muscimol has been researched along with Muscle Relaxation in 13 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of three specific GABA receptor agonists, muscimol, progabide, and gaboxadol, on kindled seizures were evaluated in amygdala-kindled rats." | 3.67 | Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats. ( Löscher, W; Schwark, WS, 1985) |
| "Pretreatment with bicuculline (GABAA antagonist) turned them to relaxation." | 2.67 | gamma-Aminobutyric acid enhances the tone of human internal anal sphincter. ( Fujita, S; Kusunoki, M; Sakanoue, Y; Shoji, Y; Utsunomiya, J; Yamamura, T; Yanagi, H, 1991) |
| " Administration of a 1 mM solution of muscimol (based on dose-response data) into this well abolished the reflex pressor response to contraction (change in mean arterial blood pressure before was 47 +/- 7 mmHg and after muscimol was 3 +/- 2 mmHg)." | 1.31 | Dorsal horn administration of muscimol abolishes the muscle pressor reflex. ( Wilson, LB, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gallos, G | 1 |
| Gleason, NR | 1 |
| Virag, L | 1 |
| Zhang, Y | 2 |
| Mizuta, K | 2 |
| Whittington, RA | 1 |
| Emala, CW | 2 |
| Petzold, BC | 1 |
| Park, SJ | 1 |
| Ponce, P | 1 |
| Roozeboom, C | 1 |
| Powell, C | 1 |
| Goodman, MB | 1 |
| Pruitt, BL | 1 |
| Bayer, S | 1 |
| Jellali, A | 1 |
| Crenner, F | 1 |
| Aunis, D | 1 |
| Angel, F | 1 |
| Xu, D | 1 |
| Pan, Y | 1 |
| Comas, G | 1 |
| Sonett, JR | 1 |
| Panettieri, RA | 1 |
| Yang, J | 1 |
| File, SE | 1 |
| Pencheva, N | 2 |
| Radomirov, R | 2 |
| Kilbinger, H | 1 |
| Ginap, T | 1 |
| Erbelding, D | 1 |
| Wilson, LB | 1 |
| Kusunoki, M | 1 |
| Shoji, Y | 1 |
| Sakanoue, Y | 1 |
| Yanagi, H | 1 |
| Fujita, S | 1 |
| Yamamura, T | 1 |
| Utsunomiya, J | 1 |
| Stefański, R | 1 |
| Plaznik, A | 1 |
| Pałejko, W | 1 |
| Kostowski, W | 1 |
| Lai, FM | 1 |
| Tanikella, T | 1 |
| Cervoni, P | 1 |
| Löscher, W | 1 |
| Schwark, WS | 1 |
1 trial available for muscimol and Muscle Relaxation
| Article | Year |
|---|---|
gamma-Aminobutyric acid enhances the tone of human internal anal sphincter.
Topics: Anal Canal; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Humans; Muscimol; Muscle Contraction; Mu | 1991 |
12 other studies available for muscimol and Muscle Relaxation
| Article | Year |
|---|---|
Endogenous gamma-aminobutyric acid modulates tonic guinea pig airway tone and propofol-induced airway smooth muscle relaxation.
Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Chromatography, High Pressure Liquid; Dose-Respons | 2009 |
Caenorhabditis elegans body mechanics are regulated by body wall muscle tone.
Topics: Animals; Biomechanical Phenomena; Body Size; Caenorhabditis elegans; Cholinergic Agonists; GABA-A Re | 2011 |
Functional evidence for a role of GABA receptors in modulating nerve activities of circular smooth muscle from rat colon in vitro.
Topics: Amino Acid Transport Systems; Animals; Baclofen; Carrier Proteins; Colon; Electric Stimulation; Ente | 2003 |
GABAA receptors are expressed and facilitate relaxation in airway smooth muscle.
Topics: Animals; Cells, Cultured; Guinea Pigs; Humans; Muscimol; Muscle Relaxation; Muscle, Smooth; Receptor | 2008 |
Chlordiazepoxide-induced ataxia, muscle relaxation and sedation in the rat: effects of muscimol, picrotoxin and naloxone.
Topics: Animals; Arousal; Chlordiazepoxide; Exploratory Behavior; Male; Motor Activity; Motor Skills; Murida | 1982 |
Biphasic GABA-A receptor-mediated effect on the spontaneous activity of the circular layer in cat terminal ileum.
Topics: Animals; Atropine; Baclofen; Bicuculline; Cats; gamma-Aminobutyric Acid; Ileum; In Vitro Techniques; | 1993 |
Two types of functionally different GABAA receptors mediate GABA modulation of cholinergic transmission in cat terminal ileum.
Topics: Animals; Atropine; Bicuculline; Cats; Dose-Response Relationship, Drug; Electric Stimulation; GABA A | 1995 |
GABAergic inhibition of nitric oxide-mediated relaxation of guinea-pig ileum.
Topics: Animals; Bicuculline; Electric Stimulation; Enzyme Inhibitors; Female; GABA Agonists; GABA-A Recepto | 1999 |
Dorsal horn administration of muscimol abolishes the muscle pressor reflex.
Topics: Afferent Pathways; Animals; Blood Pressure; Cats; Electric Stimulation; Functional Laterality; Heart | 2001 |
Myorelaxant effect of baclofen injected to the nucleus accumbens septi.
Topics: Animals; Baclofen; Behavior, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Halo | 1990 |
Effect of gamma-aminobutyric acid (GABA) on vasodilation in resistance-sized arteries isolated from the monkey, rabbit, and rat.
Topics: Animals; Arteries; Bicuculline; Dinoprost; gamma-Aminobutyric Acid; In Vitro Techniques; Macaca fasc | 1988 |
Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats.
Topics: Amygdala; Animals; Female; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Isoxazoles; Kindling, N | 1985 |