muscimol has been researched along with Heart Failure in 5 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Muscimol was also less effective in decreasing RSND, BP, and HR in HF rats than in control rats." | 1.31 | Reduced endogenous GABA-mediated inhibition in the PVN on renal nerve discharge in rats with heart failure. ( Li, YF; Patel, KP; Zhang, K, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, RJ | 1 |
| Zeng, QH | 1 |
| Wang, WZ | 1 |
| Wang, W | 1 |
| Ramchandra, R | 1 |
| Hood, SG | 1 |
| Frithiof, R | 1 |
| McKinley, MJ | 1 |
| May, CN | 1 |
| Carillo, BA | 1 |
| Oliveira-Sales, EB | 1 |
| Andersen, M | 1 |
| Tufik, S | 1 |
| Hipolide, D | 1 |
| Santos, AA | 1 |
| Tucci, PJ | 1 |
| Bergamaschi, CT | 1 |
| Campos, RR | 1 |
| Potapenko, ES | 1 |
| Biancardi, VC | 1 |
| Zhou, Y | 1 |
| Stern, JE | 1 |
| Zhang, K | 1 |
| Li, YF | 1 |
| Patel, KP | 1 |
5 other studies available for muscimol and Heart Failure
| Article | Year |
|---|---|
GABA(A) and GABA(B) receptor-mediated inhibition of sympathetic outflow in the paraventricular nucleus is blunted in chronic heart failure.
Topics: Adrenergic Fibers; Animals; Baclofen; Bicuculline; Blood Pressure; Chronic Disease; GABA Agonists; G | 2009 |
The role of the paraventricular nucleus of the hypothalamus in the regulation of cardiac and renal sympathetic nerve activity in conscious normal and heart failure sheep.
Topics: Animals; Bicuculline; Female; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Glycine; Glycin | 2013 |
Changes in GABAergic inputs in the paraventricular nucleus maintain sympathetic vasomotor tone in chronic heart failure.
Topics: Animals; Autoradiography; Blood Pressure; Disease Models, Animal; Dizocilpine Maleate; Echocardiogra | 2012 |
Astrocytes modulate a postsynaptic NMDA-GABAA-receptor crosstalk in hypothalamic neurosecretory neurons.
Topics: Animals; Astrocytes; Calcium Signaling; Electrophysiological Phenomena; Excitatory Amino Acid Transp | 2013 |
Reduced endogenous GABA-mediated inhibition in the PVN on renal nerve discharge in rats with heart failure.
Topics: Animals; Bicuculline; Blood Pressure; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hear | 2002 |