muscimol has been researched along with Dyskinesia, Drug-Induced in 16 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Dyskinesia, Drug-Induced: Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In patients with Parkinson's disease, neurones in the STN display hyperactive firing rates and rhythmic discharge activity such as tremor-related oscillations (3-8 Hz) and synchronous high-frequency oscillations (15-30 Hz)." | 1.31 | Lidocaine and muscimol microinjections in subthalamic nucleus reverse Parkinsonian symptoms. ( Dostrovsky, JO; Hutchison, WD; Lang, AE; Levy, R; Lozano, AM; Pahapill, P; Romas, J; Saint-Cyr, J, 2001) |
| " While numerous reports of the partial effectiveness of acute treatment with cholinergic or GABAergic agents have appeared, the effects of chronic administration of these substance are unclear." | 1.26 | Symptomatic treatment of tardive dyskinesia: a word of caution. ( Kucharski, LT; Unterwald, EM, 1981) |
| "Muscimol, thought to be a agonist of gamma-aminobutyric acid (GABA), was administered to eight neuroleptic-free subjects with tardive dyskinesia." | 1.26 | Improvement in tardive dyskinesia after muscimol therapy. ( Chase, TN; Crayton, JW; Tamminga, CA, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (56.25) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gale, K | 2 |
| Casu, M | 1 |
| Thaker, GK | 2 |
| Hare, TA | 1 |
| Tamminga, CA | 3 |
| Marsden, CD | 1 |
| Sheehy, MP | 1 |
| Crossman, AR | 1 |
| Sambrook, MA | 1 |
| Jackson, A | 1 |
| Kucharski, LT | 1 |
| Unterwald, EM | 1 |
| Spooren, WP | 1 |
| Mulders, WH | 1 |
| Veening, JG | 1 |
| Cools, AR | 2 |
| Goffart, L | 3 |
| Pélisson, D | 3 |
| Guillaume, A | 1 |
| Arts, MP | 1 |
| Bemelmans, FF | 1 |
| Levy, R | 1 |
| Lang, AE | 1 |
| Dostrovsky, JO | 1 |
| Pahapill, P | 1 |
| Romas, J | 1 |
| Saint-Cyr, J | 1 |
| Hutchison, WD | 1 |
| Lozano, AM | 1 |
| Crayton, JW | 1 |
| Chase, TN | 1 |
| Christensen, AV | 1 |
| Nielsen, IM | 1 |
| Cassady, SL | 1 |
| Moran, M | 1 |
| Birt, A | 1 |
| Gunne, LM | 1 |
| Bachus, SE | 1 |
| Lloyd, KG | 1 |
| Perrault, G | 1 |
| Zivkovic, B | 1 |
3 reviews available for muscimol and Dyskinesia, Drug-Induced
| Article | Year |
|---|---|
Dynamic utilization of GABA in substantia nigra: regulation by dopamine and GABA in the striatum, and its clinical and behavioral implications.
Topics: 4-Aminobutyrate Transaminase; Afferent Pathways; Aminocaproates; Animals; Basal Ganglia; Behavior, A | 1981 |
GABA system: clinical research and treatment of tardive dyskinesia.
Topics: Alkynes; Aminocaproates; Benzodiazepines; Clinical Trials as Topic; Corpus Striatum; Dopamine; Dyski | 1983 |
[Implications of GABAergic synapses in neuropsychiatry].
Topics: 4-Aminobutyrate Transaminase; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; | 1985 |
3 trials available for muscimol and Dyskinesia, Drug-Induced
| Article | Year |
|---|---|
GABA system: clinical research and treatment of tardive dyskinesia.
Topics: Alkynes; Aminocaproates; Benzodiazepines; Clinical Trials as Topic; Corpus Striatum; Dopamine; Dyski | 1983 |
GABA and movement disorders.
Topics: Anticonvulsants; Baclofen; Clinical Trials as Topic; Double-Blind Method; Dyskinesia, Drug-Induced; | 1981 |
GABA agonist-induced changes in motor, oculomotor, and attention measures correlate in schizophrenics with tardive dyskinesia.
Topics: Adult; Antipsychotic Agents; Attention; Chronic Disease; Double-Blind Method; Dyskinesia, Drug-Induc | 1992 |
11 other studies available for muscimol and Dyskinesia, Drug-Induced
| Article | Year |
|---|---|
Experimental hemichorea/hemiballismus in the monkey. Studies on the intracerebral site of action in a drug-induced dyskinesia.
Topics: Animals; Bicuculline; Brain Diseases; Brain Mapping; Chorea; Dyskinesia, Drug-Induced; Female; Globu | 1984 |
Symptomatic treatment of tardive dyskinesia: a word of caution.
Topics: Animals; Brain; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Haplorhini; Humans; Levodopa; Mus | 1981 |
The substantia innominata complex and the peripeduncular nucleus in orofacial dyskinesia: a pharmacological and anatomical study in cats.
Topics: Animals; Behavior, Animal; Cats; Cholera Toxin; Dyskinesia, Drug-Induced; Face; gamma-Aminobutyric A | 1993 |
Changes in initiation of orienting gaze shifts after muscimol inactivation of the caudal fastigial nucleus in the cat.
Topics: Animals; Cats; Cerebellar Nuclei; Dyskinesia, Drug-Induced; GABA Agonists; Head Movements; Microinje | 1997 |
Orienting gaze shifts during muscimol inactivation of caudal fastigial nucleus in the cat. II. Dynamics and eye-head coupling.
Topics: Analysis of Variance; Animals; Cats; Cerebellar Nuclei; Dyskinesia, Drug-Induced; GABA Agonists; Hea | 1998 |
Orienting gaze shifts during muscimol inactivation of caudal fastigial nucleus in the cat. I. Gaze dysmetria.
Topics: Animals; Cats; Cerebellar Nuclei; Dyskinesia, Drug-Induced; Fixation, Ocular; Functional Laterality; | 1998 |
Role of the retrorubral nucleus in striatally elicited orofacial dyskinesia in cats: effects of muscimol and bicuculline.
Topics: Animals; Bicuculline; Catecholamines; Cats; Caudate Nucleus; Dose-Response Relationship, Drug; Dyski | 1998 |
Lidocaine and muscimol microinjections in subthalamic nucleus reverse Parkinsonian symptoms.
Topics: Aged; Anesthetics, Local; Dyskinesia, Drug-Induced; Female; GABA Agonists; Humans; Injections, Intra | 2001 |
Improvement in tardive dyskinesia after muscimol therapy.
Topics: Adult; Aged; Antipsychotic Agents; Dopamine; Drug Evaluation; Dyskinesia, Drug-Induced; Extrapyramid | 1979 |
Dopaminergic supersensitivity: influence of dopamine agonists, cholinergics, anticholinergics, and drugs used for the treatment of tardive dyskinesia.
Topics: Animals; Antiparkinson Agents; Apomorphine; Atropine; Dopamine; Drug Synergism; Dyskinesia, Drug-Ind | 1979 |
Oral movements induced by interference with nigral GABA neurotransmission: relationship to tardive dyskinesias.
Topics: Animals; Bicuculline; Dyskinesia, Drug-Induced; GABA Antagonists; gamma-Aminobutyric Acid; Injection | 1988 |