muscimol has been researched along with Ataxia in 9 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "1-10 nmol; direct GABA(A) agonist); (3) YM90K (3-10 mg/kg; AMPA receptor antagonist); and (4) diazepam (2 and 5 mg/kg) and carbamazepine (5 and 20 mg/kg), two standard anticonvulsants, using the partially-kindled hippocampal model for epileptic seizures in freely moving rats." | 3.70 | Acute effects of various GABA receptor agonists and glutamate antagonists on focal hippocampal seizures in freely moving rats elicited by low-frequency stimulation. ( Ashby, CR; Katsumori, H; Minabe, Y; Osawa, M, 1998) |
| "Aromatic and heterocyclic esters of 1-methyl-4-piperidinol and 1,4-dimethyl-4-piperidinol and aromatic esters of (dialkylamino)alkanols were prepared and evaluated for antiepileptic activity by the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (scMet) assays and for minimal central neurotoxicity by the rotorod ataxia test." | 3.67 | Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters. ( Creveling, CR; Daly, JW; Hollingsworth, EB; Lewandowski, G; Waters, JA, 1986) |
| "Muscimol was a more potent stimulator of 36Cl- flux in the DS compared to the DR mice, although no difference between the lines was found in muscimol-stimulation of [3H]flunitrazepam binding." | 1.27 | Genetic selection for benzodiazepine ataxia produces functional changes in the gamma-aminobutyric acid receptor chloride channel complex. ( Allan, AM; Gallaher, EJ; Gionet, SE; Harris, RA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Holstein, SE | 1 |
| Dobbs, L | 1 |
| Phillips, TJ | 1 |
| Hwang, EJ | 1 |
| Hauschild, M | 1 |
| Wilke, M | 1 |
| Andersen, RA | 1 |
| Stahl, JS | 1 |
| Thumser, ZC | 1 |
| Oommen, BS | 1 |
| Yamaguchi, T | 1 |
| Hayashi, K | 1 |
| Murakami, H | 1 |
| Maruyama, S | 1 |
| Yamaguchi, M | 1 |
| Dar, MS | 1 |
| Katsumori, H | 1 |
| Minabe, Y | 1 |
| Osawa, M | 1 |
| Ashby, CR | 1 |
| Tirelli, E | 1 |
| Jodogne, C | 1 |
| Perikel, JJ | 1 |
| Allan, AM | 1 |
| Gallaher, EJ | 1 |
| Gionet, SE | 1 |
| Harris, RA | 1 |
| Waters, JA | 1 |
| Hollingsworth, EB | 1 |
| Daly, JW | 1 |
| Lewandowski, G | 1 |
| Creveling, CR | 1 |
9 other studies available for muscimol and Ataxia
| Article | Year |
|---|---|
Attenuation of the stimulant response to ethanol is associated with enhanced ataxia for a GABA, but not a GABA, receptor agonist.
Topics: Animals; Ataxia; Baclofen; Dose-Response Relationship, Drug; Ethanol; GABA-A Receptor Agonists; GABA | 2009 |
Inactivation of the parietal reach region causes optic ataxia, impairing reaches but not saccades.
Topics: Action Potentials; Animals; Association Learning; Ataxia; Brain Mapping; Cues; Disease Models, Anima | 2012 |
The ataxic mouse as a model for studying downbeat nystagmus.
Topics: Animals; Ataxia; Cerebellum; Female; Male; Mice; Mice, Neurologic Mutants; Models, Animal; Muscimol; | 2012 |
Distribution and characterization of the GABA receptors in the CNS of ataxic mutant mouse.
Topics: Animals; Ataxia; Binding, Competitive; Brain; gamma-Aminobutyric Acid; Kinetics; Mice; Mice, Neurolo | 1984 |
Mouse cerebellar GABAB participation in the expression of acute ethanol-induced ataxia and in its modulation by the cerebellar adenosinergic A1 system.
Topics: Adenosine; Adenylate Cyclase Toxin; Animals; Ataxia; Baclofen; Behavior, Animal; Cerebellum; Dose-Re | 1996 |
Acute effects of various GABA receptor agonists and glutamate antagonists on focal hippocampal seizures in freely moving rats elicited by low-frequency stimulation.
Topics: Animals; Anticonvulsants; Ataxia; Carbamazepine; Diazepam; Dizocilpine Maleate; Excitatory Amino Aci | 1998 |
Adult-like biphasic neurobehavioral changes induced by a GABA-A agonist in infant and weanling mice.
Topics: Aging; Animals; Animals, Newborn; Ataxia; Behavior, Animal; Catalepsy; Dose-Response Relationship, D | 1991 |
Genetic selection for benzodiazepine ataxia produces functional changes in the gamma-aminobutyric acid receptor chloride channel complex.
Topics: Animals; Ataxia; Chlorides; Diazepam; Ethanol; Flunitrazepam; Ion Channels; Isoxazoles; Mice; Muscim | 1988 |
Anticonvulsant activity of piperidinol and (dialkylamino)alkanol esters.
Topics: Amino Alcohols; Animals; Anticonvulsants; Ataxia; Bridged Bicyclo Compounds; Bridged Bicyclo Compoun | 1986 |