muscimol has been researched along with Hypotension in 13 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effects of bilateral injections of the GABA receptor agonists muscimol (GABA A) and baclofen (GABA B) into the nucleus tractus solitarius (NTS) on the bradycardia and hypotension induced by iv serotonin injections (5-HT, 2 microg/rat) in awake male Holtzman rats." | 3.73 | The bradycardic and hypotensive responses to serotonin are reduced by activation of GABAA receptors in the nucleus tractus solitarius of awake rats. ( Callera, JC; Colombari, E; De Luca, LA; Menani, JV, 2005) |
| "Plasma vasopressin (AVP) levels were measured at rest (mean arterial pressure 80-85 mmHg) and during hypotension (mean arterial pressure 38-45 mmHg) induced by ganglionic blockade (trimethaphan) in halothane-anaesthetized respirated rats with end-tidal pCO2 maintained at 34-40 mmHg." | 3.67 | Baroreceptor-independent medullary mechanism for release of vasopressin during hypotension in rats. ( Baertschi, AJ; Guyenet, PG; Hashemzadeh-Gargari, H, 1988) |
| "Intravenous injections of clonidine produce an initial transient increase in blood pressure followed by a long-lasting hypotension and bradycardia." | 3.67 | Ventrolateral medullary pressor area: site of hypotensive action of clonidine. ( Krieger, AJ; Punnen, S; Sapru, HN; Urbanski, R, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lu, Y | 1 |
| Wu, YS | 1 |
| Chen, DS | 1 |
| Wang, MM | 1 |
| Wang, WZ | 1 |
| Yuan, WJ | 1 |
| Mandel, DA | 1 |
| Schreihofer, AM | 1 |
| Dean, C | 1 |
| Göktalay, G | 1 |
| Levendusky, MC | 1 |
| Millington, WR | 1 |
| Callera, JC | 1 |
| Colombari, E | 1 |
| De Luca, LA | 1 |
| Menani, JV | 1 |
| Bousquet, P | 2 |
| Feldman, J | 2 |
| Bloch, R | 2 |
| Schwartz, J | 2 |
| Williford, DJ | 1 |
| Hamilton, BL | 1 |
| Souza, JD | 1 |
| Williams, TP | 1 |
| DiMicco, JA | 1 |
| Gillis, RA | 1 |
| Mei, L | 1 |
| Han, JS | 1 |
| Kajekar, R | 1 |
| Chen, CY | 1 |
| Mutoh, T | 1 |
| Bonham, AC | 1 |
| Magnusson, A | 1 |
| Höglund, U | 1 |
| Sjöquist, M | 1 |
| Hashemzadeh-Gargari, H | 1 |
| Baertschi, AJ | 1 |
| Guyenet, PG | 1 |
| Punnen, S | 1 |
| Urbanski, R | 1 |
| Krieger, AJ | 1 |
| Sapru, HN | 1 |
13 other studies available for muscimol and Hypotension
| Article | Year |
|---|---|
Microinjection of salusin-beta into the nucleus tractus solitarii inhibits cardiovascular function by suppressing presympathetic neurons in rostral ventrolateral medulla in rats.
Topics: Animals; Baroreflex; Bradycardia; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonist | 2015 |
Glutamatergic inputs to the CVLM independent of the NTS promote tonic inhibition of sympathetic vasomotor tone in rats.
Topics: Animals; Baroreflex; Blood Pressure; Blood Vessels; Disease Models, Animal; Excitatory Amino Acid An | 2008 |
Hemorrhagic sympathoinhibition mediated through the periaqueductal gray in the rat.
Topics: Animals; Blood Pressure; GABA Agonists; Hemorrhage; Hypotension; Kidney; Muscimol; Neural Inhibition | 2004 |
Muscimol injection into the lateral hypothalamus inhibits the hypotension and bradycardia caused by somato-visceral nociception.
Topics: Animals; Bradycardia; Cardiovascular Physiological Phenomena; GABA Agonists; Homocysteine; Hypotensi | 2004 |
The bradycardic and hypotensive responses to serotonin are reduced by activation of GABAA receptors in the nucleus tractus solitarius of awake rats.
Topics: Animals; Baclofen; Blood Pressure; Bradycardia; GABA Agonists; Heart Rate; Hypotension; Male; Muscim | 2005 |
The ventromedullary hypotensive effect of muscimol in the anaesthetized cat.
Topics: Anesthesia; Animals; Bicuculline; Blood Pressure; Brain Stem; Cats; Hypotension; Muscimol; Oxazoles; | 1981 |
Central nervous system mechanisms involving GABA influence arterial pressure and heart rate in the cat.
Topics: Animals; Autonomic Nervous System; Blood Pressure; Bradycardia; Cats; Central Nervous System; Clonid | 1980 |
The antagonistic effect of cholecystokinin octapeptide (CCK-8) on opioid effects in cardiovascular activities was mediated by CCK-B receptor.
Topics: Animals; Benzodiazepinones; Blood Pressure; Devazepide; Female; Hypotension; Muscimol; Phenylurea Co | 1993 |
GABA(A) receptor activation at medullary sympathetic neurons contributes to postexercise hypotension.
Topics: Animals; Baroreflex; Bicuculline; Blood Pressure; GABA Agonists; GABA Antagonists; GABA-A Receptor A | 2002 |
[Ventrobulbular hypotensive action of muscimol].
Topics: Animals; Bradycardia; Brain Stem; Cats; Female; Hypotension; Male; Muscimol; Oxazoles | 1978 |
Biochemical evidence for the GABA regulation of vasopressin levels in microdissected brain structures after servo-controlled hypotension.
Topics: 3-Mercaptopropionic Acid; Animals; Brain; Enzyme Inhibitors; gamma-Aminobutyric Acid; Hypotension; M | 1989 |
Baroreceptor-independent medullary mechanism for release of vasopressin during hypotension in rats.
Topics: Animals; Arginine Vasopressin; Chemoreceptor Cells; Hypotension; Kynurenic Acid; Male; Medulla Oblon | 1988 |
Ventrolateral medullary pressor area: site of hypotensive action of clonidine.
Topics: Animals; Blood Pressure; Clonidine; Dioxanes; Heart Rate; Hypotension; Idazoxan; Male; Medulla Oblon | 1987 |