muscimol has been researched along with Autism in 2 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Data from these single concentration ligand binding studies indicate that the GABAergic receptor system (3[H]-flunitrazepam labeled benzodiazepine binding sites and 3[H]-muscimol labeled GABA(A) receptors) is significantly reduced in high binding regions, marking for the first time an abnormality in the GABA system in autism." | 3.71 | Density and distribution of hippocampal neurotransmitter receptors in autism: an autoradiographic study. ( Bauman, ML; Blatt, GJ; Booker, AB; Fitzgerald, CM; Guptill, JT; Kemper, TL, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oblak, A | 1 |
| Gibbs, TT | 1 |
| Blatt, GJ | 2 |
| Fitzgerald, CM | 1 |
| Guptill, JT | 1 |
| Booker, AB | 1 |
| Kemper, TL | 1 |
| Bauman, ML | 1 |
2 other studies available for muscimol and Autism
| Article | Year |
|---|---|
Decreased GABAA receptors and benzodiazepine binding sites in the anterior cingulate cortex in autism.
Topics: Adaptor Proteins, Signal Transducing; Adult; Autistic Disorder; Down-Regulation; Female; Flunitrazep | 2009 |
Density and distribution of hippocampal neurotransmitter receptors in autism: an autoradiographic study.
Topics: Adolescent; Adult; Autistic Disorder; Autoradiography; Binding Sites; Cell Count; Culture Techniques | 2001 |