muscimol has been researched along with Autosomal Dominant Juvenile Parkinson Disease in 4 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lactacystin is a selective UPS inhibitor recently used to destroy dopamine (DA) neurons in animal models of Parkinson's disease (PD)." | 1.42 | Decreased behavioral response to intranigrally administered GABAA agonist muscimol in the lactacystin model of Parkinson's disease may result from partial lesion of nigral non-dopamine neurons: comparison to the classical neurotoxin 6-OHDA. ( Czarnecka, A; Kamińska, K; Konieczny, J; Lenda, T; Nowak, P, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Konieczny, J | 1 |
| Czarnecka, A | 1 |
| Kamińska, K | 1 |
| Lenda, T | 1 |
| Nowak, P | 1 |
| Wang, T | 1 |
| Zhang, L | 1 |
| Zhang, QJ | 1 |
| Wang, Y | 1 |
| Du, CX | 1 |
| Sun, YN | 1 |
| Zhang, J | 1 |
| Lv, SX | 1 |
| Chen, L | 1 |
| Liu, J | 1 |
| Matsumura, M | 1 |
| Kojima, J | 1 |
| Temel, Y | 1 |
| Boothman, LJ | 1 |
| Blokland, A | 1 |
| Magill, PJ | 1 |
| Steinbusch, HW | 1 |
| Visser-Vandewalle, V | 1 |
| Sharp, T | 1 |
4 other studies available for muscimol and Autosomal Dominant Juvenile Parkinson Disease
| Article | Year |
|---|---|
Decreased behavioral response to intranigrally administered GABAA agonist muscimol in the lactacystin model of Parkinson's disease may result from partial lesion of nigral non-dopamine neurons: comparison to the classical neurotoxin 6-OHDA.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcysteine; Animals; Cell Count; Corpus Striatum; Dopamine; Dose | 2015 |
Involvement of lateral habenula α1 subunit-containing GABA
Topics: Action Potentials; Animals; Apomorphine; Depression; Dopamine Agonists; GABA Antagonists; GABA-A Rec | 2017 |
The role of the pedunculopontine tegmental nucleus in experimental parkinsonism in primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Afferent Pathways; Animals; Basal Ganglia; Brain Stem; | 2001 |
Inhibition of 5-HT neuron activity and induction of depressive-like behavior by high-frequency stimulation of the subthalamic nucleus.
Topics: Action Potentials; Animals; Behavior, Animal; Deep Brain Stimulation; Depression; Disease Models, An | 2007 |