muscimol has been researched along with Cocaine-Related Disorders in 16 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Cocaine-Related Disorders: Disorders related or resulting from use of cocaine.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Separate groups of rats received bilateral intra-VTA injections of the GABA-A antagonist picrotoxin (34 ng/side, n = 7; 68 ng/side, n = 8), GABA-A agonist muscimol (14 ng/side, n = 8), GABA-B agonist baclofen (56 ng/side, n = 7; 100 ng/side, n = 6), picrotoxin (68 ng/side) co-injected with the GABA-B antagonist 2-hydroxysaclofen (100 ng/side, n = 7; 2 microg/side, n = 8) or artificial cerebrospinal fluid (aCSF, n = 6) to assess the effects of the various compounds on the cocaine self-administration dose-response curve." | 1.35 | Contribution of ventral tegmental GABA receptors to cocaine self-administration in rats. ( Backes, EN; Hemby, SE, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, W | 1 |
| Yuill, MB | 1 |
| Pelloux, Y | 1 |
| Minier-Toribio, A | 1 |
| Hoots, JK | 1 |
| Bossert, JM | 1 |
| Shaham, Y | 1 |
| Hitchcock, LN | 1 |
| Lattal, KM | 1 |
| Minogianis, EA | 1 |
| Servonnet, A | 1 |
| Filion, MP | 1 |
| Samaha, AN | 1 |
| Limpens, JH | 1 |
| Damsteegt, R | 1 |
| Broekhoven, MH | 1 |
| Voorn, P | 1 |
| Vanderschuren, LJ | 1 |
| Lasseter, HC | 2 |
| Ramirez, DR | 1 |
| Xie, X | 2 |
| Fuchs, RA | 3 |
| Watanabe, MA | 1 |
| Kucenas, S | 1 |
| Bowman, TA | 1 |
| Ruhlman, M | 1 |
| Knuepfer, MM | 1 |
| Buffalari, DM | 1 |
| See, RE | 2 |
| Wells, AM | 1 |
| Arguello, AA | 1 |
| Blanton, MA | 1 |
| Reittinger, AM | 1 |
| Diehl, GW | 1 |
| Wachtel, JM | 1 |
| Paine, TA | 1 |
| Di Ciano, P | 1 |
| Everitt, BJ | 1 |
| Evans, KA | 1 |
| Parker, MP | 1 |
| Lee, DY | 1 |
| Guttilla, M | 1 |
| Fung, KD | 1 |
| McFeron, S | 1 |
| Yan, J | 1 |
| Ranaldi, R | 1 |
| Herzig, V | 1 |
| Schmidt, WJ | 1 |
| Backes, EN | 1 |
| Hemby, SE | 1 |
| Franklin, TR | 1 |
| Druhan, JP | 1 |
16 other studies available for muscimol and Cocaine-Related Disorders
| Article | Year |
|---|---|
Role of the GABA
Topics: Animals; Baclofen; Behavior, Addictive; Central Amygdaloid Nucleus; Cocaine; Cocaine-Related Disorde | 2020 |
Opposite Effects of Basolateral Amygdala Inactivation on Context-Induced Relapse to Cocaine Seeking after Extinction versus Punishment.
Topics: Amygdala; Animals; Baclofen; Cocaine-Related Disorders; Conditioning, Operant; Extinction, Psycholog | 2018 |
Involvement of the dorsal hippocampus in expression and extinction of cocaine-induced conditioned place preference.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Classical; Extinction, Psychological; GAB | 2018 |
Role of the orbitofrontal cortex and the dorsal striatum in incentive motivation for cocaine.
Topics: Animals; Baclofen; Behavior, Addictive; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Drug-Se | 2019 |
Pharmacological inactivation of the prelimbic cortex emulates compulsive reward seeking in rats.
Topics: Animals; Baclofen; Cerebral Cortex; Cocaine; Cocaine-Related Disorders; Decision Making; Dietary Suc | 2015 |
Involvement of the lateral orbitofrontal cortex in drug context-induced reinstatement of cocaine-seeking behavior in rats.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhib | 2009 |
Angiotensin II and CRF receptors in the central nucleus of the amygdala mediate hemodynamic response variability to cocaine in conscious rats.
Topics: Amygdala; Angiotensin II Type 1 Receptor Blockers; Animals; Cocaine; Cocaine-Related Disorders; Cons | 2010 |
Inactivation of the bed nucleus of the stria terminalis in an animal model of relapse: effects on conditioned cue-induced reinstatement and its enhancement by yohimbine.
Topics: Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; Cues; Drug Therapy, Co | 2011 |
Extracellular signal-regulated kinase in the basolateral amygdala, but not the nucleus accumbens core, is critical for context-response-cocaine memory reconsolidation in rats.
Topics: Amygdala; Animals; Baclofen; Butadienes; Cocaine; Cocaine-Related Disorders; Conditioning, Operant; | 2013 |
Cue-induced conditioned activity does not incubate but is mediated by the basolateral amygdala.
Topics: Amygdala; Animals; Cocaine-Related Disorders; Conditioning, Psychological; Cues; Disease Models, Ani | 2013 |
Contribution of the ventral tegmental area to cocaine-seeking maintained by a drug-paired conditioned stimulus in rats.
Topics: Amygdala; Analysis of Variance; Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, | 2004 |
Differential involvement of orbitofrontal cortex subregions in conditioned cue-induced and cocaine-primed reinstatement of cocaine seeking in rats.
Topics: Animals; Baclofen; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological | 2004 |
Rostral-caudal differences in the effects of intra-VTA muscimol on cocaine self-administration.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Dopamine; GABA Agonists; Male; Microinjections; Muscimo | 2007 |
Amygdala cannulation alters expression of cocaine conditioned place preference and locomotion in rats.
Topics: Amygdala; Animals; Baclofen; Brain Mapping; Catheterization; Cocaine-Related Disorders; Conditioning | 2007 |
Contribution of ventral tegmental GABA receptors to cocaine self-administration in rats.
Topics: Animals; Baclofen; Cocaine-Related Disorders; Conditioning, Operant; Dose-Response Relationship, Dru | 2008 |
Involvement of the nucleus accumbens and medial prefrontal cortex in the expression of conditioned hyperactivity to a cocaine-associated environment in rats.
Topics: Amygdala; Animals; Baclofen; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Dose-R | 2000 |