muscimol has been researched along with Aura in 42 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here we have decided to investigate the participation of the GABAergic system of the zona incerta, one of its major neurotransmitters with widespread projections to the neocortex, in the pilocarpine (Pilo) model of epilepsy." | 7.71 | Inhibitory role of the zona incerta in the pilocarpine model of epilepsy. ( Bortolotto, ZA; Cavalheiro, EA; Hamani, C; Mello, LE; Sakabe, S, 2002) |
| "The pharmacodynamics of midazolam was studied in the kindling model of experimental epilepsy." | 7.70 | Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy. ( Cleton, A; Danhof, M; Ghijsen, W; Van der Graaf, PH; Voskuyl, R, 1999) |
| "The involvement of intranigral gamma-aminobutyric acid (GABA) receptors in the control of generalized non-convulsive epilepsy was investigated in the rat in 3 models of petit mal epilepsy induced by systemic administration of gamma-butyrolactone, pentylenetetrazol and 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridin 3-ol (THIP)." | 7.67 | Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents. ( Depaulis, A; Marescaux, C; Snead, OC; Vergnes, M, 1989) |
| "The substantia nigra has been identified as a critical site at which gamma-aminobutyric acid (GABA) agonist drugs act to reduce susceptibility to a number of types of experimentally induced generalized seizures." | 4.77 | Mechanisms of seizure control mediated by gamma-aminobutyric acid: role of the substantia nigra. ( Gale, K, 1985) |
| "Periodic transmeningeal administration of muscimol into the neocortical epileptogenic zone via a subdurally implanted device has been proposed for the treatment of intractable focal neocortical epilepsy." | 3.77 | Periodic transmeningeal muscimol maintains its antiepileptic efficacy over three weeks without inducing tolerance, in rats. ( Devinsky, O; French, JA; Kuzniecky, RI; Ludvig, N; Tang, HM, 2011) |
| " Here we have decided to investigate the participation of the GABAergic system of the zona incerta, one of its major neurotransmitters with widespread projections to the neocortex, in the pilocarpine (Pilo) model of epilepsy." | 3.71 | Inhibitory role of the zona incerta in the pilocarpine model of epilepsy. ( Bortolotto, ZA; Cavalheiro, EA; Hamani, C; Mello, LE; Sakabe, S, 2002) |
| "The pharmacodynamics of midazolam was studied in the kindling model of experimental epilepsy." | 3.70 | Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy. ( Cleton, A; Danhof, M; Ghijsen, W; Van der Graaf, PH; Voskuyl, R, 1999) |
| " Using the electroshock model of epilepsy, a systematic map of the anticonvulsant effects of bilateral injections of muscimol (60 ng/0." | 3.69 | Regional distribution of the anticonvulsant and behavioural effects of muscimol injected into the substantia nigra of rats. ( Dean, P; Redgrave, P; Shehab, S; Simkins, M, 1996) |
| "The involvement of intranigral gamma-aminobutyric acid (GABA) receptors in the control of generalized non-convulsive epilepsy was investigated in the rat in 3 models of petit mal epilepsy induced by systemic administration of gamma-butyrolactone, pentylenetetrazol and 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridin 3-ol (THIP)." | 3.67 | Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents. ( Depaulis, A; Marescaux, C; Snead, OC; Vergnes, M, 1989) |
| "The effects of GABAergic agents on non-convulsive epilepsy were studied by intracerebroventricular injections of muscimol and bicuculline in WAG/Rij rats." | 3.67 | Effects of GABA-ergic agents on spontaneous non-convulsive epilepsy, EEG and behaviour, in the WAG/RIJ inbred strain of rats. ( Coenen, AM; Peeters, BW; van Rijn, CM; Vossen, JM, 1989) |
| "This increased seizure susceptibility may be due to a functional immaturity of a substantia nigra, GABA-sensitive output system." | 2.37 | Epileptogenesis and the immature brain. ( Moshé, SL, 1987) |
| "Muscimol was administered in doses from 0." | 1.40 | Anticonvulsant and behavioral effects of muscimol in immature rats. ( Mareš, P; Mikulecká, A; Tichá, K, 2014) |
| "gamma-Aminobutyric acid (GABA) is a major neurotransmitter in AMG, and histamine receptor activation is also reported to stimulate GABA release." | 1.31 | Modulation of audiogenically kindled seizures by gamma-aminobutyric acid-related mechanisms in the amygdala. ( Faingold, CL; Feng, HJ; Naritoku, DK; Randall, ME, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (35.71) | 18.7374 |
| 1990's | 10 (23.81) | 18.2507 |
| 2000's | 13 (30.95) | 29.6817 |
| 2010's | 3 (7.14) | 24.3611 |
| 2020's | 1 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Gernert, M | 1 |
| MacKeigan, D | 1 |
| Deking, L | 1 |
| Kaczmarek, E | 1 |
| Feja, M | 1 |
| Mareš, P | 1 |
| Tichá, K | 1 |
| Mikulecká, A | 1 |
| Rebrov, IG | 2 |
| Karpova, MN | 2 |
| Andreev, AA | 2 |
| Klishina, NY | 1 |
| Kalinina, MV | 1 |
| Kusnetzova, LV | 1 |
| Kuramoto, S | 1 |
| Yasuhara, T | 1 |
| Agari, T | 1 |
| Kondo, A | 1 |
| Matsui, T | 1 |
| Miyoshi, Y | 1 |
| Shingo, T | 1 |
| Date, I | 1 |
| Vorobyov, V | 1 |
| Schibaev, N | 1 |
| Kaptsov, V | 1 |
| Kovalev, G | 1 |
| Sengpiel, F | 1 |
| Tang, HM | 1 |
| French, JA | 1 |
| Kuzniecky, RI | 1 |
| Devinsky, O | 1 |
| Ludvig, N | 1 |
| Zhang, DX | 1 |
| Bertram, EH | 2 |
| Kuzina, OS | 1 |
| Kalinina, MS | 1 |
| Abrosimov, IY | 1 |
| Belykh, NP | 1 |
| Zhang, D | 1 |
| Williamson, JM | 1 |
| Butuzova, MV | 1 |
| Kitchigina, VF | 1 |
| Meldrum, B | 1 |
| Kouyoumdjian, JC | 1 |
| Ebadi, M | 1 |
| Pfeiffer, M | 1 |
| Draguhn, A | 1 |
| Meierkord, H | 1 |
| Heinemann, U | 1 |
| Shehab, S | 1 |
| Simkins, M | 1 |
| Dean, P | 1 |
| Redgrave, P | 1 |
| Titulaer, MN | 1 |
| Kamphuis, W | 1 |
| Lopes da Silva, FH | 1 |
| Fukao, K | 1 |
| Momiyama, T | 1 |
| Ishihara, K | 2 |
| Ujihara, H | 2 |
| Fujita, Y | 1 |
| Taniyama, K | 1 |
| Serikawa, T | 2 |
| Sasa, M | 2 |
| Cleton, A | 1 |
| Van der Graaf, PH | 1 |
| Ghijsen, W | 1 |
| Voskuyl, R | 1 |
| Danhof, M | 1 |
| Zilles, K | 1 |
| Qü, MS | 1 |
| Köhling, R | 1 |
| Speckmann, EJ | 1 |
| Saji, M | 1 |
| Kobayashi, S | 1 |
| Ohno, K | 1 |
| Sekino, Y | 1 |
| Emanuelli, T | 1 |
| Prauchner, CA | 1 |
| Dacanal, J | 1 |
| Zeni, A | 1 |
| Reis, EC | 1 |
| de Mello, CF | 1 |
| de Souza, DO | 1 |
| Molnar, LR | 1 |
| Fleming, WW | 1 |
| Taylor, DA | 1 |
| Lin, J | 1 |
| Ritchie, GD | 1 |
| Stenger, DA | 1 |
| Nordholm, AF | 1 |
| Pancrazio, JJ | 1 |
| Rossi, J | 1 |
| Feng, HJ | 1 |
| Naritoku, DK | 1 |
| Randall, ME | 1 |
| Faingold, CL | 1 |
| Shehab, SA | 1 |
| Julyan, TE | 1 |
| Hamani, C | 1 |
| Sakabe, S | 1 |
| Bortolotto, ZA | 1 |
| Cavalheiro, EA | 1 |
| Mello, LE | 1 |
| Gale, K | 3 |
| Zhong, P | 1 |
| Miller, LP | 1 |
| Murray, TF | 1 |
| Murase, K | 1 |
| Nabeshima, T | 1 |
| Kameyama, T | 1 |
| Takaori, S | 1 |
| Yamada, J | 1 |
| Nobrega, JN | 1 |
| Kish, SJ | 1 |
| Burnham, WM | 1 |
| Caboche, J | 1 |
| Mitrovic, N | 1 |
| Le Saux, F | 1 |
| Besson, MJ | 1 |
| Sauter, A | 1 |
| Maurin, Y | 1 |
| Lee, RJ | 1 |
| Depaulis, A | 3 |
| Lomax, P | 1 |
| Olsen, RW | 1 |
| Snead, OC | 1 |
| Marescaux, C | 2 |
| Vergnes, M | 2 |
| Akahane, K | 1 |
| Sekiguchi, M | 1 |
| Une, T | 1 |
| Osada, Y | 1 |
| Peeters, BW | 1 |
| van Rijn, CM | 1 |
| Vossen, JM | 1 |
| Coenen, AM | 1 |
| Lannes, B | 1 |
| Warter, JM | 1 |
| Lloyd, KG | 1 |
| Perrault, G | 1 |
| Zivkovic, B | 1 |
| Shin, C | 2 |
| Pedersen, HB | 1 |
| McNamara, JO | 2 |
| Hattori, H | 1 |
| Ito, M | 1 |
| Mikawa, H | 1 |
| Booker, JG | 1 |
| Dailey, JW | 1 |
| Jobe, PC | 1 |
| Lane, JD | 1 |
| Moshé, SL | 1 |
| Bonhaus, DW | 1 |
5 reviews available for muscimol and Aura
| Article | Year |
|---|---|
GABA-agonists as anti-epileptic agents.
Topics: Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Disease Models, Animal; Epilepsy; Etomidate | 1981 |
GABA and epilepsy: basic concepts from preclinical research.
Topics: Aminocaproates; Animals; Anticonvulsants; Brain; Epilepsy; gamma-Aminobutyric Acid; Humans; Muscimol | 1992 |
[Implications of GABAergic synapses in neuropsychiatry].
Topics: 4-Aminobutyrate Transaminase; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; | 1985 |
Mechanisms of seizure control mediated by gamma-aminobutyric acid: role of the substantia nigra.
Topics: Animals; Bicuculline; Cell Compartmentation; Epilepsy; gamma-Aminobutyric Acid; Microinjections; Mor | 1985 |
Epileptogenesis and the immature brain.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Brain Diseases; Cerebral Cortex; Epilepsy; Humans; Kin | 1987 |
37 other studies available for muscimol and Aura
| Article | Year |
|---|---|
Acute and chronic convection-enhanced muscimol delivery into the rat subthalamic nucleus induces antiseizure effects associated with high responder rates.
Topics: Animals; Convection; Epilepsy; Female; Muscimol; Rats; Seizures; Subthalamic Nucleus | 2023 |
Anticonvulsant and behavioral effects of muscimol in immature rats.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Dr | 2014 |
Cl(-) conduction of GABAA receptor complex of synaptic membranes in the cortex of rats at the middle stage of chronic cerebral epileptization (pharmacological kindling).
Topics: Animals; Cerebral Cortex; Chlorides; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; GA | 2007 |
Injection of muscimol, a GABAa agonist into the anterior thalamic nucleus, suppresses hippocampal neurogenesis in amygdala-kindled rats.
Topics: Amygdala; Animals; Anterior Thalamic Nuclei; Bromodeoxyuridine; Cell Count; Cell Differentiation; Ce | 2009 |
Cortical and hippocampal EEG effects of neurotransmitter agonists in spontaneously hypertensive vs. kainate-treated rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Baclofen; Clonidine; Disease Models, Animal; | 2011 |
Periodic transmeningeal muscimol maintains its antiepileptic efficacy over three weeks without inducing tolerance, in rats.
Topics: Animals; Anticonvulsants; Convulsants; Drug Tolerance; Electrodes, Implanted; Electroencephalography | 2011 |
Different reactions of control and epileptic rats to administration of APV or muscimol on thalamic or CA3-induced CA1 responses.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Epilepsy; Male; Muscimol; Rats; Rats, Sprag | 2003 |
Effect of single injection of pentylenetetrazole in a subconvulsive dose on Cl- conductance of the GABAA-receptor complex.
Topics: Animals; Cerebral Cortex; Chloride Channels; Chlorides; Convulsants; Electric Conductivity; Epilepsy | 2004 |
Multiple roles of midline dorsal thalamic nuclei in induction and spread of limbic seizures.
Topics: Animals; Behavior, Animal; Bicuculline; Brain Mapping; Electrodes, Implanted; Epilepsy; Glutamates; | 2008 |
Repeated blockade of GABAA receptors in the medial septal region induces epileptiform activity in the hippocampus.
Topics: Action Potentials; Animals; Bicuculline; Biological Clocks; Electroencephalography; Epilepsy; Fornix | 2008 |
Anticonvulsant activity of muscimol and gamma-aminobutyric acid against pyridoxal phosphate-induced epileptic seizures.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Epilepsy; gamma-Aminobutyric Acid; Glutamate Decar | 1981 |
Effects of gamma-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Entorhinal Cortex; Epilepsy; Female; GABA Agoni | 1996 |
Regional distribution of the anticonvulsant and behavioural effects of muscimol injected into the substantia nigra of rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain Mapping; Electroshock; Epilepsy; Head; Injections; | 1996 |
Quantitative autoradiographic analysis of the [3H]muscimol binding in the kindled rat hippocampus: time-dependent and regional specific changes.
Topics: Animals; Autoradiography; Brain Mapping; Epilepsy; Hippocampus; Kindling, Neurologic; Male; Muscimol | 1996 |
Inhibition by gamma-aminobutyric acid system activation of epileptic seizures in spontaneously epileptic rats.
Topics: 4-Aminobutyrate Transaminase; Aminooxyacetic Acid; Animals; Brain; Electroencephalography; Enzyme In | 1998 |
Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy.
Topics: Adaptation, Physiological; Animals; Anticonvulsants; Brain; Chlorine; Disease Models, Animal; Dose-R | 1999 |
Ionotropic glutamate and GABA receptors in human epileptic neocortical tissue: quantitative in vitro receptor autoradiography.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Autoradiography; Binding Sites; Dizocilpin | 1999 |
Interruption of supramammillohippocampal afferents prevents the genesis and spread of limbic seizures in the hippocampus via a disinhibition mechanism.
Topics: Afferent Pathways; Amygdala; Animals; Behavior, Animal; Denervation; Electroencephalography; Entorhi | 2000 |
Intrastriatal administration of 5-aminolevulinic acid induces convulsions and body asymmetry through glutamatergic mechanisms.
Topics: Aminolevulinic Acid; Animals; Convulsants; Corpus Striatum; Dizocilpine Maleate; Epilepsy; Excitator | 2000 |
Alterations in neuronal gamma-aminobutyric acid(A) receptor responsiveness in genetic models of seizure susceptibility with different expression patterns.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Epilepsy; gamma-Aminobutyric Acid; Genetic P | 2000 |
Trimethylolpropane phosphate induces epileptiform discharges in the CA1 region of the rat hippocampus.
Topics: Action Potentials; Animals; Baclofen; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Diazepam | 2001 |
Modulation of audiogenically kindled seizures by gamma-aminobutyric acid-related mechanisms in the amygdala.
Topics: Acoustic Stimulation; Amygdala; Animals; Epilepsy; GABA Agonists; gamma-Aminobutyric Acid; Genetic P | 2001 |
Induction of Fos-like immunoreactivity in the basal ganglia by ether anaesthesia: effects of injections of muscimol in rostral versus caudal substantia nigra pars reticulata.
Topics: Anesthetics, Inhalation; Animals; Basal Ganglia; Brain; Disease Models, Animal; Dose-Response Relati | 2002 |
Inhibitory role of the zona incerta in the pilocarpine model of epilepsy.
Topics: Animals; Bicuculline; Brain Mapping; Disease Models, Animal; Electroencephalography; Epilepsy; GABA | 2002 |
Amino acid neurotransmitter interactions in 'area tempestas': an epileptogenic trigger zone in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Am | 1992 |
Characteristics of muscarinic cholinergic, gamma-aminobutyric acid(A) and phencyclidine receptors in spontaneously epileptic rats; in vitro quantitative autoradiographic analysis.
Topics: Animals; Autoradiography; Brain; Epilepsy; Female; Male; Muscimol; Organ Specificity; Phencyclidine; | 1991 |
Regional brain [3H]muscimol binding in kindled rat brain: a quantitative autoradiographic examination.
Topics: Animals; Autoradiography; Brain; Electrodes; Epilepsy; Kindling, Neurologic; Male; Muscimol; Radioli | 1990 |
Postnatal evolution of the gamma-aminobutyric acid/benzodiazepine receptor complex in a model of inherited epilepsy: the quaking mouse.
Topics: Aging; Animals; Brain; Brain Stem; Cerebellum; Diazepam; Diencephalon; Epilepsy; Flunitrazepam; gamm | 1989 |
Anticonvulsant effect of muscimol injected into the thalamus of spontaneously epileptic Mongolian gerbils.
Topics: Animals; Anticonvulsants; Baclofen; Dose-Response Relationship, Drug; Epilepsy; Female; Gerbillinae; | 1989 |
Suppressive effects of intranigral injection of muscimol in three models of generalized non-convulsive epilepsy induced by chemical agents.
Topics: 4-Butyrolactone; Animals; Convulsants; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; Is | 1989 |
Structure-epileptogenicity relationship of quinolones with special reference to their interaction with gamma-aminobutyric acid receptor sites.
Topics: 4-Quinolones; Animals; Anti-Infective Agents; Brain Chemistry; Epilepsy; In Vitro Techniques; Male; | 1989 |
Effects of GABA-ergic agents on spontaneous non-convulsive epilepsy, EEG and behaviour, in the WAG/RIJ inbred strain of rats.
Topics: Animals; Behavior, Animal; Bicuculline; Electroencephalography; Epilepsy; Female; gamma-Aminobutyric | 1989 |
Evidence that activation of GABA receptors in the substantia nigra suppresses spontaneous spike-and-wave discharges in the rat.
Topics: Animals; Electroencephalography; Epilepsy; Evoked Potentials; Male; Muscimol; Rats; Rats, Inbred Str | 1988 |
gamma-Aminobutyric acid and benzodiazepine receptors in the kindling model of epilepsy: a quantitative radiohistochemical study.
Topics: Animals; Binding Sites; Epilepsy; Flunitrazepam; Histocytochemistry; Kindling, Neurologic; Male; Mus | 1985 |
gamma-Aminobutyric acid, benzodiazepine binding sites and gamma-aminobutyric acid concentrations in epileptic E1 mouse brain.
Topics: Animals; Binding Sites; Brain; Epilepsy; Female; Flunitrazepam; gamma-Aminobutyric Acid; Male; Mice; | 1985 |
Cerebral cortical GABA and benzodiazepine binding sites in genetically seizure prone rats.
Topics: Animals; Cerebral Cortex; Dopamine; Epilepsy; Female; gamma-Aminobutyric Acid; Kinetics; Male; Musci | 1986 |
Role of the substantia nigra in the kindling model of limbic epilepsy.
Topics: Animals; Aspartic Acid; Epilepsy; gamma-Aminobutyric Acid; Kindling, Neurologic; Limbic System; Musc | 1986 |