muscimol has been researched along with Disease Models, Animal in 157 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia." | 7.76 | Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. ( Lee, IO; Lim, ES, 2010) |
| " The results showed that in the PRC anticonvulsant efficacy against soman-induced seizures (subcutaneously administered) was achieved by procyclidine or NBQX, but not by ketamine, scopolamine, caramiphen, or muscimol (Experiment 1)." | 7.76 | Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman. ( Aas, P; Enger, S; Myhrer, T, 2010) |
| "To determine whether muscimol delivered epidurally or into the subarachnoid space can prevent and/or terminate acetylcholine (Ach)-induced focal neocortical seizures at concentrations not affecting behavior and background electroencephalography (EEG) activity." | 7.75 | Localized transmeningeal muscimol prevents neocortical seizures in rats and nonhuman primates: therapeutic implications. ( Baptiste, SL; Charchaflieh, J; Devinsky, O; Kuzniecky, RI; Ludvig, N; Medveczky, G; Tang, HM; von Gizycki, H, 2009) |
| "The contribution of GABAergic mechanisms to rat emotional behavior in two animal models of anxiety (open field test of neophobia and aversively conditioned freezing reaction), was confirmed by pharmacological analysis, using anxiolytic (midazolam) and anxiogenic (picrotoxin) compounds." | 7.72 | Rat behavior in two models of anxiety and brain [3H]muscimol binding: pharmacological, correlation, and multifactor analysis. ( Bidziński, A; Członkowska, AI; Lehner, M; Maciejak, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J; Turzyńska, D; Wisłowska, A; Zienowicz, M, 2003) |
| " Here we have decided to investigate the participation of the GABAergic system of the zona incerta, one of its major neurotransmitters with widespread projections to the neocortex, in the pilocarpine (Pilo) model of epilepsy." | 7.71 | Inhibitory role of the zona incerta in the pilocarpine model of epilepsy. ( Bortolotto, ZA; Cavalheiro, EA; Hamani, C; Mello, LE; Sakabe, S, 2002) |
| "The pharmacodynamics of midazolam was studied in the kindling model of experimental epilepsy." | 7.70 | Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy. ( Cleton, A; Danhof, M; Ghijsen, W; Van der Graaf, PH; Voskuyl, R, 1999) |
| "The present study investigated the involvement of mediodorsal thalamic (MD) GABA-A receptors in cetirizine/morphine-induced anti-allodynia using a rat model of neuropathic pain." | 4.31 | Pharmacological activation of mediodorsal thalamic GABA-A receptors modulates morphine/cetirizine-induced changes in the prefrontal cortical GFAP expression in a rat model of neuropathic pain. ( Alijanpour, S; Asgharpour-Masouleh, N; Delphi, L; Rezayof, A, 2023) |
| "None of the five drugs was able to suppress potentiation appearing immediately after cortical epileptic afterdischarges, but all of them exhibited delayed anticonvulsant action 10 (in the case of midazolam and muscimol) or 20 min (all three steroids) after cortical seizures." | 3.96 | Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats. ( Kubová, H; Kudová, E; Mareš, P; Valeš, K, 2020) |
| "Prenatal exposure to valproic acid (VPA) enhances the risk for later development of autism spectrum disorders (ASD)." | 3.85 | Increased GABAA receptor binding in amygdala after prenatal administration of valproic acid to rats. ( Bertelsen, F; Drasbek, KR; Folloni, D; Landau, AM; Møller, A; Scheel-Krüger, J, 2017) |
| " Using the pyrithiamine-induced thiamine deficiency (PTD) rat model of human Wernicke-Korsakoff syndrome, we tested the hypothesis that co-infusion of the acetylcholinesterase inhibitor physostigmine across the PFC and HPC would recover spatial alternation performance in PTD rats." | 3.81 | The role of ventral midline thalamus in cholinergic-based recovery in the amnestic rat. ( Bobal, MG; Savage, LM, 2015) |
| "Development of angiotensin II (Ang II)-dependent hypertension involves microglial activation and proinflammatory cytokine actions in the hypothalamic paraventricular nucleus (PVN)." | 3.80 | Ang II-salt hypertension depends on neuronal activity in the hypothalamic paraventricular nucleus but not on local actions of tumor necrosis factor-α. ( Bardgett, ME; Herrera-Rosales, M; Holbein, WW; Toney, GM, 2014) |
| "Results from studies based on microinfusions into seizure controlling brain sites (area tempestas, medial septum, perirhinal cortex, posterior piriform cortex) have shown that procyclidine, muscimol, caramiphen, and NBQX, but not ketamine, exert anticonvulsant effects against soman-induced seizures." | 3.77 | Enhanced efficacy of anticonvulsants when combined with levetiracetam in soman-exposed rats. ( Aas, P; Enger, S; Jonassen, M; Myhrer, T, 2011) |
| " Glycine or muscimol reduced bicuculline-induced allodynia regardless of the administration site, whereas intrathecal taurine reduced bicuculline-induced allodynia." | 3.76 | Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. ( Lee, IO; Lim, ES, 2010) |
| "Past work has demonstrated that kainic acid (KA)-induced seizures could cause the enhancement of excitation and lead to neuronal death in rat hippocampus." | 3.76 | Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizure. ( Han, D; Li, C; Pei, DS; Wang, WW; Xu, B; Yu, HM; Yu, XJ; Zhang, GY; Zhu, J, 2010) |
| " The results showed that in the PRC anticonvulsant efficacy against soman-induced seizures (subcutaneously administered) was achieved by procyclidine or NBQX, but not by ketamine, scopolamine, caramiphen, or muscimol (Experiment 1)." | 3.76 | Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman. ( Aas, P; Enger, S; Myhrer, T, 2010) |
| "To determine whether muscimol delivered epidurally or into the subarachnoid space can prevent and/or terminate acetylcholine (Ach)-induced focal neocortical seizures at concentrations not affecting behavior and background electroencephalography (EEG) activity." | 3.75 | Localized transmeningeal muscimol prevents neocortical seizures in rats and nonhuman primates: therapeutic implications. ( Baptiste, SL; Charchaflieh, J; Devinsky, O; Kuzniecky, RI; Ludvig, N; Medveczky, G; Tang, HM; von Gizycki, H, 2009) |
| " Two animal models of TLE--amygdala kindling and pilocarpine-induced status epilepticus (Pilo-SE)--were tested." | 3.75 | Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics. ( Leung, LS; Long, JJ; Luo, T; McMurran, TJ; Shen, B; Stewart, L, 2009) |
| " This study compared the neuroprotective efficacies of muscimol, a GABA A receptor agonist, and a GABA B receptor agonist baclofen in rat brain ischemia." | 3.74 | Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade. ( Li, C; Xu, J; Yin, XH; Zhang, GY, 2008) |
| "This study investigated the effect of GABAA (muscimol, MUSC) and GABAB (baclofen, BACL) agonist receptors microinjected into medial accumbens shell on feeding and the level of fear in free-feeding rats submitted to the elevated plus-maze (EPM), an animal model of anxiety." | 3.74 | GABAA and GABAB agonist microinjections into medial accumbens shell increase feeding and induce anxiolysis in an animal model of anxiety. ( da Cunha, IC; de Lima, TC; Faria, MS; Ferraz, A; Lopes, AP; Neto, JM; Paschoalini, MA; Steffens, SM; Vargas, JC, 2007) |
| "The contribution of GABAergic mechanisms to rat emotional behavior in two animal models of anxiety (open field test of neophobia and aversively conditioned freezing reaction), was confirmed by pharmacological analysis, using anxiolytic (midazolam) and anxiogenic (picrotoxin) compounds." | 3.72 | Rat behavior in two models of anxiety and brain [3H]muscimol binding: pharmacological, correlation, and multifactor analysis. ( Bidziński, A; Członkowska, AI; Lehner, M; Maciejak, P; Płaźnik, A; Siemiatkowski, M; Sienkiewicz-Jarosz, H; Szyndler, J; Turzyńska, D; Wisłowska, A; Zienowicz, M, 2003) |
| " Here we have decided to investigate the participation of the GABAergic system of the zona incerta, one of its major neurotransmitters with widespread projections to the neocortex, in the pilocarpine (Pilo) model of epilepsy." | 3.71 | Inhibitory role of the zona incerta in the pilocarpine model of epilepsy. ( Bortolotto, ZA; Cavalheiro, EA; Hamani, C; Mello, LE; Sakabe, S, 2002) |
| "The pharmacodynamics of midazolam was studied in the kindling model of experimental epilepsy." | 3.70 | Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy. ( Cleton, A; Danhof, M; Ghijsen, W; Van der Graaf, PH; Voskuyl, R, 1999) |
| " The development of hepatic encephalopathy due to galactosamine-induced fulminant hepatic failure was consistently associated with a series of distinctive changes in the visual evoked potential waveform." | 3.67 | Visual evoked potentials in a rabbit model of hepatic encephalopathy. I. Sequential changes and comparisons with drug-induced comas. ( Brody, LE; Jacobs, R; Jones, EA; Pappas, SC; Schafer, DF, 1984) |
| "Pain is a common and debilitating symptom of inflammatory bowel disease (IBD)." | 1.72 | Peripheral GABAA receptor signaling contributes to visceral hypersensitivity in a mouse model of colitis. ( Gold, MS; Loeza-Alcocer, E, 2022) |
| "Demyelination was induced in male Wistar rats by bilaterally injection of lysophosphatidylcholine (LPC) 1% into the CA1 region of the hippocampus." | 1.48 | Inhibition of GABA A receptor improved spatial memory impairment in the local model of demyelination in rat hippocampus. ( Afghani, A; Ashrafpour, M; Ashrafpour, S; Dehghan, S; Ebrahim Tabar, F; Gol, M; Mousavi Majd, A; Pourabdolhossein, F, 2018) |
| "Itch and pain are unpleasant sensations that distress many patients with disease." | 1.43 | GABA(A) Receptors in the Central Nucleus of the Amygdala Are Involved in Pain- and Itch-Related Responses. ( Chen, L; Dong, Z; Han, H; Tan, T; Wang, W, 2016) |
| "Muscimol infusion to inactivate the mid-septotemporal hippocampus, as compared to saline infusion, significantly decreased the peak frequency of the PDs induced by GBL, decreased 30-120 Hz hippocampal gamma power, and hastened the transition of PDs to 1-2 Hz slow waves." | 1.43 | The hippocampus participates in a pharmacological rat model of absence seizures. ( Arcaro, J; Chu, L; Kuo, M; Ma, J; Mirsattari, SM; Stan Leung, L, 2016) |
| "After establishment of neuropathic pain model with the lumbar 5 spinal nerve ligation (L5 SNL), the GABA-evoked currents were recorded in the acutely dissociated L4 DRG neurons using whole-cell patch clamp." | 1.40 | The role of the GABA-A receptor of the adjacent intact dorsal root ganglion neurons in rats with neuropathic pain. ( Fu, J; Gu, J; Gu, Y; Li, G; Ran, R; Wang, L; Wang, Q; Zhang, A; Zhao, Y; Zhong, H, 2014) |
| "Muscimol was administered in doses from 0." | 1.40 | Anticonvulsant and behavioral effects of muscimol in immature rats. ( Mareš, P; Mikulecká, A; Tichá, K, 2014) |
| "Cholestasis was induced by ligation of the main bile duct using two ligatures and transsection of the duct between them." | 1.40 | Role of GABAA receptor in modulation of acute thermal pain using a rat model of cholestasis. ( Hasanein, P; Parviz, M, 2014) |
| " It is suggested that this lack of effect was possibly due to the desensitization of the GABAA receptors, as well as by the decrease on the responsiveness of the functions of μ opioid receptors, resulting from chronic administration of ethyl alcohol." | 1.40 | Impaired fear inhibitory properties of GABAA and μ opioid receptors of the dorsal periaqueductal grey in alcohol-withdrawn rats. ( Nobre, MJ; Silva, LBC, 2014) |
| "Muscimol was administered twice on d14 and twice on d15 (1 h prior to each lipopolysaccharide injection; 0." | 1.39 | Muscimol delays lipopolysaccharide-induced preterm delivery in mice: role of GABA(A) receptors and nitric oxide. ( Dehpour, AR; Fakhraei, N; Gharedaghi, MH; Javadi-Paydar, M; Javadian, P; Salehi-Sadaghiani, M; Tavangar, SM; Yousefzadeh-Fard, Y, 2013) |
| "Cervical dystonia (CD; spasmodic torticollis) can be evoked by inhibition of substantia nigra pars reticulata (SNpr) in the nonhuman primate (Burbaud et al." | 1.38 | Superior colliculus mediates cervical dystonia evoked by inhibition of the substantia nigra pars reticulata. ( Decker, AL; DesJardin, JT; Forcelli, PA; Gale, K; Holmes, AL; Malkova, L; Teferra, M; West, EA, 2012) |
| "Mechanical allodynia, the perception of innocuous tactile stimulation as painful, is a severe symptom of chronic pain often produced by damage to peripheral nerves." | 1.37 | Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy. ( Barth, DS; Benison, AM; Chumachenko, S; Falci, SP; Harrison, JA; Maier, SF; Watkins, LR, 2011) |
| "Cingulate seizure-like activities were modulated significantly by thalamic inputs." | 1.37 | Spatiotemporal organization and thalamic modulation of seizures in the mouse medial thalamic-anterior cingulate slice. ( Chang, WP; Lee, CM; Shyu, BC; Vogt, BA; Wu, JS, 2011) |
| "Muscimol was effective in reducing AEP in both LA and HA rats." | 1.36 | GABAergic regulation of auditory sensory gating in low- and high-anxiety rats submitted to a fear conditioning procedure. ( Brandão, ML; Cabral, A; Nobre, MJ, 2010) |
| "The SP-induced hyperalgesia was both GABA(A) and NMDA receptor-dependent after pre- and post-treatment with selective antagonists at the spinal level." | 1.36 | Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla. ( Dubner, R; Guo, W; Lagraize, SC; Ren, K; Wei, F; Yang, K, 2010) |
| "The pathophysiology of idiopathic dystonias is still unknown, but it is regarded as a basal ganglia disorder." | 1.36 | Effects of pharmacological entopeduncular manipulations on idiopathic dystonia in the dt(sz) mutant hamster. ( Hamann, M; Kreil, A; Richter, A; Sander, SE, 2010) |
| "At 4 weeks after Th9-10 spinal cord transection awake cystometry and recordings of external urethral sphincter electromyogram were performed to examine the effect of intrathecal application of the gamma-aminobutyric acid A and B agonists muscimol and baclofen or the gamma-aminobutyric acid A and B antagonists bicuculline and saclofen (Tocris Cookson, Ellisville, Missouri), respectively, at the level of the L6-S1 spinal cord." | 1.35 | GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats. ( Chancellor, MB; de Groat, WC; Hiragata, S; Miyazato, M; Sasatomi, K; Sugaya, K; Yoshimura, N, 2008) |
| "The treatment with muscimol, a gamma amino butyric acid receptor-A (GABA(A)) agonist, mitigates the AD syndrome and vascular dementia." | 1.35 | GABAA receptor agonist mitigates homocysteine-induced cerebrovascular remodeling in knockout mice. ( Kumar, M; Lominadze, D; Moshal, KS; Pushpakumar, SB; Sen, U; Tyagi, N; Tyagi, SC; Vacek, T, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (5.73) | 18.7374 |
| 1990's | 7 (4.46) | 18.2507 |
| 2000's | 48 (30.57) | 29.6817 |
| 2010's | 87 (55.41) | 24.3611 |
| 2020's | 6 (3.82) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Loeza-Alcocer, E | 1 |
| Gold, MS | 1 |
| Asgharpour-Masouleh, N | 1 |
| Rezayof, A | 2 |
| Alijanpour, S | 1 |
| Delphi, L | 1 |
| Mareš, P | 2 |
| Kudová, E | 1 |
| Valeš, K | 1 |
| Kubová, H | 1 |
| Sabihi, S | 1 |
| Goodpaster, C | 1 |
| Maurer, S | 1 |
| Leuner, B | 1 |
| Bourrelly, C | 1 |
| Quinet, J | 1 |
| Goffart, L | 1 |
| Shih, HC | 1 |
| Kuan, YH | 1 |
| Shyu, BC | 2 |
| Mousavi Majd, A | 1 |
| Ebrahim Tabar, F | 1 |
| Afghani, A | 1 |
| Ashrafpour, S | 1 |
| Dehghan, S | 1 |
| Gol, M | 1 |
| Ashrafpour, M | 1 |
| Pourabdolhossein, F | 1 |
| Pilipenko, V | 1 |
| Narbute, K | 1 |
| Beitnere, U | 1 |
| Rumaks, J | 1 |
| Pupure, J | 1 |
| Jansone, B | 1 |
| Klusa, V | 1 |
| Lima, JC | 1 |
| Oliveira, LM | 1 |
| Botelho, MT | 1 |
| Moreira, TS | 2 |
| Takakura, AC | 2 |
| Zhu, X | 1 |
| Yao, Y | 1 |
| Li, X | 2 |
| Dong, J | 1 |
| Zhang, A | 2 |
| Wang, H | 1 |
| Cheng, X | 1 |
| Yu, H | 1 |
| Zhang, X | 1 |
| Guan, M | 1 |
| Zhao, L | 1 |
| Liu, Y | 1 |
| Linag, Y | 1 |
| Luo, Y | 1 |
| Zhao, C | 1 |
| Whitt, JL | 1 |
| Masri, R | 2 |
| Pulimood, NS | 1 |
| Keller, A | 1 |
| Guo, N | 1 |
| Yoshizaki, K | 1 |
| Kimura, R | 1 |
| Suto, F | 1 |
| Yanagawa, Y | 1 |
| Osumi, N | 1 |
| Robert, C | 1 |
| Bourgeais, L | 1 |
| Arreto, CD | 1 |
| Condes-Lara, M | 1 |
| Noseda, R | 1 |
| Jay, T | 1 |
| Villanueva, L | 1 |
| Petri, D | 1 |
| Pum, M | 1 |
| Vesper, J | 1 |
| Huston, JP | 1 |
| Schnitzler, A | 1 |
| Lungwitz, EA | 1 |
| Stuber, GD | 1 |
| Johnson, PL | 1 |
| Dietrich, AD | 1 |
| Schartz, N | 1 |
| Hanrahan, B | 1 |
| Shekhar, A | 1 |
| Truitt, WA | 1 |
| Sardari, M | 1 |
| Khodagholi, F | 1 |
| Zarrindast, MR | 2 |
| Bardgett, ME | 1 |
| Holbein, WW | 1 |
| Herrera-Rosales, M | 1 |
| Toney, GM | 1 |
| Mansoori, BK | 1 |
| Jean-Charles, L | 1 |
| Touvykine, B | 1 |
| Liu, A | 1 |
| Quessy, S | 1 |
| Dancause, N | 1 |
| Wellman, LL | 2 |
| Fitzpatrick, ME | 2 |
| Machida, M | 1 |
| Sanford, LD | 2 |
| Tan, SN | 1 |
| Song, E | 1 |
| Dong, XD | 1 |
| Somvanshi, RK | 1 |
| Cairns, BE | 1 |
| Naseri, MH | 1 |
| Hesami-Tackallou, S | 1 |
| Torabi-Nami, M | 1 |
| Nasehi, M | 1 |
| Silva, LBC | 1 |
| Nobre, MJ | 2 |
| Damasceno, RS | 1 |
| Pezze, M | 1 |
| McGarrity, S | 1 |
| Mason, R | 1 |
| Fone, KC | 1 |
| Bast, T | 1 |
| Hasanein, P | 1 |
| Parviz, M | 1 |
| Ma, X | 1 |
| Bao, W | 1 |
| Wang, X | 2 |
| Wang, Z | 2 |
| Liu, Q | 1 |
| Yao, Z | 1 |
| Zhang, D | 1 |
| Jiang, H | 1 |
| Cui, S | 1 |
| Tichá, K | 1 |
| Mikulecká, A | 1 |
| Bondarenko, E | 1 |
| Hodgson, DM | 1 |
| Nalivaiko, E | 1 |
| Bobal, MG | 1 |
| Savage, LM | 1 |
| Sharma, RK | 2 |
| Choudhary, RC | 2 |
| Reddy, MK | 1 |
| Ray, A | 1 |
| Ravi, K | 2 |
| Limpens, JH | 1 |
| Damsteegt, R | 1 |
| Broekhoven, MH | 1 |
| Voorn, P | 1 |
| Vanderschuren, LJ | 1 |
| Zeric, T | 1 |
| Kambhampati, S | 1 |
| Bossert, JM | 1 |
| Shaham, Y | 1 |
| Ran, R | 1 |
| Gu, J | 2 |
| Fu, J | 1 |
| Zhong, H | 1 |
| Zhao, Y | 1 |
| Gu, Y | 1 |
| Li, G | 1 |
| Wang, L | 1 |
| Wang, Q | 1 |
| Okada-Ogawa, A | 1 |
| Nakaya, Y | 1 |
| Imamura, Y | 1 |
| Kobayashi, M | 1 |
| Shinoda, M | 1 |
| Kita, K | 1 |
| Sessle, BJ | 1 |
| Iwata, K | 1 |
| de Araujo, MF | 1 |
| Matsumoto, J | 1 |
| Ono, T | 1 |
| Nishijo, H | 1 |
| Gulati, K | 1 |
| Liu, J | 1 |
| Huang, D | 1 |
| Xu, J | 2 |
| Tong, J | 1 |
| Huang, L | 1 |
| Yang, Y | 1 |
| Bai, X | 1 |
| Wang, P | 1 |
| Suo, H | 1 |
| Ma, Y | 1 |
| Yu, M | 1 |
| Fei, J | 1 |
| Huang, F | 1 |
| Ronzoni, G | 1 |
| Antón, M | 1 |
| Mora, F | 1 |
| Segovia, G | 1 |
| Del Arco, A | 1 |
| Chen, L | 3 |
| Wang, W | 1 |
| Tan, T | 1 |
| Han, H | 1 |
| Dong, Z | 1 |
| Ishida, A | 1 |
| Isa, K | 1 |
| Umeda, T | 1 |
| Kobayashi, K | 2 |
| Hida, H | 1 |
| Isa, T | 1 |
| Arcaro, J | 1 |
| Ma, J | 1 |
| Chu, L | 1 |
| Kuo, M | 1 |
| Mirsattari, SM | 1 |
| Stan Leung, L | 1 |
| Li, C | 4 |
| Yan, Y | 1 |
| Cheng, J | 1 |
| Xiao, G | 1 |
| Zhang, L | 1 |
| Yuan, S | 1 |
| Wang, J | 1 |
| Shen, Y | 1 |
| Zhou, YD | 1 |
| Rodriguez-Romaguera, J | 1 |
| Greenberg, BD | 1 |
| Rasmussen, SA | 1 |
| Quirk, GJ | 1 |
| Hallum, OY | 1 |
| Sutton, AM | 1 |
| Williams, BL | 1 |
| Hirose, N | 1 |
| Saitoh, A | 1 |
| Kamei, J | 1 |
| Chiou, CS | 1 |
| Chen, CC | 1 |
| Tsai, TC | 1 |
| Huang, CC | 1 |
| Chou, D | 1 |
| Hsu, KS | 1 |
| Campus, P | 1 |
| Maiolati, M | 1 |
| Orsini, C | 1 |
| Cabib, S | 1 |
| Sindhurakar, A | 1 |
| Butensky, SD | 1 |
| Meyers, E | 1 |
| Santos, J | 1 |
| Bethea, T | 1 |
| Khalili, A | 1 |
| Sloan, AP | 1 |
| Rennaker, RL | 1 |
| Carmel, JB | 1 |
| Geng, KW | 1 |
| He, T | 1 |
| Wang, RR | 1 |
| Li, CL | 1 |
| Luo, WJ | 1 |
| Wu, FF | 1 |
| Wang, Y | 2 |
| Li, Z | 1 |
| Lu, YF | 1 |
| Guan, SM | 1 |
| Chen, J | 1 |
| Huang, YJ | 2 |
| Lee, KH | 2 |
| Murphy, L | 1 |
| Garraway, SM | 1 |
| Grau, JW | 2 |
| Bertelsen, F | 1 |
| Møller, A | 1 |
| Folloni, D | 1 |
| Drasbek, KR | 1 |
| Scheel-Krüger, J | 1 |
| Landau, AM | 1 |
| Cevikbas, F | 1 |
| Braz, JM | 1 |
| Solorzano, C | 1 |
| Sulk, M | 1 |
| Buhl, T | 1 |
| Steinhoff, M | 1 |
| Basbaum, AI | 1 |
| Kumar, M | 1 |
| Tyagi, N | 1 |
| Moshal, KS | 1 |
| Sen, U | 1 |
| Pushpakumar, SB | 1 |
| Vacek, T | 1 |
| Lominadze, D | 1 |
| Tyagi, SC | 1 |
| Mandel, DA | 1 |
| Schreihofer, AM | 1 |
| Kuramoto, S | 1 |
| Yasuhara, T | 1 |
| Agari, T | 1 |
| Kondo, A | 1 |
| Matsui, T | 1 |
| Miyoshi, Y | 1 |
| Shingo, T | 1 |
| Date, I | 1 |
| Chen, F | 1 |
| Dworak, M | 1 |
| Cham, JL | 1 |
| Badoer, E | 1 |
| Klavir, O | 2 |
| Flash, S | 1 |
| Winter, C | 4 |
| Joel, D | 3 |
| Ludvig, N | 1 |
| Baptiste, SL | 1 |
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| Medveczky, G | 1 |
| von Gizycki, H | 1 |
| Charchaflieh, J | 1 |
| Devinsky, O | 1 |
| Kuzniecky, RI | 1 |
| Li, Y | 1 |
| Lei, Z | 1 |
| Xu, ZC | 1 |
| Wang, N | 1 |
| Wang, JY | 1 |
| Luo, F | 1 |
| Frauenknecht, K | 1 |
| Plaschke, K | 1 |
| Sommer, C | 1 |
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| Grabli, D | 1 |
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| Tandé, D | 1 |
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| Leung, LS | 2 |
| Vohs, JL | 1 |
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| Yu, HM | 2 |
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| Zhang, GY | 3 |
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| Myhrer, T | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Subthalamic Nucleus Deep Brain Stimulation in Tourette's Syndrome[NCT02619084] | Phase 2 | 10 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for muscimol and Disease Models, Animal
| Article | Year |
|---|---|
Pedunculopontine stimulation from primate to patient.
Topics: Animals; Bicuculline; Biophysics; Convulsants; Deep Brain Stimulation; Disease Models, Animal; GABA- | 2011 |
GABA-agonists as anti-epileptic agents.
Topics: Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Disease Models, Animal; Epilepsy; Etomidate | 1981 |
[Implications of GABAergic synapses in neuropsychiatry].
Topics: 4-Aminobutyrate Transaminase; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; | 1985 |
The pharmacology of myoclonus.
Topics: 5-Hydroxytryptophan; Adrenocorticotropic Hormone; Animals; Anticonvulsants; Benzodiazepines; Brain; | 1985 |
Valproate and myoclonus.
Topics: 5-Hydroxytryptophan; Amino Acids; Animals; Aspartic Acid; Clonazepam; DDT; Disease Models, Animal; F | 1986 |
152 other studies available for muscimol and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Peripheral GABAA receptor signaling contributes to visceral hypersensitivity in a mouse model of colitis.
Topics: Animals; Bicuculline; Colitis; Colon; Dextran Sulfate; Diazepam; Disease Models, Animal; Inflammator | 2022 |
Pharmacological activation of mediodorsal thalamic GABA-A receptors modulates morphine/cetirizine-induced changes in the prefrontal cortical GFAP expression in a rat model of neuropathic pain.
Topics: Animals; Cetirizine; Chronic Pain; Disease Models, Animal; GABA-A Receptor Agonists; Glial Fibrillar | 2023 |
Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electrodes, Implanted; Male; Midazolam; Muscimol; | 2020 |
GABA in the medial prefrontal cortex regulates anxiety-like behavior during the postpartum period.
Topics: Animals; Anxiety; Behavior, Animal; Bicuculline; Disease Models, Animal; Female; GABA-A Receptor Ago | 2021 |
Bilateral control of interceptive saccades: evidence from the ipsipulsion of vertical saccades after caudal fastigial inactivation.
Topics: Animals; Behavior, Animal; Cerebellar Nuclei; Disease Models, Animal; Eye-Tracking Technology; GABA- | 2021 |
Targeting brain-derived neurotrophic factor in the medial thalamus for the treatment of central poststroke pain in a rodent model.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; GABA-A Receptor Agonists; Male; | 2017 |
Inhibition of GABA A receptor improved spatial memory impairment in the local model of demyelination in rat hippocampus.
Topics: Animals; Avoidance Learning; Bicuculline; Demyelinating Diseases; Disease Models, Animal; GABA-A Rec | 2018 |
Very low doses of muscimol and baclofen ameliorate cognitive deficits and regulate protein expression in the brain of a rat model of streptozocin-induced Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Baclofen; Brain; Cognition; Disease Models, Animal; Dose-Response Relati | 2018 |
The involvement of the pathway connecting the substantia nigra, the periaqueductal gray matter and the retrotrapezoid nucleus in breathing control in a rat model of Parkinson's disease.
Topics: Animals; Chemoreceptor Cells; Disease Models, Animal; GABA Agonists; Glutamate Decarboxylase; Gray M | 2018 |
Alteration of GABAergic signaling is associated with anxiety-like behavior in temporal lobe epilepsy mice.
Topics: Animals; Anxiety; Blotting, Western; Disease Models, Animal; Epilepsy, Temporal Lobe; GABAergic Neur | 2019 |
Activation of GABAA receptors enhances the behavioral recovery but not axonal sprouting in ischemic rats.
Topics: Animals; Axons; Behavior, Animal; Brain Infarction; Disease Models, Animal; GABA-A Receptor Agonists | 2019 |
Pathological activity in mediodorsal thalamus of rats with spinal cord injury pain.
Topics: Action Potentials; Afferent Pathways; Animals; Disease Models, Animal; Functional Laterality; GABA-A | 2013 |
A sensitive period for GABAergic interneurons in the dentate gyrus in modulating sensorimotor gating.
Topics: Age Factors; Animals; Behavior, Animal; Critical Period, Psychological; Dendrites; Dentate Gyrus; Di | 2013 |
Paraventricular hypothalamic regulation of trigeminovascular mechanisms involved in headaches.
Topics: Action Potentials; Animals; Biotin; Corticosterone; Dextrans; Disease Models, Animal; GABA Antagonis | 2013 |
GABAA-receptor activation in the subthalamic nucleus compensates behavioral asymmetries in the hemiparkinsonian rat.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenergic Agents; Amphetamine; Animals; Disease Models, Animal; Diz | 2013 |
The role of the medial prefrontal cortex in regulating social familiarity-induced anxiolysis.
Topics: Analysis of Variance; Animals; Antimetabolites; Anxiety; Cues; Cycloserine; Disease Models, Animal; | 2014 |
Basolateral amygdala GABA-A receptors mediate stress-induced memory retrieval impairment in rats.
Topics: Amygdala; Animals; Behavior, Animal; Bicuculline; Disease Models, Animal; GABA-A Receptor Agonists; | 2014 |
Ang II-salt hypertension depends on neuronal activity in the hypothalamic paraventricular nucleus but not on local actions of tumor necrosis factor-α.
Topics: Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; GABA-A Receptor Agonists; Hypertens | 2014 |
Acute inactivation of the contralesional hemisphere for longer durations improves recovery after cortical injury.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Efferent Pathways; Forelimb; Fun | 2014 |
The basolateral amygdala determines the effects of fear memory on sleep in an animal model of PTSD.
Topics: Analysis of Variance; Animals; Basolateral Nuclear Complex; Conditioning, Classical; Disease Models, | 2014 |
Peripheral GABAA receptor activation modulates rat tongue afferent mechanical sensitivity.
Topics: Administration, Topical; Animals; Benzodiazepines; Burning Mouth Syndrome; Disease Models, Animal; F | 2014 |
Involvement of the CA1 GABAA receptors in MK-801-induced anxiolytic-like effects: an isobologram analysis.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Bicuculline; CA1 Region, Hippocampal; D | 2014 |
Impaired fear inhibitory properties of GABAA and μ opioid receptors of the dorsal periaqueductal grey in alcohol-withdrawn rats.
Topics: Alcohols; Analgesics, Opioid; Animals; Conditioning, Classical; Disease Models, Animal; Dose-Respons | 2014 |
Regulation of the chemosensory control of breathing by Kölliker-Fuse neurons.
Topics: Animals; Bicuculline; Blood Pressure; Chemoreceptor Cells; Disease Models, Animal; GABA-A Receptor A | 2014 |
Too little and too much: hypoactivation and disinhibition of medial prefrontal cortex cause attentional deficits.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Choice Behavior; Disease Models, Animal; Dos | 2014 |
Role of GABAA receptor in modulation of acute thermal pain using a rat model of cholestasis.
Topics: Acute Pain; Animals; Bicuculline; Cholestasis; Disease Models, Animal; Muscimol; Naloxone; Rats; Rec | 2014 |
Role of spinal GABAA receptor reduction induced by stress in rat thermal hyperalgesia.
Topics: Analysis of Variance; Animals; Bicuculline; Disease Models, Animal; GABA-A Receptor Agonists; GABA-A | 2014 |
Anticonvulsant and behavioral effects of muscimol in immature rats.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Dr | 2014 |
Prelimbic prefrontal cortex mediates respiratory responses to mild and potent prolonged, but not brief, stressors.
Topics: Acoustic Stimulation; Animals; Catheters, Indwelling; Disease Models, Animal; GABA-A Receptor Agonis | 2014 |
The role of ventral midline thalamus in cholinergic-based recovery in the amnestic rat.
Topics: Animal Feed; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Functional Laterality; GABA | 2015 |
Role of posterior hypothalamus in hypobaric hypoxia induced pulmonary edema.
Topics: Altitude Sickness; Animals; Disease Models, Animal; GABA-A Receptor Agonists; Hypertension, Pulmonar | 2015 |
Pharmacological inactivation of the prelimbic cortex emulates compulsive reward seeking in rats.
Topics: Animals; Baclofen; Cerebral Cortex; Cocaine; Cocaine-Related Disorders; Decision Making; Dietary Suc | 2015 |
The central amygdala nucleus is critical for incubation of methamphetamine craving.
Topics: Amphetamine-Related Disorders; Animals; Baclofen; Basolateral Nuclear Complex; Central Amygdaloid Nu | 2015 |
The role of the GABA-A receptor of the adjacent intact dorsal root ganglion neurons in rats with neuropathic pain.
Topics: Animals; Biophysics; Cell Size; Cells, Cultured; Disease Models, Animal; Electric Stimulation; GABA- | 2014 |
Involvement of medullary GABAergic system in extraterritorial neuropathic pain mechanisms associated with inferior alveolar nerve transection.
Topics: Acetates; Action Potentials; Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kin | 2015 |
An animal model of disengagement: Temporary inactivation of the superior colliculus impairs attention disengagement in rats.
Topics: Analysis of Variance; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Conditionin | 2015 |
Role of the paraventricular nucleus in the reflex diuresis to pulmonary lymphatic obstruction in rabbits.
Topics: Animals; Disease Models, Animal; Diuresis; Gene Expression; Genes, fos; Kidney; Kynurenic Acid; Lung | 2016 |
Tiagabine Protects Dopaminergic Neurons against Neurotoxins by Inhibiting Microglial Activation.
Topics: Animals; Baclofen; Cell Line, Tumor; Disease Models, Animal; Dopaminergic Neurons; GABA Plasma Membr | 2015 |
Infralimbic cortex controls the activity of the hypothalamus-pituitary-adrenal axis and the formation of aversive memory: Effects of environmental enrichment.
Topics: Animals; Avoidance Learning; Cerebral Cortex; Corticosterone; Disease Models, Animal; Emotions; Envi | 2016 |
GABA(A) Receptors in the Central Nucleus of the Amygdala Are Involved in Pain- and Itch-Related Responses.
Topics: Animals; Behavior, Animal; Bicuculline; Central Amygdaloid Nucleus; Disease Models, Animal; GABA-A R | 2016 |
Causal Link between the Cortico-Rubral Pathway and Functional Recovery through Forced Impaired Limb Use in Rats with Stroke.
Topics: Animals; Biotin; Cerebral Hemorrhage; Deep Brain Stimulation; Dextrans; Disease Models, Animal; Doxy | 2016 |
The hippocampus participates in a pharmacological rat model of absence seizures.
Topics: 4-Butyrolactone; Animals; Cerebral Cortex; Cortical Synchronization; Disease Models, Animal; Electro | 2016 |
Toll-Like Receptor 4 Deficiency Causes Reduced Exploratory Behavior in Mice Under Approach-Avoidance Conflict.
Topics: Analysis of Variance; Animals; Anxiety; Avoidance Learning; Baclofen; Disease Models, Animal; Explor | 2016 |
An Avoidance-Based Rodent Model of Exposure With Response Prevention Therapy for Obsessive-Compulsive Disorder.
Topics: Animals; Avoidance Learning; Conditioning, Operant; Conditioning, Psychological; Deep Brain Stimulat | 2016 |
Individual Differences in Animal Stress Models: Considering Resilience, Vulnerability, and the Amygdala in Mediating the Effects of Stress and Conditioned Fear on Sleep.
Topics: Adaptation, Psychological; Amygdala; Animals; Conditioning, Psychological; Disease Models, Animal; E | 2016 |
Involvement of glutamatergic N-methyl-d-aspartate receptors in the expression of increased head-dipping behaviors in the hole-board tests of olfactory bulbectomized mice.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Dizocilpine Maleate; Excita | 2016 |
Alleviating Bone Cancer-induced Mechanical Hypersensitivity by Inhibiting Neuronal Activity in the Anterior Cingulate Cortex.
Topics: Animals; Bone Neoplasms; Disease Models, Animal; Gyrus Cinguli; Hyperalgesia; Male; Mice; Mice, Inbr | 2016 |
Altered consolidation of extinction-like inhibitory learning in genotype-specific dysfunctional coping fostered by chronic stress in mice.
Topics: Adaptation, Psychological; Analysis of Variance; Animals; Brain; Conditioning, Operant; Disease Mode | 2016 |
An Automated Test of Rat Forelimb Supination Quantifies Motor Function Loss and Recovery After Corticospinal Injury.
Topics: Animals; Automation, Laboratory; Disease Models, Animal; Equipment Design; Female; Food; Forelimb; M | 2017 |
Ethanol Increases Mechanical Pain Sensitivity in Rats via Activation of GABAA Receptors in Medial Prefrontal Cortex.
Topics: Animals; Bicuculline; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Central Nervous System Dep | 2016 |
Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization.
Topics: Acetates; Analysis of Variance; Animals; Bicuculline; Bumetanide; Capsaicin; Disease Models, Animal; | 2016 |
Complete spinal cord injury (SCI) transforms how brain derived neurotrophic factor (BDNF) affects nociceptive sensitization.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cadherins; Capsaicin; Disease Models, Animal; Electrosho | 2017 |
Increased GABAA receptor binding in amygdala after prenatal administration of valproic acid to rats.
Topics: Amygdala; Animals; Autism Spectrum Disorder; Autoradiography; Azides; Benzodiazepines; Carbon Radioi | 2017 |
Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis.
Topics: Animals; Antipruritics; Baclofen; Dermatitis, Atopic; Disease Models, Animal; Drug Synergism; GABA-A | 2017 |
GABAA receptor agonist mitigates homocysteine-induced cerebrovascular remodeling in knockout mice.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Cerebral Arteries; Cerebrovascular Circulation; Coloring | 2008 |
Glutamatergic inputs to the CVLM independent of the NTS promote tonic inhibition of sympathetic vasomotor tone in rats.
Topics: Animals; Baroreflex; Blood Pressure; Blood Vessels; Disease Models, Animal; Excitatory Amino Acid An | 2008 |
Injection of muscimol, a GABAa agonist into the anterior thalamic nucleus, suppresses hippocampal neurogenesis in amygdala-kindled rats.
Topics: Amygdala; Animals; Anterior Thalamic Nuclei; Bromodeoxyuridine; Cell Count; Cell Differentiation; Ce | 2009 |
Role of the hypothalamic PVN in the reflex reduction in mesenteric blood flow elicited by hyperthermia.
Topics: Animals; Blood Pressure; Body Temperature; Disease Models, Animal; Down-Regulation; Fever; GABA Agon | 2008 |
High frequency stimulation and pharmacological inactivation of the subthalamic nucleus reduces 'compulsive' lever-pressing in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Compulsive Behavior; Conditioning, Operant; Deep Br | 2009 |
Localized transmeningeal muscimol prevents neocortical seizures in rats and nonhuman primates: therapeutic implications.
Topics: Acetylcholine; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Dr | 2009 |
Enhancement of inhibitory synaptic transmission in large aspiny neurons after transient cerebral ischemia.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Biophysics; | 2009 |
Corticofugal outputs facilitate acute, but inhibit chronic pain in rats.
Topics: Analysis of Variance; Animals; Bicuculline; Chronic Disease; Disease Models, Animal; Freund's Adjuva | 2009 |
Transient oligemia is associated with long-term changes in binding densities of cortical inhibitory GABAA receptors in the rat brain.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Disease Models, Animal; Down-Regulation; GABA Agonis | 2009 |
Dysfunction of the subthalamic nucleus induces behavioral and movement disorders in monkeys.
Topics: Animals; Behavior, Animal; Bicuculline; Chlorocebus aethiops; Disease Models, Animal; Functional Lat | 2009 |
Pilocarpine model of temporal lobe epilepsy shows enhanced response to general anesthetics.
Topics: Anesthetics, General; Animals; Brain; Consciousness Disorders; Convulsants; Disease Models, Animal; | 2009 |
GABAergic modulation of the 40 Hz auditory steady-state response in a rat model of schizophrenia.
Topics: Animals; Animals, Newborn; Bicuculline; Disease Models, Animal; Evoked Potentials, Auditory; GABA Ag | 2010 |
Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizure.
Topics: Animals; Apoptosis; Baclofen; Disease Models, Animal; Disks Large Homolog 4 Protein; GABA Agonists; | 2010 |
Angiotensin II enhances GABA(B) receptor-mediated responses and expression in nucleus tractus solitarii of rats.
Topics: Angiotensin II; Animals; Baclofen; Baroreflex; Bicuculline; Blood Pressure; Disease Models, Animal; | 2009 |
Involvement of the lateral orbitofrontal cortex in drug context-induced reinstatement of cocaine-seeking behavior in rats.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhib | 2009 |
Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats.
Topics: 5,7-Dihydroxytryptamine; Adrenergic Agents; Analysis of Variance; Animals; Benzylamines; Catheter Ab | 2010 |
Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Electroencephalography; GABA Agon | 2010 |
Angiotensin II and CRF receptors in the central nucleus of the amygdala mediate hemodynamic response variability to cocaine in conscious rats.
Topics: Amygdala; Angiotensin II Type 1 Receptor Blockers; Animals; Cocaine; Cocaine-Related Disorders; Cons | 2010 |
The role of the striatum in compulsive behavior in intact and orbitofrontal-cortex-lesioned rats: possible involvement of the serotonergic system.
Topics: Animals; Compulsive Behavior; Conditioning, Operant; Corpus Striatum; Disease Models, Animal; Extinc | 2010 |
Inactivation of the left auditory cortex impairs temporal discrimination in the rat.
Topics: Acoustic Stimulation; Animals; Auditory Cortex; Auditory Diseases, Central; Auditory Perceptual Diso | 2010 |
Granular insular cortex inactivation as a novel therapeutic strategy for nicotine addiction.
Topics: Analysis of Variance; Animals; Association Learning; Baclofen; Behavior, Addictive; Behavior, Animal | 2010 |
Effects of pharmacological entopeduncular manipulations on idiopathic dystonia in the dt(sz) mutant hamster.
Topics: Animals; Animals, Newborn; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2010 |
Disconnection of the hippocampal-perirhinal cortical circuits severely disrupts object-place paired associative memory.
Topics: Animals; Association Learning; Discrimination, Psychological; Disease Models, Animal; Entorhinal Cor | 2010 |
Pharmacological inhibition of the lateral habenula improves depressive-like behavior in an animal model of treatment resistant depression.
Topics: Analysis of Variance; Animals; Depressive Disorder; Disease Models, Animal; GABA-A Receptor Agonists | 2011 |
Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice.
Topics: Animals; Bicuculline; Disease Models, Animal; Glycine; Hot Temperature; Hyperalgesia; Injections; In | 2010 |
Spinal cord mechanisms mediating behavioral hyperalgesia induced by neurokinin-1 tachykinin receptor activation in the rostral ventromedial medulla.
Topics: Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dizocilp | 2010 |
GABAergic regulation of auditory sensory gating in low- and high-anxiety rats submitted to a fear conditioning procedure.
Topics: Acoustic Stimulation; Animals; Anxiety; Behavior, Animal; Benzodiazepines; Bicuculline; Clonixin; Co | 2010 |
Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Biophysical Phenomena; Disease Models, Anim | 2010 |
Abnormal synaptic plasticity in basolateral amygdala may account for hyperactivity and attention-deficit in male rat exposed perinatally to low-dose bisphenol-A.
Topics: Air Pollutants, Occupational; Amygdala; Animals; Attention Deficit Disorder with Hyperactivity; Benz | 2011 |
Cortical and hippocampal EEG effects of neurotransmitter agonists in spontaneously hypertensive vs. kainate-treated rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Baclofen; Clonidine; Disease Models, Animal; | 2011 |
Modulation of conditioned fear, fear-conditioned analgesia, and brain regional c-Fos expression following administration of muscimol into the rat basolateral amygdala.
Topics: Amygdala; Analgesia; Animals; Conditioning, Psychological; Disease Models, Animal; Fear; GABA-A Rece | 2011 |
Caudal granular insular cortex is sufficient and necessary for the long-term maintenance of allodynic behavior in the rat attributable to mononeuropathy.
Topics: Analysis of Variance; Animals; Behavior, Animal; Biotin; Brain Mapping; Cerebral Cortex; Dextrans; D | 2011 |
Enhanced efficacy of anticonvulsants when combined with levetiracetam in soman-exposed rats.
Topics: Animals; Anticonvulsants; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinester | 2011 |
Neural mechanisms for smooth pursuit in strabismus.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Esotropia; Macaca mulatta; Muscimol; Oculomotor M | 2011 |
Spatiotemporal organization and thalamic modulation of seizures in the mouse medial thalamic-anterior cingulate slice.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuculline; Biol | 2011 |
The stress-induced cytokine interleukin-6 decreases the inhibition/excitation ratio in the rat temporal cortex via trans-signaling.
Topics: Androstadienes; Animals; Brefeldin A; Cytokine Receptor gp130; Disease Models, Animal; Drug Interact | 2012 |
Functional imaging reveals rapid reorganization of cortical activity after parietal inactivation in monkeys.
Topics: Animals; Disease Models, Animal; Extinction, Psychological; Functional Laterality; GABA-A Receptor A | 2012 |
Effects of early-life abuse differ across development: infant social behavior deficits are followed by adolescent depressive-like behaviors mediated by the amygdala.
Topics: Adolescent; Age Factors; Amygdala; Animals; Animals, Newborn; Conditioning, Classical; Depressive Di | 2012 |
Behavioral and EEG effects of GABAergic manipulation of the nigro-tectal pathway in the Wistar audiogenic rat (WAR) strain II: an EEG wavelet analysis and retrograde neuronal tracer approach.
Topics: Acoustic Stimulation; Animals; Behavior, Animal; Bicuculline; Brain Waves; Disease Models, Animal; E | 2012 |
Muscimol delays lipopolysaccharide-induced preterm delivery in mice: role of GABA(A) receptors and nitric oxide.
Topics: Amniotic Fluid; Animals; Bicuculline; Disease Models, Animal; Female; GABA-A Receptor Agonists; GABA | 2013 |
Superior colliculus mediates cervical dystonia evoked by inhibition of the substantia nigra pars reticulata.
Topics: Analysis of Variance; Animals; Bicuculline; Disease Models, Animal; Drug Administration Routes; Fema | 2012 |
The associative and limbic thalamus in the pathophysiology of obsessive-compulsive disorder: an experimental study in the monkey.
Topics: Animals; Anterior Thalamic Nuclei; Behavior, Animal; Bicuculline; Deep Brain Stimulation; Disease Mo | 2012 |
Changes in GABAergic inputs in the paraventricular nucleus maintain sympathetic vasomotor tone in chronic heart failure.
Topics: Animals; Autoradiography; Blood Pressure; Disease Models, Animal; Dizocilpine Maleate; Echocardiogra | 2012 |
Effects of oxymatrine on the neuropathic pain induced by chronic constriction injury in mice.
Topics: Alkaloids; Animals; Chronic Disease; Constriction; Disease Models, Animal; Dose-Response Relationshi | 2012 |
Inactivation of the parietal reach region causes optic ataxia, impairing reaches but not saccades.
Topics: Action Potentials; Animals; Association Learning; Ataxia; Brain Mapping; Cues; Disease Models, Anima | 2012 |
Blunted endogenous GABA-mediated inhibition in the hypothalamic paraventricular nucleus of rats with streptozotocin-induced diabetes.
Topics: Animals; Bicuculline; Blood Pressure; Diabetes Mellitus, Experimental; Disease Models, Animal; GABA- | 2013 |
Motor cortex stimulation activates the incertothalamic pathway in an animal model of spinal cord injury.
Topics: Action Potentials; Analysis of Variance; Animals; Brain Mapping; Disease Models, Animal; GABA-A Rece | 2013 |
Cue-induced conditioned activity does not incubate but is mediated by the basolateral amygdala.
Topics: Amygdala; Animals; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Models, Ani | 2013 |
Involvement of GABAergic system in regulation of the anxiolytic- and antidepressant-like effects of Scrophularia striata extract in rats.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Bicuculline; Brain; Depression; Diseas | 2013 |
Estradiol exacerbates hippocampal damage in a model of preterm infant brain injury.
Topics: Animals; Animals, Newborn; Cell Death; Cells, Cultured; Disease Models, Animal; Drug Synergism; Estr | 2003 |
Basal ganglia efferents to the brainstem centers controlling postural muscle tone and locomotion: a new concept for understanding motor disorders in basal ganglia dysfunction.
Topics: Animals; Atropine; Basal Ganglia; Basal Ganglia Diseases; Bicuculline; Brain Stem; Cats; Choline O-A | 2003 |
A new model for prenatal brain damage. I. GABAA receptor activation induces cell death in developing rat hippocampus.
Topics: Animals; Animals, Newborn; Brain Damage, Chronic; Calcium; Calcium Channel Blockers; Calcium Channel | 2003 |
A novel model for prenatal brain damage. II. Long-term deficits in hippocampal cell number and hippocampal-dependent behavior following neonatal GABAA receptor activation.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain Damage, Chronic; Cell Count; Chronic | 2003 |
The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Avoidance Learnin | 2003 |
Rat behavior in two models of anxiety and brain [3H]muscimol binding: pharmacological, correlation, and multifactor analysis.
Topics: Analysis of Variance; Animals; Anxiety; Autoradiography; Behavior, Animal; Binding Sites; Brain; Dis | 2003 |
Analysis of responses to valerian root extract in the feline pulmonary vascular bed.
Topics: Acetylcholine; Animals; Arachidonic Acid; Bradykinin; Calcium Channel Agonists; Cats; Disease Models | 2003 |
Sex differences and hormonal effects in a model of preterm infant brain injury.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Female; GABA Agonists; Hippocampus; Humans; Hypox | 2003 |
Effects of rubral microinjections of muscimol and bicuculline in a genetic animal model of paroxysmal dystonia.
Topics: Animals; Bicuculline; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia | 2004 |
Modulation of the gait deficit in arthritic rats by infusions of muscimol and bicuculline.
Topics: Animals; Arthralgia; Arthritis, Experimental; Body Weight; Disease Models, Animal; Dose-Response Rel | 2004 |
Modifications of local cerebral glucose utilization in thalamic structures following injection of a dopaminergic agonist in the nucleus accumbens--involvement in antiepileptic effects?
Topics: Animals; Apomorphine; Autoradiography; Basal Ganglia; Deoxyglucose; Disease Models, Animal; Dopamine | 2004 |
Hippocampal melatonin receptors modulate seizure threshold.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy | 2005 |
Centrally-mediated antinociceptive actions of GABA(A) receptor agonists in the rat spared nerve injury model of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; GABA Agonists; GABA-A | 2005 |
Anxiolytic-like actions of the hexane extract from leaves of Annona cherimolia in two anxiety paradigms: possible involvement of the GABA/benzodiazepine receptor complex.
Topics: Animals; Annona; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Disease Models, | 2006 |
Simultaneous glutamate and GABA(A) receptor agonist administration increases calbindin levels and prevents hippocampal damage induced by either agent alone in a model of perinatal brain injury.
Topics: Animals; Animals, Newborn; Blotting, Western; Brain Injuries; Calbindins; Cells, Cultured; Disease M | 2005 |
Effect of cyclooxygenase-2 (COX-2) inhibitors in various animal models (bicuculline, picrotoxin, maximal electroshock-induced convulsions) of epilepsy with possible mechanism of action.
Topics: Animals; Bicuculline; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Resp | 2006 |
Genioglossus premotoneurons and the negative pressure reflex in rats.
Topics: Animals; Disease Models, Animal; Electromyography; GABA Agonists; Hypoglossal Nerve; Male; Motor Neu | 2007 |
The lack of CB1 receptors prevents neuroadapatations of both NMDA and GABA(A) receptors after chronic ethanol exposure.
Topics: Adaptation, Physiological; Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Binding S | 2007 |
GABAA and GABAB agonist microinjections into medial accumbens shell increase feeding and induce anxiolysis in an animal model of anxiety.
Topics: Analysis of Variance; Animals; Anxiety; Baclofen; Behavior, Animal; Disease Models, Animal; Dose-Res | 2007 |
The involvement of the substantia nigra pars reticulata in hypoglycemic seizures.
Topics: Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Fasting; GABA-A Receptor Agonists; gamm | 2007 |
Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus.
Topics: Action Potentials; Animals; Behavior, Animal; Deep Brain Stimulation; Depression; Disease Models, An | 2007 |
Neurosteroid allopregnanolone mediates anxiolytic effect of etifoxine in rats.
Topics: Adrenalectomy; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bicucu | 2007 |
17alpha-Estradiol is neuroprotective in male and female rats in a model of early brain injury.
Topics: Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Brain Injuries; Cells, Cultured; | 2008 |
Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion.
Topics: Analysis of Variance; Animals; Apoptosis; Baclofen; Brain Ischemia; Cerebral Infarction; Disease Mod | 2007 |
Treatment with haloperidol and diazepam alters GABA(A) receptor density in the rat brain.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzodiazepines; Binding Sites; Brain; Diazepam; Dis | 2008 |
High frequency stimulation and temporary inactivation of the subthalamic nucleus reduce quinpirole-induced compulsive checking behavior in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Compulsive Behavior; Disease Models, Animal; Dose-R | 2008 |
GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.
Topics: Animals; Baclofen; Bicuculline; Disease Models, Animal; Female; GABA Agonists; GABA Antagonists; Glu | 2008 |
Fever response to intravenous prostaglandin E2 is mediated by the brain but does not require afferent vagal signaling.
Topics: Adipose Tissue, Brown; Animals; Body Temperature; Brain; Carbon Dioxide; Dinoprostone; Disease Model | 2008 |
Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade.
Topics: Analysis of Variance; Animals; Baclofen; Brain Ischemia; Disease Models, Animal; Dose-Response Relat | 2008 |
Angiotensin II increases GABAB receptor expression in nucleus tractus solitarii of rats.
Topics: Action Potentials; Angiotensin II; Animals; Animals, Newborn; Baclofen; Baroreflex; Blood Pressure; | 2008 |
DHEA lessens depressive-like behavior via GABA-ergic modulation of the mesolimbic system.
Topics: Animals; Antidepressive Agents; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Depression; | 2009 |
Gamma-aminobutyric acid and basal ganglia outflow pathways.
Topics: Animals; Basal Ganglia; Catalepsy; Disease Models, Animal; gamma-Aminobutyric Acid; Haloperidol; Hum | 1984 |
Visual evoked potentials in a rabbit model of hepatic encephalopathy. I. Sequential changes and comparisons with drug-induced comas.
Topics: Animals; Diazepam; Disease Models, Animal; Electrodes; Electroencephalography; Evoked Potentials, Vi | 1984 |
NMDA-GABA interactions in an animal model of behaviour: a gating mechanism from motivation toward psychotic-like symptoms.
Topics: Alprazolam; Animals; Behavior, Animal; Desipramine; Disease Models, Animal; Dizocilpine Maleate; gam | 1994 |
Gabaergic transmission and tyrosine hydroxylase expression in the nigral dopaminergic neurons: an in vivo study using a reversible ischemia model of rats.
Topics: Animals; Brain Ischemia; Cell Count; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Male | 1996 |
The neurochemical pathology of thiamine deficiency: GABAA and glutamateNMDA receptor binding sites in a goat model.
Topics: Alcoholism; Amprolium; Animals; Brain Chemistry; Diazepam; Disease Models, Animal; Dizocilpine Malea | 1996 |
Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy.
Topics: Adaptation, Physiological; Animals; Anticonvulsants; Brain; Chlorine; Disease Models, Animal; Dose-R | 1999 |
Deficit of striatal parvalbumin-reactive GABAergic interneurons and decreased basal ganglia output in a genetic rodent model of idiopathic paroxysmal dystonia.
Topics: Action Potentials; Animals; Basal Ganglia; Cell Count; Corpus Striatum; Cricetinae; Disease Models, | 2000 |
Effects of transient focal inactivation of the basal ganglia in parkinsonian primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Action Potentials; Animals; Behavior, Animal; Disease | 2002 |
Induction of Fos-like immunoreactivity in the basal ganglia by ether anaesthesia: effects of injections of muscimol in rostral versus caudal substantia nigra pars reticulata.
Topics: Anesthetics, Inhalation; Animals; Basal Ganglia; Brain; Disease Models, Animal; Dose-Response Relati | 2002 |
Inhibitory role of the zona incerta in the pilocarpine model of epilepsy.
Topics: Animals; Bicuculline; Brain Mapping; Disease Models, Animal; Electroencephalography; Epilepsy; GABA | 2002 |
Effect of intranigral muscimol on animal models of generalized absence seizures.
Topics: Animals; Convulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Epilepsy, G | 1992 |
Evidence for a critical role of GABAergic transmission within the thalamus in the genesis and control of absence seizures in the rat.
Topics: Aminocaproates; Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, | 1991 |
Recurrent spontaneous hippocampal seizures in the rat as a chronic sequela to limbic status epilepticus.
Topics: Action Potentials; Animals; Chronic Disease; Disease Models, Animal; Electric Stimulation; Electroen | 1990 |
Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Flunitrazepam; Gerbillinae; Mesencephalon; M | 1985 |
Noradrenergic rather than GABAergic processes as the common mediation of the antidepressant profile of GABA agonists and imipramine-like drugs in animals.
Topics: Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; | 1987 |
Extracorporeal cephalic blood autoperfusion method in the rat. Hemorrheological evaluation and proposed pharmacological uses.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Extracorporeal | 1986 |