muscimol has been researched along with Alzheimer Disease in 5 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| " To provide proof of concept for the nomethiazole drug class, selected examples were assayed for restoration of synaptic function in hippocampal slices from AD-transgenic mice, reversal of cognitive deficits, and brain bioavailability of the prodrug and its neuroprotective MZ metabolite." | 1.38 | Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy. ( Arancio, O; Fa', M; Luo, J; Qin, Z; Tavassoli, E; Teich, AF; Thatcher, GR; VandeVrede, L, 2012) |
| "These results suggest that cases of Alzheimer's disease express heterogeneities in neocortical pathology which are reflected in the laminar patterns of binding to postsynaptic receptors." | 1.28 | Laminar alterations in gamma-aminobutyric acidA, muscarinic, and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease. ( Crino, PB; Vogt, BA; Volicer, L, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Qin, Z | 1 |
| Luo, J | 1 |
| VandeVrede, L | 1 |
| Tavassoli, E | 1 |
| Fa', M | 1 |
| Teich, AF | 1 |
| Arancio, O | 1 |
| Thatcher, GR | 1 |
| Pilipenko, V | 1 |
| Narbute, K | 1 |
| Beitnere, U | 1 |
| Rumaks, J | 1 |
| Pupure, J | 1 |
| Jansone, B | 1 |
| Klusa, V | 1 |
| Klunk, WE | 1 |
| Debnath, ML | 1 |
| McClure, RJ | 1 |
| Pettegrew, JW | 1 |
| Vogt, BA | 1 |
| Crino, PB | 1 |
| Volicer, L | 1 |
| Greenamyre, JT | 1 |
| Penney, JB | 1 |
| D'Amato, CJ | 1 |
| Young, AB | 1 |
5 other studies available for muscimol and Alzheimer Disease
| Article | Year |
|---|---|
Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Avoidance Learning; Biological Availabil | 2012 |
Very low doses of muscimol and baclofen ameliorate cognitive deficits and regulate protein expression in the brain of a rat model of streptozocin-induced Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Baclofen; Brain; Cognition; Disease Models, Animal; Dose-Response Relati | 2018 |
Inactivity of phosphoethanolamine, an endogenous GABA analog decreased in Alzheimer's disease, at GABA binding sites.
Topics: Alzheimer Disease; Animals; Ethanolamines; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Mal | 1995 |
Laminar alterations in gamma-aminobutyric acidA, muscarinic, and beta adrenoceptors and neuron degeneration in cingulate cortex in Alzheimer's disease.
Topics: Adrenergic beta-Antagonists; Aged; Alzheimer Disease; Gyrus Cinguli; Humans; Muscimol; Nerve Degener | 1991 |
Dementia of the Alzheimer's type: changes in hippocampal L-[3H]glutamate binding.
Topics: Alzheimer Disease; Aspartic Acid; Autoradiography; Flunitrazepam; Glutamates; Glutamic Acid; Hippoca | 1987 |