muscimol has been researched along with Muscle Contraction in 44 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
Excerpt | Relevance | Reference |
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" In the first group of experiments (n = 6), the pressor response to muscle contraction was attenuated by bilateral microinjection of muscimol (a GABA receptor agonist) into the lateral PAG [change in mean arterial pressure (DeltaMAP) = 24 +/- 5 vs." | 3.72 | Central integration of muscle reflex and arterial baroreflex in midbrain periaqueductal gray: roles of GABA and NO. ( Li, J, 2004) |
" The effects of GABA on acetylcholine release and on longitudinal muscle contraction were competitively antagonized by bicuculline and picrotoxin." | 3.66 | gamma-Aminobutyric acid and cholinergic transmission in the guinea-pig ileum. ( Kilbinger, H; Kleinrok, A, 1983) |
"Pretreatment with bicuculline (GABAA antagonist) turned them to relaxation." | 2.67 | gamma-Aminobutyric acid enhances the tone of human internal anal sphincter. ( Fujita, S; Kusunoki, M; Sakanoue, Y; Shoji, Y; Utsunomiya, J; Yamamura, T; Yanagi, H, 1991) |
" Administration of a 1 mM solution of muscimol (based on dose-response data) into this well abolished the reflex pressor response to contraction (change in mean arterial blood pressure before was 47 +/- 7 mmHg and after muscimol was 3 +/- 2 mmHg)." | 1.31 | Dorsal horn administration of muscimol abolishes the muscle pressor reflex. ( Wilson, LB, 2001) |
"The muscimol contraction was blocked by tetrodotoxin, scopolamine and picrotoxin and was reduced by hexamethonium (30 microM)." | 1.29 | Excitatory and inhibitory responses mediated by GABAA and GABAB receptors in guinea pig distal colon. ( Galligan, JJ; Minocha, A, 1993) |
"835 and a parallel shift of the probit-log dosage regression line to the right." | 1.27 | Delta-aminovaleric acid antagonizes the pharmacological actions of baclofen in the central nervous system. ( Klockgether, T; Schwarz, M; Sontag, KH; Turski, L; Wüllner, U, 1988) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 18 (40.91) | 18.7374 |
1990's | 14 (31.82) | 18.2507 |
2000's | 7 (15.91) | 29.6817 |
2010's | 4 (9.09) | 24.3611 |
2020's | 1 (2.27) | 2.80 |
Authors | Studies |
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Leirão, IP | 1 |
Zoccal, DB | 1 |
Gargaglioni, LH | 1 |
da Silva, GSF | 1 |
Shaw, FZ | 1 |
Liao, YF | 1 |
Chen, RF | 1 |
Huang, YH | 1 |
Lin, RC | 1 |
Petzold, BC | 1 |
Park, SJ | 1 |
Ponce, P | 1 |
Roozeboom, C | 1 |
Powell, C | 1 |
Goodman, MB | 1 |
Pruitt, BL | 1 |
Mizuta, K | 1 |
Mizuta, F | 1 |
Xu, D | 1 |
Masaki, E | 1 |
Panettieri, RA | 1 |
Emala, CW | 1 |
Dabbish, NS | 1 |
Raizen, DM | 1 |
Koutsoviti-Papadopoulou, M | 1 |
Nikolaidis, E | 1 |
Kounenis, G | 1 |
de la Cruz, IP | 1 |
Levin, JZ | 1 |
Cummins, C | 1 |
Anderson, P | 1 |
Horvitz, HR | 1 |
Li, J | 1 |
Zizzo, MG | 1 |
Mulè, F | 1 |
Serio, R | 1 |
Desmurget, M | 1 |
Turner, RS | 1 |
Miyazato, M | 1 |
Sasatomi, K | 1 |
Hiragata, S | 1 |
Sugaya, K | 1 |
Chancellor, MB | 1 |
de Groat, WC | 1 |
Yoshimura, N | 1 |
Sillén, U | 1 |
Persson, B | 1 |
Rubenson, A | 1 |
Williford, DJ | 1 |
Ormsbee, HS | 1 |
Norman, W | 1 |
Harmon, JW | 1 |
Garvey, TQ | 1 |
DiMicco, JA | 1 |
Gillis, RA | 1 |
Wand, P | 1 |
Schwarz, M | 3 |
Kolasiewicz, W | 1 |
Sontag, KH | 3 |
Giotti, A | 1 |
Luzzi, S | 1 |
Spagnesi, S | 1 |
Zilletti, L | 1 |
Kleinrok, A | 1 |
Kilbinger, H | 1 |
Nicoletti, F | 2 |
Imperato, A | 2 |
Canonico, PL | 1 |
Piacente, B | 1 |
Raffaele, R | 1 |
Scapagnini, U | 1 |
Di Chiara, G | 1 |
File, SE | 1 |
Ha, JH | 1 |
Lee, KY | 1 |
Kim, WJ | 1 |
Pencheva, N | 4 |
Radomirov, R | 3 |
Minocha, A | 1 |
Galligan, JJ | 1 |
Tohda, Y | 1 |
Ohkawa, K | 1 |
Kubo, H | 1 |
Muraki, M | 1 |
Fukuoka, M | 1 |
Nakajima, S | 1 |
Sivarao, DV | 1 |
Krowicki, ZK | 1 |
Hornby, PJ | 1 |
Foti, D | 1 |
Patti, F | 1 |
Reggio, A | 1 |
Speciale, C | 1 |
Marano, P | 1 |
Rampello, L | 1 |
Itzev, D | 1 |
Milanov, P | 1 |
Wilson, LB | 1 |
Chen, TF | 1 |
Doyle, PT | 1 |
Ferguson, DR | 1 |
Venkova, K | 1 |
Kusunoki, M | 1 |
Shoji, Y | 1 |
Sakanoue, Y | 1 |
Yanagi, H | 1 |
Fujita, S | 1 |
Yamamura, T | 1 |
Utsunomiya, J | 1 |
Martin, JH | 1 |
Ghez, C | 1 |
Cutler, MG | 1 |
Turner, JM | 1 |
Moore, MR | 1 |
Mink, JW | 1 |
Thach, WT | 1 |
Frye, GD | 2 |
Fincher, AS | 1 |
Lorenzetti, M | 1 |
Trzeciakowski, J | 1 |
Griffith, WH | 1 |
Tonini, M | 2 |
Onori, L | 2 |
Rizzi, CA | 2 |
Perucca, E | 2 |
Manzo, L | 1 |
Crema, A | 2 |
Okamoto, T | 1 |
Kurahashi, K | 1 |
Fujiwara, M | 1 |
Oikawa, H | 1 |
Klockgether, T | 2 |
Turski, L | 2 |
Trzeciakowski, JP | 1 |
Maggi, CA | 2 |
Santicioli, P | 2 |
Meli, A | 2 |
De Ponti, F | 1 |
Budassi, P | 1 |
Wüllner, U | 1 |
Ong, J | 1 |
Tamaoki, J | 1 |
Graf, PD | 1 |
Nadel, JA | 1 |
1 trial available for muscimol and Muscle Contraction
Article | Year |
---|---|
gamma-Aminobutyric acid enhances the tone of human internal anal sphincter.
Topics: Anal Canal; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Humans; Muscimol; Muscle Contraction; Mu | 1991 |
43 other studies available for muscimol and Muscle Contraction
Article | Year |
---|---|
Differential modulation of active expiration during hypercapnia by the medullary raphe in unanesthetized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Abdominal Muscles; Animals; Diaphragm; Exhalation; GABA-A Re | 2020 |
The zona incerta modulates spontaneous spike-wave discharges in the rat.
Topics: Action Potentials; Anesthetics, Local; Animals; Cerebral Cortex; Electric Stimulation; GABA-A Recept | 2013 |
Caenorhabditis elegans body mechanics are regulated by body wall muscle tone.
Topics: Animals; Biomechanical Phenomena; Body Size; Caenorhabditis elegans; Cholinergic Agonists; GABA-A Re | 2011 |
Gi-coupled γ-aminobutyric acid-B receptors cross-regulate phospholipase C and calcium in airway smooth muscle.
Topics: Baclofen; Bradykinin; Calcium; Cells, Cultured; GABA-A Receptor Agonists; GABA-B Receptor Agonists; | 2011 |
GABAergic synaptic plasticity during a developmentally regulated sleep-like state in C. elegans.
Topics: Adjuvants, Anesthesia; Aldicarb; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Cae | 2011 |
Enhancing and inhibitory effects of H2-receptor antagonists on the GABA and the GABAA-agonist muscimol responses of the isolated guinea pig ileum: a pharmacodynamic interaction.
Topics: Animals; Cimetidine; Dose-Response Relationship, Drug; Drug Interactions; Famotidine; Female; GABA A | 2003 |
sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans.
Topics: Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cloning, Mole | 2003 |
Central integration of muscle reflex and arterial baroreflex in midbrain periaqueductal gray: roles of GABA and NO.
Topics: Animals; Arteries; Baroreflex; Bicuculline; Blood Pressure; Cats; Female; GABA Agonists; GABA Antago | 2004 |
Functional evidence for GABA as modulator of the contractility of the longitudinal muscle in mouse duodenum: role of GABA(A) and GABA(C) receptors.
Topics: Animals; Bicuculline; Cytarabine; Dose-Response Relationship, Drug; Drug Interactions; Duodenum; GAB | 2007 |
Testing basal ganglia motor functions through reversible inactivations in the posterior internal globus pallidus.
Topics: Animals; Basal Ganglia; Behavior, Animal; Brain Mapping; Dose-Response Relationship, Drug; Electromy | 2008 |
Suppression of detrusor-sphincter dysynergia by GABA-receptor activation in the lumbosacral spinal cord in spinal cord-injured rats.
Topics: Animals; Baclofen; GABA Agonists; GABA Antagonists; Lumbosacral Region; Muscimol; Muscle Contraction | 2008 |
Involvement of central GABA receptors in the regulation of the urinary bladder function of anaesthetized rats.
Topics: Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Glycine; Levodopa; Male; Muscimol; Muscle C | 1980 |
Hindbrain GABA receptors influence parasympathetic outflow to the stomach.
Topics: Animals; Bicuculline; Cats; gamma-Aminobutyric Acid; Gastrointestinal Motility; Medulla Oblongata; M | 1981 |
Nigral output neurons are engaged in regulation of static fusimotor action onto flexors in cat.
Topics: Animals; Cats; gamma-Aminobutyric Acid; Motor Neurons; Motor Neurons, Gamma; Muscimol; Muscle Contra | 1981 |
GABAA and GABAB receptor-mediated effects in guinea-pig ileum.
Topics: Animals; Baclofen; Bicuculline; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Ma | 1983 |
gamma-Aminobutyric acid and cholinergic transmission in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Bicuculline; Electric Stimulation; gamma-Aminobutyric Acid; Guinea Pigs; Ile | 1983 |
Motor and postural effects of kainic acid or GABA agonist and antagonist injection into the cerebellar nucleus fastigii.
Topics: Animals; Cerebellar Nuclei; Kainic Acid; Motor Skills; Muscimol; Muscle Contraction; Oxazoles; Picro | 1983 |
Chlordiazepoxide-induced ataxia, muscle relaxation and sedation in the rat: effects of muscimol, picrotoxin and naloxone.
Topics: Animals; Arousal; Chlordiazepoxide; Exploratory Behavior; Male; Motor Activity; Motor Skills; Murida | 1982 |
The action of diazepam in the isolated rat detrusor muscle.
Topics: Adenosine Triphosphate; Amino Acids, Diamino; Animals; Atropine; Baclofen; Calcimycin; Calcium; Calc | 1993 |
Biphasic GABA-A receptor-mediated effect on the spontaneous activity of the circular layer in cat terminal ileum.
Topics: Animals; Atropine; Baclofen; Bicuculline; Cats; gamma-Aminobutyric Acid; Ileum; In Vitro Techniques; | 1993 |
Excitatory and inhibitory responses mediated by GABAA and GABAB receptors in guinea pig distal colon.
Topics: Animals; Baclofen; Colon; Dose-Response Relationship, Drug; Drug Interactions; gamma-Aminobutyric Ac | 1993 |
Two types of functionally different GABAA receptors mediate GABA modulation of cholinergic transmission in cat terminal ileum.
Topics: Animals; Atropine; Bicuculline; Cats; Dose-Response Relationship, Drug; Electric Stimulation; GABA A | 1995 |
Role of GABA receptors in the bronchial response: studies in sensitized guinea-pigs.
Topics: Acetylcholine; Animals; Baclofen; Bicuculline; Bronchi; Electric Stimulation; GABA Agonists; gamma-A | 1998 |
Role of GABAA receptors in rat hindbrain nuclei controlling gastric motor function.
Topics: Animals; Bicuculline; GABA Agonists; GABA Antagonists; Gastrointestinal Motility; Male; Muscimol; Mu | 1998 |
[Motor and postural effects in intracerebellar injection of kainic acid: possible role of the bulbar reticular formation].
Topics: Animals; Cerebellar Nuclei; Cerebellum; Drug Interactions; Excitatory Amino Acid Agonists; GABA Agon | 1983 |
Comparison of gamma-aminobutyric acid effects in different parts of the cat ileum.
Topics: Acetylcholinesterase; Animals; Atropine; Baclofen; Bicuculline; Cats; Dose-Response Relationship, Dr | 1999 |
Dorsal horn administration of muscimol abolishes the muscle pressor reflex.
Topics: Afferent Pathways; Animals; Blood Pressure; Cats; Electric Stimulation; Functional Laterality; Heart | 2001 |
Inhibitory role of gamma-amino-butyric acid in the rabbit urinary bladder.
Topics: Animals; Baclofen; Bicuculline; Carbachol; Depression, Chemical; Dose-Response Relationship, Drug; G | 1992 |
GABAA and GABAB receptor-mediated effects on the spontaneous activity of the longitudinal layer in cat terminal ileum.
Topics: Animals; Baclofen; Bicuculline; Cats; GABA Antagonists; gamma-Aminobutyric Acid; Gastrointestinal Mo | 1991 |
Impairments in reaching during reversible inactivation of the distal forelimb representation of the motor cortex in the cat.
Topics: Animals; Cats; Cerebral Cortex; Forelimb; Microinjections; Motor Cortex; Muscimol; Muscle Contractio | 1991 |
A comparative study of the effects of delta-aminolaevulinic acid and the GABAA agonist, muscimol, in rat jejunal preparations.
Topics: Aminolevulinic Acid; Animals; Bicuculline; Drug Synergism; In Vitro Techniques; Jejunum; Muscimol; M | 1991 |
Basal ganglia motor control. III. Pallidal ablation: normal reaction time, muscle cocontraction, and slow movement.
Topics: Animals; Basal Ganglia; Electromyography; Globus Pallidus; Hippocampus; Kainic Acid; Macaca mulatta; | 1991 |
Comparison of contractile responses of the guinea pig ileum longitudinal muscle to ethanol and GABAA agonists.
Topics: Animals; Atropine; Bicuculline; Chlorides; Ethanol; Female; Guinea Pigs; Ileum; In Vitro Techniques; | 1990 |
Involvement of substance P in the excitatory action of GABAA agonists on cholinergic neurons in the guinea-pig ileum.
Topics: Animals; Capsaicin; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscimol | 1987 |
GABAA-receptor-mediated inhibition of the delayed increase in intragastric pressure to stimulation of vagal afferent fibres in cats.
Topics: Animals; Baclofen; Cats; Electric Stimulation; Female; gamma-Aminobutyric Acid; Hexamethonium Compou | 1988 |
The rat ventromedial thalamic nucleus and motor control: role of N-methyl-D-aspartate-mediated excitation, GABAergic inhibition, and muscarinic transmission.
Topics: Animals; Aspartic Acid; Electromyography; gamma-Aminobutyric Acid; Locomotion; Male; Movement; Musci | 1986 |
Pressor responses to central injection of H2 antagonists not caused by GABA blockade.
Topics: Animals; Bicuculline; Blood Pressure; Cimetidine; Electric Stimulation; Female; Guinea Pigs; Histami | 1986 |
GABAA and GABAB receptors in detrusor strips from guinea-pig bladder dome.
Topics: Animals; Baclofen; Electric Stimulation; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; | 1985 |
Dual effect of GABA on the contractile activity of the guinea-pig isolated urinary bladder.
Topics: Acetylcholine; Animals; Baclofen; Dimethylphenylpiperazinium Iodide; Drug Interactions; gamma-Aminob | 1985 |
Inhibitory action of capsaicin on cholinergic responses induced by GABAA agonists in the guinea-pig ileum.
Topics: Animals; Bicuculline; Capsaicin; Cholinergic Fibers; Female; Guinea Pigs; Ileum; In Vitro Techniques | 1986 |
Delta-aminovaleric acid antagonizes the pharmacological actions of baclofen in the central nervous system.
Topics: Animals; Baclofen; Bicuculline; Drug Antagonism; Electric Stimulation; Female; gamma-Aminobutyric Ac | 1988 |
Uptake inhibitors potentiate gamma-aminobutyric acid-induced contractile responses in the isolated ileum of the guinea-pig.
Topics: Animals; Bicuculline; Female; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male | 1987 |
Effect of gamma-aminobutyric acid on neurally mediated contraction of guinea pig trachealis smooth muscle.
Topics: Acetylcholine; Animals; Baclofen; Furosemide; gamma-Aminobutyric Acid; Guinea Pigs; Hemicholinium 3; | 1987 |