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muscimol and Muscle Contraction

muscimol has been researched along with Muscle Contraction in 44 studies

Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.

Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.

Research Excerpts

ExcerptRelevanceReference
" In the first group of experiments (n = 6), the pressor response to muscle contraction was attenuated by bilateral microinjection of muscimol (a GABA receptor agonist) into the lateral PAG [change in mean arterial pressure (DeltaMAP) = 24 +/- 5 vs."3.72Central integration of muscle reflex and arterial baroreflex in midbrain periaqueductal gray: roles of GABA and NO. ( Li, J, 2004)
" The effects of GABA on acetylcholine release and on longitudinal muscle contraction were competitively antagonized by bicuculline and picrotoxin."3.66gamma-Aminobutyric acid and cholinergic transmission in the guinea-pig ileum. ( Kilbinger, H; Kleinrok, A, 1983)
"Pretreatment with bicuculline (GABAA antagonist) turned them to relaxation."2.67gamma-Aminobutyric acid enhances the tone of human internal anal sphincter. ( Fujita, S; Kusunoki, M; Sakanoue, Y; Shoji, Y; Utsunomiya, J; Yamamura, T; Yanagi, H, 1991)
" Administration of a 1 mM solution of muscimol (based on dose-response data) into this well abolished the reflex pressor response to contraction (change in mean arterial blood pressure before was 47 +/- 7 mmHg and after muscimol was 3 +/- 2 mmHg)."1.31Dorsal horn administration of muscimol abolishes the muscle pressor reflex. ( Wilson, LB, 2001)
"The muscimol contraction was blocked by tetrodotoxin, scopolamine and picrotoxin and was reduced by hexamethonium (30 microM)."1.29Excitatory and inhibitory responses mediated by GABAA and GABAB receptors in guinea pig distal colon. ( Galligan, JJ; Minocha, A, 1993)
"835 and a parallel shift of the probit-log dosage regression line to the right."1.27Delta-aminovaleric acid antagonizes the pharmacological actions of baclofen in the central nervous system. ( Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Wüllner, U, 1988)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-199018 (40.91)18.7374
1990's14 (31.82)18.2507
2000's7 (15.91)29.6817
2010's4 (9.09)24.3611
2020's1 (2.27)2.80

Authors

AuthorsStudies
Leirão, IP1
Zoccal, DB1
Gargaglioni, LH1
da Silva, GSF1
Shaw, FZ1
Liao, YF1
Chen, RF1
Huang, YH1
Lin, RC1
Petzold, BC1
Park, SJ1
Ponce, P1
Roozeboom, C1
Powell, C1
Goodman, MB1
Pruitt, BL1
Mizuta, K1
Mizuta, F1
Xu, D1
Masaki, E1
Panettieri, RA1
Emala, CW1
Dabbish, NS1
Raizen, DM1
Koutsoviti-Papadopoulou, M1
Nikolaidis, E1
Kounenis, G1
de la Cruz, IP1
Levin, JZ1
Cummins, C1
Anderson, P1
Horvitz, HR1
Li, J1
Zizzo, MG1
Mulè, F1
Serio, R1
Desmurget, M1
Turner, RS1
Miyazato, M1
Sasatomi, K1
Hiragata, S1
Sugaya, K1
Chancellor, MB1
de Groat, WC1
Yoshimura, N1
Sillén, U1
Persson, B1
Rubenson, A1
Williford, DJ1
Ormsbee, HS1
Norman, W1
Harmon, JW1
Garvey, TQ1
DiMicco, JA1
Gillis, RA1
Wand, P1
Schwarz, M3
Kolasiewicz, W1
Sontag, KH3
Giotti, A1
Luzzi, S1
Spagnesi, S1
Zilletti, L1
Kleinrok, A1
Kilbinger, H1
Nicoletti, F2
Imperato, A2
Canonico, PL1
Piacente, B1
Raffaele, R1
Scapagnini, U1
Di Chiara, G1
File, SE1
Ha, JH1
Lee, KY1
Kim, WJ1
Pencheva, N4
Radomirov, R3
Minocha, A1
Galligan, JJ1
Tohda, Y1
Ohkawa, K1
Kubo, H1
Muraki, M1
Fukuoka, M1
Nakajima, S1
Sivarao, DV1
Krowicki, ZK1
Hornby, PJ1
Foti, D1
Patti, F1
Reggio, A1
Speciale, C1
Marano, P1
Rampello, L1
Itzev, D1
Milanov, P1
Wilson, LB1
Chen, TF1
Doyle, PT1
Ferguson, DR1
Venkova, K1
Kusunoki, M1
Shoji, Y1
Sakanoue, Y1
Yanagi, H1
Fujita, S1
Yamamura, T1
Utsunomiya, J1
Martin, JH1
Ghez, C1
Cutler, MG1
Turner, JM1
Moore, MR1
Mink, JW1
Thach, WT1
Frye, GD2
Fincher, AS1
Lorenzetti, M1
Trzeciakowski, J1
Griffith, WH1
Tonini, M2
Onori, L2
Rizzi, CA2
Perucca, E2
Manzo, L1
Crema, A2
Okamoto, T1
Kurahashi, K1
Fujiwara, M1
Oikawa, H1
Klockgether, T2
Turski, L2
Trzeciakowski, JP1
Maggi, CA2
Santicioli, P2
Meli, A2
De Ponti, F1
Budassi, P1
Wüllner, U1
Ong, J1
Tamaoki, J1
Graf, PD1
Nadel, JA1

Trials

1 trial available for muscimol and Muscle Contraction

ArticleYear
gamma-Aminobutyric acid enhances the tone of human internal anal sphincter.
    The Journal of surgical research, 1991, Volume: 51, Issue:4

    Topics: Anal Canal; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Humans; Muscimol; Muscle Contraction; Mu

1991

Other Studies

43 other studies available for muscimol and Muscle Contraction

ArticleYear
Differential modulation of active expiration during hypercapnia by the medullary raphe in unanesthetized rats.
    Pflugers Archiv : European journal of physiology, 2020, Volume: 472, Issue:11

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Abdominal Muscles; Animals; Diaphragm; Exhalation; GABA-A Re

2020
The zona incerta modulates spontaneous spike-wave discharges in the rat.
    Journal of neurophysiology, 2013, Volume: 109, Issue:10

    Topics: Action Potentials; Anesthetics, Local; Animals; Cerebral Cortex; Electric Stimulation; GABA-A Recept

2013
Caenorhabditis elegans body mechanics are regulated by body wall muscle tone.
    Biophysical journal, 2011, Apr-20, Volume: 100, Issue:8

    Topics: Animals; Biomechanical Phenomena; Body Size; Caenorhabditis elegans; Cholinergic Agonists; GABA-A Re

2011
Gi-coupled γ-aminobutyric acid-B receptors cross-regulate phospholipase C and calcium in airway smooth muscle.
    American journal of respiratory cell and molecular biology, 2011, Volume: 45, Issue:6

    Topics: Baclofen; Bradykinin; Calcium; Cells, Cultured; GABA-A Receptor Agonists; GABA-B Receptor Agonists;

2011
GABAergic synaptic plasticity during a developmentally regulated sleep-like state in C. elegans.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Nov-02, Volume: 31, Issue:44

    Topics: Adjuvants, Anesthesia; Aldicarb; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Cae

2011
Enhancing and inhibitory effects of H2-receptor antagonists on the GABA and the GABAA-agonist muscimol responses of the isolated guinea pig ileum: a pharmacodynamic interaction.
    Pharmacological research, 2003, Volume: 48, Issue:3

    Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; Famotidine; Female; GABA A

2003
sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Oct-08, Volume: 23, Issue:27

    Topics: Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cloning, Mole

2003
Central integration of muscle reflex and arterial baroreflex in midbrain periaqueductal gray: roles of GABA and NO.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:3

    Topics: Animals; Arteries; Baroreflex; Bicuculline; Blood Pressure; Cats; Female; GABA Agonists; GABA Antago

2004
Functional evidence for GABA as modulator of the contractility of the longitudinal muscle in mouse duodenum: role of GABA(A) and GABA(C) receptors.
    Neuropharmacology, 2007, Volume: 52, Issue:8

    Topics: Animals; Bicuculline; Cytarabine; Dose-Response Relationship, Drug; Drug Interactions; Duodenum; GAB

2007
Testing basal ganglia motor functions through reversible inactivations in the posterior internal globus pallidus.
    Journal of neurophysiology, 2008, Volume: 99, Issue:3

    Topics: Animals; Basal Ganglia; Behavior, Animal; Brain Mapping; Dose-Response Relationship, Drug; Electromy

2008
Suppression of detrusor-sphincter dysynergia by GABA-receptor activation in the lumbosacral spinal cord in spinal cord-injured rats.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 295, Issue:1

    Topics: Animals; Baclofen; GABA Agonists; GABA Antagonists; Lumbosacral Region; Muscimol; Muscle Contraction

2008
Involvement of central GABA receptors in the regulation of the urinary bladder function of anaesthetized rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1980, Volume: 314, Issue:2

    Topics: Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Glycine; Levodopa; Male; Muscimol; Muscle C

1980
Hindbrain GABA receptors influence parasympathetic outflow to the stomach.
    Science (New York, N.Y.), 1981, Oct-09, Volume: 214, Issue:4517

    Topics: Animals; Bicuculline; Cats; gamma-Aminobutyric Acid; Gastrointestinal Motility; Medulla Oblongata; M

1981
Nigral output neurons are engaged in regulation of static fusimotor action onto flexors in cat.
    Pflugers Archiv : European journal of physiology, 1981, Volume: 391, Issue:3

    Topics: Animals; Cats; gamma-Aminobutyric Acid; Motor Neurons; Motor Neurons, Gamma; Muscimol; Muscle Contra

1981
GABAA and GABAB receptor-mediated effects in guinea-pig ileum.
    British journal of pharmacology, 1983, Volume: 78, Issue:3

    Topics: Animals; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Ma

1983
gamma-Aminobutyric acid and cholinergic transmission in the guinea-pig ileum.
    Naunyn-Schmiedeberg's archives of pharmacology, 1983, Volume: 322, Issue:3

    Topics: Acetylcholine; Animals; Bicuculline; Electric Stimulation; gamma-Aminobutyric Acid; Guinea Pigs; Ile

1983
Motor and postural effects of kainic acid or GABA agonist and antagonist injection into the cerebellar nucleus fastigii.
    Birth defects original article series, 1983, Volume: 19, Issue:4

    Topics: Animals; Cerebellar Nuclei; Kainic Acid; Motor Skills; Muscimol; Muscle Contraction; Oxazoles; Picro

1983
Chlordiazepoxide-induced ataxia, muscle relaxation and sedation in the rat: effects of muscimol, picrotoxin and naloxone.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:6

    Topics: Animals; Arousal; Chlordiazepoxide; Exploratory Behavior; Male; Motor Activity; Motor Skills; Murida

1982
The action of diazepam in the isolated rat detrusor muscle.
    The Journal of urology, 1993, Volume: 150, Issue:1

    Topics: Adenosine Triphosphate; Amino Acids, Diamino; Animals; Atropine; Baclofen; Calcimycin; Calcium; Calc

1993
Biphasic GABA-A receptor-mediated effect on the spontaneous activity of the circular layer in cat terminal ileum.
    General pharmacology, 1993, Volume: 24, Issue:4

    Topics: Animals; Atropine; Baclofen; Bicuculline; Cats; gamma-Aminobutyric Acid; Ileum; In Vitro Techniques;

1993
Excitatory and inhibitory responses mediated by GABAA and GABAB receptors in guinea pig distal colon.
    European journal of pharmacology, 1993, Jan-12, Volume: 230, Issue:2

    Topics: Animals; Baclofen; Colon; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Ac

1993
Two types of functionally different GABAA receptors mediate GABA modulation of cholinergic transmission in cat terminal ileum.
    Journal of autonomic pharmacology, 1995, Volume: 15, Issue:4

    Topics: Animals; Atropine; Bicuculline; Cats; Dose-Response Relationship, Drug; Electric Stimulation; GABA A

1995
Role of GABA receptors in the bronchial response: studies in sensitized guinea-pigs.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1998, Volume: 28, Issue:6

    Topics: Acetylcholine; Animals; Baclofen; Bicuculline; Bronchi; Electric Stimulation; GABA Agonists; gamma-A

1998
Role of GABAA receptors in rat hindbrain nuclei controlling gastric motor function.
    Neurogastroenterology and motility, 1998, Volume: 10, Issue:4

    Topics: Animals; Bicuculline; GABA Agonists; GABA Antagonists; Gastrointestinal Motility; Male; Muscimol; Mu

1998
[Motor and postural effects in intracerebellar injection of kainic acid: possible role of the bulbar reticular formation].
    Bollettino della Societa italiana di biologia sperimentale, 1983, Mar-30, Volume: 59, Issue:3

    Topics: Animals; Cerebellar Nuclei; Cerebellum; Drug Interactions; Excitatory Amino Acid Agonists; GABA Agon

1983
Comparison of gamma-aminobutyric acid effects in different parts of the cat ileum.
    European journal of pharmacology, 1999, Feb-26, Volume: 368, Issue:1

    Topics: Acetylcholinesterase; Animals; Atropine; Baclofen; Bicuculline; Cats; Dose-Response Relationship, Dr

1999
Dorsal horn administration of muscimol abolishes the muscle pressor reflex.
    Journal of applied physiology (Bethesda, Md. : 1985), 2001, Volume: 90, Issue:3

    Topics: Afferent Pathways; Animals; Blood Pressure; Cats; Electric Stimulation; Functional Laterality; Heart

2001
Inhibitory role of gamma-amino-butyric acid in the rabbit urinary bladder.
    British journal of urology, 1992, Volume: 69, Issue:1

    Topics: Animals; Baclofen; Bicuculline; Carbachol; Depression, Chemical; Dose-Response Relationship, Drug; G

1992
GABAA and GABAB receptor-mediated effects on the spontaneous activity of the longitudinal layer in cat terminal ileum.
    General pharmacology, 1991, Volume: 22, Issue:1

    Topics: Animals; Baclofen; Bicuculline; Cats; GABA Antagonists; gamma-Aminobutyric Acid; Gastrointestinal Mo

1991
Impairments in reaching during reversible inactivation of the distal forelimb representation of the motor cortex in the cat.
    Neuroscience letters, 1991, Nov-25, Volume: 133, Issue:1

    Topics: Animals; Cats; Cerebral Cortex; Forelimb; Microinjections; Motor Cortex; Muscimol; Muscle Contractio

1991
A comparative study of the effects of delta-aminolaevulinic acid and the GABAA agonist, muscimol, in rat jejunal preparations.
    Pharmacology & toxicology, 1991, Volume: 69, Issue:1

    Topics: Aminolevulinic Acid; Animals; Bicuculline; Drug Synergism; In Vitro Techniques; Jejunum; Muscimol; M

1991
Basal ganglia motor control. III. Pallidal ablation: normal reaction time, muscle cocontraction, and slow movement.
    Journal of neurophysiology, 1991, Volume: 65, Issue:2

    Topics: Animals; Basal Ganglia; Electromyography; Globus Pallidus; Hippocampus; Kainic Acid; Macaca mulatta;

1991
Comparison of contractile responses of the guinea pig ileum longitudinal muscle to ethanol and GABAA agonists.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 252, Issue:2

    Topics: Animals; Atropine; Bicuculline; Chlorides; Ethanol; Female; Guinea Pigs; Ileum; In Vitro Techniques;

1990
Involvement of substance P in the excitatory action of GABAA agonists on cholinergic neurons in the guinea-pig ileum.
    Naunyn-Schmiedeberg's archives of pharmacology, 1987, Volume: 335, Issue:6

    Topics: Animals; Capsaicin; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscimol

1987
GABAA-receptor-mediated inhibition of the delayed increase in intragastric pressure to stimulation of vagal afferent fibres in cats.
    British journal of pharmacology, 1988, Volume: 95, Issue:1

    Topics: Animals; Baclofen; Cats; Electric Stimulation; Female; gamma-Aminobutyric Acid; Hexamethonium Compou

1988
The rat ventromedial thalamic nucleus and motor control: role of N-methyl-D-aspartate-mediated excitation, GABAergic inhibition, and muscarinic transmission.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1986, Volume: 6, Issue:6

    Topics: Animals; Aspartic Acid; Electromyography; gamma-Aminobutyric Acid; Locomotion; Male; Movement; Musci

1986
Pressor responses to central injection of H2 antagonists not caused by GABA blockade.
    European journal of pharmacology, 1986, May-27, Volume: 124, Issue:3

    Topics: Animals; Bicuculline; Blood Pressure; Cimetidine; Electric Stimulation; Female; Guinea Pigs; Histami

1986
GABAA and GABAB receptors in detrusor strips from guinea-pig bladder dome.
    Journal of autonomic pharmacology, 1985, Volume: 5, Issue:1

    Topics: Animals; Baclofen; Electric Stimulation; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques;

1985
Dual effect of GABA on the contractile activity of the guinea-pig isolated urinary bladder.
    Journal of autonomic pharmacology, 1985, Volume: 5, Issue:2

    Topics: Acetylcholine; Animals; Baclofen; Dimethylphenylpiperazinium Iodide; Drug Interactions; gamma-Aminob

1985
Inhibitory action of capsaicin on cholinergic responses induced by GABAA agonists in the guinea-pig ileum.
    European journal of pharmacology, 1986, Sep-09, Volume: 128, Issue:3

    Topics: Animals; Bicuculline; Capsaicin; Cholinergic Fibers; Female; Guinea Pigs; Ileum; In Vitro Techniques

1986
Delta-aminovaleric acid antagonizes the pharmacological actions of baclofen in the central nervous system.
    Experimental brain research, 1988, Volume: 70, Issue:3

    Topics: Animals; Baclofen; Bicuculline; Drug Antagonism; Electric Stimulation; Female; gamma-Aminobutyric Ac

1988
Uptake inhibitors potentiate gamma-aminobutyric acid-induced contractile responses in the isolated ileum of the guinea-pig.
    British journal of pharmacology, 1987, Volume: 91, Issue:1

    Topics: Animals; Bicuculline; Female; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male

1987
Effect of gamma-aminobutyric acid on neurally mediated contraction of guinea pig trachealis smooth muscle.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1

    Topics: Acetylcholine; Animals; Baclofen; Furosemide; gamma-Aminobutyric Acid; Guinea Pigs; Hemicholinium 3;

1987