muramidase and Stomatitis--Aphthous

Topics: Herpes Simplex; Herpes Zoster; Humans; Lichen Planus; Muramidase; Stomatitis, Aphthous; Virus Diseases

To assess the efficacy and safety of a toothpaste containing lysozyme for the treatment of minor recurrent aphthous stomatitis (MiRAS) in a 3-month clinical trial.. 71 participants with MiRAS were recruited to this randomized, parallel-controlled, double-blind clinical trial. Participants were allocated randomly to the test group or the control group. Demographic data and pain score (visual analogue scale, VAS) were recorded at baseline. Healing time of MiRAS, recurrence frequency and side effects were recorded at the 1-, 2- and 3-month follow-up visits. All data were analyzed using SAS software version 8.0.. There was no significant difference (P>0.05) in pain score between the treatment group (3.00 ± 1.66) and the control group (2.66 ± 1.51). The average healing time was significantly reduced (P< 0.01) in the treatment group (5.66 ± 2.02) compared with the control group (7.46 ± 2.69), while the recurrence frequency also showed a significant reduction from 4.40 ± 2.89 in the control group to 3.06 ± 1.48 in the treatment group (P< 0.05). No obvious side effects were observed.. The results of this clinical study supported the conclusion that a toothpaste containing lysozyme was effective in promoting healing and reducing recurrence frequency without significant side effects in the treatment of minor recurrent aphthous stomatitis.

Topics: Adolescent; Adult; China; Double-Blind Method; Female; Humans; Male; Middle Aged; Muramidase; Pain Measurement; Recurrence; Stomatitis, Aphthous; Toothpastes; Treatment Outcome

Topics: Adolescent; Adult; Aged; Bacitracin; Cheilitis; Child; Clinical Trials as Topic; Female; Gingivitis; Gingivitis, Necrotizing Ulcerative; Glossitis; Humans; Lichen Planus; Male; Middle Aged; Mouth Diseases; Muramidase; Papain; Salivary Gland Diseases; Stomatitis; Stomatitis, Aphthous; Tooth Extraction

Topics: Adult; Female; Humans; Lasers; Male; Middle Aged; Muramidase; Pharyngitis; Saliva; Stomatitis, Aphthous; Tonsillitis

Topics: Adult; Female; Humans; Lasers; Male; Middle Aged; Muramidase; Pharyngitis; Saliva; Stomatitis, Aphthous

The concentrations and sequential changes of some acute phase proteins, factor B, and lysozyme have been assayed in recurrent oral ulceration and Behçet's syndrome. C9 was elevated in both groups of patients and was the sensitive index of disease activity; however, it failed to discriminate between the three types of recurrent oral ulcers and four types of Behçet's syndrome. The level of alpha 1 acid glycoprotein and lysozyme were significantly increased predominantly in the ocular type, whereas factor B was significantly increased especially in the neurological type of Behçet's syndrome. It is suggested that the changes in the concentrations of some plasma proteins may help our understanding of tissue involvement in Behçet's syndrome, as well as in the selection of therapeutic agents in this disease.

Topics: Azathioprine; Behcet Syndrome; Blood Proteins; C-Reactive Protein; Complement C9; Complement Factor B; Humans; Muramidase; Orosomucoid; Prednisolone; Recurrence; Stomatitis, Aphthous; Stomatitis, Herpetic

Topics: Administration, Oral; Adult; Drug Evaluation; Female; Humans; Injections, Intramuscular; Male; Middle Aged; Muramidase; Recurrence; Remission, Spontaneous; Stomatitis, Aphthous; Tablets

Topics: Humans; Muramidase; Parotid Gland; Saliva; Stomatitis, Aphthous; Submandibular Gland