muscimol has been researched along with Dyskinesia, Medication-Induced in 16 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with Parkinson's disease, neurones in the STN display hyperactive firing rates and rhythmic discharge activity such as tremor-related oscillations (3-8 Hz) and synchronous high-frequency oscillations (15-30 Hz)." | 1.31 | Lidocaine and muscimol microinjections in subthalamic nucleus reverse Parkinsonian symptoms. ( Dostrovsky, JO; Hutchison, WD; Lang, AE; Levy, R; Lozano, AM; Pahapill, P; Romas, J; Saint-Cyr, J, 2001) |
| " While numerous reports of the partial effectiveness of acute treatment with cholinergic or GABAergic agents have appeared, the effects of chronic administration of these substance are unclear." | 1.26 | Symptomatic treatment of tardive dyskinesia: a word of caution. ( Kucharski, LT; Unterwald, EM, 1981) |
| "Muscimol, thought to be a agonist of gamma-aminobutyric acid (GABA), was administered to eight neuroleptic-free subjects with tardive dyskinesia." | 1.26 | Improvement in tardive dyskinesia after muscimol therapy. ( Chase, TN; Crayton, JW; Tamminga, CA, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (56.25) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gale, K | 2 |
| Casu, M | 1 |
| Thaker, GK | 2 |
| Hare, TA | 1 |
| Tamminga, CA | 3 |
| Marsden, CD | 1 |
| Sheehy, MP | 1 |
| Crossman, AR | 1 |
| Sambrook, MA | 1 |
| Jackson, A | 1 |
| Kucharski, LT | 1 |
| Unterwald, EM | 1 |
| Spooren, WP | 1 |
| Mulders, WH | 1 |
| Veening, JG | 1 |
| Cools, AR | 2 |
| Goffart, L | 3 |
| Pélisson, D | 3 |
| Guillaume, A | 1 |
| Arts, MP | 1 |
| Bemelmans, FF | 1 |
| Levy, R | 1 |
| Lang, AE | 1 |
| Dostrovsky, JO | 1 |
| Pahapill, P | 1 |
| Romas, J | 1 |
| Saint-Cyr, J | 1 |
| Hutchison, WD | 1 |
| Lozano, AM | 1 |
| Crayton, JW | 1 |
| Chase, TN | 1 |
| Christensen, AV | 1 |
| Nielsen, IM | 1 |
| Cassady, SL | 1 |
| Moran, M | 1 |
| Birt, A | 1 |
| Gunne, LM | 1 |
| Bachus, SE | 1 |
| Lloyd, KG | 1 |
| Perrault, G | 1 |
| Zivkovic, B | 1 |
3 reviews available for muscimol and Dyskinesia, Medication-Induced
| Article | Year |
|---|---|
Dynamic utilization of GABA in substantia nigra: regulation by dopamine and GABA in the striatum, and its clinical and behavioral implications.
Topics: 4-Aminobutyrate Transaminase; Afferent Pathways; Aminocaproates; Animals; Basal Ganglia; Behavior, A | 1981 |
GABA system: clinical research and treatment of tardive dyskinesia.
Topics: Alkynes; Aminocaproates; Benzodiazepines; Clinical Trials as Topic; Corpus Striatum; Dopamine; Dyski | 1983 |
[Implications of GABAergic synapses in neuropsychiatry].
Topics: 4-Aminobutyrate Transaminase; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; | 1985 |
3 trials available for muscimol and Dyskinesia, Medication-Induced
| Article | Year |
|---|---|
GABA system: clinical research and treatment of tardive dyskinesia.
Topics: Alkynes; Aminocaproates; Benzodiazepines; Clinical Trials as Topic; Corpus Striatum; Dopamine; Dyski | 1983 |
GABA and movement disorders.
Topics: Anticonvulsants; Baclofen; Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-Induced; | 1981 |
GABA agonist-induced changes in motor, oculomotor, and attention measures correlate in schizophrenics with tardive dyskinesia.
Topics: Adult; Antipsychotic Agents; Attention; Chronic Disease; Double-Blind Method; Dyskinesia, Drug-Induc | 1992 |
11 other studies available for muscimol and Dyskinesia, Medication-Induced
| Article | Year |
|---|---|
Experimental hemichorea/hemiballismus in the monkey. Studies on the intracerebral site of action in a drug-induced dyskinesia.
Topics: Animals; Bicuculline; Brain Diseases; Brain Mapping; Chorea; Dyskinesia, Drug-Induced; Female; Globu | 1984 |
Symptomatic treatment of tardive dyskinesia: a word of caution.
Topics: Animals; Brain; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Haplorhini; Humans; Levodopa; Mus | 1981 |
The substantia innominata complex and the peripeduncular nucleus in orofacial dyskinesia: a pharmacological and anatomical study in cats.
Topics: Animals; Behavior, Animal; Cats; Cholera Toxin; Dyskinesia, Drug-Induced; Face; gamma-Aminobutyric A | 1993 |
Changes in initiation of orienting gaze shifts after muscimol inactivation of the caudal fastigial nucleus in the cat.
Topics: Animals; Cats; Cerebellar Nuclei; Dyskinesia, Drug-Induced; GABA Agonists; Head Movements; Microinje | 1997 |
Orienting gaze shifts during muscimol inactivation of caudal fastigial nucleus in the cat. II. Dynamics and eye-head coupling.
Topics: Analysis of Variance; Animals; Cats; Cerebellar Nuclei; Dyskinesia, Drug-Induced; GABA Agonists; Hea | 1998 |
Orienting gaze shifts during muscimol inactivation of caudal fastigial nucleus in the cat. I. Gaze dysmetria.
Topics: Animals; Cats; Cerebellar Nuclei; Dyskinesia, Drug-Induced; Fixation, Ocular; Functional Laterality; | 1998 |
Role of the retrorubral nucleus in striatally elicited orofacial dyskinesia in cats: effects of muscimol and bicuculline.
Topics: Animals; Bicuculline; Catecholamines; Cats; Caudate Nucleus; Dose-Response Relationship, Drug; Dyski | 1998 |
Lidocaine and muscimol microinjections in subthalamic nucleus reverse Parkinsonian symptoms.
Topics: Aged; Anesthetics, Local; Dyskinesia, Drug-Induced; Female; GABA Agonists; Humans; Injections, Intra | 2001 |
Improvement in tardive dyskinesia after muscimol therapy.
Topics: Adult; Aged; Antipsychotic Agents; Dopamine; Drug Evaluation; Dyskinesia, Drug-Induced; Extrapyramid | 1979 |
Dopaminergic supersensitivity: influence of dopamine agonists, cholinergics, anticholinergics, and drugs used for the treatment of tardive dyskinesia.
Topics: Animals; Antiparkinson Agents; Apomorphine; Atropine; Dopamine; Drug Synergism; Dyskinesia, Drug-Ind | 1979 |
Oral movements induced by interference with nigral GABA neurotransmission: relationship to tardive dyskinesias.
Topics: Animals; Bicuculline; Dyskinesia, Drug-Induced; GABA Antagonists; gamma-Aminobutyric Acid; Injection | 1988 |