muramidase and Pruritus

A 41-year-old man presented with itching of the skin surrounding his tattoos, blurred vision, fever, general fatigue, and arthralgia. Physical examination revealed skin bulges confined to the tattoo ink lines. Histological analyses of the skin revealed non-caseating granulomas surrounding the tattoo inks. Together with other clinical manifestations including uveitis, lymph nodes swelling, and elevated serum angiotensin-converting enzyme and lysozyme, he was diagnosed with systemic sarcoidosis. The administration of prednisolone alleviated the sarcoidosis-related symptoms, including skin changes. This case illustrates that skin changes on tattoos can be a presenting manifestation of systemic sarcoidosis and that skin biopsy is useful in early diagnosis.

Topics: Adult; Biopsy; Granuloma; Humans; Male; Muramidase; Peptidyl-Dipeptidase A; Pruritus; Sarcoidosis; Skin; Tattooing; Uveitis

Topics: Animals; Biopterins; Calcium; Cell Degranulation; Chronic Pain; Female; Gene Expression; GTP Cyclohydrolase; Histamine; Humans; Hydroxychloroquine; Integrases; Ion Transport; Male; Mast Cells; Mice; Mice, Knockout; Muramidase; Nitric Oxide; Oxidation-Reduction; p-Methoxy-N-methylphenethylamine; Pruritus; Sensory Receptor Cells; Serotonin; Signal Transduction; Transgenes

The anti-anaphylactic and anti-pruritic activities of a 35% EtOH extract (IT) of the flowers of Impatiens textori MIQ. were investigated by in vivo assay. IT and apigenin (1), apigenin 7-glucoside (2) and luteolin (3), principal compounds from IT, inhibited compound 48/80 (COM)-induced by blood pressure (BP) decrease, which was an immunoglobulin (Ig)E-independent anaphylaxis-like response. Compounds 1-3 all inhibited BP decrease induced by IgE-dependent anaphylaxis. Furthermore, IT also inhibited the blood flow (BF) decrease induced by antigen-induced anaphylaxis in actively sensitized mice. IT showed a significant inhibitory effect on scratching behavior induced by COM without a central depressant. IT also significantly inhibited platelet activating factor (PAF)- and serotonin (5-HT)-induced scratching behavior and mitigated protease (PA)-induced scratching behavior. These findings showed that the flowers of I. textori can be utilized as an anti-anaphylactic and anti-pruritic agent in addition to the traditional applications of this plant.

Topics: Anaphylaxis; Animals; Behavior, Animal; Blood Pressure; Flowers; Hypnotics and Sedatives; Immunoglobulin E; Impatiens; Male; Mice; Motor Activity; Muramidase; p-Methoxy-N-methylphenethylamine; Platelet Activating Factor; Pruritus; Regional Blood Flow; Serotonin

Topics: Aged; Blood Proteins; Chemotaxis, Leukocyte; Chromatography, Gel; Chronic Disease; Cytoplasmic Granules; Eosinophil Granule Proteins; Female; Granulocytes; Humans; Lactoferrin; Leukocyte Count; Muramidase; Neutrophils; Peroxidase; Pruritus; Ribonucleases