muscimol has been researched along with Hepatic Encephalopathy in 9 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the possible implication of the allosteric coupling of different modulatory sites at the GABA-A receptor complex in hepatic encephalopathy (HE), we investigated in autopsied frontal cortex of six cirrhotic patients and six appropriately-matched controls, the modulatory effects of the benzodiazepine site agonist flunitrazepam on the binding of [3H]muscimol and the effect of the neurosteroid site agonist allopregnanolone (5alpha-pregnan-3alpha-ol-20-one) on the binding of [3H]muscimol and [3H]flunitrazepam." | 3.72 | Normal coupling of brain benzodiazepine and neurosteroid modulatory sites on the GABA-A receptor complex in human hepatic encephalopathy. ( Ahboucha, S; Butterworth, RF; Chatauret, N; Desjardins, P; Pomier-Layrargues, G, 2003) |
| " The development of hepatic encephalopathy due to galactosamine-induced fulminant hepatic failure was consistently associated with a series of distinctive changes in the visual evoked potential waveform." | 3.67 | Visual evoked potentials in a rabbit model of hepatic encephalopathy. I. Sequential changes and comparisons with drug-induced comas. ( Brody, LE; Jacobs, R; Jones, EA; Pappas, SC; Schafer, DF, 1984) |
| "The role of the GABA-benzodiazepine receptor complex in the pathogenesis of hepatic encephalopathy was investigated by recording the electrophysiological responses of single cerebellar Purkinje neurons from rabbits with hepatic encephalopathy due to galactosamine-induced fulminant hepatic failure." | 3.67 | Differential responsiveness of cerebellar Purkinje neurons to GABA and benzodiazepine receptor ligands in an animal model of hepatic encephalopathy. ( Basile, AS; Gammal, SH; Jones, EA; Mullen, KD; Skolnick, P, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahboucha, S | 4 |
| Desjardins, P | 1 |
| Chatauret, N | 1 |
| Pomier-Layrargues, G | 3 |
| Butterworth, RF | 4 |
| Araqi, F | 1 |
| Layrargues, GP | 1 |
| Mamer, O | 1 |
| Schafer, DF | 1 |
| Pappas, SC | 1 |
| Brody, LE | 1 |
| Jacobs, R | 1 |
| Jones, EA | 3 |
| Ha, JH | 1 |
| Basile, AS | 4 |
| Ostrowski, NL | 1 |
| Gammal, SH | 2 |
| Skolnick, P | 2 |
| Mullen, KD | 1 |
9 other studies available for muscimol and Hepatic Encephalopathy
| Article | Year |
|---|---|
Normal coupling of brain benzodiazepine and neurosteroid modulatory sites on the GABA-A receptor complex in human hepatic encephalopathy.
Topics: Adult; Aged; Aged, 80 and over; Brain; Female; Flumazenil; Flunitrazepam; Hepatic Encephalopathy; Hu | 2003 |
Increased brain concentrations of endogenous (non-benzodiazepine) GABA-A receptor ligands in human hepatic encephalopathy.
Topics: Adult; Aged; Aged, 80 and over; Allosteric Regulation; Animals; Benzodiazepines; Binding Sites; Bind | 2004 |
Differential effects of ammonia on the benzodiazepine modulatory site on the GABA-A receptor complex of human brain.
Topics: Ammonia; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Dose-Response Relationship, Drug | 2005 |
Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma.
Topics: Adult; Aged; Aged, 80 and over; Animals; Benzodiazepines; Brain Chemistry; Desoxycorticosterone; Fem | 2006 |
Visual evoked potentials in a rabbit model of hepatic encephalopathy. I. Sequential changes and comparisons with drug-induced comas.
Topics: Animals; Diazepam; Disease Models, Animal; Electrodes; Electroencephalography; Evoked Potentials, Vi | 1984 |
Modulation of ligand binding to components of the GABAA receptor complex by ammonia: implications for the pathogenesis of hyperammonemic syndromes.
Topics: Ammonia; Animals; Flunitrazepam; GABA Agonists; GABA Modulators; Hepatic Encephalopathy; Ligands; Ma | 1996 |
The contribution of endogenous benzodiazepine receptor ligands to the pathogenesis of hepatic encephalopathy.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, | 1991 |
The GABAA receptor complex in hepatic encephalopathy. Autoradiographic evidence for the presence of elevated levels of a benzodiazepine receptor ligand.
Topics: Animals; Autoradiography; Brain; Flunitrazepam; Galactosamine; Hepatic Encephalopathy; Muscimol; Org | 1990 |
Differential responsiveness of cerebellar Purkinje neurons to GABA and benzodiazepine receptor ligands in an animal model of hepatic encephalopathy.
Topics: Animals; Benzodiazepines; Flumazenil; Flunitrazepam; GABA Antagonists; Galactosamine; Hepatic Enceph | 1988 |