muramidase and Primary-Myelofibrosis

Topics: Aneuploidy; Basophils; Blood Platelets; Cell Transformation, Neoplastic; Child; Clinical Enzyme Tests; Cytogenetics; Eosinophilia; Fetal Hemoglobin; Fever; Hematologic Diseases; Humans; Leukemia, Myeloid; Leukocyte Count; Lymphatic Diseases; Muramidase; Primary Myelofibrosis; Prognosis; Skin Manifestations; Thrombocytosis; Vitamin B 12

The features of nonspecific defense factors were studied in 42 patients with chronic myeloid leukemia (CML) and in 18--with chronic subleukemic myelosis (CSM), in the presence of the treatment including polychemotherapy and plasmocytapheresis. Significant changes have been detected in the humoral factors of nonspecific defense (lysozyme, beta-lysins, complement components), as well as in the cellular component (phagocytic activity of the cells) in CML patients, these changes were growing with the leukemic process progressing. Plasmocytapheresis conducted produced no appreciable effect on the parameters of nonspecific resistance in the patients.

Topics: Antimicrobial Cationic Peptides; Blood Proteins; Complement System Proteins; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Monocytes; Muramidase; Neutrophils; Phagocytosis; Primary Myelofibrosis; Proteins

One patient with gastric carcinoma and secondary myelofibrosis due to disseminated bone marrow metastasis had markedly elevated lysozyme (LZM) levels in serum and urine with the intense presence of LZM within tumor tissues. It is considered to be a case of gastric carcinoma with LZM secreting functional capacities. To date, there were many reported cases to verify the LZM positive cells by LZM staining in the tissue of gastric carcinoma and to demonstrate the elevated serum levels of LZM in malignant tumor bearing patients, whereas no papers to disclose the elevated levels of LZM in serum and urine originated from the productions and secretions of gastric carcinoma cells. So, this report might be the first reported case of LZM secreting tumor verified by LZM staining of carcinoma cells except for haematological malignancies such as acute monocytic leukemia or myelomonocytic leukemia.

Topics: Adenocarcinoma; Bone Marrow; Bone Neoplasms; Humans; Male; Middle Aged; Muramidase; Primary Myelofibrosis; Stomach Neoplasms

Topics: Adult; Clinical Enzyme Tests; Hematologic Diseases; Humans; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Muramidase; Polycythemia Vera; Primary Myelofibrosis; Urine

Topics: Adult; Anemia; Anemia, Sideroblastic; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemoid Reaction; Leukocytosis; Monocytes; Muramidase; Myeloproliferative Disorders; Polycythemia Vera; Primary Myelofibrosis

Topics: Acetates; Alkaline Phosphatase; Biopsy; Blood Cell Count; Blood Proteins; Bone Marrow; Chlorine; Chronic Disease; Clinical Enzyme Tests; Diagnosis, Differential; Esterases; Humans; Leukemia; Lymphatic Diseases; Lymphoma, Large B-Cell, Diffuse; Monocytes; Muramidase; Neutrophils; Primary Myelofibrosis; Reticulocytes

Topics: Adult; Aged; Blood Urea Nitrogen; Female; Humans; Hypokalemia; Kidney Tubules; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Middle Aged; Muramidase; Myeloproliferative Disorders; Polycythemia Vera; Primary Myelofibrosis; Radiography; Spleen

Topics: Adult; Anemia, Sideroblastic; Bone Marrow Diseases; Humans; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Lymphoma; Monocytes; Multiple Myeloma; Muramidase; Polycythemia Vera; Primary Myelofibrosis