muscimol has been researched along with Multiple Sclerosis in 1 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Bicuculline treatment significantly reduced demyelination extension and increased the level of MBP expression." | 1.48 | Inhibition of GABA A receptor improved spatial memory impairment in the local model of demyelination in rat hippocampus. ( Afghani, A; Ashrafpour, M; Ashrafpour, S; Dehghan, S; Ebrahim Tabar, F; Gol, M; Mousavi Majd, A; Pourabdolhossein, F, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mousavi Majd, A | 1 |
| Ebrahim Tabar, F | 1 |
| Afghani, A | 1 |
| Ashrafpour, S | 1 |
| Dehghan, S | 1 |
| Gol, M | 1 |
| Ashrafpour, M | 1 |
| Pourabdolhossein, F | 1 |
1 other study available for muscimol and Multiple Sclerosis
| Article | Year |
|---|---|
Inhibition of GABA A receptor improved spatial memory impairment in the local model of demyelination in rat hippocampus.
Topics: Animals; Avoidance Learning; Bicuculline; Demyelinating Diseases; Disease Models, Animal; GABA-A Rec | 2018 |