Compounds > muscimol
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muscimol and Aggression

muscimol has been researched along with Aggression in 30 studies

Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.

Aggression: Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.

Research Excerpts

ExcerptRelevanceReference
"Experiments on isolated mice (CC57W males) have demonstrated that GABA antagonists (bicuculline, picrotoxin, thiosemicarbazide) increase the desocializing effects of isolation (enhance aggression and reduce intraspecies sociability), while GABA-positive drugs (muscimol, gamma-acetylenic GABA) within a certain dosage range diminish aggression and favour a temporary recovery of sociability."3.66[GABA-ergic correlates of aggression and intraspecies sociability of mice subjected to isolation]. ( Poshivalov, VP, 1981)
"Pretreatment with bicuculline (68 pmol) blocked the suppressive effects of muscimol (12 pmol) upon affective defense behavior."1.28GABA-mediated regulation of feline aggression elicited from midbrain periaqueductal gray. ( Shaikh, MB; Siegel, A, 1990)
"Muscimol was effective in the first session but did not differ significantly from saline in the second and third session."1.26Effects of sodium n-dipropylacetate, muscimol hydrobromide and (R,S) nipecotic acid amide on isolation-induced aggressive behavior in mice. ( Mandel, P; Puglisi-Allegra, S, 1980)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199013 (43.33)18.7374
1990's5 (16.67)18.2507
2000's5 (16.67)29.6817
2010's7 (23.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Morrison, TR1
Ricci, LA1
Melloni, RH1
Rysakova, MP1
Pavlova, IV1
Bondarenko, E1
Guimarães, DD1
Braga, VA1
Nalivaiko, E1
Markham, CM3
Norvelle, A3
Huhman, KL3
Lee, G1
Gammie, SC1
Takahashi, A1
Kwa, C1
Debold, JF1
Miczek, KA1
Luckett, CA1
Luckett, C1
Huhman, K1
McDonald, MM1
Albers, HE1
van der Vegt, BJ1
Lieuwes, N1
van de Wall, EH1
Kato, K1
Moya-Albiol, L1
Martínez-Sanchis, S1
de Boer, SF1
Koolhaas, JM1
Allikmets, LH1
Rägo, LK1
Potegal, M1
Yoburn, B1
Glusman, M1
Puglisi-Allegra, S2
Mandel, P4
Simler, S2
Kempf, E2
Rodgers, RJ1
Depaulis, A1
Poshivalov, VP1
Coimbra, NC1
Brandão, ML1
Miachon, S2
Cespuglio, R1
Cheu, JW1
Siegel, A2
Reynolds, SM1
Berridge, KC1
Augier, S1
Jouvenet, M1
Boucher, P1
Vallon, JJ1
Ciesielski, L2
Maitre, M1
Mack, G1
Delini-Stula, A2
Vassout, A2
Arnt, J1
Scheel-Krüger, J1
Rouhani, S1
Emmanouilidis, E1
Payan, C1
Tran, G1
Castresana, A1
Soulairac, A1
Poenaru, S1
Shaikh, MB1
Kaneyuki, H1
Krsiak, M1
Molina, V1
Gobaille, S1

Other Studies

30 other studies available for muscimol and Aggression

ArticleYear
γ-Aminobutyric acid neural signaling in the lateroanterior hypothalamus modulates aggressive behavior in adolescent anabolic/androgenic steroid-treated hamsters.
    Behavioural pharmacology, 2014, Volume: 25, Issue:7

    Topics: Aggression; Anabolic Agents; Androgens; Animals; Behavior, Animal; Bicuculline; Cricetinae; Dose-Res

2014
[Behavior of high- and low-anxiety rats after modulation of GABAergic transmission in basolateral amygdala].
    Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2014, Volume: 100, Issue:6

    Topics: Aggression; Animals; Anxiety; Basolateral Nuclear Complex; Bicuculline; Functional Laterality; GABA

2014
Integrity of the dorsolateral periaqueductal grey is essential for the fight-or-flight response, but not the respiratory component of a defense reaction.
    Respiratory physiology & neurobiology, 2016, Volume: 226

    Topics: Aggression; Animals; Arousal; Catheters, Indwelling; GABA-A Receptor Antagonists; Male; Models, Anim

2016
Role of the bed nucleus of the stria terminalis in the acquisition and expression of conditioned defeat in Syrian hamsters.
    Behavioural brain research, 2009, Mar-02, Volume: 198, Issue:1

    Topics: Aggression; Animals; Conditioning, Classical; Cricetinae; Fear; GABA Agonists; Male; Mesocricetus; M

2009
GABA(A) receptor signaling in the lateral septum regulates maternal aggression in mice.
    Behavioral neuroscience, 2009, Volume: 123, Issue:6

    Topics: Aggression; Analysis of Variance; Animals; Behavior, Animal; Bicuculline; Catheters, Indwelling; Chl

2009
GABA(A) receptors in the dorsal raphé nucleus of mice: escalation of aggression after alcohol consumption.
    Psychopharmacology, 2010, Volume: 211, Issue:4

    Topics: Aggression; Animals; Baclofen; Behavior, Animal; Bicuculline; Ethanol; GABA Agonists; GABA Antagonis

2010
The medial prefrontal cortex is both necessary and sufficient for the acquisition of conditioned defeat.
    Neuropharmacology, 2012, Volume: 62, Issue:2

    Topics: Aggression; Animals; Behavior, Animal; Bicuculline; Cricetinae; Dominance-Subordination; Fear; GABA-

2012
The role of the nucleus accumbens in the acquisition and expression of conditioned defeat.
    Behavioural brain research, 2012, Feb-01, Volume: 227, Issue:1

    Topics: Aggression; Analysis of Variance; Animals; Conditioning, Psychological; Cricetinae; Dominance-Subord

2012
GABAA receptor activation in the lateral septum reduces the expression of conditioned defeat and increases aggression in Syrian hamsters.
    Brain research, 2012, Feb-23, Volume: 1439

    Topics: Aggression; Animals; Behavior, Animal; Conditioning, Psychological; Cricetinae; Dominance-Subordinat

2012
Activation of serotonergic neurotransmission during the performance of aggressive behavior in rats.
    Behavioral neuroscience, 2003, Volume: 117, Issue:4

    Topics: Aggression; Animals; GABA Agonists; Male; Muscimol; Neurons; Rats; Serotonin; Serotonin Receptor Ago

2003
The action of benzodiazepine antagonist Ro 15-1788 on the effects of GABA-ergic drugs.
    Naunyn-Schmiedeberg's archives of pharmacology, 1983, Volume: 324, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Aggression; Animals; Baclofen; Benzodiazepines; Benzodiazepinones; B

1983
Disinhibition of muricide and irritability by intraseptal muscimol.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:4

    Topics: Aggression; Animals; Brain; Catheterization; Dose-Response Relationship, Drug; Feeding Behavior; Hum

1983
Effects of sodium n-dipropylacetate, muscimol hydrobromide and (R,S) nipecotic acid amide on isolation-induced aggressive behavior in mice.
    Psychopharmacology, 1980, Volume: 70, Issue:3

    Topics: Aggression; Animals; gamma-Aminobutyric Acid; Humans; Male; Mice; Motor Activity; Muscimol; Nipecoti

1980
Involvement of the GABAergic system on shock-induced aggressive behavior in two strains of mice.
    Pharmacology, biochemistry, and behavior, 1981, Volume: 14 Suppl 1

    Topics: 4-Aminobutyrate Transaminase; Aggression; Allylglycine; Animals; Brain Chemistry; Dose-Response Rela

1981
GABAergic influences on defensive fighting in rats.
    Pharmacology, biochemistry, and behavior, 1982, Volume: 17, Issue:3

    Topics: Aggression; Aminocaproates; Animals; Baclofen; Bicuculline; Electroshock; gamma-Aminobutyric Acid; H

1982
[GABA-ergic correlates of aggression and intraspecies sociability of mice subjected to isolation].
    Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 91, Issue:5

    Topics: Aggression; Alkynes; Aminocaproates; Animals; Bicuculline; gamma-Aminobutyric Acid; Humans; Male; Mi

1981
GABAergic nigro-collicular pathways modulate the defensive behaviour elicited by midbrain tectum stimulation.
    Behavioural brain research, 1993, Dec-31, Volume: 59, Issue:1-2

    Topics: Aggression; Animals; Bicuculline; Electric Stimulation; Escape Reaction; GABA Antagonists; gamma-Ami

1993
Prevention of ACTH- and adrenalectomy-induced muricidal behavior: by benzodiazepinic ligands.
    Peptides, 1997, Volume: 18, Issue:2

    Topics: Adrenalectomy; Adrenocorticotropic Hormone; Aggression; Animals; Benzodiazepinones; Clonazepam; Flum

1997
GABA receptor mediated suppression of defensive rage behavior elicited from the medial hypothalamus of the cat: role of the lateral hypothalamus.
    Brain research, 1998, Feb-09, Volume: 783, Issue:2

    Topics: Aggression; Animals; Bicuculline; Cats; Female; GABA Agonists; GABA Antagonists; Hypothalamic Area,

1998
Fear and feeding in the nucleus accumbens shell: rostrocaudal segregation of GABA-elicited defensive behavior versus eating behavior.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, May-01, Volume: 21, Issue:9

    Topics: Aggression; Analysis of Variance; Animals; Appetitive Behavior; Behavior, Animal; Dose-Response Rela

2001
Nutritional parameters modify muricidal behavior of male Wistar rats: preventive effects of amino acids and 4' Cl diazepam.
    Life sciences, 2001, Oct-26, Volume: 69, Issue:23

    Topics: 5-Hydroxytryptophan; Aggression; Animals; Behavior, Animal; Benzodiazepinones; Cholesterol; Diet; Di

2001
Involvement of central GABA-ergic systems in convulsions and aggressive behavior.
    Advances in experimental medicine and biology, 1979, Volume: 123

    Topics: 4-Aminobutyrate Transaminase; Aggression; Allylglycine; Animals; Bicuculline; Brain; Fatty Acids; ga

1979
Modulatory effects of baclofen muscimol and GABA on interspecific aggressive behaviour in the rat.
    Neuropharmacology, 1978, Volume: 17, Issue:12

    Topics: Aggression; Aminobutyrates; Animals; Baclofen; gamma-Aminobutyric Acid; Humans; Male; Muscimol; Olfa

1978
GABA in the ventral tegmental area: differential regional effects on locomotion, aggression and food intake after microinjection of GABA agonists and antagonists.
    Life sciences, 1979, Oct-08, Volume: 25, Issue:15

    Topics: Aggression; Animals; Apomorphine; Behavior, Animal; Bicuculline; Carbachol; Cerebral Cortex; Dopamin

1979
Influence of baclofen and GABA-minetic agents on spontaneous and olfactory-bulb-ablation-induced muricidal behaviour in the rat.
    Arzneimittel-Forschung, 1978, Volume: 28, Issue:9

    Topics: Aggression; Aminobutyrates; Animals; Baclofen; gamma-Aminobutyric Acid; Humans; Male; Motor Activity

1978
Effects of alcohol dependence on shock-induced fighting: action of muscimol and homotaurine.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:1

    Topics: Aggression; Alcoholism; Animals; Body Weight; Electroshock; Ethanol; gamma-Aminobutyric Acid; Male;

1992
GABA-mediated regulation of feline aggression elicited from midbrain periaqueductal gray.
    Brain research, 1990, Jan-15, Volume: 507, Issue:1

    Topics: Aggression; Animals; Bicuculline; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Fema

1990
[Effects of muscimol on aggressive behaviors induced by clonidine in mice].
    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1989, Volume: 9, Issue:3

    Topics: Aggression; Animals; Behavior, Animal; Bicuculline; Clonidine; Dose-Response Relationship, Drug; Dru

1989
Effects of muscimol, cetyl-GABA, pentetrazol and picrotoxin on timidity during intraspecies conflict in mice.
    Activitas nervosa superior, 1989, Volume: 31, Issue:1

    Topics: Aggression; Animals; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Pentylenetetra

1989
Effects of the potentiation of the GABAergic neurotransmission in the olfactory bulbs on mouse-killing behavior.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:3

    Topics: Aggression; Aminocaproates; Animals; Brain Chemistry; Drug Synergism; gamma-Aminobutyric Acid; Isoni

1986