neurons in rat retrosplenial cortex.
Topics: Animals; Anterior Thalamic Nuclei; Baclofen; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; | 2000 |
Inactivation of macaque lateral intraparietal area delays initiation of the second saccade predominantly from contralesional eye positions in a double-saccade task.
Topics: Animals; Functional Laterality; GABA Agonists; Macaca; Memory; Muscimol; Nerve Degeneration; Neurons | 2001 |
Laminar alterations in gamma-aminobutyric acidA, muscarinic, and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease.
Topics: Adrenergic beta-Antagonists; Aged; Alzheimer Disease; Gyrus Cinguli; Humans; Muscimol; Nerve Degener | 1991 |
Rescuing neurons from trans-synaptic degeneration after brain damage: helpful, harmful, or neutral in recovery of function?
Topics: Animals; Corpus Striatum; Dominance, Cerebral; Male; Muscimol; Nerve Degeneration; Nerve Regeneratio | 1990 |
Transsynaptic degeneration of motoneurones caudal to spinal cord lesions.
Topics: Animals; Colchicine; Male; Motor Neurons; Muscimol; Nerve Degeneration; Nomifensine; Rats; Rats, Inb | 1989 |
GABAA receptor but not muscarinic receptor density was decreased in the brain of patients with Parkinson's disease.
Topics: Aged; Brain; Choline O-Acetyltransferase; Dopamine; Female; Glutamate Decarboxylase; Humans; Male; M | 1988 |
Amacrine cells in the ganglion cell layer of the cat retina.
Topics: Animals; Autoradiography; Cats; Cell Count; Choline O-Acetyltransferase; Fluorescent Dyes; Immunohis | 1987 |
Delayed transneuronal death of substantia nigra neurons prevented by gamma-aminobutyric acid agonist.
Topics: Animals; Cell Survival; gamma-Aminobutyric Acid; Ibotenic Acid; Male; Muscimol; Nerve Degeneration; | 1987 |