muscimol has been researched along with Depression in 14 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study investigated the possible relation between muscimol-induced long-term depression and barbiturates/benzodiazepine-induced amnesia and attempts to determine the possible effect of pregnenolone sulfate on muscimol-induced long-term depression." | 7.70 | Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate. ( Akhondzadeh, S; Stone, TW, 1998) |
| "This long-term depression is reversed by bicuculline and potentiated by neurosteroids such as alphaxalone." | 5.30 | Prevention of muscimol-induced long-term depression by brain-derived neurotrophic factor. ( Akhondzadeh, S; Stone, T, 1999) |
| " The present study investigated the possible relation between muscimol-induced long-term depression and barbiturates/benzodiazepine-induced amnesia and attempts to determine the possible effect of pregnenolone sulfate on muscimol-induced long-term depression." | 3.70 | Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate. ( Akhondzadeh, S; Stone, TW, 1998) |
| "Thus, mechanical hyperalgesia and allodynia, and the pattern of c-Fos staining in the amygdala subnuclei were evaluated in rats with chronic constriction of the sciatic nerve, as well as sham-operated and naïve rats." | 1.48 | The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy. ( Antunes, GF; Assis, DV; Gouveia, F; Kuroki, M; Martinez, RCR; Oliveira, CC; Pagano, RL; Santos, LCT; Seno, MDJ, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seno, MDJ | 1 |
| Assis, DV | 1 |
| Gouveia, F | 1 |
| Antunes, GF | 1 |
| Kuroki, M | 1 |
| Oliveira, CC | 1 |
| Santos, LCT | 1 |
| Pagano, RL | 1 |
| Martinez, RCR | 1 |
| Salari, AA | 1 |
| Bakhtiari, A | 1 |
| Homberg, JR | 1 |
| Wang, T | 1 |
| Zhang, L | 1 |
| Zhang, QJ | 1 |
| Wang, Y | 1 |
| Du, CX | 1 |
| Sun, YN | 1 |
| Zhang, J | 1 |
| Lv, SX | 1 |
| Chen, L | 1 |
| Liu, J | 1 |
| Hamani, C | 1 |
| Diwan, M | 1 |
| Macedo, CE | 1 |
| Brandão, ML | 1 |
| Shumake, J | 1 |
| Gonzalez-Lima, F | 1 |
| Raymond, R | 1 |
| Lozano, AM | 1 |
| Fletcher, PJ | 1 |
| Nobrega, JN | 1 |
| Slattery, DA | 1 |
| Neumann, ID | 1 |
| Cryan, JF | 1 |
| Kosari-Nasab, M | 1 |
| Babri, S | 1 |
| Fatehi-Gharehlar, L | 1 |
| Doosti, MH | 1 |
| Pakzad, S | 1 |
| Temel, Y | 1 |
| Boothman, LJ | 1 |
| Blokland, A | 1 |
| Magill, PJ | 1 |
| Steinbusch, HW | 1 |
| Visser-Vandewalle, V | 1 |
| Sharp, T | 1 |
| Dubrovina, NI | 1 |
| Zinov'ev, DR | 1 |
| Genud, R | 1 |
| Merenlender, A | 1 |
| Gispan-Herman, I | 1 |
| Maayan, R | 1 |
| Weizman, A | 2 |
| Yadid, G | 1 |
| Drugan, RC | 2 |
| Paul, SM | 2 |
| Crawley, JN | 2 |
| Akhondzadeh, S | 2 |
| Stone, TW | 1 |
| Stone, T | 1 |
| Morrow, AL | 1 |
| Weizman, R | 1 |
| Deutsch, SI | 1 |
| Poncelet, M | 1 |
| Martin, P | 1 |
| Danti, S | 1 |
| Simon, P | 1 |
| Soubrié, P | 1 |
14 other studies available for muscimol and Depression
| Article | Year |
|---|---|
The critical role of amygdala subnuclei in nociceptive and depressive-like behaviors in peripheral neuropathy.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Basolateral Nuclear Complex; Central Amygdaloid Nucle | 2018 |
Activation of GABA-A receptors during postnatal brain development increases anxiety- and depression-related behaviors in a time- and dose-dependent manner in adult mice.
Topics: Animals; Animals, Newborn; Anxiety; Bicuculline; Brain; Corticosterone; Depression; Dose-Response Re | 2015 |
Involvement of lateral habenula α1 subunit-containing GABA
Topics: Action Potentials; Animals; Apomorphine; Depression; Dopamine Agonists; GABA Antagonists; GABA-A Rec | 2017 |
Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats.
Topics: 5,7-Dihydroxytryptamine; Adrenergic Agents; Analysis of Variance; Animals; Benzylamines; Catheter Ab | 2010 |
Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat.
Topics: Animals; Bicuculline; Deep Brain Stimulation; Depression; Male; Motor Activity; Muscimol; Prefrontal | 2011 |
Involvement of GABAergic system in regulation of the anxiolytic- and antidepressant-like effects of Scrophularia striata extract in rats.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Bicuculline; Brain; Depression; Diseas | 2013 |
Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus.
Topics: Action Potentials; Animals; Behavior, Animal; Deep Brain Stimulation; Depression; Disease Models, An | 2007 |
[Contribution of GABA receptors in extinction of memory trace in norm and depressive-like state].
Topics: Animals; Baclofen; Behavior, Animal; Bicuculline; Depression; Fear; GABA Agonists; GABA Antagonists; | 2007 |
DHEA lessens depressive-like behavior via GABA-ergic modulation of the mesolimbic system.
Topics: Animals; Antidepressive Agents; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Depression; | 2009 |
Decreased forebrain [35S]TBPS binding and increased [3H]muscimol binding in rats that do not develop stress-induced behavioral depression.
Topics: Adrenalectomy; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chloride | 1993 |
Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate.
Topics: Amnesia; Animals; Barbiturates; Benzodiazepines; Cognition Disorders; Depression; Diazepam; Drug Syn | 1998 |
Prevention of muscimol-induced long-term depression by brain-derived neurotrophic factor.
Topics: Animals; Brain-Derived Neurotrophic Factor; Depression; Down-Regulation; GABA Agonists; Hippocampus; | 1999 |
Stress-induced behavioral depression in the rat is associated with a decrease in GABA receptor-mediated chloride ion flux and brain benzodiazepine receptor occupancy.
Topics: Animals; Brain; Chlorides; Depression; Flumazenil; Male; Muscimol; Rats; Rats, Inbred Strains; Recep | 1989 |
Noradrenergic rather than GABAergic processes as the common mediation of the antidepressant profile of GABA agonists and imipramine-like drugs in animals.
Topics: Animals; Antidepressive Agents; Brain; Depression; Disease Models, Animal; gamma-Aminobutyric Acid; | 1987 |