muscimol has been researched along with Brain Edema in 1 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The treatment with muscimol, a gamma amino butyric acid receptor-A (GABA(A)) agonist, mitigates the AD syndrome and vascular dementia." | 1.35 | GABAA receptor agonist mitigates homocysteine-induced cerebrovascular remodeling in knockout mice. ( Kumar, M; Lominadze, D; Moshal, KS; Pushpakumar, SB; Sen, U; Tyagi, N; Tyagi, SC; Vacek, T, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, M | 1 |
| Tyagi, N | 1 |
| Moshal, KS | 1 |
| Sen, U | 1 |
| Pushpakumar, SB | 1 |
| Vacek, T | 1 |
| Lominadze, D | 1 |
| Tyagi, SC | 1 |
1 other study available for muscimol and Brain Edema
| Article | Year |
|---|---|
GABAA receptor agonist mitigates homocysteine-induced cerebrovascular remodeling in knockout mice.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Cerebral Arteries; Cerebrovascular Circulation; Coloring | 2008 |