muscimol has been researched along with Blood Pressure, High in 25 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Baclofen (20 mg/kg) was neuroprotective (potency ratio of 3." | 5.30 | High dose baclofen is neuroprotective but also causes intracerebral hemorrhage: a quantal bioassay study using the intraluminal suture occlusion method. ( Jackson-Friedman, C; Jin, A; Lyden, PD; Nunez, S; Zweifler, R, 1997) |
| "Development of angiotensin II (Ang II)-dependent hypertension involves microglial activation and proinflammatory cytokine actions in the hypothalamic paraventricular nucleus (PVN)." | 3.80 | Ang II-salt hypertension depends on neuronal activity in the hypothalamic paraventricular nucleus but not on local actions of tumor necrosis factor-α. ( Bardgett, ME; Herrera-Rosales, M; Holbein, WW; Toney, GM, 2014) |
| "To determine whether chronic central gamma-aminobutyric acid (GABA) stimulation would attenuate development of hypertension, tail-cuff systolic pressures were measured in male spontaneously hypertensive rats (SHR) treated with either an inhibitor of GABA breakdown (valproate, VPA), or a GABA-receptor agonist (muscimol)." | 3.68 | Chronic central GABAergic stimulation attenuates hypothalamic hyperactivity and development of spontaneous hypertension in rats. ( Hayashi, J; Kawasaki, S; Nakagawa, M; Nakata, T; Oguro, M; Sasaki, S; Takeda, K, 1990) |
| " Intraperitoneal injection of valproic acid (50-100 mg/Kg/die) for 6 weeks significantly reduced the development of DOCA-salt hypertension in rats." | 3.67 | Increased cardiovascular responsiveness to GABAergic stimulation in DOCA-salt hypertensive rats. ( Caputi, AP; Costa, G; Di Giorgio, RM; Magrì, V; Quattrone, G; Squadrito, F; Trimarchi, GR, 1984) |
| "To elucidate the role of the central gamma-aminobutyric acid (GABA) system in the maintenance of deoxycorticosterone (DOCA)NaCl hypertension, the responses of mean arterial pressure (MAP), plasma norepinephrine (NE), and epinephrine (EP) to intracerebroventricular (ICV) administration of muscimol, a GABA agonist, and the responses of MAP to bicuculline, a GABA antagonist, and to clonidine, an alpha 2-adrenoceptor agonist known to lower blood pressure by inhibiting sympathetic tone, were examined in conscious, unrestrained 4 week DOCA/NaCl hypertensive rats and age-matched uninephrectomized control rats." | 3.67 | Enhanced depressor effect of muscimol in the DOCA/NaCl hypertensive rat: evidence for altered GABAergic activity in brain. ( Dawson, R; Nagahama, S; Oparil, S, 1985) |
| "Hypertension is a major risk factor for cerebrovascular diseases, leading to vascular dementia and neurodegeneration." | 1.40 | Antihypertensive and neuroprotective effects of catestatin in spontaneously hypertensive rats: interaction with GABAergic transmission in amygdala and brainstem. ( Alò, R; Avolio, E; Canonaco, M; Facciolo, RM; Mahata, SK; Mantuano, E; Mele, M; Talani, G, 2014) |
| "Baclofen (20 mg/kg) was neuroprotective (potency ratio of 3." | 1.30 | High dose baclofen is neuroprotective but also causes intracerebral hemorrhage: a quantal bioassay study using the intraluminal suture occlusion method. ( Jackson-Friedman, C; Jin, A; Lyden, PD; Nunez, S; Zweifler, R, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (24.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bardgett, ME | 1 |
| Holbein, WW | 1 |
| Herrera-Rosales, M | 1 |
| Toney, GM | 1 |
| Avolio, E | 1 |
| Mahata, SK | 1 |
| Mantuano, E | 1 |
| Mele, M | 1 |
| Alò, R | 1 |
| Facciolo, RM | 1 |
| Talani, G | 1 |
| Canonaco, M | 1 |
| Zhang, Q | 1 |
| Yao, F | 2 |
| O'Rourke, ST | 2 |
| Qian, SY | 1 |
| Sun, C | 2 |
| Chen, F | 1 |
| Cham, JL | 1 |
| Badoer, E | 1 |
| Takakura, AC | 1 |
| Colombari, E | 1 |
| Menani, JV | 1 |
| Moreira, TS | 1 |
| Vorobyov, V | 1 |
| Schibaev, N | 1 |
| Kaptsov, V | 1 |
| Kovalev, G | 1 |
| Sengpiel, F | 1 |
| Kanaya, T | 1 |
| Okatani, H | 1 |
| Hagiwara, Y | 1 |
| Fukumori, R | 1 |
| Goshima, Y | 1 |
| Kubo, T | 1 |
| Aicher, SA | 1 |
| Fields, AM | 1 |
| Richards, TA | 1 |
| Felton, JA | 1 |
| Felton, SK | 1 |
| Bayer, EZ | 1 |
| Ibrahim, IN | 1 |
| Kaye, AD | 1 |
| Li, DP | 1 |
| Pan, HL | 1 |
| Sumners, C | 1 |
| Brennan, TJ | 1 |
| Haywood, JR | 1 |
| Ticku, MK | 1 |
| DeFeudis, FV | 1 |
| Magrì, V | 1 |
| Trimarchi, GR | 1 |
| Quattrone, G | 1 |
| Squadrito, F | 1 |
| Di Giorgio, RM | 1 |
| Costa, G | 1 |
| Caputi, AP | 1 |
| Jastrzebski, Z | 1 |
| Goźlińska, B | 1 |
| Czyzewska-Szafran, H | 1 |
| Muratani, H | 1 |
| Ferrario, CM | 1 |
| Averill, DB | 1 |
| Momohara, M | 1 |
| Imaizumi, T | 1 |
| Endo, T | 1 |
| Suzuki, S | 1 |
| Tagawa, T | 1 |
| Shiramoto, M | 1 |
| Masaki, H | 1 |
| Takeshita, A | 1 |
| Hara, K | 1 |
| Miyawaki, T | 1 |
| Minson, J | 1 |
| Arnolda, L | 1 |
| Llewellyn-Smith, I | 1 |
| Chalmers, J | 1 |
| Pilowsky, P | 1 |
| Jackson-Friedman, C | 1 |
| Lyden, PD | 1 |
| Nunez, S | 1 |
| Jin, A | 1 |
| Zweifler, R | 1 |
| Ito, S | 1 |
| Komatsu, K | 1 |
| Tsukamoto, K | 1 |
| Sved, AF | 2 |
| Allen, AM | 1 |
| Sasaki, S | 1 |
| Nakata, T | 1 |
| Kawasaki, S | 1 |
| Hayashi, J | 1 |
| Oguro, M | 1 |
| Takeda, K | 1 |
| Nakagawa, M | 1 |
| Bousquet, P | 1 |
| Feldman, J | 1 |
| Schwartz, J | 1 |
| Catelli, JM | 1 |
| Nagahama, S | 1 |
| Dawson, R | 1 |
| Oparil, S | 1 |
2 reviews available for muscimol and Blood Pressure, High
| Article | Year |
|---|---|
gamma-Aminobutyric acid and cardiovascular function.
Topics: Animals; Atropine; Baclofen; Blood Pressure; GABA Antagonists; gamma-Aminobutyric Acid; Heart Rate; | 1983 |
[GABA and central regulation of cardiovascular function].
Topics: Angiotensin II; Animals; Anti-Anxiety Agents; Antihypertensive Agents; Baclofen; Benzodiazepines; Bi | 1985 |
23 other studies available for muscimol and Blood Pressure, High
| Article | Year |
|---|---|
Ang II-salt hypertension depends on neuronal activity in the hypothalamic paraventricular nucleus but not on local actions of tumor necrosis factor-α.
Topics: Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; GABA-A Receptor Agonists; Hypertens | 2014 |
Antihypertensive and neuroprotective effects of catestatin in spontaneously hypertensive rats: interaction with GABAergic transmission in amygdala and brainstem.
Topics: Age Factors; Amygdala; Animals; Antihypertensive Agents; Blood Pressure; Brain Stem; Chromogranin A; | 2014 |
Angiotensin II enhances GABA(B) receptor-mediated responses and expression in nucleus tractus solitarii of rats.
Topics: Angiotensin II; Animals; Baclofen; Baroreflex; Bicuculline; Blood Pressure; Disease Models, Animal; | 2009 |
High-fat feeding alters the cardiovascular role of the hypothalamic paraventricular nucleus.
Topics: Adipose Tissue; Animals; Bicuculline; Blood Glucose; Blood Pressure; Body Weight; Cardiovascular Sys | 2010 |
Ventrolateral medulla mechanisms involved in cardiorespiratory responses to central chemoreceptor activation in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Chemor | 2011 |
Cortical and hippocampal EEG effects of neurotransmitter agonists in spontaneously hypertensive vs. kainate-treated rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Baclofen; Clonidine; Disease Models, Animal; | 2011 |
Projections from the caudal part to the rostral part of the lateral septal area mediate blood pressure increase.
Topics: Animals; Blood Pressure; Carbachol; Cholinergic Agonists; Dose-Response Relationship, Drug; Fluoresc | 2003 |
The gigantocellular depressor area revisited.
Topics: Animals; Autonomic Pathways; Baroreflex; Blood Pressure; Functional Laterality; GABA Agonists; Heart | 2003 |
Analysis of responses to valerian root extract in the feline pulmonary vascular bed.
Topics: Acetylcholine; Animals; Arachidonic Acid; Bradykinin; Calcium Channel Agonists; Cats; Disease Models | 2003 |
Role of gamma-aminobutyric acid (GABA)A and GABAB receptors in paraventricular nucleus in control of sympathetic vasomotor tone in hypertension.
Topics: Animals; Baclofen; Bicuculline; Blood Pressure; Heart Rate; Hypertension; Male; Microinjections; Mus | 2007 |
Angiotensin II increases GABAB receptor expression in nucleus tractus solitarii of rats.
Topics: Action Potentials; Angiotensin II; Animals; Animals, Newborn; Baclofen; Baroreflex; Blood Pressure; | 2008 |
GABA receptor binding and hemodynamic responses to ICV GABA in adult spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain; gamma-Aminobutyric Acid; Heart Rate; Hemody | 1983 |
Increased cardiovascular responsiveness to GABAergic stimulation in DOCA-salt hypertensive rats.
Topics: 4-Aminobutyrate Transaminase; Animals; Blood Pressure; Brain; Desoxycorticosterone; Ethanolamines; g | 1984 |
Pharmacodynamic interaction of clonidine and muscimol in hypertension.
Topics: Analysis of Variance; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Int | 1993 |
Ventrolateral medulla in spontaneously hypertensive rats: role of angiotensin II.
Topics: Angiotensin II; Animals; Bicuculline; Hemodynamics; Hypertension; Male; Medulla Oblongata; Microinje | 1993 |
Central GABAergic mechanisms are defective in salt-induced hypertension in borderline hypertensive rats.
Topics: Animals; Antihypertensive Agents; Bicuculline; Blood Pressure; Consciousness; GABA Antagonists; gamm | 1995 |
Role of spinal GABA receptors in depressor responses to chemical stimulation of the A5 area in normal and hypertensive rats.
Topics: Animals; Bicuculline; Blood Pressure; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor An | 1997 |
High dose baclofen is neuroprotective but also causes intracerebral hemorrhage: a quantal bioassay study using the intraluminal suture occlusion method.
Topics: Animals; Baclofen; Biological Assay; Cerebral Hemorrhage; Cold Temperature; Dizocilpine Maleate; Exc | 1997 |
Excitatory amino acids in the rostral ventrolateral medulla support blood pressure in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Excitatory Amino Acid Antagonists; GABA Agonists; Glutamic Acid; Heart Rate | 2000 |
Inhibition of the hypothalamic paraventricular nucleus in spontaneously hypertensive rats dramatically reduces sympathetic vasomotor tone.
Topics: Animals; Bicuculline; Blood Pressure; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Hear | 2002 |
Chronic central GABAergic stimulation attenuates hypothalamic hyperactivity and development of spontaneous hypertension in rats.
Topics: Animals; Blood Pressure; Electric Stimulation; gamma-Aminobutyric Acid; Heart Rate; Hemodynamics; Hy | 1990 |
Enhanced pressor response to GABA in the nucleus tractus solitarii of the spontaneously hypertensive rat.
Topics: Animals; Baclofen; Blood Pressure; Brain Stem; gamma-Aminobutyric Acid; Heart Rate; Hypertension; Ma | 1988 |
Enhanced depressor effect of muscimol in the DOCA/NaCl hypertensive rat: evidence for altered GABAergic activity in brain.
Topics: Animals; Bicuculline; Blood Pressure; Brain Chemistry; Clonidine; Desoxycorticosterone; Drug Interac | 1985 |