muscimol has been researched along with Dementia Praecox in 25 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
| Excerpt | Relevance | Reference |
|---|---|---|
| "M, 385+/-44 fmol/mg ETE) and control (383+/-44 fmol/mg ETE) subjects, there was an increase in the density of [(3)H]flumazenil binding to the benzodiazepine binding site on the GABA(A) receptor in subjects with bipolar disorder (451+/-17 fmol/mg ETE; P<0." | 7.71 | A change in the density of [(3)H]flumazenil, but not [(3)H]muscimol binding, in Brodmann's Area 9 from subjects with bipolar disorder. ( Copolov, D; Dean, B; Keks, N; McLeod, M; Opeskin, K; Pavey, G, 2001) |
| " Chronic administration of clozapine to rats was reported to significantly reduce the numbers of [3H]MUS binding sites in temporal cortex and hippocampus which may be due to selective blockade of GABA(A) receptors on GABAergic interneurons that make synaptic contact with pyramidal cells." | 5.31 | Additivities of compounds that increase the numbers of high affinity [3H]muscimol binding sites by different amounts define more than 9 GABA(A) receptor complexes in rat forebrain: implications for schizophrenia and clozapine research. ( Saederup, E; Squires, RF, 2000) |
| "Postmortem CNS studies have suggested an uncoupling of the gamma-aminobutyric acid (GABA) and benzodiazepine binding sites on the hippocampal GABA(A) receptor in schizophrenia." | 3.73 | Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder. ( Dean, B; McLeod, M; Scarr, E, 2005) |
| "M, 385+/-44 fmol/mg ETE) and control (383+/-44 fmol/mg ETE) subjects, there was an increase in the density of [(3)H]flumazenil binding to the benzodiazepine binding site on the GABA(A) receptor in subjects with bipolar disorder (451+/-17 fmol/mg ETE; P<0." | 3.71 | A change in the density of [(3)H]flumazenil, but not [(3)H]muscimol binding, in Brodmann's Area 9 from subjects with bipolar disorder. ( Copolov, D; Dean, B; Keks, N; McLeod, M; Opeskin, K; Pavey, G, 2001) |
| "The alteration in circulating levels of PRL, GH, TSH, and cortisol was studied after the oral administration of muscimol (3-hydroxy-5-aminomethylisoxazole) to human subjects with Huntington's disease (n = 4) and chronic schizophrenia (n = 5)." | 3.66 | Stimulation of prolactin and growth hormone secretion by muscimol, a gamma-aminobutyric acid agonist. ( Chase, TN; Frohman, LA; Neophytides, A; Tamminga, CA, 1978) |
| " Chronic administration of clozapine to rats was reported to significantly reduce the numbers of [3H]MUS binding sites in temporal cortex and hippocampus which may be due to selective blockade of GABA(A) receptors on GABAergic interneurons that make synaptic contact with pyramidal cells." | 1.31 | Additivities of compounds that increase the numbers of high affinity [3H]muscimol binding sites by different amounts define more than 9 GABA(A) receptor complexes in rat forebrain: implications for schizophrenia and clozapine research. ( Saederup, E; Squires, RF, 2000) |
| "Muscimol, thought to be a agonist of gamma-aminobutyric acid (GABA), was administered to eight neuroleptic-free subjects with tardive dyskinesia." | 1.26 | Improvement in tardive dyskinesia after muscimol therapy. ( Chase, TN; Crayton, JW; Tamminga, CA, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (28.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 10 (40.00) | 29.6817 |
| 2010's | 4 (16.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, N | 1 |
| Yoshizaki, K | 1 |
| Kimura, R | 1 |
| Suto, F | 1 |
| Yanagawa, Y | 1 |
| Osumi, N | 1 |
| Yee, BK | 1 |
| Feldon, J | 1 |
| Vohs, JL | 1 |
| Chambers, RA | 1 |
| Krishnan, GP | 1 |
| O'Donnell, BF | 1 |
| Berg, S | 1 |
| Morzorati, SL | 1 |
| McLeod, MC | 2 |
| Scarr, E | 2 |
| Dean, B | 4 |
| Verdurand, M | 1 |
| Fillman, SG | 1 |
| Weickert, CS | 1 |
| Zavitsanou, K | 2 |
| McLeod, M | 2 |
| Deng, C | 1 |
| Huang, XF | 2 |
| Newell, KA | 1 |
| Jew, SK | 1 |
| Skilbeck, KJ | 2 |
| O'Reilly, JN | 2 |
| Johnston, GA | 2 |
| Hinton, T | 2 |
| Sundram, S | 1 |
| Gale, K | 1 |
| Casu, M | 1 |
| Meldrum, B | 1 |
| Hanada, S | 2 |
| Nishino, N | 2 |
| Mita, T | 2 |
| Kuno, T | 1 |
| Kuyama, T | 1 |
| Isoda, K | 1 |
| Hosomi, T | 1 |
| Uchida, S | 1 |
| Kasai, T | 1 |
| Nakai, H | 1 |
| Young, KA | 1 |
| Randall, PK | 1 |
| Wilcox, RE | 1 |
| Benes, FM | 2 |
| Vincent, SL | 2 |
| Marie, A | 1 |
| Khan, Y | 1 |
| Tomitaka, S | 1 |
| Tomitaka, M | 1 |
| Tolliver, BK | 1 |
| Sharp, FR | 1 |
| Squires, RF | 1 |
| Saederup, E | 1 |
| Pavey, G | 1 |
| Opeskin, K | 1 |
| Keks, N | 1 |
| Copolov, D | 1 |
| Tamminga, CA | 3 |
| Crayton, JW | 1 |
| Chase, TN | 2 |
| Neophytides, A | 1 |
| Frohman, LA | 1 |
| McDonald, A | 1 |
| Cassady, SL | 1 |
| Thaker, GK | 1 |
| Moran, M | 1 |
| Birt, A | 1 |
| Alsterberg, G | 1 |
| Bird, ED | 1 |
| SanGiovanni, JP | 1 |
| Tanaka, C | 1 |
2 reviews available for muscimol and Dementia Praecox
| Article | Year |
|---|---|
Dynamic utilization of GABA in substantia nigra: regulation by dopamine and GABA in the striatum, and its clinical and behavioral implications.
Topics: 4-Aminobutyrate Transaminase; Afferent Pathways; Aminocaproates; Animals; Basal Ganglia; Behavior, A | 1981 |
GABA and acute psychoses.
Topics: Acute Disease; Animals; Brain; Cats; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Humans; Limbi | 1982 |
1 trial available for muscimol and Dementia Praecox
| Article | Year |
|---|---|
GABA agonist-induced changes in motor, oculomotor, and attention measures correlate in schizophrenics with tardive dyskinesia.
Topics: Adult; Antipsychotic Agents; Attention; Chronic Disease; Double-Blind Method; Dyskinesia, Drug-Induc | 1992 |
22 other studies available for muscimol and Dementia Praecox
| Article | Year |
|---|---|
A sensitive period for GABAergic interneurons in the dentate gyrus in modulating sensorimotor gating.
Topics: Age Factors; Animals; Behavior, Animal; Critical Period, Psychological; Dendrites; Dentate Gyrus; Di | 2013 |
Distinct forms of prepulse inhibition disruption distinguishable by the associated changes in prepulse-elicited reaction.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Hippocampus; Microinjections; Muscimol; N-Methy | 2009 |
GABAergic modulation of the 40 Hz auditory steady-state response in a rat model of schizophrenia.
Topics: Animals; Animals, Newborn; Bicuculline; Disease Models, Animal; Evoked Potentials, Auditory; GABA Ag | 2010 |
Effects of benzodiazepine treatment on cortical GABA(A) and muscarinic receptors: studies in schizophrenia and rats.
Topics: Adult; Aged; Analysis of Variance; Animals; Benzodiazepines; Cerebral Cortex; Female; Flumazenil; GA | 2010 |
Increases in [3H]muscimol and [3H]flumazenil binding in the dorsolateral prefrontal cortex in schizophrenia are linked to α4 and γ2S mRNA levels respectively.
Topics: Adult; Aged; Allosteric Site; Autoradiography; Case-Control Studies; Cohort Studies; Female; Flumaze | 2013 |
Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder.
Topics: Adult; Aged; Binding, Competitive; Bipolar Disorder; Brain Chemistry; Clonazepam; Female; Flumazenil | 2005 |
Increased density of GABAA receptors in the superior temporal gyrus in schizophrenia.
Topics: Adaptation, Physiological; Adult; Binding, Competitive; GABA Agonists; gamma-Aminobutyric Acid; Hall | 2006 |
Alterations of muscarinic and GABA receptor binding in the posterior cingulate cortex in schizophrenia.
Topics: Adult; Aged; Autoradiography; Female; GABA Agonists; Gyrus Cinguli; Humans; Male; Middle Aged; Musca | 2007 |
The effects of antipsychotic drugs on GABAA receptor binding depend on period of drug treatment and binding site examined.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Binding, Competitive; Flunitrazepam; GABA Agonists; | 2007 |
Antipsychotic drug administration differentially affects [3H]muscimol and [3H]flunitrazepam GABA(A) receptor binding sites.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzodiazepines; Densitometry; Flunitrazepam; Halope | 2008 |
Treatment with haloperidol and diazepam alters GABA(A) receptor density in the rat brain.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzodiazepines; Binding Sites; Brain; Diazepam; Dis | 2008 |
[Increased 3H-muscimol binding in post-mortem brains of chronic schizophrenics].
Topics: Adult; Aged; Binding Sites; Chronic Disease; Female; Frontal Lobe; Glutamate Decarboxylase; Humans; | 1984 |
Startle and sensorimotor correlates of ventral thalamic dopamine and GABA in rodents.
Topics: Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Dopamine; gamma-Aminobutyric Acid; Mus | 1995 |
Up-regulation of GABAA receptor binding on neurons of the prefrontal cortex in schizophrenic subjects.
Topics: Adult; Aged; Aged, 80 and over; Aging; Autoradiography; Female; Humans; Male; Middle Aged; Models, N | 1996 |
Bilateral blockade of NMDA receptors in anterior thalamus by dizocilpine (MK-801) injures pyramidal neurons in rat retrosplenial cortex.
Topics: Animals; Anterior Thalamic Nuclei; Baclofen; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; | 2000 |
Additivities of compounds that increase the numbers of high affinity [3H]muscimol binding sites by different amounts define more than 9 GABA(A) receptor complexes in rat forebrain: implications for schizophrenia and clozapine research.
Topics: Animals; Antipsychotic Agents; Binding Sites; Binding, Competitive; Cadaver; Clozapine; GABA Antagon | 2000 |
A change in the density of [(3)H]flumazenil, but not [(3)H]muscimol binding, in Brodmann's Area 9 from subjects with bipolar disorder.
Topics: Adult; Aged; Autoradiography; Bipolar Disorder; Brain Mapping; Female; Flumazenil; Frontal Lobe; Hum | 2001 |
Improvement in tardive dyskinesia after muscimol therapy.
Topics: Adult; Aged; Antipsychotic Agents; Dopamine; Drug Evaluation; Dyskinesia, Drug-Induced; Extrapyramid | 1979 |
Stimulation of prolactin and growth hormone secretion by muscimol, a gamma-aminobutyric acid agonist.
Topics: Adult; Aged; Chronic Disease; Female; gamma-Aminobutyric Acid; Growth Hormone; Humans; Huntington Di | 1978 |
Unpleasant side effects of muscimol.
Topics: Humans; Muscimol; Oxazoles; Schizophrenia | 1979 |
Increased GABAA receptor binding in superficial layers of cingulate cortex in schizophrenics.
Topics: Adult; Aged; Autoradiography; Bicuculline; Gyrus Cinguli; Humans; Muscimol; Phenothiazines; Receptor | 1992 |
[3H]muscimol binding sites increased in autopsied brains of chronic schizophrenics.
Topics: Adult; Aged; Aged, 80 and over; Binding Sites; Brain Chemistry; Glutamate Decarboxylase; Humans; Mid | 1987 |