muscimol has been researched along with Hypercapnia in 15 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Bilateral inhibition of the RTN neurons with the GABA(A) agonist muscimol (100 pmol in 50 nl) reduced resting ventilation (52 ± 34, versus saline, 250 ± 56 ml min(-1) kg(-1) with absolute values) and attenuated the respiratory response to hypercapnia and hypoxia." | 3.79 | Control of breathing and blood pressure by parafacial neurons in conscious rats. ( Colombari, E; De Paula, PM; Menani, JV; Moreira, TS; Takakura, AC, 2013) |
| " In the present study, we investigated the cardiorespiratory responses to hypoxia or hypercapnia in anesthetized and conscious rats treated with injections of the GABA-A agonist muscimol into the caudal portion of the commNTS." | 3.77 | Chemosensory control by commissural nucleus of the solitary tract in rats. ( Colombari, E; de Paula, PM; Favero, MT; Menani, JV; Moreira, TS; Takakura, AC, 2011) |
| " We measured mean arterial blood pressure (MAP), heart rate (HR), renal sympathetic nerve activity (RSNA), and phrenic nerve activity (PNA) before and after blocking neurotransmission within the PVN by bilateral microinjection of 2% lidocaine (100 nl) during specific stimulation of peripheral chemoreceptors by potassium cyanide (KCN, 75 microg/kg iv, bolus dose) or stimulation of central chemoreceptors with hypercapnia (10% CO(2))." | 3.73 | Differential role of the paraventricular nucleus of the hypothalamus in modulating the sympathoexcitatory component of peripheral and central chemoreflexes. ( Patel, KP; Reddy, MK; Schultz, HD, 2005) |
| "We hypothesized that inhibition of the rostral medullary raphe region (MRR), a putative central chemoreceptor location, with the GABA(A) receptor agonist muscimol would decrease ventilatory responses to hypercapnia and hypoxia in conscious rats, and that its known effect at this site on body temperature might alter its effect upon these ventilatory responses." | 3.73 | Ventilatory effects of muscimol microdialysis into the rostral medullary raphé region of conscious rats. ( Li, A; Nattie, EE; Taylor, NC, 2006) |
| " In urethane-chloralose-anaesthetized rats, bilateral inhibition of the RTN with muscimol eliminated the phrenic nerve discharge (PND) at rest, during hyperoxic hypercapnia (10% CO(2)), and during peripheral chemoreceptor stimulation (hypoxia and/or i." | 3.73 | Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats. ( Colombari, E; Guyenet, PG; Moreira, TS; Stornetta, RL; Takakura, AC; West, GH, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Leirão, IP | 1 |
| Zoccal, DB | 1 |
| Gargaglioni, LH | 1 |
| da Silva, GSF | 1 |
| Lima, JC | 1 |
| Oliveira, LM | 1 |
| Botelho, MT | 1 |
| Moreira, TS | 8 |
| Takakura, AC | 8 |
| Damasceno, RS | 2 |
| Silva, JN | 2 |
| Tanabe, FM | 1 |
| Lucena, EV | 1 |
| Silva, TM | 1 |
| Bongianni, F | 1 |
| Mutolo, D | 1 |
| Cinelli, E | 1 |
| Pantaleo, T | 1 |
| Colombari, E | 4 |
| Menani, JV | 3 |
| Favero, MT | 1 |
| de Paula, PM | 2 |
| Liu, X | 1 |
| Sood, S | 1 |
| Liu, H | 1 |
| Nolan, P | 1 |
| Morrison, JL | 1 |
| Horner, RL | 1 |
| Reddy, MK | 1 |
| Patel, KP | 1 |
| Schultz, HD | 1 |
| Taylor, NC | 1 |
| Li, A | 2 |
| Nattie, EE | 1 |
| West, GH | 1 |
| Stornetta, RL | 1 |
| Guyenet, PG | 1 |
| Nattie, E | 1 |
| Gieroba, ZJ | 1 |
| Fullerton, MJ | 1 |
| Funder, JW | 1 |
| Blessing, WW | 1 |
15 other studies available for muscimol and Hypercapnia
| Article | Year |
|---|---|
Differential modulation of active expiration during hypercapnia by the medullary raphe in unanesthetized rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Abdominal Muscles; Animals; Diaphragm; Exhalation; GABA-A Re | 2020 |
The involvement of the pathway connecting the substantia nigra, the periaqueductal gray matter and the retrotrapezoid nucleus in breathing control in a rat model of Parkinson's disease.
Topics: Animals; Chemoreceptor Cells; Disease Models, Animal; GABA Agonists; Glutamate Decarboxylase; Gray M | 2018 |
Regulation of the chemosensory control of breathing by Kölliker-Fuse neurons.
Topics: Animals; Bicuculline; Blood Pressure; Chemoreceptor Cells; Disease Models, Animal; GABA-A Receptor A | 2014 |
Neuroanatomical and physiological evidence that the retrotrapezoid nucleus/parafacial region regulates expiration in adult rats.
Topics: Abdomen; Animals; Blood Pressure; Diaphragm; Exhalation; GABA-A Receptor Agonists; Homeodomain Prote | 2016 |
Inhibition of the pontine Kölliker-Fuse nucleus reduces genioglossal activity elicited by stimulation of the retrotrapezoid chemoreceptor neurons.
Topics: Animals; Chemoreceptor Cells; Diaphragm; Glutamate Decarboxylase; Glutamic Acid; Hypercapnia; Male; | 2016 |
Respiratory responses induced by blockades of GABA and glycine receptors within the Bötzinger complex and the pre-Bötzinger complex of the rabbit.
Topics: Animals; Bicuculline; GABA Antagonists; GABA-A Receptor Agonists; Glycine Agents; Hypercapnia; Male; | 2010 |
Ventrolateral medulla mechanisms involved in cardiorespiratory responses to central chemoreceptor activation in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Chemor | 2011 |
Chemosensory control by commissural nucleus of the solitary tract in rats.
Topics: Animals; Chemoreceptor Cells; GABA-A Receptor Agonists; Hypercapnia; Hypoxia; Male; Muscimol; Rats; | 2011 |
Control of breathing and blood pressure by parafacial neurons in conscious rats.
Topics: Animals; Blood Pressure; Consciousness; Hypercapnia; Hypoxia; Male; Muscimol; N-Methylaspartate; Neu | 2013 |
Suppression of genioglossus muscle tone and activity during reflex hypercapnic stimulation by GABA(A) mechanisms at the hypoglossal motor nucleus in vivo.
Topics: Animals; Bicuculline; Blood Pressure; Diaphragm; Electroencephalography; Electromyography; GABA Agon | 2003 |
Differential role of the paraventricular nucleus of the hypothalamus in modulating the sympathoexcitatory component of peripheral and central chemoreflexes.
Topics: Anesthetics, Local; Animals; Bicuculline; Carotid Body; Chemoreceptor Cells; Denervation; GABA Agoni | 2005 |
Ventilatory effects of muscimol microdialysis into the rostral medullary raphé region of conscious rats.
Topics: Analysis of Variance; Animals; Body Temperature; GABA Agonists; Hypercapnia; Hypoxia; Male; Microdia | 2006 |
Peripheral chemoreceptor inputs to retrotrapezoid nucleus (RTN) CO2-sensitive neurons in rats.
Topics: Action Potentials; Animals; Biotin; Carbon Dioxide; Carotid Body; Chemoreceptor Cells; Cholera Toxin | 2006 |
Muscimol dialysis in the retrotrapezoid nucleus region inhibits breathing in the awake rat.
Topics: Animals; Carbon Dioxide; Cerebrospinal Fluid; Dose-Response Relationship, Drug; GABA Agonists; Hyper | 2000 |
Medullary pathways for adrenocorticotropic hormone and vasopressin secretion in rabbits.
Topics: 2-Amino-5-phosphonovalerate; Adrenocorticotropic Hormone; Animals; Cardiovascular System; Constricti | 1992 |