muscimol has been researched along with Absence Seizure in 180 studies
Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.
muscimol : A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seizure-induced release of the neuromodulator adenosine is a potent endogenous anticonvulsant mechanism, which limits the extension of seizures and mediates seizure arrest." | 7.78 | Adenosine release during seizures attenuates GABAA receptor-mediated depolarization. ( Akerman, CJ; Ilie, A; Raimondo, JV, 2012) |
| " The results showed that in the PRC anticonvulsant efficacy against soman-induced seizures (subcutaneously administered) was achieved by procyclidine or NBQX, but not by ketamine, scopolamine, caramiphen, or muscimol (Experiment 1)." | 7.76 | Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman. ( Aas, P; Enger, S; Myhrer, T, 2010) |
| " We investigate whether microinjections of GABAergic agonists into the AN were protective against pilocarpine-induced generalized seizures and status epilepticus (SE)." | 7.76 | Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus. ( Andrade, D; Bittencourt, S; Covolan, L; Dubiela, FP; Hamani, C; Lozano, A; Mello, LE; Queiroz, C, 2010) |
| "To determine whether muscimol delivered epidurally or into the subarachnoid space can prevent and/or terminate acetylcholine (Ach)-induced focal neocortical seizures at concentrations not affecting behavior and background electroencephalography (EEG) activity." | 7.75 | Localized transmeningeal muscimol prevents neocortical seizures in rats and nonhuman primates: therapeutic implications. ( Baptiste, SL; Charchaflieh, J; Devinsky, O; Kuzniecky, RI; Ludvig, N; Medveczky, G; Tang, HM; von Gizycki, H, 2009) |
| "Methylmalonic acid (MMA) is an endogenous convulsing compound that accumulates in methylmalonic acidemia, an inborn error of the metabolism characterized by severe neurological dysfunction, including seizures." | 7.74 | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? ( Fighera, MR; Garrido-Sanabria, ER; Malfatti, CR; Mello, CF; Muller, AP; Paquetti, L; Perry, ML; Rigo, FK; Schweigert, ID, 2007) |
| "This work aims to describe behavioral/electroencephalographic (EEG) seizures induced by bicuculline microinjection intracerebroventricularly (ICV) and in the dorsal hippocampal formation (DHF) or ventral hippocampal formation/amygdala area (VHF-AMY)." | 7.72 | Behavioral effects of bicuculline microinjection in the dorsal versus ventral hippocampal formation of rats, and control of seizures by nigral muscimol. ( Beleboni, Rde O; Coutinho-Netto, J; dos Santos, WF; Garcia-Cairasco, N; Rodrigues, MC, 2004) |
| "The effects of drugs affecting GABA and glutamic acid receptors on theophylline-induced seizures were investigated in mice." | 7.70 | Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. ( Amabeoku, GJ, 1999) |
| "The effects of GABAmimetic drugs on inhibition of amygdaloid kindled seizures induced by clobenpropit were investigated to clarify the relationship between histaminergic and GABAergic systems in seizures." | 7.70 | Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures. ( Chen, Z; Fujii, Y; Ishizawa, K; Kamei, C; Okuma, C; Sugimoto, Y, 2000) |
| " The effects of some GABAergic and dopaminergic agents on pyrimethamine-induced tonic seizures were investigated in mice." | 7.69 | GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice. ( Amabeoku, G; Chikuni, O, 1994) |
| " Here, using this method we examined the anatomical locations of muscimol-induced absence seizures in the rat forebrain." | 7.69 | Fos oncoprotein expression in the rat forebrain following muscimol-induced absence seizures. ( Ju, G; Le Gal La Salle, G; Ridoux, V; Yu, PH; Zhang, X, 1996) |
| "The effects of muscimol, aminooxyacetic acid (AOAA), diamino-n-butyric acid (DABA), baclofen, bicuculline, picrotoxin, strychnine, diazepam, phenobarbitone and phenytoin on cimetidine-induced seizures were studied in mice." | 7.68 | Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents. ( Amabeoku, GJ; Chikuni, O, 1993) |
| "The effects of some GABAergic agents on seizures induced by quinine were studied in mice." | 7.68 | Effects of some GABAergic agents on quinine-induced seizures in mice. ( Amabeoku, GJ; Chikuni, O, 1992) |
| "The binding of 3H-muscimol and 3H-diazepam to rat striatum membranes after picrotoxin- and bicuculline-induced seizures was characterized." | 7.68 | [Effects of GABA antagonist-induced seizures on 3H-muscimol and 3H-diazepam binding in the rat striatum]. ( Golovko, AI; Sofronov, GA, 1992) |
| " The influence of some GABAergic agents on tonic seizures elicited by chloroquine was investigated in mice." | 7.68 | Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice. ( Amabeoku, G, 1992) |
| "Motor limbic seizures occur following a systemic injection of pilocarpine (380 mg/kg) in rats." | 7.67 | 2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats. ( Meldrum, BS; Mello, LM; Millan, MH; Patel, S, 1986) |
| "Pentobarbital and phenobarbital exhibited anticonvulsant effect against maximal electroshock (MES) and picrotoxin-induced seizures in rats." | 7.67 | Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats. ( Mehta, AK; Ticku, MK, 1986) |
| "Microinjection of muscimol (406 pmol) into the rat entopeduncular nucleus, the analogue of the primate globus pallidus pars interna, significantly suppressed pilocarpine but not maximal electroshock seizures in a spatially specific manner." | 7.67 | Microinjection of muscimol into entopeduncular nucleus suppresses pilocarpine but not maximal electroshock seizures in rats. ( Hosford, DA; McNamara, JO, 1988) |
| "Intraperitoneal injection of ethanol (1-2 g/kg) and chlordiazepoxide (2-16 mg/kg) suppressed susceptibility to audiogenically induced, clonic-tonic seizures and antagonized forelimb tremor in rats undergoing ethanol withdrawal, 30 min after treatment." | 7.66 | Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. ( Breese, GR; Frye, GD; McCown, TJ, 1983) |
| "Muscimol has potent antiepileptic efficacy after transmeningeal administration in animals." | 5.37 | Transmeningeal muscimol can prevent focal EEG seizures in the rat neocortex without stopping multineuronal activity in the treated area. ( Artan, NS; Baptiste, SL; Darisi, S; Devinsky, O; French, JA; Kuzniecky, RI; Ludvig, N; Medveczky, G; Mirowski, P; Tang, HM, 2011) |
| "Its involvement in control of tonic-clonic seizures is contradictory." | 5.33 | Sex-specific control of flurothyl-induced tonic-clonic seizures by the substantia nigra pars reticulata during development. ( Giorgi, FS; Moshé, SL; Velísek, L; Velísková, J, 2006) |
| "Procyclidine and propofol were considered as the most relevant double regimen to replace a previous triple regimen (procyclidine, diazepam, pentobarbital) against soman-induced seizures." | 5.33 | Pharmacological therapies against soman-induced seizures in rats 30 min following onset and anticonvulsant impact. ( Aas, P; Enger, S; Myhrer, T, 2006) |
| "In mice, tonic convulsive seizure induced by intravenous administration of caffeine (adenosine A1, A2 receptors antagonist) was significantly potentiated by any one of L-PIA (adenosine A1 receptor agonist), NECA (adenosine A2 receptor agonist) and 2-ClAd (adenosine A1, A2 receptors agonist)." | 5.28 | [Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice]. ( Inano, S, 1992) |
| "The substantia nigra has been identified as a critical site at which gamma-aminobutyric acid (GABA) agonist drugs act to reduce susceptibility to a number of types of experimentally induced generalized seizures." | 4.77 | Mechanisms of seizure control mediated by gamma-aminobutyric acid: role of the substantia nigra. ( Gale, K, 1985) |
| "None of the five drugs was able to suppress potentiation appearing immediately after cortical epileptic afterdischarges, but all of them exhibited delayed anticonvulsant action 10 (in the case of midazolam and muscimol) or 20 min (all three steroids) after cortical seizures." | 3.96 | Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats. ( Kubová, H; Kudová, E; Mareš, P; Valeš, K, 2020) |
| "Seizure-induced release of the neuromodulator adenosine is a potent endogenous anticonvulsant mechanism, which limits the extension of seizures and mediates seizure arrest." | 3.78 | Adenosine release during seizures attenuates GABAA receptor-mediated depolarization. ( Akerman, CJ; Ilie, A; Raimondo, JV, 2012) |
| "Previous studies have demonstrated that kainic acid (KA)-induced seizures can cause the enhancement of excitation and lead to neuronal death in rat hippocampus." | 3.78 | Neuroprotection of co-activation of GABA receptors by preventing caspase-3 denitrosylation in KA-induced seizures. ( Li, C; Wei, XW; Wu, YP; Xu, B; Yan, H; Zhang, GY, 2012) |
| "Periodic transmeningeal administration of muscimol into the neocortical epileptogenic zone via a subdurally implanted device has been proposed for the treatment of intractable focal neocortical epilepsy." | 3.77 | Periodic transmeningeal muscimol maintains its antiepileptic efficacy over three weeks without inducing tolerance, in rats. ( Devinsky, O; French, JA; Kuzniecky, RI; Ludvig, N; Tang, HM, 2011) |
| "Theophylline-associated convulsions are frequently exacerbated by fever, but the mechanisms behind it are still not completely understood." | 3.77 | Effect of heat exposure on aminophylline-induced convulsions in mice. ( Araki, H; Kawasaki, H; Ochi, R; Suemaru, K; Takechi, K; Watanabe, S; Yamaguchi, T, 2011) |
| "Results from studies based on microinfusions into seizure controlling brain sites (area tempestas, medial septum, perirhinal cortex, posterior piriform cortex) have shown that procyclidine, muscimol, caramiphen, and NBQX, but not ketamine, exert anticonvulsant effects against soman-induced seizures." | 3.77 | Enhanced efficacy of anticonvulsants when combined with levetiracetam in soman-exposed rats. ( Aas, P; Enger, S; Jonassen, M; Myhrer, T, 2011) |
| "Past work has demonstrated that kainic acid (KA)-induced seizures could cause the enhancement of excitation and lead to neuronal death in rat hippocampus." | 3.76 | Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizure. ( Han, D; Li, C; Pei, DS; Wang, WW; Xu, B; Yu, HM; Yu, XJ; Zhang, GY; Zhu, J, 2010) |
| " The results showed that in the PRC anticonvulsant efficacy against soman-induced seizures (subcutaneously administered) was achieved by procyclidine or NBQX, but not by ketamine, scopolamine, caramiphen, or muscimol (Experiment 1)." | 3.76 | Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman. ( Aas, P; Enger, S; Myhrer, T, 2010) |
| "This study compared the potencies of epidurally delivered muscimol, lidocaine, midazolam, pentobarbital and gamma-aminobutyric acid (GABA) to prevent focal neocortical seizures induced by locally applied acetylcholine (Ach), in rats (n=5)." | 3.76 | Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats. ( Baptiste, SL; Devinsky, O; French, JA; Kuzniecky, RI; Ludvig, N; Tang, HM, 2010) |
| " We investigate whether microinjections of GABAergic agonists into the AN were protective against pilocarpine-induced generalized seizures and status epilepticus (SE)." | 3.76 | Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus. ( Andrade, D; Bittencourt, S; Covolan, L; Dubiela, FP; Hamani, C; Lozano, A; Mello, LE; Queiroz, C, 2010) |
| "To determine whether muscimol delivered epidurally or into the subarachnoid space can prevent and/or terminate acetylcholine (Ach)-induced focal neocortical seizures at concentrations not affecting behavior and background electroencephalography (EEG) activity." | 3.75 | Localized transmeningeal muscimol prevents neocortical seizures in rats and nonhuman primates: therapeutic implications. ( Baptiste, SL; Charchaflieh, J; Devinsky, O; Kuzniecky, RI; Ludvig, N; Medveczky, G; Tang, HM; von Gizycki, H, 2009) |
| "Methylmalonic acid (MMA) is an endogenous convulsing compound that accumulates in methylmalonic acidemia, an inborn error of the metabolism characterized by severe neurological dysfunction, including seizures." | 3.74 | Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients? ( Fighera, MR; Garrido-Sanabria, ER; Malfatti, CR; Mello, CF; Muller, AP; Paquetti, L; Perry, ML; Rigo, FK; Schweigert, ID, 2007) |
| "This work aims to describe behavioral/electroencephalographic (EEG) seizures induced by bicuculline microinjection intracerebroventricularly (ICV) and in the dorsal hippocampal formation (DHF) or ventral hippocampal formation/amygdala area (VHF-AMY)." | 3.72 | Behavioral effects of bicuculline microinjection in the dorsal versus ventral hippocampal formation of rats, and control of seizures by nigral muscimol. ( Beleboni, Rde O; Coutinho-Netto, J; dos Santos, WF; Garcia-Cairasco, N; Rodrigues, MC, 2004) |
| "1-10 nmol; direct GABA(A) agonist); (3) YM90K (3-10 mg/kg; AMPA receptor antagonist); and (4) diazepam (2 and 5 mg/kg) and carbamazepine (5 and 20 mg/kg), two standard anticonvulsants, using the partially-kindled hippocampal model for epileptic seizures in freely moving rats." | 3.70 | Acute effects of various GABA receptor agonists and glutamate antagonists on focal hippocampal seizures in freely moving rats elicited by low-frequency stimulation. ( Ashby, CR; Katsumori, H; Minabe, Y; Osawa, M, 1998) |
| "The effects of drugs affecting GABA and glutamic acid receptors on theophylline-induced seizures were investigated in mice." | 3.70 | Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice. ( Amabeoku, GJ, 1999) |
| " We tested this hypothesis by examining the influence of gamma-aminobutyric acid (GABA) ergic and glutamatergic transmission in the NTS on seizures evoked by systemic and focal bicuculline and systemic pentylenetetrazol (PTZ) in rats." | 3.70 | Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius. ( Easton, A; Gale, K; Walker, BR, 1999) |
| " The gamma-aminobutyric acid(A) receptor agonist, muscimol, potentiated ketamine-induced anesthesia." | 3.70 | Evidence for GABA(A) receptor agonistic properties of ketamine: convulsive and anesthetic behavioral models in mice. ( Dohi, T; Irifune, M; Kamata, Y; Kawahara, M; Nishikawa, T; Sato, T, 2000) |
| "The effects of GABAmimetic drugs on inhibition of amygdaloid kindled seizures induced by clobenpropit were investigated to clarify the relationship between histaminergic and GABAergic systems in seizures." | 3.70 | Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures. ( Chen, Z; Fujii, Y; Ishizawa, K; Kamei, C; Okuma, C; Sugimoto, Y, 2000) |
| " The anesthesia induced by 1-amino-5-bromouracil was potentiated by diazepam, pentobarbital, and muscimol, and was antagonized by picrotoxin but not by bicuculline." | 3.69 | Effects of 1-amino-5-bromouracil on the benzodiazepine-GABAA receptor complex. ( Imaizumi, M; Machida, H; Miyazaki, S, 1994) |
| " The effects of some GABAergic and dopaminergic agents on pyrimethamine-induced tonic seizures were investigated in mice." | 3.69 | GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice. ( Amabeoku, G; Chikuni, O, 1994) |
| " The GABAA receptor agonist, muscimol (390 pmol) was microinjected unilaterally into the posterior piriform cortex and adjacent regions in the same hemisphere from which seizures were evoked by focal application of bicuculline into AT." | 3.69 | Posterior piriform and perirhinal cortex relay seizures evoked from the area tempestas: role of excitatory and inhibitory amino acid receptors. ( Gale, K; Halonen, T; Tortorella, A; Zrebeet, H, 1994) |
| " Here, using this method we examined the anatomical locations of muscimol-induced absence seizures in the rat forebrain." | 3.69 | Fos oncoprotein expression in the rat forebrain following muscimol-induced absence seizures. ( Ju, G; Le Gal La Salle, G; Ridoux, V; Yu, PH; Zhang, X, 1996) |
| "The effects of muscimol, aminooxyacetic acid (AOAA), diamino-n-butyric acid (DABA), baclofen, bicuculline, picrotoxin, strychnine, diazepam, phenobarbitone and phenytoin on cimetidine-induced seizures were studied in mice." | 3.68 | Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents. ( Amabeoku, GJ; Chikuni, O, 1993) |
| "The effects of some GABAergic agents on seizures induced by quinine were studied in mice." | 3.68 | Effects of some GABAergic agents on quinine-induced seizures in mice. ( Amabeoku, GJ; Chikuni, O, 1992) |
| "The binding of 3H-muscimol and 3H-diazepam to rat striatum membranes after picrotoxin- and bicuculline-induced seizures was characterized." | 3.68 | [Effects of GABA antagonist-induced seizures on 3H-muscimol and 3H-diazepam binding in the rat striatum]. ( Golovko, AI; Sofronov, GA, 1992) |
| " The influence of some GABAergic agents on tonic seizures elicited by chloroquine was investigated in mice." | 3.68 | Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice. ( Amabeoku, G, 1992) |
| " Similarly, following pretreatment with intranigral isoniazid, neither severity nor latency to onset of seizures elicited by systemic injection of kainic acid (9 mg/kg) were modified." | 3.68 | Lack of proconvulsant action of GABA depletion in substantia nigra in several seizure models. ( Gale, K; Maggio, R; Sohn, E, 1991) |
| "Medetomidine, a new selective alpha 2-adrenoceptor agonist, potentiated bicuculline seizures in mice." | 3.68 | The effect of medetomidine on GABA and benzodiazepine receptors in vivo: lack of anxiolytic but some evidence of possible stress-protective activity. ( Airaksinen, MM; MacDonald, E; Rägo, L; Saano, V, 1991) |
| " Injections of the GABAA-agonist piperidine-4-sulfonic acid and the GABAB-agonist (-)baclofen in the CeM markedly facilitated myoclonic and clonic seizures, but had different effects on tonic seizures." | 3.68 | The central medial nucleus: thalamic site of seizure regulation. ( Ferrendelli, JA; Miller, JW, 1990) |
| "Involvement of the GABAergic nigro-collicular pathway in the control of audiogenic seizures was examined in genetically sensitive rats by studying the effects of bilateral injections into the substantia nigra of muscimol, a gamma-Aminobutyric acid (GABA) agonist, and those of bilateral injections into the superior colliculus of picrotoxin, a GABA antagonist, and of muscimol." | 3.68 | The GABAergic nigro-collicular pathway is not involved in the inhibitory control of audiogenic seizures in the rat. ( Depaulis, A; Liu, Z; Marescaux, C; Vergnes, M, 1990) |
| " Muscimol potently inhibited the seizures and reversed increases in cell firing elicited by Ro 5-4864." | 3.67 | Electrophysiological and pharmacological actions of the convulsant benzodiazepine Ro 5-4864. ( Cott, J; Hommer, D; Paul, S; Skolnick, P; Weissman, BA, 1984) |
| " Of amino-gamma-carbolines, Trp-P-1 antagonized the suppressive effect of diazepam on the pentylenetetrazol-induced convulsions and death, whereas Trp-P-2 by itself precipitated seizures and death in male mice." | 3.67 | Inhibition of benzodiazepine and GABA receptor binding by amino-gamma-carbolines and other amino acid pyrolysate mutagens. ( Kato, R; Muraki, T; Yamazoe, Y, 1984) |
| "25 mg/kg produced partial protection against 3-mercaptopropionic acid (MPA)-induced seizures." | 3.67 | Synergistic anticonvulsant effects of a GABA agonist and glycine. ( Sarhan, S; Seiler, N, 1984) |
| "Two strains of mice were shown to possess a differential sensitivity to picrotoxinin-induced convulsions; picrotoxinin elicited both tonic and clonic seizures at lower doses in the DBA/2J (DBA) strain compared to the BALB/c ByJ (BALB) strain." | 3.67 | Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding. ( Paul, SM; Schwartz, RD; Seale, TW; Skolnick, P, 1989) |
| " We determined the role of gamma-aminobutyric acid (GABA)ergic activity of the SN and the target sites of SN efferents, the pedunculopontine nucleus (PPN) and superior colliculus (SC), in pentylenetetrazol-induced seizures in rats." | 3.67 | The role of the nigrotegmental GABAergic pathway in the propagation of pentylenetetrazol-induced seizures. ( Nagaya, H; Negishi, N; Okada, R, 1989) |
| "The effects of three specific GABA receptor agonists, muscimol, progabide, and gaboxadol, on kindled seizures were evaluated in amygdala-kindled rats." | 3.67 | Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats. ( Löscher, W; Schwark, WS, 1985) |
| "Motor limbic seizures occur following a systemic injection of pilocarpine (380 mg/kg) in rats." | 3.67 | 2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats. ( Meldrum, BS; Mello, LM; Millan, MH; Patel, S, 1986) |
| "Repeated administration of the beta-carboline benzodiazepine receptor ligand FG 7142 produces sensitization to its effects so that full seizures develop (chemical kindling); initially it is only pro-convulsant." | 3.67 | The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142. ( Little, HJ; Nutt, DJ; Taylor, SC, 1986) |
| "Pentobarbital and phenobarbital exhibited anticonvulsant effect against maximal electroshock (MES) and picrotoxin-induced seizures in rats." | 3.67 | Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats. ( Mehta, AK; Ticku, MK, 1986) |
| "The effects of intraamygdala injections of either gamma-vinyl GABA or muscimol on the behavioral and electrographic expression of stable, fully generalized, kindled seizures were assessed." | 3.67 | Microinjections of GABA agonists into the amygdala complex attenuates kindled seizure expression in the rat. ( Applegate, CD; Burchfiel, JL, 1988) |
| "Microinjection of muscimol (406 pmol) into the rat entopeduncular nucleus, the analogue of the primate globus pallidus pars interna, significantly suppressed pilocarpine but not maximal electroshock seizures in a spatially specific manner." | 3.67 | Microinjection of muscimol into entopeduncular nucleus suppresses pilocarpine but not maximal electroshock seizures in rats. ( Hosford, DA; McNamara, JO, 1988) |
| "Microinjection of 2-amino-phosphonoheptanoic acid (2APH, 1 nmol), and antagonist for n-methyl-d-aspartate-sensitive receptors, into the deep prepiriform cortex (DPC) of the rat, prevented seizures induced by the intravenous administration of bicuculline." | 3.67 | Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid and muscimol in the deep prepiriform cortex. ( Gale, K; Piredda, S, 1986) |
| " The onset of generalized seizures induced by isoniazid (800 mg/kg) or by thiosemicarbazide (64 mg/kg) i." | 3.66 | Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats. ( Hamon, M; Hery, F; Jobert, A; Montastruc, JL; Soubrie, P; Thiebot, MH, 1980) |
| "Intraperitoneal injection of ethanol (1-2 g/kg) and chlordiazepoxide (2-16 mg/kg) suppressed susceptibility to audiogenically induced, clonic-tonic seizures and antagonized forelimb tremor in rats undergoing ethanol withdrawal, 30 min after treatment." | 3.66 | Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors. ( Breese, GR; Frye, GD; McCown, TJ, 1983) |
| " Blockade of tonic hindlimb extension in the maximal electroshock test and blockade of tonic and clonic seizures produced by pentylenetetrazole and bicuculline were obtained by elevating GABA in the ventral midbrain tegmentum." | 3.66 | Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid. ( Gale, K; Iadarola, MJ, 1982) |
| " Taurine, an inhibitory non-GABA-mimetic amino acid, and muscimol (another direct GABA-agonist) reduced the number of seizures and lesions in the brain but were less effective than homotaurine." | 3.66 | Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. ( Fariello, RG; Golden, GT; Pisa, M, 1982) |
| "This increased seizure susceptibility may be due to a functional immaturity of a substantia nigra, GABA-sensitive output system." | 2.37 | Epileptogenesis and the immature brain. ( Moshé, SL, 1987) |
| "Muscimol has been used to increase our knowledge of central GABAergic systems, CNS physiology, and behavior." | 2.36 | Physiological and behavioral studies with muscimol. ( DeFeudis, FV, 1980) |
| "The high incidence of epileptic seizures in neonates and their frequent refractoriness to pharmacologic therapies require identification of new therapeutical options." | 1.51 | Taurine potentiates the anticonvulsive effect of the GABA ( Kilb, W; Luhmann, HJ; Winkler, P, 2019) |
| "Muscimol infusion to inactivate the mid-septotemporal hippocampus, as compared to saline infusion, significantly decreased the peak frequency of the PDs induced by GBL, decreased 30-120 Hz hippocampal gamma power, and hastened the transition of PDs to 1-2 Hz slow waves." | 1.43 | The hippocampus participates in a pharmacological rat model of absence seizures. ( Arcaro, J; Chu, L; Kuo, M; Ma, J; Mirsattari, SM; Stan Leung, L, 2016) |
| "Muscimol was administered in doses from 0." | 1.40 | Anticonvulsant and behavioral effects of muscimol in immature rats. ( Mareš, P; Mikulecká, A; Tichá, K, 2014) |
| "How the brain transitions into a seizure is poorly understood." | 1.38 | Transition to seizure: ictal discharge is preceded by exhausted presynaptic GABA release in the hippocampal CA3 region. ( Carlen, PL; Florez, CM; Koifman, J; Shin, DS; Valiante, TA; Ye, H; Zhang, L; Zhang, ZJ, 2012) |
| "Long-term, periodic, transmeningeal muscimol delivery with the SPD is essentially a safe procedure." | 1.38 | Long-term behavioral, electrophysiological, and neurochemical monitoring of the safety of an experimental antiepileptic implant, the muscimol-delivering Subdural Pharmacotherapy Device in monkeys. ( Baptiste, SL; Carlson, C; Devinsky, O; French, JA; Kuzniecky, RI; Ludvig, N; Medveczky, G; Stefanov, DG; Tang, HM; Vaynberg, JK; Vazquez-DeRose, J, 2012) |
| "Muscimol has potent antiepileptic efficacy after transmeningeal administration in animals." | 1.37 | Transmeningeal muscimol can prevent focal EEG seizures in the rat neocortex without stopping multineuronal activity in the treated area. ( Artan, NS; Baptiste, SL; Darisi, S; Devinsky, O; French, JA; Kuzniecky, RI; Ludvig, N; Medveczky, G; Mirowski, P; Tang, HM, 2011) |
| "The pSC has proconvulsant audiogenic seizure activity in Wistar audiogenic rats." | 1.37 | Behavioral and EEG effects of GABAergic manipulation of the nigrotectal pathway in the Wistar audiogenic rat strain. ( de Oliveira, JA; Garcia-Cairasco, N; Rodrigues, MC; Rossetti, F, 2011) |
| "In addition, seizure onset and propagation are difficult to determine in vivo in ACC." | 1.37 | Spatiotemporal organization and thalamic modulation of seizures in the mouse medial thalamic-anterior cingulate slice. ( Chang, WP; Lee, CM; Shyu, BC; Vogt, BA; Wu, JS, 2011) |
| "muscimol (1 mg/kg) blocked the convulsions induced by bicuculline, but not those induced by NMDA at 3 mg/kg." | 1.34 | Involvement of NMDA receptors in thiopental-induced loss of righting reflex, antinociception and anticonvulsion effects in mice. ( Cui, GX; Da, TJ; Ge, ZJ; Liu, GJ; Tan, YF; Wang, JK; Zeng, YM; Zhang, LC; Zhao, YP, 2007) |
| "Effects of hyperthermia-induced seizures (HS) on GABAA and benzodiazepine (BDZ) receptor binding in immature rat brain were evaluated using in vitro autoradiography." | 1.33 | Hyperthermia-induced seizures modify the GABAA and benzodiazepine receptor binding in immature rat brain. ( Feria, A; González-Ramírez, M; Orozco, S; Rocha, L; Salgado, H, 2005) |
| "Its involvement in control of tonic-clonic seizures is contradictory." | 1.33 | Sex-specific control of flurothyl-induced tonic-clonic seizures by the substantia nigra pars reticulata during development. ( Giorgi, FS; Moshé, SL; Velísek, L; Velísková, J, 2006) |
| "Procyclidine and propofol were considered as the most relevant double regimen to replace a previous triple regimen (procyclidine, diazepam, pentobarbital) against soman-induced seizures." | 1.33 | Pharmacological therapies against soman-induced seizures in rats 30 min following onset and anticonvulsant impact. ( Aas, P; Enger, S; Myhrer, T, 2006) |
| "P(2)X(7) receptor immunoreactivity in seizure-resistant (SR) gerbils was similar to that in pre-seizure group of seizure-sensitive (SS) gerbils." | 1.32 | GABA(B) receptor-mediated regulation of P2X7 receptor expression in the gerbil hippocampus. ( An, SJ; Hwang, IK; Kang, TC; Park, SK; Won, MH, 2004) |
| "Using flurothyl to induce clonic seizures, it was reported that bilateral microinfusions of muscimol into the anterior substantia nigra pars reticulata were anticonvulsant, while similar infusions into the posterior pars reticulata were proconvulsant." | 1.31 | Lack of robust anticonvulsant effects of muscimol microinfusions in the anterior substantia nigra of kindled rats. ( Gernert, M; Löscher, W, 2001) |
| "Tonic-clonic convulsions appeared only when the motor cerebral cortex was involved." | 1.31 | Comparative study of the epileptogenic effect of kainic acid injected into the cerebral cortex, hippocampus and amygdala in adult cats chronically implanted. ( Cartier, L; Infante, C; Motles, E, 2002) |
| "Convulsions were prevented by intrastriatal preinjection of muscimol." | 1.30 | Pharmacological evidence for GABAergic and glutamatergic involvement in the convulsant and behavioral effects of glutaric acid. ( Begnini, J; de Bastiani, J; de Mello, CF; Fialho, DB; Jurach, A; Lima, TT; Ribeiro, MC; Wajner, M, 1998) |
| "Limbic motor seizures in animals, analogous to complex partial seizures in humans, result in a consistent activation of the mediodorsal thalamus (MD) and, with prolonged seizures, damage to MD." | 1.30 | Mediodorsal thalamus plays a critical role in the development of limbic motor seizures. ( Cassidy, RM; Gale, K, 1998) |
| "Bicuculline plus cyclosporine-induced convulsions were significantly suppressed by an activation of GABAergic transmission with diazepam, phenobarbital and valproate." | 1.30 | Inhibition of GABA system involved in cyclosporine-induced convulsions. ( Fujisaki, K; Fujiwara, M; Kataoka, Y; Miura, I; Nakao, T; Oishi, R; Shuto, H; Sueyasu, M; Watanabe, Y, 1999) |
| " In the mouse pentylenetetrazole (PTZ) convulsive model, intravenous pretreatment with cefazolin (800 mg/kg) or imipenem (200 mg/kg) shifted the dose-response curve of PTZ (i." | 1.30 | Low convulsive activity of a new carbapenem antibiotic, DK-35C, as compared with existing congeners. ( Cho, JH; Jin, C; Jung, I; Kim, DH; Kim, M; Ku, HJ; Oh, CH; Yook, J, 1999) |
| " In the flurothyl seizure model, SNR microinjection of the selective GABAA receptor agonist muscimol results in a biphasic dose-response curve in adults: Intermediate doses are anticonvulsant, but high doses have proconvulsant effects." | 1.29 | Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions. ( Garant, DS; Moshé, SL; Sperber, EF; Xu, SG, 1995) |
| "In contrast, ofloxacin caused no convulsions even at 100 mg/kg, the highest dose tested." | 1.29 | Quantitation of GABAA receptor inhibition required for quinolone-induced convulsions in mice. ( Akahane, K; Matsubayashi, K; Tsutomi, Y, 1994) |
| ", significantly lowered the convulsive threshold of pentylenetetrazol (PTZ) in mice and shifted the dose-response curve of PTZ." | 1.29 | Correlation between in vitro and in vivo models of proconvulsive activity with the carbapenem antibiotics, biapenem, imipenem/cilastatin and meropenem. ( Day, IP; Goudie, J; Nishiki, K; Williams, PD, 1995) |
| "Laudanosine was almost ineffective at [3H]muscimol binding to high-affinity GABA receptors (IC50 = 100 microM)." | 1.29 | Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity. ( Fonia, O; Gavish, M; Katz, Y; Liu, L; Pasternak, GW; Pick, CG; Weizman, A, 1994) |
| "In mice, tonic convulsive seizure induced by intravenous administration of caffeine (adenosine A1, A2 receptors antagonist) was significantly potentiated by any one of L-PIA (adenosine A1 receptor agonist), NECA (adenosine A2 receptor agonist) and 2-ClAd (adenosine A1, A2 receptors agonist)." | 1.28 | [Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice]. ( Inano, S, 1992) |
| " In the present study, we determined, in rat pups, the effect of nigral infusions of gamma-vinyl-GABA (GVG) on clonic-tonic seizures induced by flurothyl, generated a dose-response curve of the GVG effect and investigated the possible role of the nigral GABAA receptor in mediating the GVG effect." | 1.28 | Is the anticonvulsant effect of substantia nigra infusion of gamma-vinyl-GABA (GVG) mediated by the GABAA receptor in rat pups? ( Moshé, SL; Sperber, EF; Xu, SG, 1991) |
| "The effects of acute and chronic administration of a subconvulsive dose of picrotoxin on t-[35S]butylbicyclophosphorothionate ([3S]TBPS), [3H]muscimol, and [3H]flunitrazepam binding characteristics in various regions and on the convulsant potency of picrotoxin in Sprague-Dawley rats were examined." | 1.28 | Effects of picrotoxin treatment on GABAA receptor supramolecular complexes in rat brain. ( Ho, IK; Ito, Y; Lim, DK; Nabeshima, T, 1989) |
| "Baclofen infusions were found to have no effect on seizures." | 1.28 | Evidence for the involvement of nigral GABAA receptors in seizures of adult rats. ( Moshé, SL; Sperber, EF; Wurpel, JN; Zhao, DY, 1989) |
| "The data indicate that seizures evoked from the AT of one hemisphere are susceptible to suppression by inhibition in the SN, but only when the inhibition occurs in the SN of both hemispheres." | 1.28 | Seizures evoked from area tempestas are subject to control by GABA and glutamate receptors in substantia nigra. ( Gale, K; Maggio, R, 1989) |
| "Audiogenic seizures were suppressed for at least 3 hr after muscimol (30 ng)." | 1.27 | Characterization of susceptibility to audiogenic seizures in ethanol-dependent rats after microinjection of gamma-aminobutyric acid (GABA) agonists into the inferior colliculus, substantia nigra or medial septum. ( Breese, GR; Frye, GD; McCown, TJ, 1983) |
| "This diazepam-elicited increase in Bmax is blocked in mice receiving the diazepam antagonist Ro 15-1788 (ethyl-8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5a]-[1,4] benzodiazepine-3-carboxylate)." | 1.27 | Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam. ( Costa, E; Ferrero, P; Guidotti, A, 1984) |
| "Seizures were markedly suppressed in animals with bilateral destruction of the SN but not in animals in which the SN was spared bilaterally." | 1.27 | Evidence implicating substantia nigra in regulation of kindled seizure threshold. ( Galloway, MT; McNamara, JO; Rigsbee, LC; Shin, C, 1984) |
| "Haloperidol pretreatment prevents stereotyped behaviour induced by 2-amino-7-phosphonoheptanoic acid, but does not change the effect on the electroshock test." | 1.27 | Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra. ( De Sarro, G; Meldrum, BS; Reavill, C, 1984) |
| "The onset of tremors and convulsions, which occur as pressure is increased, were used as endpoints for assessing the onset and severity of the HPNS." | 1.27 | Interactions of gamma-aminobutyric acid and noradrenaline in the high pressure neurological syndrome. ( Angel, A; Halsey, MJ; Wardley-Smith, B, 1983) |
| "Amygdaloid kindled generalized convulsion was reversibly blocked despite continued afterdischarge generation by amygdaloid stimulation for about 60 h following intracerebral administration of gabaculine, a GABA-transaminase inhibitor, into the substantia innominata (SI) ipsilateral to the side of amygdaloid kindling." | 1.27 | Reversible suppression of amygdaloid kindled convulsion following unilateral gabaculine injection into the substantia innominata. ( Okamoto, M; Wada, JA, 1984) |
| "This result indicates that while the seizure-suppressant effect of intranigral GVG requires alpha 2-mediated NE neurotransmission, the mechanism of this anticonvulsant action is not by increasing NE neuronal activity." | 1.27 | Anticonvulsant action of intranigral gamma-vinyl-GABA: role of nonadrenergic neurotransmission. ( Bonhaus, DW; McNamara, JO, 1988) |
| "The effects of chronic cortical seizures on the autoradiographic distributions of two markers of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor--chloride ionophore complex within local and long circuits connected to the focus were examined." | 1.27 | Effects of chronic cortical seizures on GABA and benzodiazepine receptors within seizure pathways. ( Collins, RC; Santori, EM, 1988) |
| "We have used limbic convulsions induced by systemic pilocarpine in rats combined with focal intracerebral injections concurrently to study the initiation and spread of seizure activity." | 1.27 | Decrease in excitatory transmission within the lateral habenula and the mediodorsal thalamus protects against limbic seizures in rats. ( Meldrum, BS; Millan, MH; Patel, S, 1988) |
| "Using a model in which seizure activity was elicited electrically from the inferior colliculus, the influence of both inhibitory and excitatory putative neurotransmitter amino acids on this seizure activity was assessed by manipulating neurotransmitter amino acid function." | 1.27 | Amino acid influences on seizures elicited within the inferior colliculus. ( Breese, GR; Givens, BS; McCown, TJ, 1987) |
| "Sensitivity to flurothyl-induced seizures was also strain dependent, but the rank order of sensitivity was different than for MP." | 1.27 | Genetic influences on GABA-related seizures. ( Gaffney, D; Marley, RJ; Wehner, JM, 1986) |
| "Both electroshock and kindled seizures were studied." | 1.27 | Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol. ( Bonhaus, DW; Butler, LS; McNamara, JO; Platt, K, 1987) |
| "Striatal function in partial seizure development induced by low frequency cortical stimulation of the ipsilateral premotor cortex was investigated by either electrolytic lesion placement or microinjection of putative neurotransmitter-related drugs into the ipsilateral striatum." | 1.27 | A role of the striatum in premotor cortical seizure development. ( Baba, H; Mori, K; Ono, K; Wada, JA, 1987) |
| " Bilateral nigral infusions of muscimol markedly facilitated the development of flurothyl seizures in a dose-response manner and differed significantly from the vehicle controls or rats infused with muscimol dorsally to the substantia nigra." | 1.27 | Age-related substantia nigra-mediated seizure facilitation. ( Moshe, SL; Okada, R; Sperber, EF; Wong, BY; Zhao, DY, 1986) |
| "Electrographic seizures started 1-10 min after unilateral injections of large doses of bicuculline and pictrotoxin (2-4 nmol)." | 1.27 | Injections of picrotoxin and bicuculline into the amygdaloid complex of the rat: an electroencephalographic, behavioural and morphological analysis. ( Calderazzo-Filho, LS; Cavalheiro, EA; Czuczwar, SJ; Kleinrok, Z; Turski, L; Turski, WA, 1985) |
| "Muscimol is a potent agonist at GABA-inhibitory synapses in mammalian brain." | 1.26 | Anticonvulsant effects of muscimol. ( Collins, RC, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 73 (40.56) | 18.7374 |
| 1990's | 52 (28.89) | 18.2507 |
| 2000's | 33 (18.33) | 29.6817 |
| 2010's | 19 (10.56) | 24.3611 |
| 2020's | 3 (1.67) | 2.80 |
| Authors | Studies |
|---|---|
| Nakada, K | 1 |
| Yoshikawa, M | 1 |
| Ide, S | 1 |
| Suemasa, A | 1 |
| Kawamura, S | 1 |
| Kobayashi, T | 1 |
| Masuda, E | 1 |
| Ito, Y | 2 |
| Hayakawa, W | 1 |
| Katayama, T | 1 |
| Yamada, S | 1 |
| Arisawa, M | 1 |
| Minami, M | 1 |
| Shuto, S | 1 |
| Gernert, M | 2 |
| MacKeigan, D | 1 |
| Deking, L | 1 |
| Kaczmarek, E | 1 |
| Feja, M | 1 |
| Ajaz, R | 1 |
| Mousavi, SR | 1 |
| Mirsattari, SM | 2 |
| Leung, LS | 3 |
| Mareš, P | 2 |
| Kudová, E | 1 |
| Valeš, K | 1 |
| Kubová, H | 1 |
| Winkler, P | 1 |
| Luhmann, HJ | 1 |
| Kilb, W | 1 |
| Tichá, K | 1 |
| Mikulecká, A | 1 |
| Arcaro, J | 1 |
| Ma, J | 3 |
| Chu, L | 1 |
| Kuo, M | 1 |
| Stan Leung, L | 1 |
| Rebrov, IG | 1 |
| Karpova, MN | 1 |
| Andreev, AA | 1 |
| Klishina, NY | 1 |
| Kalinina, MV | 1 |
| Kusnetzova, LV | 1 |
| Kim, DY | 1 |
| Fenoglio, KA | 1 |
| Kerrigan, JF | 1 |
| Rho, JM | 1 |
| Ludvig, N | 5 |
| Baptiste, SL | 4 |
| Tang, HM | 5 |
| Medveczky, G | 3 |
| von Gizycki, H | 1 |
| Charchaflieh, J | 1 |
| Devinsky, O | 5 |
| Kuzniecky, RI | 5 |
| Li, C | 2 |
| Xu, B | 2 |
| Wang, WW | 1 |
| Yu, XJ | 1 |
| Zhu, J | 1 |
| Yu, HM | 1 |
| Han, D | 1 |
| Pei, DS | 1 |
| Zhang, GY | 2 |
| Myhrer, T | 4 |
| Enger, S | 4 |
| Aas, P | 4 |
| French, JA | 4 |
| Bittencourt, S | 1 |
| Dubiela, FP | 1 |
| Queiroz, C | 1 |
| Covolan, L | 1 |
| Andrade, D | 1 |
| Lozano, A | 1 |
| Mello, LE | 1 |
| Hamani, C | 1 |
| Sloan, DM | 1 |
| Zhang, D | 1 |
| Bertram, EH | 2 |
| Artan, NS | 1 |
| Mirowski, P | 1 |
| Darisi, S | 1 |
| Ochi, R | 1 |
| Suemaru, K | 1 |
| Watanabe, S | 1 |
| Yamaguchi, T | 1 |
| Takechi, K | 1 |
| Kawasaki, H | 1 |
| Araki, H | 1 |
| Jonassen, M | 1 |
| Rossetti, F | 1 |
| Rodrigues, MC | 2 |
| de Oliveira, JA | 1 |
| Garcia-Cairasco, N | 2 |
| Chang, WP | 1 |
| Wu, JS | 1 |
| Lee, CM | 1 |
| Vogt, BA | 1 |
| Shyu, BC | 1 |
| Zhang, ZJ | 1 |
| Koifman, J | 1 |
| Shin, DS | 1 |
| Ye, H | 1 |
| Florez, CM | 1 |
| Zhang, L | 1 |
| Valiante, TA | 1 |
| Carlen, PL | 1 |
| Ilie, A | 1 |
| Raimondo, JV | 1 |
| Akerman, CJ | 1 |
| Vaynberg, JK | 1 |
| Vazquez-DeRose, J | 1 |
| Stefanov, DG | 1 |
| Carlson, C | 1 |
| Wei, XW | 1 |
| Yan, H | 1 |
| Wu, YP | 1 |
| Kralic, JE | 2 |
| Korpi, ER | 1 |
| O'Buckley, TK | 2 |
| Homanics, GE | 2 |
| Morrow, AL | 2 |
| Verleye, M | 1 |
| Pansart, Y | 1 |
| Gillardin, J | 1 |
| Khisti, RT | 1 |
| Hodge, CW | 1 |
| Kang, TC | 2 |
| Park, SK | 1 |
| Hwang, IK | 1 |
| An, SJ | 1 |
| Won, MH | 2 |
| Beleboni, Rde O | 1 |
| Coutinho-Netto, J | 1 |
| dos Santos, WF | 1 |
| Shen, B | 1 |
| Rajakumar, N | 1 |
| Kwak, SE | 1 |
| Kim, JE | 1 |
| Kim, DS | 1 |
| Jung, JY | 1 |
| Kwon, OS | 1 |
| Choi, SY | 1 |
| Stewart, LS | 1 |
| González-Ramírez, M | 1 |
| Orozco, S | 1 |
| Salgado, H | 1 |
| Feria, A | 1 |
| Rocha, L | 1 |
| Fighera, MR | 2 |
| Royes, LF | 1 |
| Furian, AF | 1 |
| Oliveira, MS | 1 |
| Fiorenza, NG | 1 |
| Frussa-Filho, R | 1 |
| Petry, JC | 1 |
| Coelho, RC | 1 |
| Mello, CF | 2 |
| Nguyen, NH | 1 |
| Dhir, A | 1 |
| Naidu, PS | 1 |
| Kulkarni, SK | 2 |
| Shehab, SA | 1 |
| Ljubisavljevic, M | 1 |
| Al-Halhali, F | 1 |
| Al-Awadhi, A | 1 |
| Madathil, M | 1 |
| Abdul-Kareem, A | 1 |
| Redgrave, P | 1 |
| Velísek, L | 2 |
| Velísková, J | 4 |
| Giorgi, FS | 1 |
| Moshé, SL | 13 |
| Malfatti, CR | 1 |
| Perry, ML | 1 |
| Schweigert, ID | 1 |
| Muller, AP | 1 |
| Paquetti, L | 1 |
| Rigo, FK | 1 |
| Garrido-Sanabria, ER | 1 |
| Ge, ZJ | 1 |
| Zhang, LC | 1 |
| Zeng, YM | 1 |
| Da, TJ | 1 |
| Wang, JK | 1 |
| Cui, GX | 1 |
| Tan, YF | 1 |
| Zhao, YP | 1 |
| Liu, GJ | 1 |
| Chudomel, O | 1 |
| Poon, KL | 1 |
| Marshall, B | 1 |
| Heida, JG | 1 |
| Zhu, L | 1 |
| Polley, N | 1 |
| Mathews, GC | 1 |
| Delpire, E | 1 |
| Tacke, U | 1 |
| Braestrup, C | 1 |
| Soubrie, P | 1 |
| Thiebot, MH | 1 |
| Jobert, A | 1 |
| Montastruc, JL | 1 |
| Hery, F | 1 |
| Hamon, M | 1 |
| DeFeudis, FV | 1 |
| Iadarola, MJ | 2 |
| Gale, K | 12 |
| Bichard, AR | 1 |
| Little, HJ | 2 |
| Liljequist, S | 1 |
| Engel, J | 1 |
| Frye, GD | 3 |
| McCown, TJ | 4 |
| Breese, GR | 4 |
| Griffiths, R | 2 |
| Williams, DC | 1 |
| O'Neill, C | 1 |
| Dewhurst, IC | 1 |
| Ekuwem, CE | 1 |
| Sinclair, CD | 1 |
| Weissman, BA | 1 |
| Cott, J | 1 |
| Hommer, D | 1 |
| Paul, S | 1 |
| Skolnick, P | 2 |
| Muraki, T | 1 |
| Yamazoe, Y | 1 |
| Kato, R | 1 |
| Ferrero, P | 1 |
| Guidotti, A | 1 |
| Costa, E | 1 |
| Gonzalez, LP | 1 |
| Hettinger, MK | 1 |
| McNamara, JO | 4 |
| Galloway, MT | 1 |
| Rigsbee, LC | 1 |
| Shin, C | 1 |
| Buu, NT | 1 |
| Duhaime, J | 1 |
| Kuchel, O | 1 |
| Seiler, N | 1 |
| Sarhan, S | 1 |
| De Sarro, G | 2 |
| Meldrum, BS | 6 |
| Reavill, C | 1 |
| Angel, A | 1 |
| Halsey, MJ | 1 |
| Wardley-Smith, B | 1 |
| File, SE | 1 |
| Simmonds, MA | 1 |
| Albala, BJ | 1 |
| Okamoto, M | 2 |
| Wada, JA | 3 |
| Ashton, D | 1 |
| Leysen, JE | 1 |
| Wauquier, A | 1 |
| George, ME | 1 |
| Pinkerton, MK | 1 |
| Back, KC | 1 |
| Collins, RC | 2 |
| Fariello, RG | 1 |
| Golden, GT | 1 |
| Pisa, M | 1 |
| Menon, MK | 1 |
| Vivonia, CA | 1 |
| Unnerstall, JR | 1 |
| Pizzi, WJ | 1 |
| Imperato, A | 1 |
| Di Chiara, G | 1 |
| Titulaer, MN | 3 |
| Kamphuis, W | 3 |
| Lopes da Silva, FH | 3 |
| Garant, DS | 4 |
| Xu, SG | 4 |
| Sperber, EF | 8 |
| Koff, JM | 1 |
| Miller, LG | 1 |
| Miyazaki, S | 1 |
| Imaizumi, M | 1 |
| Machida, H | 1 |
| Tsutomi, Y | 2 |
| Matsubayashi, K | 1 |
| Akahane, K | 2 |
| Ammendola, D | 1 |
| Nava, F | 1 |
| De Sarro, A | 1 |
| Obara, N | 1 |
| Ghijsen, WE | 1 |
| De Rijk, TC | 1 |
| Day, IP | 1 |
| Goudie, J | 1 |
| Nishiki, K | 2 |
| Williams, PD | 1 |
| Kimura, Y | 1 |
| Hayakawa, I | 1 |
| Clark, M | 1 |
| Massenburg, GS | 1 |
| Weiss, SR | 1 |
| Post, RM | 1 |
| Amabeoku, G | 2 |
| Chikuni, O | 3 |
| Halonen, T | 1 |
| Tortorella, A | 1 |
| Zrebeet, H | 1 |
| Kapur, J | 2 |
| Lothman, EW | 3 |
| DeLorenzo, RJ | 1 |
| Pool, CW | 1 |
| van Heerikhuize, JJ | 1 |
| Katz, Y | 1 |
| Weizman, A | 1 |
| Pick, CG | 1 |
| Pasternak, GW | 1 |
| Liu, L | 1 |
| Fonia, O | 1 |
| Gavish, M | 1 |
| Amabeoku, GJ | 3 |
| Hikida, M | 1 |
| Masukawa, Y | 1 |
| Inomata, N | 1 |
| Zhang, X | 1 |
| Le Gal La Salle, G | 1 |
| Ridoux, V | 1 |
| Yu, PH | 1 |
| Ju, G | 1 |
| Katsumori, H | 1 |
| Minabe, Y | 1 |
| Osawa, M | 1 |
| Ashby, CR | 1 |
| Fukuda, M | 1 |
| Morimoto, T | 1 |
| Nagao, H | 1 |
| Kida, K | 1 |
| Lima, TT | 1 |
| Begnini, J | 1 |
| de Bastiani, J | 1 |
| Fialho, DB | 1 |
| Jurach, A | 1 |
| Ribeiro, MC | 1 |
| Wajner, M | 1 |
| de Mello, CF | 1 |
| Cassidy, RM | 1 |
| Leung, LW | 1 |
| Walker, BR | 1 |
| Easton, A | 1 |
| Shuto, H | 1 |
| Kataoka, Y | 2 |
| Fujisaki, K | 1 |
| Nakao, T | 1 |
| Sueyasu, M | 1 |
| Miura, I | 1 |
| Watanabe, Y | 1 |
| Fujiwara, M | 1 |
| Oishi, R | 1 |
| Jin, C | 1 |
| Jung, I | 1 |
| Ku, HJ | 1 |
| Yook, J | 1 |
| Kim, DH | 1 |
| Kim, M | 1 |
| Cho, JH | 1 |
| Oh, CH | 1 |
| Calixto, E | 1 |
| López-Colomé, AM | 1 |
| Casasola, C | 1 |
| Montiel, T | 1 |
| Bargas, J | 1 |
| Brailowsky, S | 1 |
| Irifune, M | 1 |
| Sato, T | 1 |
| Kamata, Y | 1 |
| Nishikawa, T | 1 |
| Dohi, T | 1 |
| Kawahara, M | 1 |
| Ishizawa, K | 1 |
| Chen, Z | 1 |
| Okuma, C | 1 |
| Sugimoto, Y | 1 |
| Fujii, Y | 1 |
| Kamei, C | 1 |
| Dybdal, D | 1 |
| Kanie, S | 1 |
| Yokoyama, O | 1 |
| Komatsu, K | 1 |
| Kodama, K | 1 |
| Yotsuyanagi, S | 1 |
| Niikura, S | 1 |
| Nagasaka, Y | 1 |
| Miyamoto, KI | 1 |
| Namiki, M | 1 |
| Deransart, C | 1 |
| Lê-Pham, BT | 1 |
| Hirsch, E | 1 |
| Marescaux, C | 3 |
| Depaulis, A | 3 |
| Löscher, W | 3 |
| Infante, C | 1 |
| Cartier, L | 1 |
| Motles, E | 1 |
| Furtmüller, R | 1 |
| Schlag, MG | 1 |
| Berger, M | 1 |
| Hopf, R | 1 |
| Huck, S | 1 |
| Sieghart, W | 1 |
| Redl, H | 1 |
| Pedley, TA | 1 |
| Horton, RW | 1 |
| Matthews, WD | 1 |
| McCafferty, GP | 1 |
| Mandel, P | 2 |
| Ciesielski, L | 2 |
| Maitre, M | 1 |
| Simler, S | 1 |
| Mack, G | 1 |
| Kempf, E | 2 |
| Frey, HH | 1 |
| Popp, C | 1 |
| Mesdjian, E | 1 |
| Sofronov, GA | 1 |
| Golovko, AI | 1 |
| Inano, S | 1 |
| Brown, LL | 1 |
| Tempel, A | 1 |
| Kokka, N | 1 |
| Sapp, DW | 1 |
| Witte, U | 1 |
| Olsen, RW | 2 |
| Xie, XH | 1 |
| Tietz, EI | 2 |
| Rosenberg, HC | 3 |
| Maggio, R | 2 |
| Sohn, E | 1 |
| Motomura, M | 1 |
| Takeo, G | 1 |
| Shibayama, K | 1 |
| Ohishi, K | 1 |
| Nakamura, T | 1 |
| Niwa, M | 1 |
| Tsujihata, M | 1 |
| Nagataki, S | 1 |
| Bansinath, M | 1 |
| Ramabadran, K | 1 |
| Turndorf, H | 1 |
| Shukla, VK | 1 |
| Buck, KJ | 1 |
| McQuilkin, SJ | 1 |
| Harris, RA | 1 |
| Gautam, SK | 1 |
| Rägo, L | 1 |
| MacDonald, E | 1 |
| Saano, V | 1 |
| Airaksinen, MM | 1 |
| Stringer, JL | 2 |
| Vergnes, M | 2 |
| Liu, Z | 2 |
| Turski, WA | 2 |
| Urbanska, E | 1 |
| Dziki, M | 1 |
| Parada-Turska, J | 1 |
| Ikonomidou, C | 1 |
| Pericić, D | 1 |
| Tvrdeić, A | 1 |
| Miller, JW | 1 |
| Ferrendelli, JA | 2 |
| Perez, J | 1 |
| Zucchi, I | 1 |
| Maggi, A | 1 |
| Lim, DK | 1 |
| Nabeshima, T | 1 |
| Ho, IK | 1 |
| Schwartz, RD | 1 |
| Seale, TW | 1 |
| Paul, SM | 1 |
| Wurpel, JN | 2 |
| Zhao, DY | 2 |
| Chesnut, TJ | 1 |
| Swann, JW | 1 |
| Okada, R | 2 |
| Negishi, N | 1 |
| Nagaya, H | 1 |
| Zhang, H | 1 |
| Bonhaus, DW | 2 |
| Santori, EM | 1 |
| Patel, S | 3 |
| Millan, MH | 3 |
| Yokoi, I | 1 |
| Tsuruta, K | 1 |
| Shiraga, H | 1 |
| Mori, A | 1 |
| Shigara, H | 1 |
| Lloyd, KG | 1 |
| Perrault, G | 1 |
| Zivkovic, B | 1 |
| Givens, BS | 1 |
| Morita, K | 1 |
| Seki, K | 1 |
| Schwark, WS | 1 |
| Santucci, V | 1 |
| Fournier, M | 1 |
| Chambon, JP | 1 |
| Biziere, K | 1 |
| Wamsley, JK | 1 |
| McCabe, RT | 1 |
| Lee, RJ | 1 |
| Lomax, P | 1 |
| Egbuta, JO | 1 |
| Mello, LM | 1 |
| Peterson, SL | 1 |
| Marley, RJ | 1 |
| Gaffney, D | 1 |
| Wehner, JM | 1 |
| Ito, M | 1 |
| Chiu, TH | 1 |
| Nutt, DJ | 1 |
| Taylor, SC | 1 |
| Mehta, AK | 1 |
| Ticku, MK | 1 |
| Platt, K | 1 |
| Butler, LS | 1 |
| Applegate, CD | 1 |
| Burchfiel, JL | 1 |
| Hosford, DA | 1 |
| Ono, K | 1 |
| Mori, K | 1 |
| Baba, H | 1 |
| Wong, BY | 2 |
| Mirski, MA | 1 |
| Garant, D | 1 |
| Piredda, S | 1 |
| Cavalheiro, EA | 1 |
| Calderazzo-Filho, LS | 1 |
| Kleinrok, Z | 1 |
| Czuczwar, SJ | 1 |
| Turski, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Seizures After Cardiac Surgery -- A Prospective Study With Continuous EEG Monitoring[NCT01291992] | 100 participants (Actual) | Observational | 2010-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for muscimol and Absence Seizure
| Article | Year |
|---|---|
Physiological and behavioral studies with muscimol.
Topics: Animals; Behavior; Behavior, Animal; Blood-Brain Barrier; Dopamine; Feeding Behavior; gamma-Aminobut | 1980 |
Cellular compartments of GABA in brain and their relationship to anticonvulsant activity.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; | 1981 |
[Implications of GABAergic synapses in neuropsychiatry].
Topics: 4-Aminobutyrate Transaminase; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidepressive Agents; | 1985 |
Drugs acting on amino acid neurotransmitters.
Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiolo | 1986 |
Mechanisms of seizure control mediated by gamma-aminobutyric acid: role of the substantia nigra.
Topics: Animals; Bicuculline; Cell Compartmentation; Epilepsy; gamma-Aminobutyric Acid; Microinjections; Mor | 1985 |
Epileptogenesis and the immature brain.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Brain Diseases; Cerebral Cortex; Epilepsy; Humans; Kin | 1987 |
174 other studies available for muscimol and Absence Seizure
| Article | Year |
|---|---|
Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports.
Topics: Animals; Anticonvulsants; Brain; Cyclopropanes; GABA Modulators; GABA Plasma Membrane Transport Prot | 2013 |
Acute and chronic convection-enhanced muscimol delivery into the rat subthalamic nucleus induces antiseizure effects associated with high responder rates.
Topics: Animals; Convection; Epilepsy; Female; Muscimol; Rats; Seizures; Subthalamic Nucleus | 2023 |
Paroxysmal slow-wave discharges in a model of absence seizure are coupled to gamma oscillations in the thalamocortical and limbic systems.
Topics: Animals; Epilepsy, Absence; Hippocampus; Humans; Muscimol; Rats; Rats, Long-Evans; Seizures | 2023 |
Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electrodes, Implanted; Male; Midazolam; Muscimol; | 2020 |
Taurine potentiates the anticonvulsive effect of the GABA
Topics: Animals; Animals, Newborn; Anticonvulsants; Drug Synergism; GABA-A Receptor Agonists; Hippocampus; M | 2019 |
Anticonvulsant and behavioral effects of muscimol in immature rats.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Dr | 2014 |
The hippocampus participates in a pharmacological rat model of absence seizures.
Topics: 4-Butyrolactone; Animals; Cerebral Cortex; Cortical Synchronization; Disease Models, Animal; Electro | 2016 |
Cl(-) conduction of GABAA receptor complex of synaptic membranes in the cortex of rats at the middle stage of chronic cerebral epileptization (pharmacological kindling).
Topics: Animals; Cerebral Cortex; Chlorides; Chronic Disease; Dose-Response Relationship, Drug; Epilepsy; GA | 2007 |
Bicarbonate contributes to GABAA receptor-mediated neuronal excitation in surgically resected human hypothalamic hamartomas.
Topics: Adolescent; Bicarbonates; Calcium; Calcium Channels, L-Type; Child; Child, Preschool; Electrophysiol | 2009 |
Localized transmeningeal muscimol prevents neocortical seizures in rats and nonhuman primates: therapeutic implications.
Topics: Acetylcholine; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Dr | 2009 |
Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizure.
Topics: Animals; Apoptosis; Baclofen; Disease Models, Animal; Disks Large Homolog 4 Protein; GABA Agonists; | 2010 |
Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Electroencephalography; GABA Agon | 2010 |
Comparison of the antiepileptic properties of transmeningeally delivered muscimol, lidocaine, midazolam, pentobarbital and GABA, in rats.
Topics: Acetylcholine; Animals; Anticonvulsants; Electrodes, Implanted; Electroencephalography; gamma-Aminob | 2010 |
Microinjection of GABAergic agents into the anterior nucleus of the thalamus modulates pilocarpine-induced seizures and status epilepticus.
Topics: Animals; Anterior Thalamic Nuclei; Bicuculline; Convulsants; Electroencephalography; GABA Agents; Hu | 2010 |
Increased GABAergic inhibition in the midline thalamus affects signaling and seizure spread in the hippocampus-prefrontal cortex pathway.
Topics: Animals; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Evoked Potentials; G | 2011 |
Transmeningeal muscimol can prevent focal EEG seizures in the rat neocortex without stopping multineuronal activity in the treated area.
Topics: Action Potentials; Animals; Drug Delivery Systems; Electroencephalography; Male; Meninges; Muscimol; | 2011 |
Periodic transmeningeal muscimol maintains its antiepileptic efficacy over three weeks without inducing tolerance, in rats.
Topics: Animals; Anticonvulsants; Convulsants; Drug Tolerance; Electrodes, Implanted; Electroencephalography | 2011 |
Effect of heat exposure on aminophylline-induced convulsions in mice.
Topics: Aminophylline; Animals; Dizocilpine Maleate; Fever; Male; Mice; Muscimol; Seizures; Theophylline | 2011 |
Enhanced efficacy of anticonvulsants when combined with levetiracetam in soman-exposed rats.
Topics: Animals; Anticonvulsants; Antidotes; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinester | 2011 |
Behavioral and EEG effects of GABAergic manipulation of the nigrotectal pathway in the Wistar audiogenic rat strain.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Bicuculline; Corpus Striatum; Electroencephalog | 2011 |
Spatiotemporal organization and thalamic modulation of seizures in the mouse medial thalamic-anterior cingulate slice.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Bicuculline; Biol | 2011 |
Transition to seizure: ictal discharge is preceded by exhausted presynaptic GABA release in the hippocampal CA3 region.
Topics: Animals; CA3 Region, Hippocampal; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Inhib | 2012 |
Adenosine release during seizures attenuates GABAA receptor-mediated depolarization.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; CA3 Region, Hippocampal; Chlorides; Epilepsy, Te | 2012 |
Long-term behavioral, electrophysiological, and neurochemical monitoring of the safety of an experimental antiepileptic implant, the muscimol-delivering Subdural Pharmacotherapy Device in monkeys.
Topics: Animals; Anticonvulsants; Behavior, Animal; Body Weight; Cerebrospinal Fluid Proteins; Chromatograph | 2012 |
Neuroprotection of co-activation of GABA receptors by preventing caspase-3 denitrosylation in KA-induced seizures.
Topics: Animals; Apoptosis; Baclofen; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Caspase 3; Caspase I | 2012 |
Molecular and pharmacological characterization of GABA(A) receptor alpha1 subunit knockout mice.
Topics: Animals; Autoradiography; Bicuculline; Blotting, Western; Cerebral Cortex; Chlorides; Convulsants; F | 2002 |
Effects of etifoxine on ligand binding to GABA(A) receptors in rodents.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Dose-Response Relationship, Drug; Flunitrazepam | 2002 |
GABA(A) receptor alpha-1 subunit deletion alters receptor subtype assembly, pharmacological and behavioral responses to benzodiazepines and zolpidem.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Behavior, Animal; Benzodiazepines; Chlorides; Diazepa | 2002 |
GABA(B) receptor-mediated regulation of P2X7 receptor expression in the gerbil hippocampus.
Topics: Analysis of Variance; Animals; Baclofen; Bicuculline; Cell Count; GABA Agonists; GABA Antagonists; G | 2004 |
Behavioral effects of bicuculline microinjection in the dorsal versus ventral hippocampal formation of rats, and control of seizures by nigral muscimol.
Topics: Animals; Bicuculline; Electroencephalography; Hippocampus; Male; Microinjections; Muscimol; Rats; Ra | 2004 |
The medial septum mediates impairment of prepulse inhibition of acoustic startle induced by a hippocampal seizure or phencyclidine.
Topics: Animals; Antibodies, Monoclonal; Behavior, Animal; Brain Injuries; Cell Count; Choline O-Acetyltrans | 2004 |
Effects of GABAergic transmissions on the immunoreactivities of calcium binding proteins in the gerbil hippocampus.
Topics: Animals; Baclofen; Bicuculline; Calbindin 2; Calbindins; Calcium-Binding Proteins; Cell Count; GABA | 2005 |
Hippocampal melatonin receptors modulate seizure threshold.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy | 2005 |
Hyperthermia-induced seizures modify the GABAA and benzodiazepine receptor binding in immature rat brain.
Topics: Animals; Animals, Newborn; Autoradiography; Brain; Child; Female; Fever; Flunitrazepam; GABA Agonist | 2005 |
GM1 ganglioside prevents seizures, Na+,K+-ATPase activity inhibition and oxidative stress induced by glutaric acid and pentylenetetrazole.
Topics: Animals; Convulsants; Dizocilpine Maleate; Electroencephalography; Excitatory Amino Acid Antagonists | 2006 |
Anticonvulsant effects of GABA(A) modulators microinfused into area tempestas or substantia nigra in rats exposed to soman.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Chemical Warfare Agents; Diazepam; Drug Therapy, Combinat | 2006 |
Effect of cyclooxygenase-2 (COX-2) inhibitors in various animal models (bicuculline, picrotoxin, maximal electroshock-induced convulsions) of epilepsy with possible mechanism of action.
Topics: Animals; Bicuculline; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Resp | 2006 |
Experimental manipulations of the subthalamic nucleus fail to suppress tonic seizures in the electroshock model of epilepsy.
Topics: Animals; Behavior, Animal; Electric Stimulation; Electrodes, Implanted; Electroshock; Epilepsy, Gene | 2006 |
Sex-specific control of flurothyl-induced tonic-clonic seizures by the substantia nigra pars reticulata during development.
Topics: 2-Amino-5-phosphonovalerate; Acrylates; Age Factors; Analysis of Variance; Animals; Animals, Newborn | 2006 |
Pharmacological therapies against soman-induced seizures in rats 30 min following onset and anticonvulsant impact.
Topics: Animals; Anticonvulsants; Antidotes; Ethanol; GABA Modulators; Hippocampus; Male; Muscarinic Antagon | 2006 |
Convulsions induced by methylmalonic acid are associated with glutamic acid decarboxylase inhibition in rats: a role for GABA in the seizures presented by methylmalonic acidemic patients?
Topics: Analysis of Variance; Animals; Baclofen; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relati | 2007 |
Involvement of NMDA receptors in thiopental-induced loss of righting reflex, antinociception and anticonvulsion effects in mice.
Topics: Analgesics; Anesthetics, Intravenous; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Dizoc | 2007 |
The involvement of the substantia nigra pars reticulata in hypoglycemic seizures.
Topics: Animals; Baclofen; Behavior, Animal; Disease Models, Animal; Fasting; GABA-A Receptor Agonists; gamm | 2007 |
Blockade of androgen receptors is sufficient to alter the sexual differentiation of the substantia nigra pars reticulata seizure-controlling network.
Topics: Androgen Receptor Antagonists; Animals; Convulsants; Female; GABA Agonists; Male; Muscimol; Nerve Ne | 2008 |
NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus.
Topics: 4-Aminopyridine; Animals; Blotting, Western; Chlorides; Electrophysiology; Extracellular Space; GABA | 2008 |
A study on benzodiazepine receptor binding in audiogenic seizure-susceptible rats.
Topics: Acoustic Stimulation; Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; C | 1984 |
Decreased convulsant potency of picrotoxin and pentetrazol and enhanced [3H]flunitrazepam cortical binding following stressful manipulations in rats.
Topics: Animals; Anti-Anxiety Agents; Cerebral Cortex; Diazepam; Flunitrazepam; GABA Antagonists; gamma-Amin | 1980 |
Drugs that increase gamma-aminobutyric acid transmission protect against the high pressure neurological syndrome.
Topics: Anesthetics; Animals; Bicuculline; Body Temperature; Flurazepam; gamma-Aminobutyric Acid; Male; Mice | 1982 |
Effects of GABAergic agonists and antagonists on various ethanol-induced behavioral changes.
Topics: Animals; Behavior, Animal; Bicuculline; Body Temperature Regulation; Dose-Response Relationship, Dru | 1982 |
Differential sensitivity of ethanol withdrawal signs in the rat to gamma-aminobutyric acid (GABA)mimetics: blockade of audiogenic seizures but not forelimb tremors.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aminobutyrates; Animals; Chlordiazepoxide; Disea | 1983 |
Characterization of susceptibility to audiogenic seizures in ethanol-dependent rats after microinjection of gamma-aminobutyric acid (GABA) agonists into the inferior colliculus, substantia nigra or medial septum.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Ethanol; GABA Antagonists; Humans; Infe | 1983 |
Synergistic inhibition of [3H]muscimol binding to calf-brain synaptic membranes in the presence of L-homocysteine and pyridoxal 5'-phosphate. A possible mechanism for homocysteine-induced seizures.
Topics: Animals; Binding, Competitive; Brain; Cattle; Drug Synergism; Homocysteine; In Vitro Techniques; Kin | 1983 |
Electrophysiological and pharmacological actions of the convulsant benzodiazepine Ro 5-4864.
Topics: Animals; Benzodiazepinones; Binding Sites; Brain; Convulsants; Electrophysiology; Male; Muscimol; Ra | 1984 |
Inhibition of benzodiazepine and GABA receptor binding by amino-gamma-carbolines and other amino acid pyrolysate mutagens.
Topics: Animals; Binding, Competitive; Carbolines; Chlorides; Diazepam; Flunitrazepam; Harmine; Indoles; Ion | 1984 |
Increase in the Bmax of gamma-aminobutyric acid-A recognition sites in brain regions of mice receiving diazepam.
Topics: Animals; Brain; Cerebellum; Diazepam; gamma-Aminobutyric Acid; Isoniazid; Kinetics; Mice; Motor Acti | 1984 |
Intranigral muscimol suppresses ethanol withdrawal seizures.
Topics: Acoustic Stimulation; Alcoholism; Animals; gamma-Aminobutyric Acid; Humans; Male; Muscimol; Oxazoles | 1984 |
Evidence implicating substantia nigra in regulation of kindled seizure threshold.
Topics: Aminocaproates; Amygdala; Animals; Behavior, Animal; Brain; Differential Threshold; Dose-Response Re | 1984 |
The bicuculline-like properties of dopamine sulfate in rat brain.
Topics: Animals; Bicuculline; Brain; Diazepam; Dopamine; Drug Interactions; gamma-Aminobutyric Acid; Male; M | 1984 |
Synergistic anticonvulsant effects of a GABA agonist and glycine.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Drug Synergism; gamma-Aminobutyric Acid; Glycine | 1984 |
Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Caudate Nucleus; Electroshock; Haloperidol; Hippo | 1984 |
Interactions of gamma-aminobutyric acid and noradrenaline in the high pressure neurological syndrome.
Topics: Aminobutyrates; Animals; Brain; Drug Interactions; Female; Hydroxydopamines; Injections, Intraventri | 1983 |
Interactions of two phenylquinolines with picrotoxin and benzodiazepines in vivo and in vitro.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Interactions; gamma-Aminobutyric Acid; Male; Mice; M | 1984 |
Nigral muscimol infusions facilitate the development of seizures in immature rats.
Topics: Age Factors; Animals; Flurothyl; gamma-Aminobutyric Acid; Muscimol; Oxazoles; Rats; Seizures; Substa | 1984 |
Reversible suppression of amygdaloid kindled convulsion following unilateral gabaculine injection into the substantia innominata.
Topics: Action Potentials; Aminocaproates; Amygdala; Animals; Anticonvulsants; Basal Ganglia; Cyclohexanecar | 1984 |
Neurotransmitters and receptor binding in amygdaloid kindled rats: serotonergic and noradrenergic modulatory effects.
Topics: 5-Hydroxytryptophan; Amygdala; Animals; Brain; Clonidine; Dexetimide; Electric Stimulation; Male; Mi | 1980 |
Therapeutics of monomethylhydrazine intoxication.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Methylhydrazin | 1982 |
Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid.
Topics: Animals; Bicuculline; Brain Mapping; GABA Antagonists; gamma-Aminobutyric Acid; Male; Muscimol; Pent | 1982 |
Anticonvulsant effects of muscimol.
Topics: Animals; Bicuculline; GABA Antagonists; Muscimol; Neurons; Oxazoles; Penicillins; Picrotoxin; Rats; | 1980 |
Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid.
Topics: Animals; Anticonvulsants; Brain; Caudate Nucleus; Electroencephalography; Evoked Potentials; Kainic | 1982 |
Muscimol-induced myoclonic jerks in mice.
Topics: Animals; Drug Interactions; Kinetics; Male; Mice; Muscimol; Oxazoles; Picrotoxin; Seizures | 1981 |
Muscimol and gamma-hydroxybutyrate: similar interactions with convulsant agents.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; D | 1981 |
Behavioural effects of GABA-agonists and antagonists infused in the mesencephalic reticular formation - deep layers of superior colliculus.
Topics: Animals; Behavior, Animal; Bicuculline; Dominance, Cerebral; gamma-Aminobutyric Acid; Mesencephalon; | 1981 |
Long-term and regional specific changes in [3H]flunitrazepam binding in kindled rat hippocampus.
Topics: Animals; Autoradiography; Electrodes, Implanted; Flunitrazepam; GABA Modulators; Hippocampus; Image | 1995 |
Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions.
Topics: Age Factors; Animals; Animals, Newborn; Dose-Response Relationship, Drug; Flurothyl; GABA Agonists; | 1995 |
Prenatal lorazepam exposure: 4. Persistent alterations in pentylenetetrazole-induced seizure threshold and GABA-dependent chloride uptake after prenatal lorazepam exposure.
Topics: Animals; Brain Chemistry; Chlorides; Chlorine; Female; gamma-Aminobutyric Acid; Lorazepam; Mice; Mus | 1995 |
Effects of 1-amino-5-bromouracil on the benzodiazepine-GABAA receptor complex.
Topics: Anesthesia; Animals; Anti-Anxiety Agents; Anticonvulsants; Bridged Bicyclo Compounds; Bridged Bicycl | 1994 |
Quantitation of GABAA receptor inhibition required for quinolone-induced convulsions in mice.
Topics: Animals; Anti-Infective Agents; Brain; Female; Fluoroquinolones; GABA-A Receptor Antagonists; Male; | 1994 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Anticonvuls | 1995 |
[Involvement of GABAergic and NMDA systems in drug-induced convulsions in mice].
Topics: Animals; Anticonvulsants; Bicuculline; Calcium Channels; Chloride Channels; Male; Mice; Mice, Inbred | 1995 |
Opposite changes in GABAA receptor function in the CA1-3 area and fascia dentata of kindled rat hippocampus.
Topics: Animals; Chlorides; Hippocampus; Kindling, Neurologic; Male; Microscopy, Electron; Muscimol; Osmolar | 1995 |
Correlation between in vitro and in vivo models of proconvulsive activity with the carbapenem antibiotics, biapenem, imipenem/cilastatin and meropenem.
Topics: Analysis of Variance; Animals; Binding, Competitive; Cilastatin; Dose-Response Relationship, Drug; g | 1995 |
Possible intermolecular interaction between quinolones and biphenylacetic acid inhibits gamma-aminobutyric acid receptor sites.
Topics: Animals; Binding Sites; Drug Interactions; GABA Antagonists; Magnetic Resonance Spectroscopy; Muscim | 1994 |
Analysis of the hippocampal GABAA receptor system in kindled rats by autoradiographic and in situ hybridization techniques: contingent tolerance to carbamazepine.
Topics: Affinity Labels; Amygdala; Animals; Autoradiography; Azides; Benzodiazepines; Bridged Bicyclo Compou | 1994 |
GABAergic and dopaminergic systems may be involved in seizures induced by pyrimethamine in mice.
Topics: Animals; Bicuculline; Diazepam; Dopamine; Drug Interactions; gamma-Aminobutyric Acid; Levodopa; Mice | 1994 |
Posterior piriform and perirhinal cortex relay seizures evoked from the area tempestas: role of excitatory and inhibitory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Entorhinal Cort | 1994 |
Loss of GABAA receptors during partial status epilepticus.
Topics: Animals; Electrophysiology; Epilepsia Partialis Continua; Kinetics; Lithium Chloride; Male; Muscimol | 1994 |
Kindling induces time-dependent and regional specific changes in the [3H]muscimol binding in the rat hippocampus: a quantitative autoradiographic study.
Topics: Allosteric Site; Animals; Autoradiography; Electric Stimulation; gamma-Aminobutyric Acid; Hippocampu | 1994 |
Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity.
Topics: Animals; Bicuculline; Binding, Competitive; Brain; Cell Membrane; Cerebral Ventricles; GABA Antagoni | 1994 |
The influence of thalamic GABA transmission on the susceptibility of adult rats to flurothyl induced seizures.
Topics: Aminocaproates; Animals; Anticonvulsants; Baclofen; Behavior, Animal; Bicuculline; Flurothyl; gamma- | 1993 |
Cimetidine-induced seizures in mice. Antagonism by some GABAergic agents.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cimetidine; Diazepam; Female; M | 1993 |
Low neurotoxicity of LJC 10,627, a novel 1 beta-methyl carbapenem antibiotic: inhibition of gamma-aminobutyric acidA, benzodiazepine, and glycine receptor binding in relation to lack of central nervous system toxicity in rats.
Topics: Animals; Behavior, Animal; Binding, Competitive; Central Nervous System Diseases; Diazepam; GABA-A R | 1993 |
Fos oncoprotein expression in the rat forebrain following muscimol-induced absence seizures.
Topics: Animals; Electroencephalography; Epilepsy, Absence; GABA Agonists; Immunohistochemistry; Male; Musci | 1996 |
Acute effects of various GABA receptor agonists and glutamate antagonists on focal hippocampal seizures in freely moving rats elicited by low-frequency stimulation.
Topics: Animals; Anticonvulsants; Ataxia; Carbamazepine; Diazepam; Dizocilpine Maleate; Excitatory Amino Aci | 1998 |
The effect of GABAergic system activity on hyperthermia-induced seizures in rats.
Topics: Analysis of Variance; Animals; Bicuculline; Body Temperature Regulation; Electroencephalography; Fem | 1997 |
Pharmacological evidence for GABAergic and glutamatergic involvement in the convulsant and behavioral effects of glutaric acid.
Topics: Animals; Behavior, Animal; Convulsants; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relation | 1998 |
Mediodorsal thalamus plays a critical role in the development of limbic motor seizures.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Bicuculline; Brain Mapping; Carbon Radioisoto | 1998 |
Gamma-aminobutyric acid and glutamic acid receptors may mediate theophylline-induced seizures in mice.
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Cl | 1999 |
Medial septum mediates the increase in post-ictal behaviors and hippocampal gamma waves after an electrically induced seizure.
Topics: Animals; Behavior, Animal; Electric Stimulation; Electroencephalography; Electrophysiology; Hippocam | 1999 |
Regulation of limbic motor seizures by GABA and glutamate transmission in nucleus tractus solitarius.
Topics: Animals; Bicuculline; Electric Stimulation Therapy; Excitatory Amino Acid Antagonists; GABA Agonists | 1999 |
Inhibition of GABA system involved in cyclosporine-induced convulsions.
Topics: Animals; Anticonvulsants; Bicuculline; Binding Sites; Brain; Cells, Cultured; Cerebellum; Cyclospori | 1999 |
Low convulsive activity of a new carbapenem antibiotic, DK-35C, as compared with existing congeners.
Topics: Animals; Carbapenems; Cefazolin; Cephalosporins; GABA Agonists; Imipenem; Injections, Intraventricul | 1999 |
Neocortical hyperexcitability after GABA withdrawal in vitro.
Topics: Animals; Flunitrazepam; GABA Agonists; GABA Modulators; gamma-Aminobutyric Acid; Muscimol; Neocortex | 2000 |
Evidence for GABA(A) receptor agonistic properties of ketamine: convulsive and anesthetic behavioral models in mice.
Topics: Allylglycine; Anesthesia; Anesthetics, Dissociative; Animals; Behavior, Animal; Bicuculline; Dose-Re | 2000 |
Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures.
Topics: Amygdala; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Histamine; Imidazoles; Kindling, | 2000 |
Postural and anticonvulsant effects of inhibition of the rat subthalamic nucleus.
Topics: Animals; Anticonvulsants; Bicuculline; Functional Laterality; GABA-A Receptor Agonists; Kynurenic Ac | 2000 |
GABAergic contribution to rat bladder hyperactivity after middle cerebral artery occlusion.
Topics: Animals; Baclofen; Bicuculline; Cerebral Infarction; Cerebral Ventricles; Dose-Response Relationship | 2000 |
Inhibition of the substantia nigra suppresses absences and clonic seizures in audiogenic rats, but not tonic seizures: evidence for seizure specificity of the nigral control.
Topics: Acoustic Stimulation; Animals; Auditory Pathways; Electroencephalography; Epilepsy, Absence; Epileps | 2001 |
Sexual dimorphism and developmental regulation of substantia nigra function.
Topics: Aging; Animals; Animals, Newborn; Castration; Convulsants; Disease Susceptibility; Female; GABA Agon | 2001 |
Lack of robust anticonvulsant effects of muscimol microinfusions in the anterior substantia nigra of kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Female; Flur | 2001 |
Comparative study of the epileptogenic effect of kainic acid injected into the cerebral cortex, hippocampus and amygdala in adult cats chronically implanted.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amygdala; Animals; Cats; Cerebral Cortex; Electroencephalograp | 2002 |
Tranexamic acid, a widely used antifibrinolytic agent, causes convulsions by a gamma-aminobutyric acid(A) receptor antagonistic effect.
Topics: Animals; Antifibrinolytic Agents; Binding, Competitive; Brain Chemistry; Cell Line; Dizocilpine Male | 2002 |
Electroencephalographic and behavioral effects of a GABA agonist (muscimol) on photosensitive epilepsy in the baboon, papio papio.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electroencephalography; Haplorhini; Muscimol | 1979 |
Anticonvulsant activity of muscimol against seizures induced by impairment of GABA-mediated neurotransmission.
Topics: Animals; Anticonvulsants; Bicuculline; gamma-Aminobutyric Acid; Isoniazid; Male; Muscimol; Oxazoles; | 1979 |
Involvement of central GABA-ergic systems in convulsions and aggressive behavior.
Topics: 4-Aminobutyrate Transaminase; Aggression; Allylglycine; Animals; Bicuculline; Brain; Fatty Acids; ga | 1979 |
Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in mice.
Topics: Animals; Atropine; Brain Chemistry; Electroshock; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Nip | 1979 |
Effects of some GABAergic agents on quinine-induced seizures in mice.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Bicuculline; Diazepam; Male; Mice; Mice, Inb | 1992 |
GABAA sodium independent receptor sites in a strain of rats presenting generalized non-convulsive seizures.
Topics: Animals; Brain Chemistry; In Vitro Techniques; Kinetics; Male; Membranes; Muscimol; Rats; Rats, Inbr | 1992 |
[Effects of GABA antagonist-induced seizures on 3H-muscimol and 3H-diazepam binding in the rat striatum].
Topics: Animals; Bicuculline; Binding Sites; Corpus Striatum; Diazepam; GABA Antagonists; Male; Muscimol; Pi | 1992 |
[Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice].
Topics: Animals; Baclofen; Benzodiazepines; Caffeine; Diazepam; Dizocilpine Maleate; Flumazenil; Male; Mice; | 1992 |
Age-dependent changes in substantia nigra GABA-mediated seizure suppression.
Topics: Aging; Animals; Animals, Newborn; Baclofen; Bicuculline; Dominance, Cerebral; Energy Metabolism; Flu | 1992 |
Sex differences in sensitivity to pentylenetetrazol but not in GABAA receptor binding.
Topics: Anesthetics; Animals; Anticonvulsants; Autoradiography; Benzodiazepinones; Bridged Bicyclo Compounds | 1992 |
Involvement of GABAergic mechanisms in chloroquine-induced seizures in mice.
Topics: Aminobutyrates; Aminooxyacetic Acid; Animals; Baclofen; Chloroquine; Diazepam; gamma-Aminobutyric Ac | 1992 |
Anti-pentylenetetrazol effect of intranigral 2-amino-7-phosphonoheptanoate attenuated by muscimol.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Drug Combinations; Male; Muscimo | 1991 |
Is the anticonvulsant effect of substantia nigra infusion of gamma-vinyl-GABA (GVG) mediated by the GABAA receptor in rat pups?
Topics: Aminocaproates; Animals; Anticonvulsants; Bicuculline; Muscimol; Rats; Rats, Inbred Strains; Recepto | 1991 |
Lack of proconvulsant action of GABA depletion in substantia nigra in several seizure models.
Topics: Animals; Bicuculline; Cerebral Cortex; gamma-Aminobutyric Acid; Isoniazid; Kainic Acid; Male; Microi | 1991 |
Hippocampus and frontal cortex are the potential mediatory sites for convulsions induced by new quinolones and non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Cortex; Drug Combinations; Enoxacin; Hipp | 1991 |
Intracerebroventricular administration of kappa-agonists induces convulsions in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1991 |
Modulation of gamma-aminobutyric acidA receptor-operated chloride channels by benzodiazepine inverse agonists is related to genetic differences in ethanol withdrawal seizure severity.
Topics: Animals; Benzodiazepines; Carbolines; Chloride Channels; Chlorides; Convulsants; Ethanol; Flunitraze | 1991 |
GABA/BZ-and NMDA-receptor interaction in digoxin-induced convulsions in rats.
Topics: Animals; Baclofen; Diazepam; Digoxin; Dizocilpine Maleate; Female; gamma-Aminobutyric Acid; Injectio | 1991 |
The effect of medetomidine on GABA and benzodiazepine receptors in vivo: lack of anxiolytic but some evidence of possible stress-protective activity.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Brain; Cerebral Cortex; Flumazenil; Flu | 1991 |
Pharmacological evidence indicating a role of GABAergic systems in termination of limbic seizures.
Topics: Animals; Baclofen; Bicuculline; Chloride Channels; GABA-A Receptor Antagonists; gamma-Aminobutyric A | 1990 |
Effects of substantia nigra gamma-vinyl-GABA infusions on flurothyl seizures in adult rats.
Topics: Aminocaproates; Analysis of Variance; Animals; Anticonvulsants; Flurothyl; Infusions, Parenteral; Ma | 1991 |
Involvement of the nigral output pathways in the inhibitory control of the substantia nigra over generalized non-convulsive seizures in the rat.
Topics: Animals; Brain; Dopamine; Electroencephalography; GABA Antagonists; gamma-Aminobutyric Acid; Hydroxy | 1990 |
Excitatory amino acid antagonists protect mice against seizures induced by bicuculline.
Topics: Animals; Bicuculline; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; M | 1990 |
Species dependent dual modulation of the benzodiazepine/GABA receptor chloride channel by dihydroergosine.
Topics: Animals; Bicuculline; Brain; Chloride Channels; Diazepam; Ergotamines; Female; gamma-Aminobutyric Ac | 1990 |
The central medial nucleus: thalamic site of seizure regulation.
Topics: Animals; Baclofen; Bicuculline; Dose-Response Relationship, Drug; Female; Muscimol; Rats; Rats, Inbr | 1990 |
The GABAergic nigro-collicular pathway is not involved in the inhibitory control of audiogenic seizures in the rat.
Topics: Acoustic Stimulation; Animals; Male; Microinjections; Muscimol; Neural Pathways; Picrotoxin; Rats; R | 1990 |
Recurrent spontaneous hippocampal seizures in the rat as a chronic sequela to limbic status epilepticus.
Topics: Action Potentials; Animals; Chronic Disease; Disease Models, Animal; Electric Stimulation; Electroen | 1990 |
Estrogen modulation of the gamma-aminobutyric acid receptor complex in the central nervous system of rat.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Diazepam; Dose-R | 1988 |
Effects of picrotoxin treatment on GABAA receptor supramolecular complexes in rat brain.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Re | 1989 |
Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Dose-Respons | 1989 |
Evidence for the involvement of nigral GABAA receptors in seizures of adult rats.
Topics: Animals; Baclofen; Bicuculline; Dose-Response Relationship, Drug; Male; Muscimol; Rats; Rats, Inbred | 1989 |
Disinhibitory actions of the GABAA agonist muscimol in immature hippocampus.
Topics: Animals; Hippocampus; In Vitro Techniques; Membrane Potentials; Muscimol; Neural Inhibition; Rats; R | 1989 |
Seizures evoked from area tempestas are subject to control by GABA and glutamate receptors in substantia nigra.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Bicuculline; Glutamates; Male; Morphine; Musc | 1989 |
The role of the nigrotegmental GABAergic pathway in the propagation of pentylenetetrazol-induced seizures.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Male; Muscimol; Pentylenetetrazole; Pons; Rats; Rats, | 1989 |
Injection of benzodiazepines but not GABA or muscimol into pars reticulata substantia nigra suppresses pentylenetetrazol seizures.
Topics: Animals; Benzodiazepines; Flurazepam; gamma-Aminobutyric Acid; Male; Midazolam; Muscimol; Pentylenet | 1989 |
Anticonvulsant action of intranigral gamma-vinyl-GABA: role of nonadrenergic neurotransmission.
Topics: Aminocaproates; Animals; Anticonvulsants; Dihydroxyphenylalanine; Dioxanes; Dioxins; Idazoxan; Musci | 1988 |
Effects of chronic cortical seizures on GABA and benzodiazepine receptors within seizure pathways.
Topics: Animals; Brain; Cerebral Cortex; Electric Stimulation; Flunitrazepam; Male; Models, Neurological; Mu | 1988 |
Decrease in excitatory transmission within the lateral habenula and the mediodorsal thalamus protects against limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Injections; Limbic System; Male; | 1988 |
Delta-guanidinovaleric acid as an endogenous and specific GABA-receptor antagonist: electroencephalographic study.
Topics: Animals; Arginine; Cerebral Cortex; Diazepam; Electroencephalography; gamma-Aminobutyric Acid; Male; | 1987 |
Amino acid influences on seizures elicited within the inferior colliculus.
Topics: Amino Acids; Aminobutyrates; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic A | 1987 |
Suppression of amygdala-kindled seizure in cats by enhanced GABAergic transmission in the substantia innominata.
Topics: Amygdala; Animals; Basal Ganglia; Cats; Cyclohexanecarboxylic Acids; gamma-Aminobutyric Acid; Inject | 1985 |
Evaluation of different GABA receptor agonists in the kindled amygdala seizure model in rats.
Topics: Amygdala; Animals; Female; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Isoxazoles; Kindling, N | 1985 |
Electroencephalographic study of SR 95103, a GABAA antagonist: interaction with inhibitory amino acids and muscimol.
Topics: Animals; Drug Interactions; Electroencephalography; gamma-Aminobutyric Acid; Glycine; Male; Muscimol | 1985 |
Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Flunitrazepam; Gerbillinae; Mesencephalon; M | 1985 |
A double inhibition kinetic analysis of [3H]-muscimol binding to the gamma-aminobutyric acid receptor on calf brain synaptic membranes. Further studies on the mechanism of homocysteine-induced seizures.
Topics: Animals; Binding, Competitive; Brain; Cattle; Drug Synergism; Homocysteine; Kinetics; Macromolecular | 1985 |
2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Basal Ganglia; Male; Muscimol; N | 1986 |
GABAergic modulation of inferior colliculus excitability: role in the ethanol withdrawal audiogenic seizures.
Topics: Acoustic Stimulation; Animals; Baclofen; Benzodiazepinones; Bicuculline; Ethanol; Geniculate Bodies; | 1986 |
Genetic influences on GABA-related seizures.
Topics: 3-Mercaptopropionic Acid; Animals; Female; Flurothyl; gamma-Aminobutyric Acid; Genetics, Behavioral; | 1986 |
Effects of pentylenetetrazol on GABA-A/benzodiazepine/picrotoxinin receptor complexes in rat brain regions.
Topics: Animals; Brain; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; C | 1986 |
The effects of drugs acting at the GABAA-receptor/ionophore after chemical kindling with the benzodiazepine receptor ligand FG 7142.
Topics: Animals; Bicuculline; Body Temperature; Carbolines; gamma-Aminobutyric Acid; Kindling, Neurologic; M | 1986 |
Comparison of anticonvulsant effect of pentobarbital and phenobarbital against seizures induced by maximal electroshock and picrotoxin in rats.
Topics: Amino Acids; Amino Acids, Neutral; Animals; Anticonvulsants; Bicuculline; Electroshock; Male; Muscim | 1986 |
Neurotransmission in the pedunculopontine nucleus and pilocarpine-induced motor limbic seizures in rats.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Basal Ganglia; Cerebellum; Limbic System; Male; M | 1987 |
Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol.
Topics: Animals; Anticonvulsants; Dioxanes; Idazoxan; Kindling, Neurologic; Male; Microinjections; Muscimol; | 1987 |
Microinjections of GABA agonists into the amygdala complex attenuates kindled seizure expression in the rat.
Topics: Aminocaproates; Amygdala; Animals; Behavior, Animal; Cerebral Cortex; gamma-Aminobutyric Acid; Kindl | 1988 |
Microinjection of muscimol into entopeduncular nucleus suppresses pilocarpine but not maximal electroshock seizures in rats.
Topics: Animals; Electroshock; Globus Pallidus; Male; Microinjections; Muscimol; Pilocarpine; Rats; Rats, In | 1988 |
A role of the striatum in premotor cortical seizure development.
Topics: Animals; Anticonvulsants; Carbachol; Cerebral Cortex; Corpus Callosum; Corpus Striatum; Electric Sti | 1987 |
Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats.
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Muscimol; Rats; Rats, Inbred Strains; Seizur | 1987 |
Anterior thalamic mediation of generalized pentylenetetrazol seizures.
Topics: Aminocaproates; Animals; Behavior, Animal; Bicuculline; Cerebral Cortex; Electroencephalography; Fem | 1986 |
Substantia nigra-mediated anticonvulsant actions: role of nigral output pathways.
Topics: Animals; Male; Muscimol; Neural Pathways; Rats; Rats, Inbred Strains; Seizures; Stereotyped Behavior | 1987 |
Intranigral muscimol attenuates electrographic signs of seizure activity induced by intravenous bicuculline in rats.
Topics: Animals; Anticonvulsants; Bicuculline; Electroencephalography; Injections; Male; Muscimol; Rats; Rat | 1986 |
Age-related substantia nigra-mediated seizure facilitation.
Topics: Animals; Animals, Newborn; gamma-Aminobutyric Acid; Muscimol; Rats; Rats, Inbred Strains; Seizures; | 1986 |
Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid and muscimol in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Bicuculline; Cerebral Cortex; Ma | 1986 |
Injections of picrotoxin and bicuculline into the amygdaloid complex of the rat: an electroencephalographic, behavioural and morphological analysis.
Topics: Amygdala; Animals; Behavior, Animal; Bicuculline; Drug Interactions; Electroencephalography; Male; M | 1985 |