muscimol has been researched along with Chronic Disease in 15 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The alteration in circulating levels of PRL, GH, TSH, and cortisol was studied after the oral administration of muscimol (3-hydroxy-5-aminomethylisoxazole) to human subjects with Huntington's disease (n = 4) and chronic schizophrenia (n = 5)." | 3.66 | Stimulation of prolactin and growth hormone secretion by muscimol, a gamma-aminobutyric acid agonist. ( Chase, TN; Frohman, LA; Neophytides, A; Tamminga, CA, 1978) |
| "In animals exhibiting maximal thermal hyperalgesia as one sign of neuropathic pain 7 days after loose ligation of the sciatic nerve, spinal application of muscimol (5, 10 or 20 microg) before the high-frequency (50 Hz) tetanus produced a long-lasting depression (rather than potentiation) of spinal dorsal horn field potentials." | 1.32 | Muscimol prevents long-lasting potentiation of dorsal horn field potentials in rats with chronic constriction injury exhibiting decreased levels of the GABA transporter GAT-1. ( Draganic, P; Miletic, G; Miletic, V; Pankratz, MT, 2003) |
| "Muscimol was chronically administrated to the third ventricle of thalamic pigeons by means of osmotic minipumps at the rate of 0." | 1.27 | Effects of chronic intracerebroventricular GABAergic treatment on basal and chronic or acute stress-induced adrenocortical activities in the thalamic pigeon. ( Baylé, JD; Ramade, F, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (20.00) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 8 (53.33) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rebrov, IG | 1 |
| Karpova, MN | 1 |
| Andreev, AA | 1 |
| Klishina, NY | 1 |
| Kalinina, MV | 1 |
| Kusnetzova, LV | 1 |
| Wang, N | 1 |
| Wang, JY | 1 |
| Luo, F | 1 |
| Wang, RJ | 1 |
| Zeng, QH | 1 |
| Wang, WZ | 1 |
| Wang, W | 1 |
| Liu, HY | 1 |
| Li, YX | 1 |
| Hao, YJ | 1 |
| Wang, HY | 1 |
| Dai, XY | 1 |
| Sun, T | 1 |
| Yu, JQ | 1 |
| Nuñez, JL | 1 |
| Alt, JJ | 1 |
| McCarthy, MM | 1 |
| Miletic, G | 1 |
| Draganic, P | 1 |
| Pankratz, MT | 1 |
| Miletic, V | 1 |
| Bhatnagar, S | 1 |
| Vining, C | 1 |
| Denski, K | 1 |
| Warnault, V | 1 |
| Houchi, H | 1 |
| Barbier, E | 1 |
| Pierrefiche, O | 1 |
| Vilpoux, C | 1 |
| Ledent, C | 1 |
| Daoust, M | 1 |
| Naassila, M | 1 |
| Hanada, S | 1 |
| Nishino, N | 1 |
| Mita, T | 1 |
| Kuno, T | 1 |
| Kuyama, T | 1 |
| Isoda, K | 1 |
| Hosomi, T | 1 |
| Uchida, S | 1 |
| Kasai, T | 1 |
| Nakai, H | 1 |
| Mehta, AK | 1 |
| Ticku, MK | 1 |
| Grobin, AC | 1 |
| Matthews, DB | 1 |
| Montoya, D | 1 |
| Wilson, WA | 1 |
| Morrow, AL | 1 |
| Swartzwelder, HS | 1 |
| Tamminga, CA | 2 |
| Neophytides, A | 1 |
| Chase, TN | 1 |
| Frohman, LA | 1 |
| Cassady, SL | 1 |
| Thaker, GK | 1 |
| Moran, M | 1 |
| Birt, A | 1 |
| Lothman, EW | 1 |
| Bertram, EH | 1 |
| Kapur, J | 1 |
| Stringer, JL | 1 |
| Ramade, F | 1 |
| Baylé, JD | 1 |
1 trial available for muscimol and Chronic Disease
| Article | Year |
|---|---|
GABA agonist-induced changes in motor, oculomotor, and attention measures correlate in schizophrenics with tardive dyskinesia.
Topics: Adult; Antipsychotic Agents; Attention; Chronic Disease; Double-Blind Method; Dyskinesia, Drug-Induc | 1992 |
14 other studies available for muscimol and Chronic Disease
| Article | Year |
|---|---|
Cl(-) conduction of GABAA receptor complex of synaptic membranes in the cortex of rats at the middle stage of chronic cerebral epileptization (pharmacological kindling).
Topics: Animals; Cerebral Cortex; Chlorides; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; GA | 2007 |
Corticofugal outputs facilitate acute, but inhibit chronic pain in rats.
Topics: Analysis of Variance; Animals; Bicuculline; Chronic Disease; Disease Models, Animal; Freund's Adjuva | 2009 |
GABA(A) and GABA(B) receptor-mediated inhibition of sympathetic outflow in the paraventricular nucleus is blunted in chronic heart failure.
Topics: Adrenergic Fibers; Animals; Baclofen; Bicuculline; Blood Pressure; Chronic Disease; GABA Agonists; G | 2009 |
Effects of oxymatrine on the neuropathic pain induced by chronic constriction injury in mice.
Topics: Alkaloids; Animals; Chronic Disease; Constriction; Disease Models, Animal; Dose-Response Relationshi | 2012 |
A novel model for prenatal brain damage. II. Long-term deficits in hippocampal cell number and hippocampal-dependent behavior following neonatal GABAA receptor activation.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain Damage, Chronic; Cell Count; Chronic | 2003 |
Muscimol prevents long-lasting potentiation of dorsal horn field potentials in rats with chronic constriction injury exhibiting decreased levels of the GABA transporter GAT-1.
Topics: Action Potentials; Animals; Carrier Proteins; Chronic Disease; Electric Stimulation; GABA Plasma Mem | 2003 |
Regulation of chronic stress-induced changes in hypothalamic-pituitary-adrenal activity by the basolateral amygdala.
Topics: Adrenocorticotropic Hormone; Amygdala; Animals; Chronic Disease; GABA Agonists; Hypothalamo-Hypophys | 2004 |
The lack of CB1 receptors prevents neuroadapatations of both NMDA and GABA(A) receptors after chronic ethanol exposure.
Topics: Adaptation, Physiological; Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Binding S | 2007 |
[Increased 3H-muscimol binding in post-mortem brains of chronic schizophrenics].
Topics: Adult; Aged; Binding Sites; Chronic Disease; Female; Frontal Lobe; Glutamate Decarboxylase; Humans; | 1984 |
Prevalence of the GABAA receptor assemblies containing alpha1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: lack of modulation by chronic ethanol administration.
Topics: Affinity Labels; Alcoholism; Animals; Azides; Benzodiazepines; Brain Chemistry; Central Nervous Syst | 1999 |
Age-related differences in neurosteroid potentiation of muscimol-stimulated 36Cl(-) flux following chronic ethanol treatment.
Topics: Adolescent; Aging; Alcohol-Induced Disorders, Nervous System; Animals; Anti-Anxiety Agents; Brain; C | 2001 |
Stimulation of prolactin and growth hormone secretion by muscimol, a gamma-aminobutyric acid agonist.
Topics: Adult; Aged; Chronic Disease; Female; gamma-Aminobutyric Acid; Growth Hormone; Humans; Huntington Di | 1978 |
Recurrent spontaneous hippocampal seizures in the rat as a chronic sequela to limbic status epilepticus.
Topics: Action Potentials; Animals; Chronic Disease; Disease Models, Animal; Electric Stimulation; Electroen | 1990 |
Effects of chronic intracerebroventricular GABAergic treatment on basal and chronic or acute stress-induced adrenocortical activities in the thalamic pigeon.
Topics: Acute Disease; Adrenal Cortex; Animals; Chronic Disease; Columbidae; Corticosterone; Decerebrate Sta | 1986 |