muscimol has been researched along with Cerebral Ischemia in 22 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 7.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "Muscimol was infused into the third ventricle continuously for 7 days beginning just prior to the insult." | 5.29 | GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils. ( Ijaz, S; Mazagri, R; Shuaib, A, 1993) |
| " This study compared the neuroprotective efficacies of muscimol, a GABA A receptor agonist, and a GABA B receptor agonist baclofen in rat brain ischemia." | 3.74 | Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade. ( Li, C; Xu, J; Yin, XH; Zhang, GY, 2008) |
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 3.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "In global cerebral ischemia, focal cerebral ischemia and oxygen-glucose deprivation, application of muscimol and baclofen, agonists of GABA(A) receptor and GABA(B) receptor, exerted neuroprotection." | 1.35 | Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion. ( Han, D; Li, C; Wang, W; Yan, JZ; Yu, CZ; Zhang, GY; Zhang, QG; Zong, YY, 2008) |
| "Transient focal cerebral ischemia was induced in male Wistar rats for 2 h using the suture occlusion technique." | 1.32 | Exogenous brain-derived neurotrophic factor prevents postischemic downregulation of [3H]muscimol binding to GABA(A) receptors in the cortical penumbra. ( Kiessling, M; Kollmar, R; Schäbitz, WR; Schwab, S; Sommer, C, 2003) |
| "Lubeluzole was applied intravenously as a single bolus (0." | 1.31 | Transient up-regulation of gamma-aminobutyric acid(A) receptor binding by lubeluzole after neocortical specify lesion in rats. ( Que, M; Witte, OW; Zilles, K, 2000) |
| "Muscimol was infused into the third ventricle continuously for 7 days beginning just prior to the insult." | 1.29 | GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils. ( Ijaz, S; Mazagri, R; Shuaib, A, 1993) |
| "Rats treated with muscimol or MK-801 exhibited significantly better visual-spatial learning compared with saline-treated subjects (p less than 0." | 1.28 | Protective effect of synaptic inhibition during cerebral ischemia in rats and rabbits. ( Hedges, B; Lyden, PD, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 10 (45.45) | 18.2507 |
| 2000's | 11 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, C | 2 |
| Li, C | 4 |
| Yu, HM | 2 |
| Zhang, F | 2 |
| Han, D | 3 |
| Zhang, GY | 5 |
| Qi, SH | 1 |
| Liu, Y | 1 |
| Wang, WW | 1 |
| Wang, M | 1 |
| Sommer, C | 2 |
| Kollmar, R | 1 |
| Schwab, S | 1 |
| Kiessling, M | 2 |
| Schäbitz, WR | 1 |
| Wang, R | 1 |
| Zhang, QG | 2 |
| Zong, YY | 1 |
| Yu, CZ | 1 |
| Wang, W | 1 |
| Yan, JZ | 1 |
| Xu, J | 1 |
| Yin, XH | 1 |
| Lyden, PD | 3 |
| Lonzo, L | 1 |
| Aoki, H | 1 |
| Onodera, H | 1 |
| Yae, T | 1 |
| Jian, Z | 1 |
| Kogure, K | 2 |
| Kato, H | 1 |
| Araki, T | 1 |
| Murase, K | 1 |
| Shuaib, A | 1 |
| Mazagri, R | 1 |
| Ijaz, S | 1 |
| Heary, RF | 1 |
| Maniker, AH | 1 |
| Krieger, AJ | 1 |
| Sapru, HN | 1 |
| Yamada, K | 2 |
| Goto, S | 2 |
| Yoshikawa, M | 2 |
| Ushio, Y | 2 |
| Okamura, A | 1 |
| Kulinskiĭ, VI | 2 |
| Mikhel'son, GV | 2 |
| Ito, H | 1 |
| Watanabe, Y | 1 |
| Isshiki, A | 1 |
| Uchino, H | 1 |
| Jackson-Friedman, C | 1 |
| Shin, C | 1 |
| Hassid, S | 1 |
| Green, AR | 1 |
| Hainsworth, AH | 1 |
| Jackson, DM | 1 |
| Que, M | 1 |
| Witte, OW | 1 |
| Zilles, K | 1 |
| Fahrner, A | 1 |
| Hedges, B | 1 |
| Durussel, JJ | 1 |
| Claperon, N | 1 |
| Dufaux, J | 1 |
| Quemada, D | 1 |
| Rossignol, P | 1 |
1 review available for muscimol and Cerebral Ischemia
| Article | Year |
|---|---|
GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke.
Topics: Acute Disease; Animals; Brain; Brain Ischemia; Chlormethiazole; GABA Agonists; gamma-Aminobutyric Ac | 2000 |
21 other studies available for muscimol and Cerebral Ischemia
| Article | Year |
|---|---|
Neuroprotection of gamma-aminobutyric acid receptor agonists via enhancing neuronal nitric oxide synthase (Ser847) phosphorylation through increased neuronal nitric oxide synthase and PSD95 interaction and inhibited protein phosphatase activity in cerebra
Topics: Animals; Baclofen; Blotting, Western; Brain Ischemia; Disks Large Homolog 4 Protein; Dizocilpine Mal | 2008 |
Neuroprotection of ethanol against cerebral ischemia/reperfusion induced brain injury through GABA receptor activation.
Topics: Animals; Benzamides; Bicuculline; Brain; Brain Injuries; Brain Ischemia; Cell Death; Ethanol; GABA A | 2009 |
Exogenous brain-derived neurotrophic factor prevents postischemic downregulation of [3H]muscimol binding to GABA(A) receptors in the cortical penumbra.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Brain Ische | 2003 |
Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion.
Topics: Analysis of Variance; Animals; Apoptosis; Baclofen; Brain Ischemia; Cerebral Infarction; Disease Mod | 2007 |
Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion.
Topics: Animals; Apoptosis; Baclofen; Brain Ischemia; Disks Large Homolog 4 Protein; GABA Agonists; GluK2 Ka | 2008 |
Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade.
Topics: Analysis of Variance; Animals; Baclofen; Brain Ischemia; Disease Models, Animal; Dose-Response Relat | 2008 |
Combination therapy protects ischemic brain in rats. A glutamate antagonist plus a gamma-aminobutyric acid agonist.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Dizocilpine Maleate; Drug Combinations; Excitat | 1994 |
Neural grafting to ischemic CA1 lesions in the rat hippocampus: an autoradiographic study.
Topics: Acetylcholinesterase; Animals; Autoradiography; Brain Ischemia; Brain Tissue Transplantation; Fetal | 1993 |
Alterations in [3H]MK-801, [3H]muscimol, [3H]cyclic AMP, and [3H]rolipram binding in the gerbil hippocampus following repeated ischemic insults.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Autoradiography; Brain Ischemia; Cyclic AMP; Dizocilpi | 1993 |
GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Corpus Striatum; gamma-Aminobutyric Acid; Gerbillinae; Hip | 1993 |
Cardiovascular responses to global cerebral ischemia: role of excitatory amino acids in the ventrolateral medullary pressor area.
Topics: Acetylcholine; Amino Acids; Animals; Antidiuretic Hormone Receptor Antagonists; Atropine; Blood Pres | 1993 |
Gabaergic transmission and tyrosine hydroxylase expression in the nigral dopaminergic neurons: an in vivo study using a reversible ischemia model of rats.
Topics: Animals; Brain Ischemia; Cell Count; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Male | 1996 |
GABA receptor agonist promotes reformation of the striatonigral pathway by transplant derived from fetal striatal primordia in the lesioned striatum.
Topics: Animals; Apomorphine; Brain Damage, Chronic; Brain Ischemia; Brain Tissue Transplantation; Cell Coun | 1997 |
[Receptor mechanism of the neuroprotective effect of GABAergic agents].
Topics: Animals; Baclofen; Brain Ischemia; Female; GABA Agonists; GABA Antagonists; Injections, Intraventric | 1998 |
Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Baclofen; Brain Ischemia; Dose-Response Relationship, Drug; GABA | 1999 |
Synergistic combinatorial stroke therapy: A quantal bioassay of a GABA agonist and a glutamate antagonist.
Topics: Animals; Blood Pressure; Body Temperature; Brain Ischemia; Dizocilpine Maleate; Drug Therapy, Combin | 2000 |
Transient up-regulation of gamma-aminobutyric acid(A) receptor binding by lubeluzole after neocortical specify lesion in rats.
Topics: Animals; Brain Ischemia; Male; Muscimol; Neocortex; Neuroprotective Agents; Photochemistry; Piperidi | 2000 |
Additivity and independence of neuroprotective effects of GABAA and GABAB receptor agonists in complete global cerebral ischemia.
Topics: Animals; Baclofen; Bicuculline; Brain Ischemia; Drug Interactions; Female; GABA Agonists; GABA Antag | 2000 |
[3H]muscimol binding to gamma-aminobutyric acid(A) receptors is upregulated in CA1 neurons of the gerbil hippocampus in the ischemia-tolerant state.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competi | 2002 |
Protective effect of synaptic inhibition during cerebral ischemia in rats and rabbits.
Topics: Animals; Brain Ischemia; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Aci | 1992 |
Extracorporeal cephalic blood autoperfusion method in the rat. Hemorrheological evaluation and proposed pharmacological uses.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Extracorporeal | 1986 |