muscimol has been researched along with Hypertension in 25 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Baclofen (20 mg/kg) was neuroprotective (potency ratio of 3." | 5.30 | High dose baclofen is neuroprotective but also causes intracerebral hemorrhage: a quantal bioassay study using the intraluminal suture occlusion method. ( Jackson-Friedman, C; Jin, A; Lyden, PD; Nunez, S; Zweifler, R, 1997) |
| "Development of angiotensin II (Ang II)-dependent hypertension involves microglial activation and proinflammatory cytokine actions in the hypothalamic paraventricular nucleus (PVN)." | 3.80 | Ang II-salt hypertension depends on neuronal activity in the hypothalamic paraventricular nucleus but not on local actions of tumor necrosis factor-α. ( Bardgett, ME; Herrera-Rosales, M; Holbein, WW; Toney, GM, 2014) |
| "To determine whether chronic central gamma-aminobutyric acid (GABA) stimulation would attenuate development of hypertension, tail-cuff systolic pressures were measured in male spontaneously hypertensive rats (SHR) treated with either an inhibitor of GABA breakdown (valproate, VPA), or a GABA-receptor agonist (muscimol)." | 3.68 | Chronic central GABAergic stimulation attenuates hypothalamic hyperactivity and development of spontaneous hypertension in rats. ( Hayashi, J; Kawasaki, S; Nakagawa, M; Nakata, T; Oguro, M; Sasaki, S; Takeda, K, 1990) |
| " Intraperitoneal injection of valproic acid (50-100 mg/Kg/die) for 6 weeks significantly reduced the development of DOCA-salt hypertension in rats." | 3.67 | Increased cardiovascular responsiveness to GABAergic stimulation in DOCA-salt hypertensive rats. ( Caputi, AP; Costa, G; Di Giorgio, RM; Magrì, V; Quattrone, G; Squadrito, F; Trimarchi, GR, 1984) |
| "To elucidate the role of the central gamma-aminobutyric acid (GABA) system in the maintenance of deoxycorticosterone (DOCA)NaCl hypertension, the responses of mean arterial pressure (MAP), plasma norepinephrine (NE), and epinephrine (EP) to intracerebroventricular (ICV) administration of muscimol, a GABA agonist, and the responses of MAP to bicuculline, a GABA antagonist, and to clonidine, an alpha 2-adrenoceptor agonist known to lower blood pressure by inhibiting sympathetic tone, were examined in conscious, unrestrained 4 week DOCA/NaCl hypertensive rats and age-matched uninephrectomized control rats." | 3.67 | Enhanced depressor effect of muscimol in the DOCA/NaCl hypertensive rat: evidence for altered GABAergic activity in brain. ( Dawson, R; Nagahama, S; Oparil, S, 1985) |
| "Hypertension is a major risk factor for cerebrovascular diseases, leading to vascular dementia and neurodegeneration." | 1.40 | Antihypertensive and neuroprotective effects of catestatin in spontaneously hypertensive rats: interaction with GABAergic transmission in amygdala and brainstem. ( Alò, R; Avolio, E; Canonaco, M; Facciolo, RM; Mahata, SK; Mantuano, E; Mele, M; Talani, G, 2014) |
| "Baclofen (20 mg/kg) was neuroprotective (potency ratio of 3." | 1.30 | High dose baclofen is neuroprotective but also causes intracerebral hemorrhage: a quantal bioassay study using the intraluminal suture occlusion method. ( Jackson-Friedman, C; Jin, A; Lyden, PD; Nunez, S; Zweifler, R, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bardgett, ME | 1 |
| Holbein, WW | 1 |
| Herrera-Rosales, M | 1 |
| Toney, GM | 1 |
| Avolio, E | 1 |
| Mahata, SK | 1 |
| Mantuano, E | 1 |
| Mele, M | 1 |
| Alò, R | 1 |
| Facciolo, RM | 1 |
| Talani, G | 1 |
| Canonaco, M | 1 |
| Zhang, Q | 1 |
| Yao, F | 2 |
| O'Rourke, ST | 2 |
| Qian, SY | 1 |
| Sun, C | 2 |
| Chen, F | 1 |
| Cham, JL | 1 |
| Badoer, E | 1 |
| Takakura, AC | 1 |
| Colombari, E | 1 |
| Menani, JV | 1 |
| Moreira, TS | 1 |
| Vorobyov, V | 1 |
| Schibaev, N | 1 |
| Kaptsov, V | 1 |
| Kovalev, G | 1 |
| Sengpiel, F | 1 |
| Kanaya, T | 1 |
| Okatani, H | 1 |
| Hagiwara, Y | 1 |
| Fukumori, R | 1 |
| Goshima, Y | 1 |
| Kubo, T | 1 |
| Aicher, SA | 1 |
| Fields, AM | 1 |
| Richards, TA | 1 |
| Felton, JA | 1 |
| Felton, SK | 1 |
| Bayer, EZ | 1 |
| Ibrahim, IN | 1 |
| Kaye, AD | 1 |
| Li, DP | 1 |
| Pan, HL | 1 |
| Sumners, C | 1 |
| Brennan, TJ | 1 |
| Haywood, JR | 1 |
| Ticku, MK | 1 |
| DeFeudis, FV | 1 |
| Magrì, V | 1 |
| Trimarchi, GR | 1 |
| Quattrone, G | 1 |
| Squadrito, F | 1 |
| Di Giorgio, RM | 1 |
| Costa, G | 1 |
| Caputi, AP | 1 |
| Jastrzebski, Z | 1 |
| Goźlińska, B | 1 |
| Czyzewska-Szafran, H | 1 |
| Muratani, H | 1 |
| Ferrario, CM | 1 |
| Averill, DB | 1 |
| Momohara, M | 1 |
| Imaizumi, T | 1 |
| Endo, T | 1 |
| Suzuki, S | 1 |
| Tagawa, T | 1 |
| Shiramoto, M | 1 |
| Masaki, H | 1 |
| Takeshita, A | 1 |
| Hara, K | 1 |
| Miyawaki, T | 1 |
| Minson, J | 1 |
| Arnolda, L | 1 |
| Llewellyn-Smith, I | 1 |
| Chalmers, J | 1 |
| Pilowsky, P | 1 |
| Jackson-Friedman, C | 1 |
| Lyden, PD | 1 |
| Nunez, S | 1 |
| Jin, A | 1 |
| Zweifler, R | 1 |
| Ito, S | 1 |
| Komatsu, K | 1 |
| Tsukamoto, K | 1 |
| Sved, AF | 2 |
| Allen, AM | 1 |
| Sasaki, S | 1 |
| Nakata, T | 1 |
| Kawasaki, S | 1 |
| Hayashi, J | 1 |
| Oguro, M | 1 |
| Takeda, K | 1 |
| Nakagawa, M | 1 |
| Bousquet, P | 1 |
| Feldman, J | 1 |
| Schwartz, J | 1 |
| Catelli, JM | 1 |
| Nagahama, S | 1 |
| Dawson, R | 1 |
| Oparil, S | 1 |
2 reviews available for muscimol and Hypertension
| Article | Year |
|---|---|
gamma-Aminobutyric acid and cardiovascular function.
Topics: Animals; Atropine; Baclofen; Blood Pressure; GABA Antagonists; gamma-Aminobutyric Acid; Heart Rate; | 1983 |
[GABA and central regulation of cardiovascular function].
Topics: Angiotensin II; Animals; Anti-Anxiety Agents; Antihypertensive Agents; Baclofen; Benzodiazepines; Bi | 1985 |
23 other studies available for muscimol and Hypertension
| Article | Year |
|---|---|
Ang II-salt hypertension depends on neuronal activity in the hypothalamic paraventricular nucleus but not on local actions of tumor necrosis factor-α.
Topics: Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; GABA-A Receptor Agonists; Hypertens | 2014 |
Antihypertensive and neuroprotective effects of catestatin in spontaneously hypertensive rats: interaction with GABAergic transmission in amygdala and brainstem.
Topics: Age Factors; Amygdala; Animals; Antihypertensive Agents; Blood Pressure; Brain Stem; Chromogranin A; | 2014 |
Angiotensin II enhances GABA(B) receptor-mediated responses and expression in nucleus tractus solitarii of rats.
Topics: Angiotensin II; Animals; Baclofen; Baroreflex; Bicuculline; Blood Pressure; Disease Models, Animal; | 2009 |
High-fat feeding alters the cardiovascular role of the hypothalamic paraventricular nucleus.
Topics: Adipose Tissue; Animals; Bicuculline; Blood Glucose; Blood Pressure; Body Weight; Cardiovascular Sys | 2010 |
Ventrolateral medulla mechanisms involved in cardiorespiratory responses to central chemoreceptor activation in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Chemor | 2011 |
Cortical and hippocampal EEG effects of neurotransmitter agonists in spontaneously hypertensive vs. kainate-treated rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Baclofen; Clonidine; Disease Models, Animal; | 2011 |
Projections from the caudal part to the rostral part of the lateral septal area mediate blood pressure increase.
Topics: Animals; Blood Pressure; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Fluoresc | 2003 |
The gigantocellular depressor area revisited.
Topics: Animals; Autonomic Pathways; Baroreflex; Blood Pressure; Functional Laterality; GABA Agonists; Heart | 2003 |
Analysis of responses to valerian root extract in the feline pulmonary vascular bed.
Topics: Acetylcholine; Animals; Arachidonic Acid; Bradykinin; Calcium Channel Agonists; Cats; Disease Models | 2003 |
Role of gamma-aminobutyric acid (GABA)A and GABAB receptors in paraventricular nucleus in control of sympathetic vasomotor tone in hypertension.
Topics: Animals; Baclofen; Bicuculline; Blood Pressure; Heart Rate; Hypertension; Male; Microinjections; Mus | 2007 |
Angiotensin II increases GABAB receptor expression in nucleus tractus solitarii of rats.
Topics: Action Potentials; Angiotensin II; Animals; Animals, Newborn; Baclofen; Baroreflex; Blood Pressure; | 2008 |
GABA receptor binding and hemodynamic responses to ICV GABA in adult spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain; gamma-Aminobutyric Acid; Heart Rate; Hemody | 1983 |
Increased cardiovascular responsiveness to GABAergic stimulation in DOCA-salt hypertensive rats.
Topics: 4-Aminobutyrate Transaminase; Animals; Blood Pressure; Brain; Desoxycorticosterone; Ethanolamines; g | 1984 |
Pharmacodynamic interaction of clonidine and muscimol in hypertension.
Topics: Analysis of Variance; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Int | 1993 |
Ventrolateral medulla in spontaneously hypertensive rats: role of angiotensin II.
Topics: Angiotensin II; Animals; Bicuculline; Hemodynamics; Hypertension; Male; Medulla Oblongata; Microinje | 1993 |
Central GABAergic mechanisms are defective in salt-induced hypertension in borderline hypertensive rats.
Topics: Animals; Antihypertensive Agents; Bicuculline; Blood Pressure; Consciousness; GABA Antagonists; gamm | 1995 |
Role of spinal GABA receptors in depressor responses to chemical stimulation of the A5 area in normal and hypertensive rats.
Topics: Animals; Bicuculline; Blood Pressure; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor An | 1997 |
High dose baclofen is neuroprotective but also causes intracerebral hemorrhage: a quantal bioassay study using the intraluminal suture occlusion method.
Topics: Animals; Baclofen; Biological Assay; Cerebral Hemorrhage; Cold Temperature; Dizocilpine Maleate; Exc | 1997 |
Excitatory amino acids in the rostral ventrolateral medulla support blood pressure in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Excitatory Amino Acid Antagonists; GABA Agonists; Glutamic Acid; Heart Rate | 2000 |
Inhibition of the hypothalamic paraventricular nucleus in spontaneously hypertensive rats dramatically reduces sympathetic vasomotor tone.
Topics: Animals; Bicuculline; Blood Pressure; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hear | 2002 |
Chronic central GABAergic stimulation attenuates hypothalamic hyperactivity and development of spontaneous hypertension in rats.
Topics: Animals; Blood Pressure; Electric Stimulation; gamma-Aminobutyric Acid; Heart Rate; Hemodynamics; Hy | 1990 |
Enhanced pressor response to GABA in the nucleus tractus solitarii of the spontaneously hypertensive rat.
Topics: Animals; Baclofen; Blood Pressure; Brain Stem; gamma-Aminobutyric Acid; Heart Rate; Hypertension; Ma | 1988 |
Enhanced depressor effect of muscimol in the DOCA/NaCl hypertensive rat: evidence for altered GABAergic activity in brain.
Topics: Animals; Bicuculline; Blood Pressure; Brain Chemistry; Clonidine; Desoxycorticosterone; Drug Interac | 1985 |