muramidase and Rotavirus-Infections

To evaluate the efficacy and safety of Bifilac on reducing the episodes (frequency) and duration of diarrhea induced by rotaviral infection and to evaluate the efficacy of Bifilac to ameliorate the associated symptoms like dehydration and duration of rotaviral shedding in faeces.. 80 children aged between 3 months and 3 years were enrolled and divided into 2 groups, one group received standard therapy + placebo, the other group received standard therapy + probiotic (Bifilac) randomly. Children assessed for frequency and duration of diarrhea. Degree of dehydration, duration and volume of oral rehydration salt [ORS] therapy, duration and volume of Intra venous fluids and duration of rotaviral shedding.. When compared to the placebo, Bifilac showed clinical as well as statistically significant reduction in Number of episodes (frequency) of diarrhea in a day, mean duration of diarrhea (in days) degree of dehydration, duration and volume of oral rehydration salt [ORS] therapy, duration and volume of intravenous fluid [IVF] therapy, duration of rotaviral shedding (P<0.01).. The synbiotic, bifilac, appears to be a safe and very effective adjuvant in the management of acute rotaviral diarrhea.

Topics: Acute Disease; Anti-Infective Agents; Child, Preschool; Dehydration; Diarrhea; Double-Blind Method; Drug Combinations; Female; Fluid Therapy; Humans; Infant; Male; Muramidase; Probiotics; Rehydration Solutions; Rotavirus; Rotavirus Infections; Treatment Outcome; Virus Shedding

Topics: Diarrhea, Infantile; Fluid Therapy; Humans; Infant; Infant, Newborn; Lactoferrin; Milk Proteins; Milk, Human; Muramidase; Rehydration Solutions; Rotavirus Infections; Viral Vaccines

The purpose of this work was to investigate the relationship between rotavirus infection, diagnosed in faeces using the serological test, in calves with diarrhoea and the activity of lysozyme, alpha-amylase, lipase and trypsin in the same material. The faeces were taken from 28 sick and 1 healthy animals, aged from 1 to 5 days, for microbiological and enzymatic examination. No correlation was found between lysozyme activity in faeces and rotavirus infection. Similar results were obtained with the other enzymes.

Topics: Amylases; Animals; Animals, Newborn; Cattle; Cattle Diseases; Diarrhea; Feces; Lipase; Muramidase; Rotavirus Infections; Trypsin

Fecal lysozyme excretion was determined in two hundred children and adolescent. In sixty three infants with enteritis due to Rotavirus the fecal lysozyme level was found to be significant higher than in the feces of a group of healthy infants (p less than 0.01). Elevated fecal lysozyme excretion could be detected in patients with untreated Crohn's disease. After treatment with Salazosulfapyridine, Prednisone and elemental diet during six week a significant drop in fecal lysozyme level was observed (p less than 0.01). In eighteen adolescent with Colitis ulcerosa and Crohn's disease the lysozyme level of colonic mucosa was found to be significant higher than a control group (p less than 0.01). The fecal lysozyme excretion can be used as an indicator for the clinical activity of the disease, as a control for therapeutic efficiency and a marker for a relapse.

Topics: Adolescent; Adult; Child; Child, Preschool; Colitis, Ulcerative; Crohn Disease; Feces; Female; Gastroenteritis; Humans; Infant; Infant, Newborn; Intestinal Mucosa; Male; Muramidase; Rotavirus Infections