muscimol has been researched along with Dystonia in 6 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pathophysiology of idiopathic dystonias is still unknown, but it is regarded as a basal ganglia disorder." | 1.36 | Effects of pharmacological entopeduncular manipulations on idiopathic dystonia in the dt(sz) mutant hamster. ( Hamann, M; Kreil, A; Richter, A; Sander, SE, 2010) |
| "The underlying mechanisms of idiopathic dystonias are poorly understood." | 1.31 | Effects of striatal injections of GABA(A) receptor agonists and antagonists in a genetic animal model of paroxysmal dystonia. ( Hamann, M; Richter, A, 2002) |
| "The most frequent type of dystonia is idiopathic generalized dystonia, whose pathophysiology is largely unknown." | 1.29 | Alterations in the brain GABAA/benzodiazepine receptor-chloride ionophore complex in a genetic model of paroxysmal dystonia: a quantitative autoradiographic analysis. ( Burnham, WM; Lôscher, W; Nobrega, JN; Richter, A, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hamann, M | 4 |
| Sander, SE | 1 |
| Kreil, A | 1 |
| Richter, A | 5 |
| Nobrega, JN | 1 |
| Burnham, WM | 1 |
| Lôscher, W | 2 |
| Gernert, M | 1 |
| Bennay, M | 1 |
| Beales, M | 1 |
| Lorden, JF | 1 |
| Walz, E | 1 |
| Oltmans, GA | 1 |
6 other studies available for muscimol and Dystonia
| Article | Year |
|---|---|
Effects of pharmacological entopeduncular manipulations on idiopathic dystonia in the dt(sz) mutant hamster.
Topics: Animals; Animals, Newborn; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2010 |
Effects of rubral microinjections of muscimol and bicuculline in a genetic animal model of paroxysmal dystonia.
Topics: Animals; Bicuculline; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia | 2004 |
Alterations in the brain GABAA/benzodiazepine receptor-chloride ionophore complex in a genetic model of paroxysmal dystonia: a quantitative autoradiographic analysis.
Topics: Animals; Autoradiography; Binding Sites; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds | 1995 |
Deficit of striatal parvalbumin-reactive GABAergic interneurons and decreased basal ganglia output in a genetic rodent model of idiopathic paroxysmal dystonia.
Topics: Action Potentials; Animals; Basal Ganglia; Cell Count; Corpus Striatum; Cricetinae; Disease Models, | 2000 |
Effects of striatal injections of GABA(A) receptor agonists and antagonists in a genetic animal model of paroxysmal dystonia.
Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Cricetinae; Dystonia; Female; Flumazenil; Flur | 2002 |
Quantitative autoradiography reveals selective changes in cerebellar GABA receptors of the rat mutant dystonic.
Topics: Animals; Autoradiography; Cerebellar Nuclei; Dystonia; Flunitrazepam; Muscimol; Rats; Rats, Mutant S | 1990 |