muscimol has been researched along with Brain Ischemia in 22 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 7.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "Muscimol was infused into the third ventricle continuously for 7 days beginning just prior to the insult." | 5.29 | GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils. ( Ijaz, S; Mazagri, R; Shuaib, A, 1993) |
| " This study compared the neuroprotective efficacies of muscimol, a GABA A receptor agonist, and a GABA B receptor agonist baclofen in rat brain ischemia." | 3.74 | Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade. ( Li, C; Xu, J; Yin, XH; Zhang, GY, 2008) |
| "These results indicate that activation of GABAA receptors, which include the specific binding subunits for propofol and midazolam, but not pentobarbital, plays a role in the inhibition of neuronal death induced by brain ischemia." | 3.70 | Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors. ( Isshiki, A; Ito, H; Uchino, H; Watanabe, Y, 1999) |
| "In global cerebral ischemia, focal cerebral ischemia and oxygen-glucose deprivation, application of muscimol and baclofen, agonists of GABA(A) receptor and GABA(B) receptor, exerted neuroprotection." | 1.35 | Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion. ( Han, D; Li, C; Wang, W; Yan, JZ; Yu, CZ; Zhang, GY; Zhang, QG; Zong, YY, 2008) |
| "Transient focal cerebral ischemia was induced in male Wistar rats for 2 h using the suture occlusion technique." | 1.32 | Exogenous brain-derived neurotrophic factor prevents postischemic downregulation of [3H]muscimol binding to GABA(A) receptors in the cortical penumbra. ( Kiessling, M; Kollmar, R; Schäbitz, WR; Schwab, S; Sommer, C, 2003) |
| "Lubeluzole was applied intravenously as a single bolus (0." | 1.31 | Transient up-regulation of gamma-aminobutyric acid(A) receptor binding by lubeluzole after neocortical specify lesion in rats. ( Que, M; Witte, OW; Zilles, K, 2000) |
| "Muscimol was infused into the third ventricle continuously for 7 days beginning just prior to the insult." | 1.29 | GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils. ( Ijaz, S; Mazagri, R; Shuaib, A, 1993) |
| "Rats treated with muscimol or MK-801 exhibited significantly better visual-spatial learning compared with saline-treated subjects (p less than 0." | 1.28 | Protective effect of synaptic inhibition during cerebral ischemia in rats and rabbits. ( Hedges, B; Lyden, PD, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 10 (45.45) | 18.2507 |
| 2000's | 11 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, C | 2 |
| Li, C | 4 |
| Yu, HM | 2 |
| Zhang, F | 2 |
| Han, D | 3 |
| Zhang, GY | 5 |
| Qi, SH | 1 |
| Liu, Y | 1 |
| Wang, WW | 1 |
| Wang, M | 1 |
| Sommer, C | 2 |
| Kollmar, R | 1 |
| Schwab, S | 1 |
| Kiessling, M | 2 |
| Schäbitz, WR | 1 |
| Wang, R | 1 |
| Zhang, QG | 2 |
| Zong, YY | 1 |
| Yu, CZ | 1 |
| Wang, W | 1 |
| Yan, JZ | 1 |
| Xu, J | 1 |
| Yin, XH | 1 |
| Lyden, PD | 3 |
| Lonzo, L | 1 |
| Aoki, H | 1 |
| Onodera, H | 1 |
| Yae, T | 1 |
| Jian, Z | 1 |
| Kogure, K | 2 |
| Kato, H | 1 |
| Araki, T | 1 |
| Murase, K | 1 |
| Shuaib, A | 1 |
| Mazagri, R | 1 |
| Ijaz, S | 1 |
| Heary, RF | 1 |
| Maniker, AH | 1 |
| Krieger, AJ | 1 |
| Sapru, HN | 1 |
| Yamada, K | 2 |
| Goto, S | 2 |
| Yoshikawa, M | 2 |
| Ushio, Y | 2 |
| Okamura, A | 1 |
| Kulinskiĭ, VI | 2 |
| Mikhel'son, GV | 2 |
| Ito, H | 1 |
| Watanabe, Y | 1 |
| Isshiki, A | 1 |
| Uchino, H | 1 |
| Jackson-Friedman, C | 1 |
| Shin, C | 1 |
| Hassid, S | 1 |
| Green, AR | 1 |
| Hainsworth, AH | 1 |
| Jackson, DM | 1 |
| Que, M | 1 |
| Witte, OW | 1 |
| Zilles, K | 1 |
| Fahrner, A | 1 |
| Hedges, B | 1 |
| Durussel, JJ | 1 |
| Claperon, N | 1 |
| Dufaux, J | 1 |
| Quemada, D | 1 |
| Rossignol, P | 1 |
1 review available for muscimol and Brain Ischemia
| Article | Year |
|---|---|
GABA potentiation: a logical pharmacological approach for the treatment of acute ischaemic stroke.
Topics: Acute Disease; Animals; Brain; Brain Ischemia; Chlormethiazole; GABA Agonists; gamma-Aminobutyric Ac | 2000 |
21 other studies available for muscimol and Brain Ischemia
| Article | Year |
|---|---|
Neuroprotection of gamma-aminobutyric acid receptor agonists via enhancing neuronal nitric oxide synthase (Ser847) phosphorylation through increased neuronal nitric oxide synthase and PSD95 interaction and inhibited protein phosphatase activity in cerebra
Topics: Animals; Baclofen; Blotting, Western; Brain Ischemia; Disks Large Homolog 4 Protein; Dizocilpine Mal | 2008 |
Neuroprotection of ethanol against cerebral ischemia/reperfusion induced brain injury through GABA receptor activation.
Topics: Animals; Benzamides; Bicuculline; Brain; Brain Injuries; Brain Ischemia; Cell Death; Ethanol; GABA A | 2009 |
Exogenous brain-derived neurotrophic factor prevents postischemic downregulation of [3H]muscimol binding to GABA(A) receptors in the cortical penumbra.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Brain Ische | 2003 |
Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion.
Topics: Analysis of Variance; Animals; Apoptosis; Baclofen; Brain Ischemia; Cerebral Infarction; Disease Mod | 2007 |
Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion.
Topics: Animals; Apoptosis; Baclofen; Brain Ischemia; Disks Large Homolog 4 Protein; GABA Agonists; GluK2 Ka | 2008 |
Additive neuroprotection of GABA A and GABA B receptor agonists in cerebral ischemic injury via PI-3K/Akt pathway inhibiting the ASK1-JNK cascade.
Topics: Analysis of Variance; Animals; Baclofen; Brain Ischemia; Disease Models, Animal; Dose-Response Relat | 2008 |
Combination therapy protects ischemic brain in rats. A glutamate antagonist plus a gamma-aminobutyric acid agonist.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Dizocilpine Maleate; Drug Combinations; Excitat | 1994 |
Neural grafting to ischemic CA1 lesions in the rat hippocampus: an autoradiographic study.
Topics: Acetylcholinesterase; Animals; Autoradiography; Brain Ischemia; Brain Tissue Transplantation; Fetal | 1993 |
Alterations in [3H]MK-801, [3H]muscimol, [3H]cyclic AMP, and [3H]rolipram binding in the gerbil hippocampus following repeated ischemic insults.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Autoradiography; Brain Ischemia; Cyclic AMP; Dizocilpi | 1993 |
GABA agonist "muscimol" is neuroprotective in repetitive transient forebrain ischemia in gerbils.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Corpus Striatum; gamma-Aminobutyric Acid; Gerbillinae; Hip | 1993 |
Cardiovascular responses to global cerebral ischemia: role of excitatory amino acids in the ventrolateral medullary pressor area.
Topics: Acetylcholine; Amino Acids; Animals; Antidiuretic Hormone Receptor Antagonists; Atropine; Blood Pres | 1993 |
Gabaergic transmission and tyrosine hydroxylase expression in the nigral dopaminergic neurons: an in vivo study using a reversible ischemia model of rats.
Topics: Animals; Brain Ischemia; Cell Count; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Male | 1996 |
GABA receptor agonist promotes reformation of the striatonigral pathway by transplant derived from fetal striatal primordia in the lesioned striatum.
Topics: Animals; Apomorphine; Brain Damage, Chronic; Brain Ischemia; Brain Tissue Transplantation; Cell Coun | 1997 |
[Receptor mechanism of the neuroprotective effect of GABAergic agents].
Topics: Animals; Baclofen; Brain Ischemia; Female; GABA Agonists; GABA Antagonists; Injections, Intraventric | 1998 |
Neuroprotective properties of propofol and midazolam, but not pentobarbital, on neuronal damage induced by forebrain ischemia, based on the GABAA receptors.
Topics: Anesthetics, Intravenous; Animals; Baclofen; Brain Ischemia; Dose-Response Relationship, Drug; GABA | 1999 |
Synergistic combinatorial stroke therapy: A quantal bioassay of a GABA agonist and a glutamate antagonist.
Topics: Animals; Blood Pressure; Body Temperature; Brain Ischemia; Dizocilpine Maleate; Drug Therapy, Combin | 2000 |
Transient up-regulation of gamma-aminobutyric acid(A) receptor binding by lubeluzole after neocortical specify lesion in rats.
Topics: Animals; Brain Ischemia; Male; Muscimol; Neocortex; Neuroprotective Agents; Photochemistry; Piperidi | 2000 |
Additivity and independence of neuroprotective effects of GABAA and GABAB receptor agonists in complete global cerebral ischemia.
Topics: Animals; Baclofen; Bicuculline; Brain Ischemia; Drug Interactions; Female; GABA Agonists; GABA Antag | 2000 |
[3H]muscimol binding to gamma-aminobutyric acid(A) receptors is upregulated in CA1 neurons of the gerbil hippocampus in the ischemia-tolerant state.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competi | 2002 |
Protective effect of synaptic inhibition during cerebral ischemia in rats and rabbits.
Topics: Animals; Brain Ischemia; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Aci | 1992 |
Extracorporeal cephalic blood autoperfusion method in the rat. Hemorrheological evaluation and proposed pharmacological uses.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Extracorporeal | 1986 |