muscimol has been researched along with Epilepsy, Temporal Lobe in 10 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Epilepsy, Temporal Lobe: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seizure-induced release of the neuromodulator adenosine is a potent endogenous anticonvulsant mechanism, which limits the extension of seizures and mediates seizure arrest." | 7.78 | Adenosine release during seizures attenuates GABAA receptor-mediated depolarization. ( Akerman, CJ; Ilie, A; Raimondo, JV, 2012) |
| "Seizure-induced release of the neuromodulator adenosine is a potent endogenous anticonvulsant mechanism, which limits the extension of seizures and mediates seizure arrest." | 3.78 | Adenosine release during seizures attenuates GABAA receptor-mediated depolarization. ( Akerman, CJ; Ilie, A; Raimondo, JV, 2012) |
| " Two animal models of TLE--amygdala kindling and pilocarpine-induced status epilepticus (Pilo-SE)--were tested." | 3.75 | Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. ( Leung, LS; Long, JJ; Luo, T; McMurran, TJ; Shen, B; Stewart, L, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, X | 1 |
| Yao, Y | 1 |
| Li, X | 1 |
| Dong, J | 1 |
| Zhang, A | 1 |
| Long, JJ | 1 |
| Shen, B | 1 |
| Luo, T | 1 |
| Stewart, L | 1 |
| McMurran, TJ | 1 |
| Leung, LS | 2 |
| Langlois, M | 1 |
| Polack, PO | 1 |
| Bernard, H | 1 |
| David, O | 1 |
| Charpier, S | 1 |
| Depaulis, A | 1 |
| Deransart, C | 1 |
| Sloan, DM | 1 |
| Zhang, D | 1 |
| Bertram, EH | 2 |
| Ilie, A | 1 |
| Raimondo, JV | 1 |
| Akerman, CJ | 1 |
| Stewart, LS | 1 |
| Vorobyov, V | 1 |
| Schibaev, N | 1 |
| Kovalev, G | 1 |
| Alzheimer, C | 1 |
| Ma, J | 1 |
| Brudzynski, SM | 1 |
| Leung, LW | 1 |
| Zhang, X | 1 |
| Le Gal La Salle, G | 1 |
| Ridoux, V | 1 |
| Yu, PH | 1 |
| Ju, G | 1 |
| Lothman, EW | 1 |
| Kapur, J | 1 |
| Stringer, JL | 1 |
10 other studies available for muscimol and Epilepsy, Temporal Lobe
| Article | Year |
|---|---|
Alteration of GABAergic signaling is associated with anxiety-like behavior in temporal lobe epilepsy mice.
Topics: Animals; Anxiety; Blotting, Western; Disease Models, Animal; Epilepsy, Temporal Lobe; GABAergic Neur | 2019 |
Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics.
Topics: Anesthetics, General; Animals; Brain; Consciousness Disorders; Convulsants; Disease Models, Animal; | 2009 |
Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Biophysical Phenomena; Disease Models, Anim | 2010 |
Increased GABAergic inhibition in the midline thalamus affects signaling and seizure spread in the hippocampus-prefrontal cortex pathway.
Topics: Animals; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials; G | 2011 |
Adenosine release during seizures attenuates GABAA receptor-mediated depolarization.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; CA3 Region, Hippocampal; Chlorides; Epilepsy, Te | 2012 |
Hippocampal melatonin receptors modulate seizure threshold.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy | 2005 |
Effects of neurotransmitter agonists on electrocortical activity in the rat kainate model of temporal lobe epilepsy and the modulatory action of basic fibroblast growth factor.
Topics: Animals; Baclofen; Clonidine; Electroencephalography; Epilepsy, Temporal Lobe; Fibroblast Growth Fac | 2005 |
Involvement of the nucleus accumbens-ventral pallidal pathway in postictal behavior induced by a hippocampal afterdischarge in rats.
Topics: Animals; Behavior, Animal; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Electric Stimulat | 1996 |
Prevention of kainic acid-induced limbic seizures and Fos expression by the GABA-A receptor agonist muscimol.
Topics: Animals; Behavior, Animal; Brain Chemistry; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; | 1997 |
Recurrent spontaneous hippocampal seizures in the rat as a chronic sequela to limbic status epilepticus.
Topics: Action Potentials; Animals; Chronic Disease; Disease Models, Animal; Electric Stimulation; Electroen | 1990 |