muscimol has been researched along with Alcoholism in 22 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Long-term alcohol abuse is known to target specific areas of the brain such as the superior frontal cortex (SFC), resulting in neuronal cell loss." | 1.31 | Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex. ( Buckley, ST; Dodd, PR; Eckert, AL, 2000) |
| "Sleep-wake states were studied following withdrawal in 36 adult male wistar alcohol-dependent rats, after chronic administration of ethanol (10 g/kg/24 h) for 13 days." | 1.30 | Effects of muscimol or homotaurine on sleep-wake states in alcohol-dependent rats during withdrawal. ( Bajenaru, O; Dall'Ava-Santucci, J; Dinh-Xuan, AT; Emmanouilidis, E; Manicom, R; Poenaru, S; Rouhani, S; Tran, G, 1998) |
| "Whereas cases with concomitant Wernicke encephalopathy may also have had greater numbers of superior frontal [3H]muscimol binding sites than controls, alcoholics with cirrhosis of the liver showed more muted differences." | 1.29 | GABAA receptors in damaged cerebral cortex areas in human chronic alcoholics. ( Dodd, PR, 1994) |
| "The effect of alcohol dependence induced by ethanol inhalation on GABA-dependent 36Cl- influx into membrane vesicles prepared from the mouse brain has been examined." | 1.28 | Functional alterations in cerebral GABAA receptor complex associated with formation of alcohol dependence: analysis using GABA-dependent 36Cl- influx into neuronal membrane vesicles. ( Kuriyama, K; Ueha, T, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (22.73) | 18.7374 |
| 1990's | 10 (45.45) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bianchi, PC | 1 |
| Carneiro de Oliveira, PE | 1 |
| Palombo, P | 1 |
| Leão, RM | 1 |
| Cogo-Moreira, H | 1 |
| Planeta, CDS | 1 |
| Cruz, FC | 1 |
| Mehta, AK | 3 |
| Ticku, MK | 3 |
| Warnault, V | 1 |
| Houchi, H | 1 |
| Barbier, E | 1 |
| Pierrefiche, O | 1 |
| Vilpoux, C | 1 |
| Ledent, C | 1 |
| Daoust, M | 1 |
| Naassila, M | 1 |
| Moore, EM | 1 |
| Serio, KM | 1 |
| Goldfarb, KJ | 1 |
| Stepanovska, S | 1 |
| Linsenbardt, DN | 1 |
| Boehm, SL | 1 |
| Marutha Ravindran, CR | 1 |
| Lê, AD | 1 |
| Lê Dzung, A | 1 |
| Funk, D | 1 |
| Harding, S | 1 |
| Juzytsch, W | 1 |
| Li, Z | 1 |
| Fletcher, PJ | 1 |
| DeFeudis, FV | 1 |
| Unwin, JW | 1 |
| Taberner, PV | 1 |
| Gonzalez, LP | 1 |
| Hettinger, MK | 1 |
| Klein, RL | 1 |
| Mascia, MP | 1 |
| Whiting, PJ | 1 |
| Harris, RA | 1 |
| Hodge, CW | 1 |
| Chappelle, AM | 1 |
| Samson, HH | 1 |
| Dodd, PR | 4 |
| Thomas, GJ | 2 |
| McCloskey, A | 1 |
| Crane, DI | 1 |
| Smith, ID | 1 |
| Roberts, AJ | 1 |
| Cole, M | 1 |
| Koob, GF | 1 |
| Kril, JJ | 1 |
| Watson, WE | 1 |
| Johnston, GA | 1 |
| Harper, CG | 1 |
| Rouhani, S | 2 |
| Dall'Ava-Santucci, J | 1 |
| Bajenaru, O | 1 |
| Emmanouilidis, E | 2 |
| Tran, G | 2 |
| Manicom, R | 1 |
| Dinh-Xuan, AT | 1 |
| Poenaru, S | 2 |
| Buckley, ST | 1 |
| Eckert, AL | 1 |
| Kuriyama, K | 1 |
| Ueha, T | 1 |
| Payan, C | 1 |
| Castresana, A | 1 |
| Soulairac, A | 1 |
| Ulrichsen, J | 1 |
| Clemmesen, L | 1 |
| Barry, D | 1 |
| Hemmingsen, R | 1 |
| Korpi, ER | 1 |
| Lindroos, F | 1 |
| Pyykkö, I | 1 |
| Malminen, O | 1 |
| Kaheinen, P | 1 |
| Ignatius, J | 1 |
| Mäntysalo, S | 1 |
1 review available for muscimol and Alcoholism
| Article | Year |
|---|---|
Psychoactive agents and GABA-receptors.
Topics: Alcoholism; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Barbiturates; Benzodiazepines; Ethan | 1983 |
21 other studies available for muscimol and Alcoholism
| Article | Year |
|---|---|
Functional inactivation of the orbitofrontal cortex disrupts context-induced reinstatement of alcohol seeking in rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Baclofen; Conditioning, Operant; Drug-Seeking Behavior; Femal | 2018 |
Effect of chronic administration of ethanol on GABAA receptor assemblies derived from alpha2-, alpha3-, beta2- and gamma2-subunits in the rat cerebral cortex.
Topics: Alcoholism; Animals; Central Nervous System Depressants; Cerebral Cortex; Ethanol; Flunitrazepam; GA | 2005 |
The lack of CB1 receptors prevents neuroadapatations of both NMDA and GABA(A) receptors after chronic ethanol exposure.
Topics: Adaptation, Physiological; Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Binding S | 2007 |
GABAergic modulation of binge-like ethanol intake in C57BL/6J mice.
Topics: Alcoholism; Animals; Baclofen; Central Nervous System Depressants; Darkness; Dose-Response Relations | 2007 |
Effect of chronic administration of ethanol on the regulation of the delta-subunit of GABA(A) receptors in the rat brain.
Topics: Alcoholism; Animals; Central Nervous System Depressants; Cerebellum; Ethanol; GABA Agonists; Male; M | 2007 |
Intra-median raphe nucleus (MRN) infusions of muscimol, a GABA-A receptor agonist, reinstate alcohol seeking in rats: role of impulsivity and reward.
Topics: 5,7-Dihydroxytryptamine; Alcoholism; Animals; Attention; Choice Behavior; Conditioning, Classical; E | 2008 |
Sex and strain differences in GABA receptor binding after chronic ethanol drinking in mice.
Topics: Alcoholism; Animals; Behavior, Animal; Brain Chemistry; Female; Humans; Kinetics; Male; Mice; Muscim | 1980 |
Intranigral muscimol suppresses ethanol withdrawal seizures.
Topics: Acoustic Stimulation; Alcoholism; Animals; gamma-Aminobutyric Acid; Humans; Male; Muscimol; Oxazoles | 1984 |
GABAA receptor function and binding in stably transfected cells: chronic ethanol treatment.
Topics: Alcoholism; Animals; Cattle; Cell Line; Dose-Response Relationship, Drug; Ethanol; Flunitrazepam; Ge | 1995 |
GABAergic transmission in the nucleus accumbens is involved in the termination of ethanol self-administration in rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobut | 1995 |
The neurochemical pathology of thiamine deficiency: GABAA and glutamateNMDA receptor binding sites in a goat model.
Topics: Alcoholism; Amprolium; Animals; Brain Chemistry; Diazepam; Disease Models, Animal; Dizocilpine Malea | 1996 |
Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats.
Topics: Alcoholism; Amygdala; Animals; Brain Mapping; Conditioning, Operant; gamma-Aminobutyric Acid; Male; | 1996 |
Receptor binding sites and uptake activities mediating GABA neurotransmission in chronic alcoholics with Wernicke encephalopathy.
Topics: Adult; Aged; Aged, 80 and over; Alcoholism; Binding Sites; Diazepam; Female; Fibrosis; Flunitrazepam | 1996 |
GABAA receptors in damaged cerebral cortex areas in human chronic alcoholics.
Topics: Adult; Aged; Alcoholism; Binding Sites; Case-Control Studies; Cerebral Cortex; Diazepam; Flunitrazep | 1994 |
Effects of muscimol or homotaurine on sleep-wake states in alcohol-dependent rats during withdrawal.
Topics: Alcoholic Intoxication; Alcoholism; Animals; Behavior, Animal; Body Weight; Central Nervous System D | 1998 |
Prevalence of the GABAA receptor assemblies containing alpha1-subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: lack of modulation by chronic ethanol administration.
Topics: Affinity Labels; Alcoholism; Animals; Azides; Benzodiazepines; Brain Chemistry; Central Nervous Syst | 1999 |
Expression and distribution of GABAA receptor subtypes in human alcoholic cerebral cortex.
Topics: Alcoholism; Autoradiography; Blotting, Northern; Cerebral Cortex; Flunitrazepam; GABA Agonists; GABA | 2000 |
Functional alterations in cerebral GABAA receptor complex associated with formation of alcohol dependence: analysis using GABA-dependent 36Cl- influx into neuronal membrane vesicles.
Topics: Administration, Inhalation; Alcohol Withdrawal Delirium; Alcoholism; Animals; Brain; Bridged Bicyclo | 1992 |
Effects of alcohol dependence on shock-induced fighting: action of muscimol and homotaurine.
Topics: Aggression; Alcoholism; Animals; Body Weight; Electroshock; Ethanol; gamma-Aminobutyric Acid; Male; | 1992 |
The GABA/benzodiazepine receptor chloride channel complex during repeated episodes of physical ethanol dependence in the rat.
Topics: Alcoholism; Animals; Chlorides; Diazepam; Ion Channels; Male; Muscimol; Radioligand Assay; Rats; Rat | 1988 |
Ethanol-induced modulation of hippocampal EEG and cerebral 2-deoxyglucose accumulation in rat lines with differing alcohol sensitivities.
Topics: Alcoholism; Animals; Brain Chemistry; Cerebellum; Deoxy Sugars; Deoxyglucose; Drug Tolerance; Electr | 1987 |