muraymycin-a1 and Escherichia-coli-Infections

muraymycin-a1 has been researched along with Escherichia-coli-Infections* in 1 studies

Other Studies

1 other study(ies) available for muraymycin-a1 and Escherichia-coli-Infections

Article	Year
Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics. ChemMedChem, 2018, 04-23, Volume: 13, Issue:8 Muraymycins are a subclass of antimicrobially active uridine-derived natural products. Biological data on several muraymycin analogues have been reported, including some inhibitory in vitro activities toward their target protein, the bacterial membrane enzyme MraY. However, a structure-activity relationship (SAR) study on naturally occurring muraymycins based on such in vitro data has been missing so far. In this work, we report a detailed SAR investigation on representatives of the four muraymycin subgroups A-D using a fluorescence-based in vitro MraY assay. For some muraymycins, inhibition of MraY with IC Topics: Anti-Bacterial Agents; Bacterial Proteins; Crystallography, X-Ray; Escherichia coli; Escherichia coli Infections; Humans; Molecular Docking Simulation; Nucleosides; Nucleotides; Peptides; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship; Transferases; Transferases (Other Substituted Phosphate Groups); Urea	2018

Article

Year

Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics.

ChemMedChem, 2018, 04-23, Volume: 13, Issue:8

Muraymycins are a subclass of antimicrobially active uridine-derived natural products. Biological data on several muraymycin analogues have been reported, including some inhibitory in vitro activities toward their target protein, the bacterial membrane enzyme MraY. However, a structure-activity relationship (SAR) study on naturally occurring muraymycins based on such in vitro data has been missing so far. In this work, we report a detailed SAR investigation on representatives of the four muraymycin subgroups A-D using a fluorescence-based in vitro MraY assay. For some muraymycins, inhibition of MraY with IC

Topics: Anti-Bacterial Agents; Bacterial Proteins; Crystallography, X-Ray; Escherichia coli; Escherichia coli Infections; Humans; Molecular Docking Simulation; Nucleosides; Nucleotides; Peptides; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship; Transferases; Transferases (Other Substituted Phosphate Groups); Urea

2018