muramidase and Tetanus

In experiments on rats and rabbits with tetanus poisoning, activation of the nonspecific defence factors (humoral and cellular) was found in the early periods after administration of tetanus toxin. The growth of specific hemagglutinins was recorded later. The survival of the animals was prolonged and the titers of specific antibodies decreased in the course of administering the alpha-adrenoblocker butyroxan.

Topics: Animals; Complement System Proteins; Dioxanes; Immune Sera; Leukocytes; Lymph Nodes; Muramidase; Phagocytosis; Plasma Cells; Properdin; Pyrrolidines; Rabbits; Rats; Spleen; Tetanus

The effect of tetracycline and oleandomycin on the complement titer, lysozyme content, serum bactericidal properties and presence of specific antibiotic antibodies in the blood serum was studied. The latter were shown with the Hoigné reaction under conditions of aseptic inflammation caused against the background of latent tetanus intoxication. It was shown that tetracycline and oleandomycin used in treatment of the animals with aseptic inflammation developed at the background of latent tatanus intoxication induced an increased in the complement titer, lysozyme content and bactericidal properties of the serum. Reduction of the above indices was observed by the 15th-20th day after discontinuation of the drug use. The increase in the factors of non-specific immunity under the effect of tetracycline and oleandomycin in the animals with aseptic inflammation caused against the background of latent tetanus intoxication was accompanied by appearance in the blood serum on non-specific antibodies revealed with the Hoigné reaction. Changed reactivity because of latent tetanus intoxication was accompanied by a delay in the formation of the non-specific antibodies in the blood serum. However, later the rate of their accumulation became higher and as a result the maximum titers of the antibodies were 2-3 times higher than those in the control animals.

Topics: Animals; Antibody Specificity; Antigen-Antibody Reactions; Blood Bactericidal Activity; Complement Fixation Tests; Immunity; Inflammation; Muramidase; Oleandomycin; Rabbits; Tetanus; Tetracycline; Time Factors

Topics: Animals; Antibody Formation; Blood Bactericidal Activity; Complement System Proteins; Cortisone; Diphtheria; Diphtheria Toxoid; Drug Combinations; Hydrocortisone; Immunity; Immunity, Active; Immunosuppressive Agents; Muramidase; Pertussis Vaccine; Properdin; Rabbits; Tetanus; Tetanus Toxoid; Time Factors; Vaccination; Whooping Cough

Topics: Animals; Antibody Formation; Blood Bactericidal Activity; Bloodletting; Complement System Proteins; Dysentery, Bacillary; gamma-Globulins; Immunity; Mice; Muramidase; Phagocytosis; Properdin; Rabbits; Salmonella Infections; Tetanus