muscimol has been researched along with Hypoxia in 23 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Bilateral inhibition of the RTN neurons with the GABA(A) agonist muscimol (100 pmol in 50 nl) reduced resting ventilation (52 ± 34, versus saline, 250 ± 56 ml min(-1) kg(-1) with absolute values) and attenuated the respiratory response to hypercapnia and hypoxia." | 3.79 | Control of breathing and blood pressure by parafacial neurons in conscious rats. ( Colombari, E; De Paula, PM; Menani, JV; Moreira, TS; Takakura, AC, 2013) |
| " In the present study, we investigated the cardiorespiratory responses to hypoxia or hypercapnia in anesthetized and conscious rats treated with injections of the GABA-A agonist muscimol into the caudal portion of the commNTS." | 3.77 | Chemosensory control by commissural nucleus of the solitary tract in rats. ( Colombari, E; de Paula, PM; Favero, MT; Menani, JV; Moreira, TS; Takakura, AC, 2011) |
| " Microinjection of GABA or muscimol (1 mM) attenuated the ventilatory response to hypoxia (12% O2) in NMS rats only." | 3.74 | Neonatal maternal separation and enhancement of the hypoxic ventilatory response in rat: the role of GABAergic modulation within the paraventricular nucleus of the hypothalamus. ( Balon, N; Drolet, G; Genest, SE; Kinkead, R; Laforest, S, 2007) |
| "We hypothesized that inhibition of the rostral medullary raphe region (MRR), a putative central chemoreceptor location, with the GABA(A) receptor agonist muscimol would decrease ventilatory responses to hypercapnia and hypoxia in conscious rats, and that its known effect at this site on body temperature might alter its effect upon these ventilatory responses." | 3.73 | Ventilatory effects of muscimol microdialysis into the rostral medullary raphé region of conscious rats. ( Li, A; Nattie, EE; Taylor, NC, 2006) |
| " In urethane-chloralose-anaesthetized rats, bilateral inhibition of the RTN with muscimol eliminated the phrenic nerve discharge (PND) at rest, during hyperoxic hypercapnia (10% CO(2)), and during peripheral chemoreceptor stimulation (hypoxia and/or i." | 3.73 | Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats. ( Colombari, E; Guyenet, PG; Moreira, TS; Stornetta, RL; Takakura, AC; West, GH, 2006) |
| " Baroreflex curves were obtained under conditions of normoxia and hypoxia (10% O(2) + 3% CO(2)) after injections into the A5 region of the GABA receptor agonist muscimol or vehicle solution." | 3.70 | Influence of pontine A5 region on renal sympathetic nerve activity in conscious rabbits. ( Head, GA; Maiorov, DN; Malpas, SC, 2000) |
| "In pentobarbital sodium-anesthetized, paralyzed, and ventilated rats, systemic hypoxia, produced by intratracheal N2 administration for 20 s, rapidly increased activities of reticulospinal vasomotor neurons in the rostroventolateral reticular nucleus (RVL) of the medulla oblongata (by 23." | 3.69 | Medullary vasomotor activity and hypoxic sympathoexcitation in pentobarbital-anesthetized rats. ( Reis, DJ; Sun, MK, 1996) |
| "Treatment with gabapentin (50 and 100 mg/kg) significantly increased ambulatory movements, exerted anti-anxiety like effect and reduced oxidative damage in mice subjected to acute hypoxic stress." | 1.35 | Gabapentin attenuates acute hypoxic stress-induced behavioral alterations and oxidative damage in mice: possible involvement of GABAergic mechanism. ( Goyal, R; Kumar, A, 2008) |
| "Strychnine was used to block transmission by glycine." | 1.31 | Neurogenesis of gasping does not require inhibitory transmission using GABA(A) or glycine receptors. ( Paton, JF; St-John, WM, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.04) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 6 (26.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sharpe, AL | 1 |
| Calderon, AS | 1 |
| Andrade, MA | 1 |
| Cunningham, JT | 1 |
| Mifflin, SW | 1 |
| Toney, GM | 1 |
| Damasceno, RS | 1 |
| Takakura, AC | 4 |
| Moreira, TS | 4 |
| Sharma, RK | 1 |
| Choudhary, RC | 1 |
| Reddy, MK | 1 |
| Ray, A | 1 |
| Ravi, K | 1 |
| Schlenker, EH | 1 |
| Nattie, E | 1 |
| Li, A | 2 |
| Mandel, DA | 1 |
| Schreihofer, AM | 1 |
| Favero, MT | 1 |
| de Paula, PM | 2 |
| Colombari, E | 3 |
| Menani, JV | 2 |
| St-John, WM | 1 |
| Paton, JF | 1 |
| Madden, CJ | 1 |
| Morrison, SF | 1 |
| Taylor, NC | 1 |
| Nattie, EE | 1 |
| West, GH | 1 |
| Stornetta, RL | 1 |
| Guyenet, PG | 1 |
| Genest, SE | 1 |
| Balon, N | 1 |
| Laforest, S | 1 |
| Drolet, G | 1 |
| Kinkead, R | 1 |
| Kumar, A | 1 |
| Goyal, R | 1 |
| Ostrovskaia, RU | 1 |
| Sun, MK | 2 |
| Reis, DJ | 2 |
| Coles, SK | 1 |
| Dick, TE | 1 |
| Maiorov, DN | 1 |
| Malpas, SC | 1 |
| Head, GA | 1 |
| Tabata, M | 1 |
| Kurosawa, H | 1 |
| Kikuchi, Y | 1 |
| Hida, W | 1 |
| Ogawa, H | 1 |
| Okabe, S | 1 |
| Tun, Y | 1 |
| Hattori, T | 1 |
| Shirato, K | 1 |
| Gieroba, ZJ | 1 |
| Fullerton, MJ | 1 |
| Funder, JW | 1 |
| Blessing, WW | 1 |
| Ninomiya, H | 1 |
| Taniguchi, T | 1 |
| Fujiwara, M | 1 |
| Meldrum, BS | 1 |
1 review available for muscimol and Hypoxia
| Article | Year |
|---|---|
Drugs acting on amino acid neurotransmitters.
Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiolo | 1986 |
22 other studies available for muscimol and Hypoxia
| Article | Year |
|---|---|
Chronic intermittent hypoxia increases sympathetic control of blood pressure: role of neuronal activity in the hypothalamic paraventricular nucleus.
Topics: Animals; Blood Pressure; GABA-A Receptor Agonists; Heart Rate; Hypoxia; Male; Muscimol; Neurons; Par | 2013 |
Regulation of the chemosensory control of breathing by Kölliker-Fuse neurons.
Topics: Animals; Bicuculline; Blood Pressure; Chemoreceptor Cells; Disease Models, Animal; GABA-A Receptor A | 2014 |
Role of posterior hypothalamus in hypobaric hypoxia induced pulmonary edema.
Topics: Altitude Sickness; Animals; Disease Models, Animal; GABA-A Receptor Agonists; Hypertension, Pulmonar | 2015 |
Muscimol microinjected in the arcuate nucleus affects metabolism, body temperature & ventilation.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Body Temperature; Dose-Response Relationship, Drug; Female | 2016 |
Muscimol dialysis into the caudal aspect of the Nucleus tractus solitarii of conscious rats inhibits chemoreception.
Topics: Analysis of Variance; Animals; Body Temperature; Carbon Dioxide; Dialysis; Electroencephalography; E | 2008 |
Modulation of the sympathetic response to acute hypoxia by the caudal ventrolateral medulla in rats.
Topics: Animals; Bicuculline; Blood Pressure; Excitatory Amino Acid Antagonists; GABA Agonists; GABA-A Recep | 2009 |
Chemosensory control by commissural nucleus of the solitary tract in rats.
Topics: Animals; Chemoreceptor Cells; GABA-A Receptor Agonists; Hypercapnia; Hypoxia; Male; Muscimol; Rats; | 2011 |
Control of breathing and blood pressure by parafacial neurons in conscious rats.
Topics: Animals; Blood Pressure; Consciousness; Hypercapnia; Hypoxia; Male; Muscimol; N-Methylaspartate; Neu | 2013 |
Neurogenesis of gasping does not require inhibitory transmission using GABA(A) or glycine receptors.
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA-A Rece | 2002 |
Hypoxic activation of arterial chemoreceptors inhibits sympathetic outflow to brown adipose tissue in rats.
Topics: Adipose Tissue, Brown; Animals; Arteries; Bicuculline; Body Temperature; Carotid Body; Chemoreceptor | 2005 |
Ventilatory effects of muscimol microdialysis into the rostral medullary raphé region of conscious rats.
Topics: Analysis of Variance; Animals; Body Temperature; GABA Agonists; Hypercapnia; Hypoxia; Male; Microdia | 2006 |
Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats.
Topics: Action Potentials; Animals; Biotin; Carbon Dioxide; Carotid Body; Chemoreceptor Cells; Cholera Toxin | 2006 |
Neonatal maternal separation and enhancement of the hypoxic ventilatory response in rat: the role of GABAergic modulation within the paraventricular nucleus of the hypothalamus.
Topics: Animals; Animals, Newborn; Anxiety, Separation; Female; Flunitrazepam; GABA Agonists; GABA Modulator | 2007 |
Gabapentin attenuates acute hypoxic stress-induced behavioral alterations and oxidative damage in mice: possible involvement of GABAergic mechanism.
Topics: Amines; Analysis of Variance; Animals; Brain; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobu | 2008 |
[Differences in the mechanism of the antihypoxic action of benzodiazepine receptor agonists and muscimol].
Topics: Animals; Anti-Anxiety Agents; Diazepam; Drug Evaluation, Preclinical; gamma-Aminobutyric Acid; Hypox | 1984 |
Intrathecal kynurenate but not benextramine blocks hypoxic sympathoexcitation in chemodenervated anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Blood Pressure; Catecholamines; Cystamine; Hypoxi | 1994 |
Medullary vasomotor activity and hypoxic sympathoexcitation in pentobarbital-anesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Hypoxia; Male; Medulla Oblongata; Microinjections; Muscimol; Ne | 1996 |
Neurones in the ventrolateral pons are required for post-hypoxic frequency decline in rats.
Topics: Animals; Brain; Capsaicin; GABA Agonists; Hypoxia; Lobeline; Male; Microinjections; Muscimol; Neuron | 1996 |
Influence of pontine A5 region on renal sympathetic nerve activity in conscious rabbits.
Topics: Animals; Baroreflex; Electrophysiology; GABA Agonists; Hypoxia; Kidney; Muscimol; Pons; Rabbits; Ref | 2000 |
Role of GABA within the nucleus tractus solitarii in the hypoxic ventilatory decline of awake rats.
Topics: Animals; Baclofen; Bicuculline; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hypoxia; M | 2001 |
Medullary pathways for adrenocorticotropic hormone and vasopressin secretion in rabbits.
Topics: 2-Amino-5-phosphonovalerate; Adrenocorticotropic Hormone; Animals; Cardiovascular System; Constricti | 1992 |
Effects of hypoxia on muscarinic cholinergic and benzodiazepine/gamma-aminobutyric acid receptors in the rat brain.
Topics: Animals; Brain; Choline O-Acetyltransferase; Flunitrazepam; Glutamate Decarboxylase; Hypoxia; Kineti | 1988 |