muscimol has been researched along with Anesthesia in 24 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intravenous administration of 2-[2-methoxyethoxy]-ethyl 8-[cis-2-n-octylcyclopropyl]-octanoate (A2C) was found to disorder brain membranes but did not produce intoxication or anesthesia in mice." | 7.67 | Fluidization of brain membranes by A2C does not produce anesthesia and does not augment muscimol-stimulated 36Cl- influx. ( Allan, AM; Buck, KJ; Harris, RA, 1989) |
| " The gamma-aminobutyric acid(A) receptor agonist, muscimol, potentiated ketamine-induced anesthesia." | 3.70 | Evidence for GABA(A) receptor agonistic properties of ketamine: convulsive and anesthetic behavioral models in mice. ( Dohi, T; Irifune, M; Kamata, Y; Kawahara, M; Nishikawa, T; Sato, T, 2000) |
| " The anesthesia induced by 1-amino-5-bromouracil was potentiated by diazepam, pentobarbital, and muscimol, and was antagonized by picrotoxin but not by bicuculline." | 3.69 | Effects of 1-amino-5-bromouracil on the benzodiazepine-GABAA receptor complex. ( Imaizumi, M; Machida, H; Miyazaki, S, 1994) |
| "In pentobarbital sodium-anesthetized, paralyzed, and ventilated rats, systemic hypoxia, produced by intratracheal N2 administration for 20 s, rapidly increased activities of reticulospinal vasomotor neurons in the rostroventolateral reticular nucleus (RVL) of the medulla oblongata (by 23." | 3.69 | Medullary vasomotor activity and hypoxic sympathoexcitation in pentobarbital-anesthetized rats. ( Reis, DJ; Sun, MK, 1996) |
| "Intravenous administration of 2-[2-methoxyethoxy]-ethyl 8-[cis-2-n-octylcyclopropyl]-octanoate (A2C) was found to disorder brain membranes but did not produce intoxication or anesthesia in mice." | 3.67 | Fluidization of brain membranes by A2C does not produce anesthesia and does not augment muscimol-stimulated 36Cl- influx. ( Allan, AM; Buck, KJ; Harris, RA, 1989) |
| "Muscimol was without effect in pylorus-ligated rats, whereas baclofen produced a significant decrease in acid secretion, which was fully prevented by phaclofen." | 1.28 | Central GABAA excitatory and GABAB inhibitory receptors regulate gastric acid secretion in rats. ( Bernardini, MC; Blandizzi, C; Del Tacca, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (20.83) | 18.7374 |
| 1990's | 10 (41.67) | 18.2507 |
| 2000's | 7 (29.17) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, C | 1 |
| Shi, F | 1 |
| Fu, B | 1 |
| Luo, T | 1 |
| Zhang, L | 1 |
| Zhang, Y | 2 |
| Yu, S | 1 |
| Yu, T | 1 |
| Mease, RA | 1 |
| Sumser, A | 1 |
| Sakmann, B | 1 |
| Groh, A | 1 |
| Kumar, S | 1 |
| Szymusiak, R | 1 |
| Bashir, T | 1 |
| Suntsova, N | 1 |
| Rai, S | 1 |
| McGinty, D | 1 |
| Alam, MN | 1 |
| Díaz-Casares, A | 1 |
| López-González, MV | 1 |
| Peinado-Aragonés, CA | 1 |
| Lara, JP | 1 |
| González-Barón, S | 1 |
| Dawid-Milner, MS | 1 |
| Badoer, E | 1 |
| Ng, CW | 1 |
| De Matteo, R | 1 |
| Takeda, M | 1 |
| Matsumoto, S | 1 |
| Pajolla, GP | 1 |
| de Aguiar Corrêa, FM | 1 |
| Tsoucaris-Kupfer, D | 1 |
| Liblau, L | 1 |
| Legrand, M | 1 |
| Schmitt, H | 1 |
| Bousquet, P | 1 |
| Feldman, J | 1 |
| Bloch, R | 1 |
| Schwartz, J | 1 |
| Menon, MK | 1 |
| Clark, WG | 1 |
| Vivonia, C | 1 |
| Persson, B | 1 |
| Lin, WC | 1 |
| Miyazaki, S | 1 |
| Imaizumi, M | 1 |
| Machida, H | 1 |
| Sun, MK | 2 |
| Reis, DJ | 2 |
| Kinney, GG | 1 |
| Kocsis, B | 1 |
| Vertes, RP | 1 |
| Koshiya, N | 1 |
| Guyenet, PG | 1 |
| Goshima, Y | 1 |
| Honjo, K | 1 |
| Miyamae, T | 1 |
| Misu, Y | 1 |
| Irifune, M | 1 |
| Sato, T | 1 |
| Kamata, Y | 1 |
| Nishikawa, T | 1 |
| Dohi, T | 1 |
| Kawahara, M | 1 |
| Ma, J | 1 |
| Shen, B | 1 |
| Stewart, LS | 1 |
| Herrick, IA | 1 |
| Leung, LS | 1 |
| Varga, K | 1 |
| Kunos, G | 1 |
| Del Tacca, M | 1 |
| Blandizzi, C | 1 |
| Bernardini, MC | 1 |
| Kaneko, T | 1 |
| Hicks, TP | 1 |
| Buck, KJ | 1 |
| Allan, AM | 1 |
| Harris, RA | 1 |
24 other studies available for muscimol and Anesthesia
| Article | Year |
|---|---|
GABA
Topics: Anesthesia; Animals; Basal Forebrain; Electroencephalography; gamma-Aminobutyric Acid; Muscimol; Pro | 2022 |
Corticothalamic Spike Transfer via the L5B-POm Pathway in vivo.
Topics: Action Potentials; Anesthesia; Animals; Computer Simulation; Excitatory Postsynaptic Potentials; GAB | 2016 |
Inactivation of median preoptic nucleus causes c-Fos expression in hypocretin- and serotonin-containing neurons in anesthetized rat.
Topics: Anesthesia; Animals; Arousal; Cell Count; GABA Agonists; GABA-A Receptor Agonists; Gene Expression R | 2008 |
Role of the parabrachial complex in the cardiorespiratory response evoked from hypothalamic defense area stimulation in the anesthetized rat.
Topics: Action Potentials; Anesthesia; Animals; Blood Pressure; Brain Stem; Electric Stimulation; GABA Agoni | 2009 |
Tonic sympathoinhibition arising from the hypothalamic PVN in the conscious rabbit.
Topics: Anesthesia; Animals; Blood Pressure; Brain; Electrodes, Implanted; Electrophysiology; Excitatory Ami | 2002 |
Effects of GABA(A) and glycine receptor agonists on the medullary inspiratory neuronal activity during spontaneous augmented breaths in anesthetized rats.
Topics: Anesthesia; Animals; Electrophysiology; Extracellular Space; GABA Agonists; GABA-A Receptor Agonists | 2002 |
Cardiovascular responses to the injection of L-glutamate in the lateral hypothalamus of unanesthetized or anesthetized rats.
Topics: Analysis of Variance; Anesthesia; Animals; Blood Pressure; Cardiovascular System; Dose-Response Rela | 2004 |
Central cardiovascular action of penicillin in anaesthetized dogs and rats.
Topics: Adrenalectomy; Anesthesia; Animals; Blood Pressure; Clonidine; Dogs; Female; gamma-Aminobutyric Acid | 1983 |
The ventromedullary hypotensive effect of muscimol in the anaesthetized cat.
Topics: Anesthesia; Animals; Bicuculline; Blood Pressure; Brain Stem; Cats; Hypotension; Muscimol; Oxazoles; | 1981 |
Interaction between phencyclidine (PCP) and GABA-ergic drugs: clinical implications.
Topics: Aminooxyacetic Acid; Anesthesia; Animals; Baclofen; Dextroamphetamine; Diazepam; Drug Interactions; | 1980 |
Cardiovascular effects of intracerebroventricular GABA, glycine and muscimol in the rat.
Topics: Anesthesia; Animals; Dopamine; gamma-Aminobutyric Acid; Glycine; Hemodynamics; Injections, Intravent | 1980 |
Stimulatory effect of muscimol on gastric acid secretion stimulated by secretagogues in vagotomized rats under anesthesia.
Topics: Anesthesia; Animals; Atropine; Bicuculline; Cimetidine; Drug Interactions; Electric Stimulation; GAB | 1995 |
Effects of 1-amino-5-bromouracil on the benzodiazepine-GABAA receptor complex.
Topics: Anesthesia; Animals; Anti-Anxiety Agents; Anticonvulsants; Bridged Bicyclo Compounds; Bridged Bicycl | 1994 |
Intrathecal kynurenate but not benextramine blocks hypoxic sympathoexcitation in chemodenervated anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Blood Pressure; Catecholamines; Cystamine; Hypoxi | 1994 |
Injections of muscimol into the median raphe nucleus produce hippocampal theta rhythm in the urethane anesthetized rat.
Topics: Anesthesia; Animals; Dose-Response Relationship, Drug; Electroencephalography; Hippocampus; Male; Mu | 1995 |
Medullary vasomotor activity and hypoxic sympathoexcitation in pentobarbital-anesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Hypoxia; Male; Medulla Oblongata; Microinjections; Muscimol; Ne | 1996 |
Tonic sympathetic chemoreflex after blockade of respiratory rhythmogenesis in the rat.
Topics: Anesthesia; Animals; Chemoreceptor Cells; Cranial Nerves; Decerebrate State; Diaphragm; Electrophysi | 1996 |
The evidence for tonic GABAergic regulation of basal L-DOPA release via activation of inhibitory GABA(A) receptors in the nucleus tractus solitarii of anesthetized rats.
Topics: Anesthesia; Animals; Bicuculline; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A | 1999 |
Evidence for GABA(A) receptor agonistic properties of ketamine: convulsive and anesthetic behavioral models in mice.
Topics: Allylglycine; Anesthesia; Anesthetics, Dissociative; Animals; Behavior, Animal; Bicuculline; Dose-Re | 2000 |
The septohippocampal system participates in general anesthesia.
Topics: Anesthesia; Anesthetics, General; Animals; Behavior, Animal; Electroencephalography; GABA Agonists; | 2002 |
Ethanol inhibition of baroreflex bradycardia: role of brainstem GABA receptors.
Topics: 3-Mercaptopropionic Acid; Anesthesia; Animals; Azides; Benzodiazepines; Bicuculline; Blood Pressure; | 1990 |
Central GABAA excitatory and GABAB inhibitory receptors regulate gastric acid secretion in rats.
Topics: Anesthesia; Animals; Baclofen; Bicuculline; Central Nervous System; Dose-Response Relationship, Drug | 1990 |
GABA(B)-related activity involved in synaptic processing of somatosensory information in S1 cortex of the anaesthetized cat.
Topics: Anesthesia; Animals; Baclofen; Bicuculline; Cats; Electric Stimulation; Electrodes; Female; gamma-Am | 1990 |
Fluidization of brain membranes by A2C does not produce anesthesia and does not augment muscimol-stimulated 36Cl- influx.
Topics: Anesthesia; Animals; Benzyl Alcohols; Brain Chemistry; Bridged Bicyclo Compounds; Bridged Bicyclo Co | 1989 |